Present and future of cancer nano-immunotherapy: opportunities, obstacles and challenges by Man Wang, Fei Yu, Yuan Zhang

“…Strategies to remove these hindrances mainly focus on the development of combinatorial therapies or the exploitation of novel immunotherapeutic mediations. Nanomaterials carrying anticancer agents to the target site are considered as practical approaches for cancer treatment. …”
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Results of experimental infection of vaccinated and non-vaccinated ducklings with duck hepatitis virus by A. A. Chesnokova, E. V. Ivanova, V. V. Pronin, O. A. Chupina, V. Yu. Fomenko, M. S. Volkov, V. N. Irza

“…It has been shown that in case of immunization of 3-day-old ducklings, the experimental vaccine induces antibody-mediated immune response, no harmful effect is produced on poultry if a tenfold dose is admin­istered which indicates its safety, and the vaccine ensures protection against infection with a control virulent strain of hepatitis virus.…”
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Role of nasal microbiota in regulating host anti-influenza immunity in dogs by Jinzhu Geng, Yuhao Dong, Hao Huang, Xia Wen, Ting Xu, Yanbing Zhao, Yongjie Liu

“…Considering that influenza A virus is increasingly recognized as an important canine respiratory pathogen, this study investigated the cross-talk between nasal and lung tissues mediated by microbes and its association with influenza susceptibility in a beagle dog model. …”
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Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome by Kathryn Jespersen, Chenxin Li, Rishi Batra, Christopher A. Stephenson, Paul Harding, Kylie Sestak, Ryan T. Foley, Harrison Greene, Trevor Meisinger, Jason R. Cook, B. Timothy Baxter, Wanfen Xiong

“…Enhanced Notch3 activation in MFS contributed to aortic aneurysm formation in MFS. This might be mediated by inducing a contractile phenotypic change of SMC. …”
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Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons by Eduardo Pérez-Palma, Víctor Andrade, Mario O. Caracci, Bernabé I. Bustos, Camilo Villaman, Matías A. Medina, Miguel E. Ávila, Giorgia D. Ugarte, Giancarlo V. De Ferrari

“…Our results indicate that Wnt/β-catenin mediated transcription controls multiple biological processes related to neuronal structure and activity that are affected in synaptic dysfunction disorders.…”
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Yersinia Infection with Clostridium Difficile Colitis by M.J. Fishman, M.A. Noble, H.J. Freeman

“…Antibimic associated diarrhea appears to be largely due to Closcridium difficile and may have, at least in part. a toxin mediated pathogenesis. Because a poor correlation exists between measurable toxin titres and symptoms, additional copathogenic factors may be important. …”
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Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance by Santiago Rodríguez de Córdoba, Andrea Reparaz, Daniel Sanchez, Sheila Pinto, Lucia Juana Lopez, Héctor Martin Merinero, Iria Calvete, Julian Perez-Perez, Sydney S. Jellison, Yuzhou Zhang, Richard J. H. Smith, Inmaculada Moreno, Mercedes Dominguez

“…Factor H (FH) is a crucial complement regulator that prevents complement-mediated injury to healthy cells and tissues. This regulatory function can be disrupted by Factor H autoantibodies (FHAA), which then leads to diseases such as atypical hemolytic uremic syndrome (aHUS) and C3 Glomerulopathy (C3G). …”
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Epidermal stem cell derived exosomes-induced dedifferentiation of myofibroblasts inhibits scarring via the miR-203a-3p/PIK3CA axis by Shixin Zhao, Haoran Kong, Dahu Qi, Yushuang Qiao, Yu Li, Zhiming Cao, Hanwen Wang, Xuefeng He, Hengdeng Liu, Hao Yang, Suyue Gao, Tao Liu, Julin Xie

“…In this study, we used comparative transcriptomics and single-cell sequencing to identify key molecules and pathways that mediate fibrosis and myofibroblast transdifferentiation. …”
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The Role of Antioxidant Activity of Chitosan-Pinus merkusii Extract Nanoparticle in against Lead Acetate-Induced Toxicity in Rat Pancreas by G. Wardani, Ernawati, K. Eraiko, S. A. Sudjarwo

“…It could be concluded that Chitosan-Pinus merkusii nanoparticle has a potential to be a powerful agent and may be useful as an antioxidant against free radical-induced oxidative stress and pancreatic cell damage mediated by lead acetate intoxication.…”
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Comprehensive phenotypic analysis of multiple gene deletions of α-glucan synthase and Crh-transglycosylase gene families in Aspergillus niger highlighting the versatility of the fu... by Katharina J. Ost, Mark Arentshorst, Bruno M. Moerschbacher, Mareike E. Dirks-Hofmeister, Arthur F.J. Ram

“…To determine whether the ags and crh gene families have redundant functions, both gene families were deleted using iterative CRISPR/Cas9 mediated genome editing. The 12-fold deletion mutant was viable and did not exhibit growth defects under non-stressing growth conditions. …”
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Biosynthetic pathway for leukotrienes is stimulated by lipopolysaccharide and cytokines in pig endometrial stromal cells by Barbara Jana, Aneta Andronowska, Jarosław Całka, Aleksandra Mówińska

“…Abstract An inflammatory response is related to different inflammatory mediators generated by immune and endometrial cells. …”
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Social Cognition in Patients with Early-Onset Parkinson’s Disease by Ana Natalia Seubert-Ravelo, Ma Guillermina Yáñez-Téllez, María Lizbeth Lazo-Barriga, Alejandra Calderón Vallejo, Carlos Eduardo Martínez-Cortés, Adela Hernández-Galván

“…Only decision-making seems to be mediated by overall cognitive ability. The confounding or contributing effect of other clinical PD variables should be studied further.…”
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Soil microbiome composition is highly responsive to precipitation and plant composition manipulations in a field biodiversity experiment by Haley M. Burrill, Haley M. Burrill, Susan M. Magnoli, James D. Bever

“…IntroductionClimate change and plant biodiversity loss have large impacts on terrestrial ecosystem function, with the soil microbiome being primary mediators of these effects. The soil microbiome is a complex system, consisting of multiple functional groups with contrasting life histories. …”
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Comparative transcriptome analysis reveals potential regulatory mechanisms in response to changes in physiological functions in Oreochromis aureus under salinity stress by Chang Yuan, Kangqi Zhou, Xianhui Pan, Yong Lin, Junqi Qin, Dapeng Wang, Zhong Chen, Xuesong Du, Yin Huang

“…This study enhances our understanding of O. aureus adaptive strategies under salinity stress, while also providing relevant theoretical insights into the domestication of fish under saline conditions and the mechanisms mediating adaptations to saline aquatic environments.…”
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Gastrospheres as a Model of Gastric Cancer Stem Cells Skew Th17/Treg Balance toward Antitumor Th17 Cells by Alaleh Rezalotfi, Ghasem Solgi, Marzieh Ebrahimi

“…Gastrosphere, an enriched cellular population with stem-like properties believed to be responsible for an escape from immune-mediated destruction. Th17 and Treg cells play a major role in gastric cancer; however, their interaction with gastrospheres remained elusive. …”
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Ecological portraits: Mapping functional spectra and space characteristics of birds in China by Fei Duan, Ming Gao, Shuyi Zhu, Xiaoli Shen, Sheng Li

“…The functions of wildlife species in ecosystems and their responses to environmental changes are mediated through their functional traits. By mapping the gradient across the diversity of bird ecological strategies (functional spectra) and quantifying the functional spaces of the focus taxon, we can better understand their ecological requirements and acquire critical information needed for developing effective conservation strategies. …”
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Effect of Bacillus subtilis JZXJ-7, a Strain Isolated from Shrimp Paste, on Colonic Function and Microbial Community in Mice Infected with Vibrio parahaemolyticus by ZHOU Kui, WANG Rundong, GONG Mengxue, MOU Jingyuan, DENG Yijia, LI Xuepeng, ZHANG Yuhao, LI Jianrong

“…Moreover, high-dose JZXJ-7 significantly inhibited cytokine-mediated inflammation, increased antioxidant enzyme activities and enhanced intestinal permeability. …”
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Unveiling the role of melatonin‐related gene CSNK1D in osteoclastogenesis and its implications for osteoporosis treatment by Jiewen Zhang, Shaobo Wu, Fangze Xing, Ning Kong, Yiwei Zhao, Xudong Duan, Yiyang Li, Kunzheng Wang, Run Tian, Pei Yang

“…Functional analyses showed involvement of CSNK1D in OC differentiation and inflammatory pathways. in vitro experiments confirmed CSNK1D upregulation during OC differentiation, and small interfering RNA‐mediated knockdown reduced OC marker expression and TRAP+ cell formation. in vivo, CSNK1D expression is associated with bone loss in OP rats. …”
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Effect of non-surgical periodontal therapy on salivary and gingival crevicular fluid concentration of visfatin in periodontal health and disease by Hira Ismail, Anjani Kumar Pathak, Nand Lal, Pavitra Rastogi, Kaleem Ahmad, Mohd. Aamir Khan

“…Background and objective: Visfatin, a pleotropic mediator mostly produced by visceral fat, is crucial in controlling the immunological and defensive systems. …”
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Calreticulin as an Adjuvant In Vivo to Promote Dendritic Cell Maturation and Enhance Antigen-Specific T Lymphocyte Responses against Melanoma by Zheng Gong, Ming Chen, Jie Miao, Chao-Jie Han, Qiao Zhong, Fang-Yuan Gong, Xiao-Ming Gao

“…OVAp-CRT-immunized mice generated significantly increased OVAp-specific antibody and CD4+/CD8+ memory T cells, which mediated long-term protective effects. OVAp-CRT upregulated CD40, CD80, and CD86 expressions in splenic conventional DCs. …”
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