Intracellular Ca2+ Stores and Ca2+ Influx Are Both Required for BDNF to Rapidly Increase Quantal Vesicular Transmitter Release by Michelle D. Amaral, Lucas Pozzo-Miller

“…In response to local BDNF application to CA1 pyramidal neurons, the frequency of miniature excitatory postsynaptic currents (mEPSC) increased significantly within 30 seconds; mEPSC amplitude and kinetics were unchanged. This effect was mediated via TrkB receptor activation and required both full intracellular Ca2+ stores as well as extracellular Ca2+. …”
Get full text

Expression Profiles of Differentially Expressed Circular RNAs and circRNA–miRNA–mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5 by Jing Li, Heng Yang, Huaran Shi, Jihong Zhang, Wei Chen

“…Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses showed that the differentially expressed circRNAs were mainly involved in ubiquitin-mediated proteolysis and signaling pathways during CVB5 infection. …”
Get full text

Inhibitory Effect of (2S)-Pinocembrin From Goniothalamus macrophyllus on the Prostaglandin E2 Production in Macrophage Cell Lines by Hilwan Yuda Teruna, Kamal Rullah, Rudi Hendra, Rahayu Utami, Deri Islami, Siti Munirah Mohd Faudzi, Mohd Fadhlizil Fasihi Mohd Aluwi, Kok Wai Lam

“…To evaluate deeper into the anti-inflammatory potential of the specific enantiomer of natural PCB, we conducted the first investigation into the efficacy of the pure enantiomer (2S)-PCB in modulating inflammatory mediators induced by lipopolysaccharide (LPS) in both murine RAW 264.7 and human U937 macrophage cell lines. …”
Get full text

TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility by Elijah Edmondson, Takahito Kimura, Eunmi Hwang, Minjun Kim, Andrew Warner, Yuelin Zhu, Li Zhao, Yanlin Yu, Xuguang Zhu, Maria Hernandez, Noemi Kedei, Sheue-yann Cheng

“…Abstract Thyroid hormone receptors (TRs) mediate the genomic actions of thyroid hormone. Mutations of THRA gene cause a human disease known as resistance to thyroid hormone (RTHα). …”
Get full text

Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach by Chuwei Liu, Heng Liang, Arabella H. Wan, Min Xiao, Lei Sun, Yiling Yu, Shijia Yan, Yuan Deng, Ruonian Liu, Juan Fang, Zhi Wang, Weiling He, Guohui Wan

“…We further apply pum6a to study the dynamic regulation of m6A demethylases in gastric cancer under hypoxia, revealing distinct roles for FTO and ALKBH5 in modulating m6A modifications and uncovering key insights into m6A -mediated transcript stability. Our findings highlight the potential of pum6a as a powerful tool for advancing the understanding of epitranscriptomic regulation in health and disease, paving the way for biotechnological and therapeutic applications.…”
Get full text

Validation of <i>Monilinia fructicola</i> Putative Effector Genes in Different Host Peach (<i>Prunus persica</i>) Cultivars and Defense Response Investigation by Lucia Landi, Annamaria Lucrezia D’Ortenzio, Sarah Mojela Makau, Rita Milvia De Miccolis Angelini, Gianfranco Romanazzi

“…Knowledge of gene expression mediating host–pathogen interaction is essential to manage fungal plant diseases. …”
Get full text

Characterization of lysine acetyltransferase and deacetylase genes and their roles in anthocyanin biosynthesis in grape by Wen Tang, Feiyue Li, Danni Yang, Mengyu Xu, Jinggui Fang, Suwen Lu

“…Abstract Lysine acetylation is pivotal in regulating growth, development, and stress responses across numerous plant species. This modification, mediated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), is both dynamic and reversible. …”
Get full text

The <i>MCPH7</i> Gene Product STIL Is Essential for Dendritic Spine Formation by Tohru Matsuki, Hidenori Tabata, Masashi Ueda, Hideaki Ito, Koh-ichi Nagata, Yumi Tsuneura, Shima Eda, Kenji Kasai, Atsuo Nakayama

“…Rescue experiments indicated that the STIL requirement for spine formation/maintenance depended on its coiled coil domain that mediates the association with ARHGEF7. The overexpression of Rac1/Cdc42 compensated for the spine reduction caused by STIL knockdown. …”
Get full text

Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway by Jinke Huang, Jiaqi Zhang, Zhihong Liu, Jing Ma, Fengyun Wang, Xudong Tang

“…The aim of this study was to explore whether modified Gegen Qinlian decoction (MGQD) ameliorates UC in mice via mediating ferroptosis. Methods. Mice with dextran sulfate sodium- (DSS-) induced colitis were administered with MGQD for seven days. …”
Get full text

Neural recordings can differentiate between spontaneously metastasizing melanomas and melanomas with low metastatic potential. by Jay Shiralkar, Tiana Anthony, Grant A McCallum, Dominique M Durand

“…Further, to explore the origins of neural activity, 6-Hydroxidopamine mediated chemical sympathectomy was performed followed by daily microneurographic recordings. …”
Get full text

Diabetes-Resistant NOR Mice Are More Severely Affected by Streptozotocin Compared to the Diabetes-Prone NOD Mice: Correlations with Liver and Kidney GLUT2 Expressions by S. Kahraman, C. Aydin, G. O. Elpek, E. Dirice, A. D. Sanlioglu

“…Furthermore, use of NOR mice in STZ-mediated experimental diabetes settings should be considered accordingly.…”
Get full text

Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis by Maryam Mukhtar, Andleeb Batool, Abdul Wajid, Iram Qayyum

“…The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D. …”
Get full text

CONDITIONS OF SKIN AND INTESTINE MICROBIOTES IN PATIENTS WITH PSORIASIS by Ya.O. Yemchenko, K.E. Ishcheikin, I.P. Kaidashev, G.Yu. Morokhovets

“…Despite the fact that psoriasis is one of the most common immune-mediated inflammatory skin diseases, its exact driving factor remains unclear. …”
Get full text

The effects of environmental patents on renewable energy consumption by Mihaela Onofrei, Bogdan Narcis Fîrțescu, Florin Oprea, Dana Claudia Cojocaru

“…The empirical results demonstrated that environmental technology patents can be interpreted as effective mediating mechanisms for increasing renewable energy consumption, thus contributing to a reorientation of activities and consumption toward sustainable development. …”
Get full text

Nonarteritic Anterior Ischemic Optic Neuropathy following COVID-19 Vaccination: Consequence or Coincidence by Rika Tsukii, Yuka Kasuya, Shinji Makino

“…Although it is uncertain whether the development of NA-AION after COVID-19 vaccination was consequential or coincidental, we speculate that the close temporal relationship with COVID-19 vaccination suggests the possibility of vasculopathy on the microvascular network of optic nerve head as background of inflammatory or immune-mediated element to the timing of the onset of NA-AION. …”
Get full text

Induced Pluripotent Stem Cell Derivation and Ex Vivo Gene Correction Using a Mucopolysaccharidosis Type 1 Disease Mouse Model by Toshio Miki, Ludivina Vazquez, Lisa Yanuaria, Omar Lopez, Irving M. Garcia, Kazuo Ohashi, Natalie S. Rodriguez

“…The Idua-deficient cells were competent to be reprogrammed to iPSCs, and pluripotency was maintained through CRISPR/CAS9-mediated gene correction. These results support the concept of ex vivo gene editing therapy using iPSC and CRISPR/Cas9 technologies for MPS-1 patients.…”
Get full text

Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats by Yonghua Zong, Mingxiao Zhang, Shuai Li, Wenqian Qi, Juan Li, Tonghua Liu, Huijun Yang, Chen Lu, Xiaosong Hu

“…The results suggested that EP administration could effectively inhibit the liver fibrosis induced by BDL in rat, which may be associated with the enhanced activity of Nrf2 to mediate antioxidant enzyme system and downregulate the inflammatory genes.…”
Get full text

Alzheimer’s Disease and <i>Porphyromonas gingivalis</i>: Exploring the Links by Ivana Shawkatova, Vladimira Durmanova, Juraj Javor

“…This review underscores the need for further investigation into <i>P. gingivalis</i>-mediated mechanisms and their interplay with host responses. …”
Get full text

Signaling Crosstalk between PPARγ and BMP2 in Mesenchymal Stem Cells by Ichiro Takada, Yoshiko Yogiashi, Shigeaki Kato

“…Although BMP2 did not interfere with PPARγ-mediated adipogenesis, BMP2 increased mRNA expression levels of PPARγ target genes (such as Fabp4 and Nr1h3) when cells were first treated with troglitazone (TRO). …”
Get full text

Hydrogen Sulfide Increases Nitric Oxide Production and Subsequent S-Nitrosylation in Endothelial Cells by Ping-Ho Chen, Yaw-Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang

“…By using a biotin switch, the level of NO-mediated protein S-nitrosylation was also enhanced. …”
Get full text