A novel imatinib analogue inhibitor of chronic myeloid leukaemia: design, synthesis and characterization—explanation of its folded conformation by Rodolfo Moreno-Fuquen, Juan F. Avellaneda-Tamayo, Kevin Arango-Daraviña, Javier Ellena, Alan R. Kennedy

“…Additionally, supramolecular interactions in the crystal are mediated by hydrogen bonds and dispersion forces, forming dimers and layered structures. …”
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Flammulina velutipes polysaccharide-iron(III) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters by Chenying Shi, Chen Cheng, Xiaotong Lin, Yanfang Qian, Yufeng Du, Guitang Chen

“…These results showed that in vitro, the uptake of FVP1-Fe(III) was mediated by sodium-dependent glucose transporter-1 (SGLT1) and facilitated glucose transporter-2 (GLUT2) and GLUT2 played a dominant function. …”
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Recurrence of Herpetic Keratitis after COVID-19 Vaccination: A Report of Two Cases by Ali Mahdavi Fard, Jeffrey Desilets, Sangita Patel

“…The general activation of the T-cell-mediated immune response and proinflammatory cytokines such as IFNγ may underlie the role of the COVID vaccines in reactivation of herpetic stromal keratitis and the clinical findings in our reported cases.…”
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The Relationship of immunoglobulin-e and tumor necrosis factor in patients with allergic rhinitis in Babylon province by Bushra Jihad Sabbar, Zenaa Abbass Ali, Tariq Hussein Mgheer

“…It is caused by immunoglobulin E (IgE)-mediated reactions to inhaled allergens, smoking and alcohol use, gender, age, overweight, adoption of pets, race, educational achievement, and family history can represent a risk factor for allergic rhinitis (AR). …”
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An Emerging Role for IQGAP1 in Regulating Protein Traffic by Mahasin Osman

“…New evidence suggests a conserved role for IQGAP1 in protein synthesis and membrane traffic, which may help to explain the diversity of its cellular functions. Membrane traffic mediates infections by intracellular pathogens and a range of degenerative human diseases arise from dysfunctions in intracellular traffic; thus, elucidating the mechanisms of cellular traffic will be important in order to understand the basis of a wide range of inherited and acquired human diseases. …”
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Molecular Characterization of Antibiotic Resistance and Genetic Diversity of Klebsiella pneumoniae Strains by Bahareh Arabzadeh, Zeynab Ahmadi, Reza Ranjbar

“…The occurrence of plasmid-mediated quinolone resistance genes (qnrA, qnrB, and qnrS) was also investigated by PCR. …”
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Foreigner in contemporary Japanese state discourse: Constructing differences between the nation and the Other by D. S. Alekseev

“…In “Friends of Japan,” foreigners are portrayed as enthusiasts of Japanese culture, expected to mediate between Japan and the world without being fully integrated. …”
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Fission yeast cells deficient in siderophore biosynthesis require Str2 for ferrichrome-dependent growth by Berthy Mbuya, Samuel Plante, Tobias Vahsen, Ariane Brault, Simon Labbé

“…Ferrichrome (Fc) acquisition in Schizosaccharomyces pombe is mediated by the cell-surface siderophore-iron transporter Str1. …”
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Early Detection of Pancreatic Cancer: Opportunities Provided by Cancer-induced Paraneoplastic Phenomena and Artificial Intelligence by Wei-Chih Liao

“…S100A9 and galectin-3 are novel PDAC-derived factors mediating pancreatic cancer-associated diabetes and have shown promise in facilitating the early detection of PDAC. …”
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The neurohormone tyramine stimulates the secretion of an insulin-like peptide from the Caenorhabditis elegans intestine to modulate the systemic stress response. by Tania Veuthey, Jeremy T Florman, Sebastián Giunti, Stefano Romussi, María José De Rosa, Mark J Alkema, Diego Rayes

“…The release of INS-3 systemically activates the DAF-2 pathway, resulting in the inhibition of cytoprotective mechanisms mediated by DAF-16/FOXO. These studies offer mechanistic insights into a brain-gut communication pathway that weighs adaptive strategies to respond to acute and long-term stressors.…”
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Les hominoïdes fossiles : une aide pour l’éducation en Afrique by Brigitte Senut

“…Generally, the local populations have been marginalized; feelings of frustration appear, in particular because of the mediatic impact of the discoveries from which they are often excluded. …”
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Mechanism Underlying Tissue Cryotherapy to Combat Obesity/Overweight: Triggering Thermogenesis by Suvaddhana Loap, Richard Lathe

“…A contrasting view is that AT loss via targeted cryotherapy might be mediated by thermogenic fat metabolism without cell disruption. …”
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Study and personal resources of university students’ academic resilience and the relationship with positive psychological outcomes by Dalia Bagdžiūnienė, Irena Žukauskaitė, Laima Bulotaitė, Rūta Sargautytė

“…Our findings highlight the role of academic resilience in mediating the interplay between study-related resources, student engagement, and well-being. …”
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Notary independence in the course of notarial acts by M. Ye. Vasylenko

“…It has been noted that in the course of notarial acts, a notary must be an independent and impartial mediator between the parties, and act exclusively in compliance with the applicable law. …”
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IL6 Induces mtDNA Leakage to Affect the Immune Escape of Endometrial Carcinoma via cGAS-STING by Xue Zeng, Xiaosong Li, Yundong Zhang, Chaoxia Cao, Qin Zhou

“…Finally, anti-PD-L1 treatment in mice showed that blockade of PD-L1 significantly reversed tumor immune escape mediated by IL6-induced EVs. Together, we provide evidence that IL6 induced mtDNA leakage to regulate the immune escape of EC cells. …”
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Interleukin-15 and Tumor Necrosis Factor-α in Iraqi Patients with Alopecia Areata by Zainab A. Kamil, Galawish A. Abdullah, Haider Hashim Zalzala

“…Most evidence supports the hypothesis that it is disease of the hair follicle of autoimmune nature mediated by T-cells, with important cytokine role. …”
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General Approach to Identifying Potential Targets for Cancer Imaging by Integrated Bioinformatics Analysis of Publicly Available Genomic Profiles by Yongliang Yang, S. James Adelstein, Amin I. Kassis

“…Previously, we published a literature mining of potential targets for our in-house enzyme-mediated cancer imaging and therapy technology. Here we present a simple and integrated bioinformatics analysis approach that assembles a public cancer microarray database with a pathway knowledge base for ascertaining and prioritizing upregulated genes encoding cell surface- or membrane-bound proteins, which could serve imaging targets. …”
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Over-the-counter carrageenan-based sprays may interfere with PCR testing of nasopharyngeal swabs to detect SARS-CoV-2. by Taylor Corocher, Kira Edwards, Yvonne Hersusianto, Donald Campbell, Hui Yin Lim, Paul Monagle, Prahlad Ho

“…A direct comparison of carrageenan- and heparin-mediated PCR interference demonstrated that carrageenan PCR interference occurs to a lesser degree, but is not reversible by the addition of heparinase I. …”
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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies by Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke

“…Key circulating neurotoxins are ammonia and inflammatory mediators. In the brain, pathophysiology is less well understood, but is thought to be driven by glial cell dysfunction. …”
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Spreading the load: mobile information and communications technologies and their effect on information overload by D.K. Allan, M. Shoard

“…</b> A conceptual model of the interactions and relationships among the key elements that drive and mediate the information flows and information behaviour within a complex organizational environment was developed. …”
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