CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

“…Altogether, our data indicate that navarixin blocks CCL21/CCR7-mediated neuron-microglia communication and could be used as a therapeutic strategy against PD. …”
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The moderating effects of physical activity on social anxiety and sleep disturbance: managing gaming disorder in young e-sports players by Serdar Solmaz, Mehmet İnan, Mustafa Yaşar Şahin

“…This study aims to examine the potential relationship between IGD, social anxiety, and insomnia, investigate the mediating role of social anxiety in this relationship, and explore the moderating role of physical activity in alleviating the negative effects of IGD.MethodsThe study involved 475 adolescent and young e-sports players aged 14–24, who typically engage in an average of 6 h of gaming per day. …”
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Applying Educational Programming Language-Based Learning to Enhance the Programming Skills of Non-ICT Engineering College Students by Jorge Rodas-Silva, Jorge Parraga-Alava, Mariuxi Vinueza-Morales, Ana Eva Chacón Luna, Jesennia Cárdenas-Cobo

“…The study results showed that students who received EPL-mediated learning with App Lab had significant increase in their programming skills. …”
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Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Secretory phospholipase A2 (sPLA2), an inflammatory enzyme, plays a critical role in producing platelet-activating factor (PAF), a key mediator of vascular leak. Elevated sPLA2 activity has been linked to the progression of DHF. …”
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Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways by El-Shaimaa A. Arafa, Noura T. Shurrab, Manal A. Buabeid

“…Furthermore, tangeretin works through mitigating levels of inflammatory mediators in the immune system. Using tangeretin in combination with clinically applied anticancer drugs could be a good strategy for increasing the efficiency of these agents and protecting noncancerous cells from damage caused by chemotherapy. …”
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High SERS performance of functionalized carbon dots in the detection of dye contaminants by Yanqiu Yang, Lingru Kong, Yong Ding, Lixin Xia, Shuo Cao, Peng Song

“…Conclusion: Based on this deeper insight on plasmon-mediated mechanism, the SERS substrate was successfully practiced for quantitative determination in real water and fish samples. …”
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Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells by Gifty A. Mensah, Anastasia Williams, Pooja Khatkar, Yuriy Kim, James Erickson, Alexandra Duverger, Heather Branscome, Kajal Patil, Hafsa Chaudhry, Yuntao Wu, Olaf Kutsch, Fatah Kashanchi

“…Recently, we have found that exosomes, which are small, membrane-enclosed particles released by virtually all cell types and known to mediate intercellular communication, caused an increase in RNA Polymerase II loading onto the HIV-1 promoter. …”
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Geranylgeranyl Transferase-I Knockout Inhibits Oxidative Injury of Vascular Smooth Muscle Cells and Attenuates Diabetes-Accelerated Atherosclerosis by Guo-Ping Chen, Jian Yang, Guo-Feng Qian, Wei-Wei Xu, Xiao-Qin Zhang

“…Geranylgeranyl transferase-I (GGTase-I) is an essential enzyme mediating posttranslational modification, especially the geranylgeranylation of small GTPase, Rac1. …”
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Transcriptomic dynamics and cell-to-cell communication during the transition of prospermatogonia to spermatogonia revealed at single-cell resolution by Zhen He, Rong-Ge Yan, Qin-Bang Shang, Qi-En Yang

“…Specifically, we found that prospermatogonia mainly receive signals, while Leydig cells and peritubular myoid cells are the mediators for transmitting signals, indicating their potential roles in regulating the development and differentiation of prospermatogonia. …”
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Two-stage efficiency evaluation of industrial water resources and the role of digital inclusive finance: insight from Yangtze River Delta by Linjie Feng, Tingting Liu, Zhenjie Yang, Yi Shi, Hongxi Chen, Ka Leong Chan, Bin Chen

“…As shown by the Kernel density Estimation, the degree of efficiency dispersion within same metropolitan area is reducing; and (4) digital inclusive finance will boost overall efficiency and water treatment efficiency, with green innovation as a mediating factor. The findings herein offer compelling evidence that financial development increases the effectiveness of water resources, introduce fresh perspectives for the government to put forward water-related policies, and provide ideas for high-quality economy.…”
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Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System by Bella S. Guerrouahen, Heba Sidahmed, Asma Al Sulaiti, Moza Al Khulaifi, Chiara Cugno

“…The precise mechanism by which MSCs affect functions of most immune effector cells is not completely understood but involves direct contact with immune cells, soluble mediators, and local microenvironmental factors. Recently, it has been shown that their homeostatic resting state requires activation, which can be achieved in vitro with various cytokines, including interferon-γ. …”
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Enhanced Laser Damage Threshold in Optically Addressable Light Valves via Aluminum Nitride Photoconductors by Soroush Ghandiparsi, Bikram Chatterjee, Jimmy‐Xuan Shen, Miranda S. Gottlieb, Clint D. Frye, Joseph D. Schneider, Ryan D. Muir, Brandon W. Buckley, Sara E. Harrison, Qinghui Shao, Joel B. Varley, Lars F. Voss

“…Design considerations for OALVs incorporating UWBG photoconductors are discussed, and the photoresponsivity from defect‐mediated sub‐bandgap absorption in AlN crystals is verified as sufficient for OALVs operating under high light fluences. …”
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Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis by Jie Yang, Lin Yang, Yanjiao Wang, Lu Huai, Bohan Shi, Di Zhang, Wei Xu, Di Cui

“…This article summarized the inflammatory mechanisms of IL-6 cross-talked with other mediators of some chronic diseases in vitro, animal models, and human experiments, leading to the activation of pathways and accelerating the progression of sepsis. …”
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Salivary Levels of Interleukin-17 in Iranian Patients With Systemic Sclerosis by Ali Tadayon, Javad Moayedi, Mohamad Ali Nazarinia, Mahyar Malekzadeh, Sara Kazemi, Maryam Mardani

“… Systemic sclerosis (SSc) is a rare immune-mediated rheumatic disease in which the skin, muscles, blood vessels, and internal organs are damaged through chronic inflammation. …”
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Positive resonance: Successful interpersonal emotion regulation facilitated relationship closeness by enhanced inter-brain synchronization by Tongtong Zhu, Xiaoxuan Zhang, Luyao Jin, Linzi Wang, Yanmei Wang

“…The increased IBS pattern of these brain regions played a mediational role between the effectiveness of down-regulating targets’ negative emotions and the increment of IRC. …”
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CHOLINE TRANSPORTER-RELATED 4 (CTR4) Is Involved in Drought and Saline Tolerance in Rice by Yu Shicong, Luo Ruxian, Zheng Shuqin, Ning Jing, Shi Yuanzhu, Guo Daiming, Jia Liangmeng, Wang Sen, Xiao Guizong, Guo Pengwang, Li Yang, Ma Xiaoding

“…These findings suggest that CTR4 mediates choline transport and influences cell membrane formation, thereby enhancing rice defenses against drought and salt stress by maintaining lipid homeostasis.…”
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Modulatory Effect of 1,25-Dihydroxyvitamin D3 on IL1β-Induced RANKL, OPG, TNFα, and IL-6 Expression in Human Rheumatoid Synoviocyte MH7A by Xiaoke Feng, Chengyin Lv, Fang Wang, Ke Gan, Miaojia Zhang, Wenfeng Tan

“…In summary, although it has a biological function to induce RANKL expression, 1,25(OH)2D3 could upregulate OPG/RANKL ratio and mediate anti-inflammatory action in an inflammatory milieu of synoviocyte, contributing to the inhibition of inflammation-induced osteoclastogenesis in RA.…”
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Characterization of tumor prognosis and sensitive chemotherapy drugs based on cuproptosis-related gene signature in ovarian cancer by Wei Tan, Fangfang Dai, Qinyu Ci, Zhimin Deng, Hua Liu, Yanxiang Cheng

“…Abstract Background Cuproptosis is a novel form of cell death, acting on the tricarboxylic acid cycle in mitochondrial respiration and mediated by protein lipoylation. Other cancer cell death processes, such as necroptosis, pyroptosis, and ferroptosis, have been shown to play crucial roles in the therapy and prognosis of ovarian cancer. …”
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Integrated information theory reveals the potential role of the posterior parietal cortex in sustaining conditioning responses in classical conditioning tasks by Tien Cuong Phi, Shin Ishii, Shin Ishii, Shin Ishii, Masashi Kondo, Masanori Matsuzaki, Masanori Matsuzaki, Masanori Matsuzaki, Masanori Matsuzaki, Ken Nakae

“…Previous research has identified key neural regions involved in processing reward-predicting cues and mediating licking behavior. However, the mechanisms that sustain high conditioned response rates across repeated sessions remain elusive, particularly regarding how the reward expectation is represented on a session-by-session basis. …”
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SECTM1 acts as an immune-related biomarker of poor prognosis and promotes cancer progression by modulating M2 macrophage polarization in esophageal squamous cell carcinoma by Pengzhou Kong, Pengzhou Kong, Pengzhou Kong, Ye Jiao, Ye Jiao, Meng Sun, Meng Sun, Zhinan Zhou, Zhinan Zhou, Yingying Zhang, Yingying Zhang, Xin Yang, Xin Yang, Jing Ren, Jing Ren, Mengyuan Yang, Mengyuan Yang, Yanyan Dong, Yanyan Dong, Yanyan Dong, Bin Song

“…Furthermore, its overexpression promoted macrophage polarization towards the M2-like phenotype and promoted the migration of M2-like macrophage cells and C-C Motif Chemokine Ligand 5 (CCL5) was the key mediator in the pro-cancer effect of SECTM1. In a Conclusion, our study established a prognostic prediction model based on immune-related gene signature, which provided a reliable prognostic tool for ESCC and identified SECTM1 as a potential biomarker in ESCC.…”
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