Effect of Mitochondrial Tu Translation Elongation Factor on Water-holding Capacity of Qinchuan Cattle Meat during Postmortem Aging by SI Jianfang, ZHANG Jing, GAO Shuang, MA Jiarong, CAO Songmin, LI Yalei, LUO Ruiming

“…Through proteomics, 23 differential proteins related to TUFM were identified, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the differential proteins could mediate cellular autophagy by participating in energy metabolism through a variety of pathways. …”
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Ranolazine Improves Glycemic Variability and Endothelial Function in Patients with Diabetes and Chronic Coronary Syndromes: Results from an Experimental Study by Annunziata Nusca, Federico Bernardini, Fabio Mangiacapra, Ernesto Maddaloni, Rosetta Melfi, Elisabetta Ricottini, Francesco Piccirillo, Silvia Manfrini, Gian Paolo Ussia, Francesco Grigioni

“…Patients starting ranolazine (n=16) were evaluated for short-term GV, haemoglobin 1Ac (Hb1Ac) levels, endothelial-dependent flow-mediated vasodilation (FMD), and oxidative stress levels at enrolment and after 3-month follow-up. …”
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Osobnost a dílo Matouše Radouše a tvorba renesančních epitafů v Chrudimi by Ondřej Jakubec, Radka Milotová

“…One of them is formal characteristic of the epitaphs representing a typical Central-European works of art adopting the Mannerist art influence mediated though the court of Rudolph II in Prague. …”
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Emotional Intervention and Education System Construction for Rural Children Based on Semantic Analysis by Xiaobo Zhang

“…Adversity beliefs played a partial mediating role between children’s parent-child bonding and positive emotions. …”
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CREDIT RISK MANAGEMENT AND PROFITABILITY OF DEPOSIT MONEY BANKS IN NIGERIA by Alade Ayodeji ADEMOKOYA, Mubarak Olajide SALAMI, Halimat Bukola ISAU, Habeeb Abiola IBRAHIM

“… Banks in all climes are primarily faced with problem of credit risk whenever they mediate between the surplus and the deficit units of the economy. …”
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Successful Treatment of Plasma Cell-Rich Acute Rejection Using Bortezomib: A Case Report by Sara Hashemi, Reut Hod-Dvorai, Rebecca Tong, Liye Suo

“…The allograft biopsy showed acute T cell–mediated rejection (TCMR), Grade IIA, plasma cell-rich variant. …”
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Humoral and Cellular Immune Regulation in Albino Rat Exposed to Glyphosate and Aluminum Phosphide by Ujuamala Ezeani, Onyemaechi Afonne, Michael Ezeani

“…Additionally, there was a notable reduction in CD4+ levels at the second and third months post-exposure (p=0.001 and p<0.001, respectively).Conclusion: This study identified a deregulation of the immune system characterized by a progressive immunosuppression of CD4 T cell counts, indicating a down regulation of antibody-mediated (humoral) immune responses alongside an up regulation of cytotoxic T cells. …”
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Exosomal miR-141-3p from PDLSCs Alleviates High Glucose-Induced Senescence of PDLSCs by Activating the KEAP1-NRF2 Signaling Pathway by Min Liu, Rui Chen, Yunxuan Xu, Jiawen Zheng, Min Wang, Ping Wang

“…Further analyses revealed that microRNA-141-3p (miR-141-3p) was expressed at relatively high levels in PDLSC-Exos and was instrumental in PDLSC-Exo-mediated restoration by downregulating Kelch-like ECH-associated protein 1 (KEAP1), which is a negative regulator of NRF2 expression. …”
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Exploring body mass index and gender-based self-esteem differences in Saudi Arabia by Maaidah Algamdi

“…For men, the indirect effects show that education (Estimate = 0.0173*) and marital status (Estimate = −0.0405*) significantly influence SE, with other factors mediating these effects. Both genders experience significant and detrimental impacts from BMI on SE, with males experiencing a more pronounced impact. …”
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Effect of Differently Polarized Human Macrophages on the SH-SY5Y Cells Damaged by Ischemia and Hypoxia In Vitro by Ivan Mikhailovich Rashchupkin, Ekaterina Yakovlevna Shevela, Aleksandra Aleksandrovna Maksimova, Marina Aleksandrovna Tikhonova, Aleksandr Anatolevich Ostanin, Elena Removna Chernykh

“…The results obtained indicate that human macrophages have neuroprotective and neuroregenerative activity, which is mediated by soluble factors, is most characteristic for macrophages activated by efferocytosis (M2(LS)), and is most prominent under in vitro conditions simulating the combined effect of ischemia/hypoxia.…”
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The Effects of Exposure to Repeated Minor Pain During the Neonatal Period on Formalin Pain Behavior and Thermal Withdrawal Latencies by C Celeste Johnston, Claire-Dominique Walker

“…The results suggest that changes in maternal care may be an important factor mediating the long-term effects of repeated neonatal experiences of pain.…”
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Acute Genetic Damage Induced by Ethanol and Corticosterone Seems to Modulate Hippocampal Astrocyte Signaling by Ana Laura Reyes-Ábalos, Magdalena Álvarez-Zabaleta, Silvia Olivera-Bravo, María Vittoria Di Tomaso

“…Obtained results revealed that astrocytes exposed to acute EtOH and/or CTS preserved their typical morphology but presented severe DNA damage, triggered canonical DDR pathways, and early changes in the cell signaling mediated by EVs and NTs. Further deepening of this initial morphological and quantitative analysis is necessary to identify the mechanistic links between genetic damage, DDR, cell-cell communication, and their possible impact on hippocampal neural cells.…”
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Metabolism-Related Adipokines and Metabolic Diseases: Their Role in Osteoarthritis by Zhang Q, Zhao YX, Li LF, Fan QQ, Huang BB, Du HZ, Li C, Li W

“…This condition contributes to the formation of a distinct phenotype, termed metabolic syndrome-associated osteoarthritis (MetS-OA),which differs from other metabolically related diseases by its unique pathophysiological mechanisms and clinical presentation. As key mediators of MetS, metabolic adipokines such as leptin, lipocalin, and resistin regulate inflammation and bone metabolism through distinct or synergistic signaling pathways. …”
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Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vitro, HPDENs showed light dose-dependent cytotoxicity against human melanoma cells, characterized by elevated ROS production and apoptosis induction. In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis by Dongxu Lin, Mengyang Zhang, Changcheng Luo, Pengyu Wei, Kai Cui, Zhong Chen

“…EAP rats performed serious leukocyte infiltration, advanced inflammatory grade, and abnormal expression of inflammatory mediators. Abundant collagen deposition, enhanced RhoA, ROCK1, and α-SMA protein levels indicated that EAP rats were prone to suffer from stromal fibrosis compared with control group. …”
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Mycobacterium spp. exposure, childhood vaccinations, and early childhood brain and CNS cancers by Samer Singh, Rakesh K. Singh

“…However, interestingly, prevailing tuberculin immunoreactivity, a surrogate for the existence of heterologous cell-mediated immunity resulting from exposure to Mycobacterium spp., including Bacille Calmette-Guérin (BCG) vaccination, for these populations, is found consistently negatively correlated with the BCNS cancer incidence in 0-4Y-olds for countries mandating neonatal BCG vaccination [r(24): -0.7226, p-value:&lt;0.0001]. …”
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How does individualised physiotherapy work for people with low back pain? A Bayesian Network analysis using randomised controlled trial data. by Bernard X W Liew, Jon J Ford, Marco Scutari, Andrew J Hahne

“…The current study cannot rule out that unmeasured mechanisms (such as tissue healing or reduced inflammation) may mediate the relationship between individualised physiotherapy treatment and improvement in disability. …”
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Background and Foreground: Connections and Distinctions When Health Professions Faculty Teach Both Interprofessional Collaborative Practice and Quality Improvement—A Case Study by Katherine Stevenson, Johan Thor, Marcel D’Eon, Linda A Headrick, Boel Andersson Gäre

“…Furthermore, they described the relationship between QI and ICP as one mediated by systems thinking, where ICP is backgrounded as a critical pre-requisite and QI is foregrounded as a vector for developing interprofessional competencies. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…ABSTRACT Background and Aims Sensitivity to immune checkpoint inhibitor (ICI) therapy depends in part on the genetic and epigenetic makeup of cancer cells, and CD8 T‐lymphocytes that mediate immune responses. Epigenetics are heritable reversible changes in gene expression that occur without any changes in the nuclear DNA sequence or DNA copy number. …”
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Metapoznanie – czy możemy być świadomi przebiegu własnego procesu uczenia się stosując neurofeedback by Irena Grochowska

“…The human mind is the mediator of knowledge about the world because no human being has direct knowledge of their surrounding reality. …”
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