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7861
Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in Mucopolysaccharidosis VII
Published 2025-03-01“…We found that both autophagosome biogenesis and lysosome-mediated autophagosomal turnover were impaired in the CG2135−/− fly brain. …”
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7862
Green transformational and transactional leadership in fostering green creativity among university students
Published 2023-07-01“…The aim of this study is to investigate the dynamic relationship between green transformational leadership, green transactional leadership and green creativity that are mediated by green intrinsic motivation.METHODS: This study used adapted constructs from previous environmental research as well as a newly-developed green transactional leadership construct. …”
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7863
Structural insights into dynamics of the BMV TLS aminoacylation
Published 2025-02-01“…Upon binding, TLS undergoes dynamic rearrangements, particularly with helices B3 and E pivoting, mediated by the unpaired A36 residue, ensuring effective recognition by TyrRS. …”
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7864
Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food.
Published 2024-06-01“…Animal models show that programmed offspring obesity is preceded by hyperphagia, but the mechanisms that mediate these changes are unknown. Using a mouse model of maternal obesity, we observed increased intake of a high-fat diet (HFD) in offspring of obese mothers that precedes the development of obesity. …”
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7865
Culture-independent detection of Mycobacterium tuberculosis complex DNA using targeted next generation sequencing in African buffalo (Syncerus caffer) oronasal swabs in South Afric...
Published 2025-02-01“…Controlling aTB in South Africa relies on mycobacterial culture as the gold standard for M. bovis confirmation, with the single intradermal comparative cervical test (SICCT) and Bovigam™ assays as validated cell-mediated immunological assays for detection. However, these methods are not without their shortfalls, with a suboptimal ability to discern true positive results amidst certain non-tuberculous mycobacteria (NTM) interference. …”
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7866
Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
Published 2024-09-01“…The study will help in designing effective and novel therapeutic interventions for targeting signaling pathways and other regulators involved in mediating CaCx progression, which will eventually help in effective management of CaCx.…”
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7867
Playful brains: a possible neurobiological pathway to cognitive health in aging
Published 2025-02-01“…In this theory and hypothesis manuscript, we propose a neurobiological pathway mediating the effects of social playfulness on cognition. …”
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7868
Search for electroweak production of a vector-like T quark using fully hadronic final states
Published 2020-01-01“…Upper limits at 95% confidence level are set on the cross sections for T quark-mediated production of tHQq, tZQq, and their sum, where Q is the associated top or bottom heavy quark and q is another associated quark. …”
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7869
MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies
Published 2025-01-01“…Mechanically, MELK binds to fatty acid-binding protein 5 (FABP5), and affects its ubiquitination through the K48R pathway to increase its stability, thereby activating protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling axis to weaken the RFA-mediated antitumor effect. In addition, the synthesis of arginylglycylaspartic acid (RGD)-lipid nanoparticles (LNPs) targeting tumor cell-intrinsic MELK enhanced RFA efficacy in HCC. …”
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7870
Radiofrequency ablation combined with immunotherapy to treat hepatocellular carcinoma: a comprehensive review
Published 2025-01-01“…On the one hand, RFA can induce the immunogenic substances including Ficolin-3, IL-1 and heat shock protein and regulate the immune cells by mediating the Th1/Th2 ratio, increasing Th17 cells, etc. …”
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7871
Inhibitory effects of estetrol on the invasion and migration of immortalized human endometrial stromal cells
Published 2024-02-01“…WASF-1 was found to be a potential mediator based on metastasis PCR array. WASF-1 was upregulated by E2 and downregulated by E4. …”
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7872
Antibacterial action of penicillin against Mycobacterium avium complex
Published 2024-08-01“…However, ODE model parameter estimates vs. exposure were a better fit. The exposure mediating E max was 84.6% (95% CI 76.91–82.98) of time concentration exceeded the minimum inhibitory concentration (MIC). …”
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7873
Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma
Published 2025-02-01“…The TRAIL and perforin/granzyme B pathways are largely involved in this cytotoxic mechanism, as indicated by the reduction in cytotoxicity induced by TRAIL inhibitory antibodies and concanamycin A, which inhibits perforin/granzyme B-mediated cytotoxicity. Our data suggest that eNK cells, whose functions have been enhanced by genetic engineering, have the potential to improve HCC treatment.…”
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7874
Transformation of NO in Combustion Gases by DC Corona
Published 2025-01-01“…The reactions involving O and OH radicals were more important in positive corona, whereas ozone-mediated oxidation dominated in negative corona. The research results demonstrate that ESP technology with DC corona offers a promising, energy-efficient solution for NO<sub>x</sub> control in small-scale combustion systems.…”
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7875
Evaluation of Retinal Layers and Choroidal Structures Using Optical Coherence Tomography in Alopecia Areata
Published 2023-06-01“…Conclusions: Along with T-lymphocyte-mediated hair follicle damage, choroidal melanocyte damage and inflammation can also be observed in AA patients. …”
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7876
Mechanisms of Herbal Nephroprotection in diabetes mellitus
Published 2020-01-01“…The pathogenesis of DN is viewed as a continuum going from the original offense, high glucose, through the noxious products it generates (advanced glycation end-products, products of oxidative and nitrosative stress) and the signaling chains consequently brought into action, to the harmful mediators of inflammation, sclerosis, and proliferation that eventually lead to DN, despite the countervailing attempts of the protective mechanisms. …”
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7877
CAFs-released exosomal CREB1 promotes cell progression and immune evasion in thyroid cancer via the positive regulation of CCL20
Published 2025-12-01“…Exosomal CREB1 knockdown receded cell progression and enhanced CD8+ T function by mediating CCL20. CAFs-associated exosomal CREB1 downregulation inhibited tumorigenesis through affecting CCL20.Conclusion CAFs-derived exosomes accelerated the malignant behaviors and immune evasion in TC by carrying CREB1 to up-regulate CCL20.…”
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7878
Salivary stimulatory and anti-inflammatory effects of aqueous Lilium brownii var. viridulum Baker extract for Sjögren’s syndrome: in vitro and in vivo studies
Published 2025-01-01“…AQP-5 and M3 muscarinic acetylcholine receptor (M3R) expression and inflammatory mediator levels were determined using western blotting and enzyme-linked immunosorbent assay. …”
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7879
Polysaccharide Fraction Isolated from <i>Saccharina japonica</i> Exhibits Anti-Cancer Effects Through Immunostimulating Activities
Published 2025-01-01“…</i>) injection of SJP boosted the cytolytic activity mediated by NK cells and CTLs against tumor cells. …”
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7880
Control of BKPyV-DNAemia by a Tailored Viro-Immunologic Approach Does Not Lead to BKPyV-Nephropathy Progression and Development of Donor-Specific Antibodies in Pediatric Kidney Tra...
Published 2024-12-01“…In our cohort, no significant correlation was observed between BKPyV-DNAemia and the development of DSA and antibody-mediated rejection. However, patients who experienced and cleared BKPyV-DNAemia had a worse allograft survival at a median follow-up of 18.9 years (<i>p</i> = 0.048). …”
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