Demethylnobiletin and its major metabolites: Efficient preparation and mechanism of their anti-proliferation activity in HepG2 cells by Yanping Xin, Ting Zheng, Man Zhang, Ruiqiang Zhang, Siyue Zhu, Dongli Li, Denggao Zhao, Yanyan Ma, Chi-Tang Ho, Qingrong Huang

“…The expression of cleaved caspase-3 was the highest in cells treated with 5,4'-DDMN, implying that the apoptosis induced by other OH-PMFs might be mediated by other apoptotic execution proteins. Our research reveals the application potential and scientific evidence for the production and functionality of OH-PMFs.…”
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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger oxidative stress through enhanced ROS production in hepatocytes and Kupffer cells, leading to mitochondrial dysfunction and lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation of endotoxins like LPS, which activate inflammatory pathways through TLR4 signaling and promote oxidative stress via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB and Nrf2 serve as crucial mediators in the gut-liver axis, with NF-κB regulating inflammatory responses and Nrf2 orchestrating antioxidant defenses; (4) Oxidative stress-induced damage to intestinal barrier function creates a destructive feedback loop, further exacerbating liver inflammation and disease progression. …”
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ENHANCING PROFESSIONAL DEVELOPMENT THROUGH INTERNATIONAL COLLABORATIVE DIALOGUE: A STUDY OF MALAYSIAN AND AUSTRALIAN PRE-SERVICE TEACHERS by Vegneskumar Maniam, Tay Gerard, Ingrid Harrington, Hayley Trenchard, Susan Bennett

“…Findings - Analysis of the interview data revealed six key themes: (1) Games in the Classroom, (2) Inclusive Mindsets, (3) Planning in Teaching and Learning, (4) Computer-Mediated Communication (CMC), (5) International and Comparative Education, and (6) Workshop Sustainability. …”
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Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS by Federica Pilotto, Paulien Hermine Smeele, Olivier Scheidegger, Rim Diab, Martina Schobesberger, Julieth Andrea Sierra-Delgado, Smita Saxena

“…Considerable progress has been made in identifying C9ORF72-mediated disease and resolving its underlying etiopathogenesis. …”
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GNA15 predicts poor outcomes as a novel biomarker related to M2 macrophage infiltration in ovarian cancer by Qin Liu, Qin Liu, Yabing Sun, Yabing Sun, Tao Zhang, Wanrun Lin, Jing Zhang, Huijuan Zhang, Huijuan Zhang, Wenxin Zheng, Hong Xu, Hong Xu, Feng Zhou, Feng Zhou

“…Subsequently, in vitro cell experiments and OC cohorts were performed.ResultsGene set enrichment analysis revealed that GNA15 is involved in immune responses like leukocyte transendothelial migration and FcγR-mediated phagocytosis. GNA15 was up-regulated in cisplatin-resistant OC cells, and its in vitro down-regulation decreased cell proliferation. …”
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Efficacy of CLT4A variants as immunoregulatory molecules among Vitiligo patients in Saudi Arabia by Amal F. Alshammary, Ghada BinSaif, Imran Ali Khan

“…Abstract Vitiligo is a skin depigmentation condition caused by the immune-mediated perdition of melanocytes. In vitiligo, cytotoxic T-lymphocytes damage melanocytes, causing skin depigmentation. …”
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Oral Hygiene in Children with Autism: Teaching Self-Toothbrushing via Behavioural Intervention Including Parents by Marco Esposito, Carlotta Piersanti, Roberta Fadda, Marco Boitani, Monica Mazza, Giuseppina Marrocco

“…In this study, the efficacy is explored of a behavioral intervention mediated by staff and parents in teaching self-brushing teeth in eight autistic children. …”
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Natural products based on Correa's cascade for the treatment of gastric cancer trilogy: Current status and future perspective by Wenhao Liao, Jing Wang, Yuchen Li

“…In Phase II, NPs modulate multiple pathways and mediators regulating gastric mucosal cell cycle, apoptosis, autophagy, and angiogenesis to reverse gastric precancerous lesions. …”
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Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease by Naphatthakarn Kerdsaeng, Sittiruk Roytrakul, Suwannee Chanprasertyothin, Piangporn Charernwat, Sirintorn Chansirikarnjana, Piyamitr Sritara, Jintana Sirivarasai

“…Unique AD glycoproteins were associated with numerous pathways, including Alzheimer’s disease-presenilin pathway (16.6%), inflammation pathway mediated by chemokine and cytokine signaling (9.2%), Wnt signaling pathway (8.2%), and apoptosis signaling pathway (6.7%). …”
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Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts through regulation of the HOXA6/ZBTB12 axis by Liu Haibo, Luo Shicheng, Sha Xiaofeng, Chen Zhiping, Yang Dongdong

“…Astragaloside IV was demonstrated to regulate the expression of ZBTB12 by mediating the transcriptional activity of HOXA6. Our findings shed light on the therapeutic value of astragaloside IV for gastric cancer.…”
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WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation by Mario Mauthe, Wenqi Yu, Oleg Krut, Martin Krönke, Friedrich Götz, Horst Robenek, Tassula Proikas-Cezanne

“…Moreover, the number of WIPI-1 positive autophagosome-like vesicles entrapping Staphylococci significantly increased upon (i) lysosomal inhibition by bafilomycin A1 and (ii) blocking PIKfyve-mediated PtdIns(3,5)P2 generation by YM201636. In summary, our results provide evidence that the PtdIns(3)P effector function of WIPI-1 is utilized during xenophagy of Staphylococcus aureus. …”
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Cannabinoid receptor 2 selective agonist ameliorates adjuvant-induced arthritis by modulating the balance between Treg and Th17 cells by Na Tian, Cui Yang, Yu Du, Miao Chen, Bin Li, Bin Li, Bin Li, Bin Li, Bin Li, Dan Li, Sheng-Ming Dai

“…The findings indicate that HU-308 holds potential as an immunomodulatory agent for RA, providing valuable insights into CB2-mediated therapeutic strategies for autoimmune diseases.…”
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Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens by Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa

“…Intriguingly, chloroquine treatment enhanced the R-848-mediated expression of MAPK11, LRRK2, and GATA3. These results align with transcriptomic findings and highlight the upregulation of STAT1 and STAT3 as potential contributors to the induction of Th1 and Th2 immune responses by R-848 in chickens. …”
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Association of qnr Genes and OqxAB Efflux Pump in Fluoroquinolone-Resistant Klebsiella pneumoniae Strains by Fereshteh Amereh, Mohammad Reza Arabestani, Seyed Mostafa Hosseini, Leili Shokoohizadeh

“…The aim of this study was to investigate the frequency and relationship between plasmid-mediated quinolone resistance genes and OqxAB pump genes, as well as the genetic linkage in K. pneumoniae strains isolated from Hamadan hospitals in the west of Iran. …”
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Rapid depletion of “catch-and-release” anti-ASGR1 antibody in vivo by Siva Charan Devanaboyina, Peng Li, Edward L. LaGory, Carrie Poon-Andersen, Kevin D. Cook, Marcus Soto, Zhe Wang, Khue Dang, Craig Uyeda, Ryan B. Case, Veena A. Thomas, Ronya Primack, Manuel Ponce, Mei Di, Brian Ouyang, Joelle Kaner, Sheung Kwan Lam, Mina Mostafavi

“…Targeting antigens with antibodies exhibiting pH/Ca2+-dependent binding against an antigen is an attractive strategy to mitigate target-mediated disposition and antigen buffering. Studies have reported improved serum exposure of antibodies exhibiting pH/Ca2+-binding against membrane-bound receptors. …”
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Mas'uliyah Society Brand Resonance: Enhancing Sustainable Marketing Performance of the National Health Insurance Program by Dina Lusianti, Widodo Widodo, Mulyana Mulyana

“…Mas'uliyah Appraisal Brand Resonance and Mas'uliyah Self-esteem Brand Resonance can mediate between Mas'uliyah Belonging Brand Resonance and Mas'uliyah Tangible Brand Resonance on sustainable marketing performance. …”
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Assessment of Protective Effects of Carvacrol on Haloperidol-Induced Oxidative Stress and Genotoxicity in Human Peripheral Blood Lymphocytes by Ehsan Zamani, Alireza Ahmadi Shad, Hediye Fatemi, Saba Mahboubi, Azadeh Motavallian, Mehdi Evazalipour

“…It can be presumed that the induction of oxidative stress by haloperidol is the critical event associated with haloperidol-mediated genotoxicity. Therefore, using carvacrol as a natural antioxidant protected human lymphocytes against haloperidol genetic damage.…”
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Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements by Lorenzo I. Finci, Mayukh Chakrabarti, Gulcin Gulten, Joseph Finney, Carissa Grose, Tara Fox, Renbin Yang, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Trent E. Balius, Dhirendra K. Simanshu

“…Our findings provide valuable insight into the contributions of HSP90 and CDC37 in mediating client folding.…”
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Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL by Ruiqing Wang, Huimin Xie, Zhaofeng Huang, Weirong Shang, Zuoming Sun

“…Activated T cells upregulate Bcl-xL to enhance their own survival. Bcl-xL-mediated survival is required for the generation of effectors that carry out the actual immune responses. …”
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Generation and analysis of mouse embryonic stem cells with knockout of the <i>Mcph1</i> (microcephalin) gene by A. M. Yunusova, A. V. Smirnov, T. A. Shnaider, I. E. Pristyazhnuk, S. Y. Korableva, N. R. Battulin

“…Thus, this evidence questions the hypothesis that Mcph1 knockout-mediated chromatin reorganization governs gene expression in mESCs. …”
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