Effectiveness of a commercial LAMP technology-based kit for rapid detection of Bursaphelenchus xylophilus in Pinus pinaster by María Menéndez-Gutiérrez, Lucía Villar, Raquel Díaz

“… Aim of study: To assess the usefulness of the commercial Loop-Mediated Isothermal Amplification (LAMP) kit for detecting Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle in Pinus pinaster Aiton and Pinus radiata D. …”
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The adaptation of rainbow trout to warmer water: Oxidative damage in the germinal line by Vianel Sevastei, Sonia A. Crichigno, M. Victoria Santos, Andrea Trochine, Julio C. Painefilú, Noemí Zaritzky, Víctor E. Cussac

“…Our results suggest that the acquired thermal tolerance traits may be part of a wide spectrum of novel characteristics produced as a consequence of an enhanced mutation rate and/or a different DNA methylation pattern, induced by higher temperatures and mediated by ROS.…”
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iNOS-Produced Nitric Oxide from Cancer Cells as an Intermediate of Stemness Regulation by PARP-1 in Colorectal Cancer by María del Moral-Martinez, Paula Sánchez-Uceta, Ruben Clemente-Gonzalez, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Huda Khaldy, David Lopez-Perez, Javier Arnedo, Jorge Casado, Luis Martínez-Heredia, Angel Carazo, Josefa León

“…In this study, we propose that nitric oxide (NO) produced by inducible nitric oxide synthase (iNOS) could act as a mediator. We evaluated the expression of iNOS in a cohort of patients previously used to analyze the effects of PARP-1 on CRC in relation to p53 status. …”
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Exosomes in neuron-glia communication: A review on neurodegeneration by Naeimeh Akbari-Gharalari, Sina Khodakarimi, Farshad Nezhadshahmohammad, Mohammad Karimipour, Abbas Ebrahimi-Kalan, Jiagian Wu

“…This review presents a comprehensive overview of contemporary insights into the pivotal roles played by exosomes as agents mediating communication between neurons and glial cells within the central nervous system (CNS). …”
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Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study by Kaylie I. Kirkwood-Donelson, Alan K. Jarmusch, Carl D. Bortner, Bruce Alex Merrick, Birandra K. Sinha

“…Erastin (ER), a ferroptosis inducer, kills tumor cells by generating and accumulating reactive oxygen species (ROS) within the cell, resulting in an iron-dependent oxidative damage-mediated ferroptotic cell death.MethodsWe have utilized human ovarian cancer cell lines, OVCAR-8 and its adriamycin-selected, multi-drug resistance protein (MDR1)-expressing NCI/ADR-RES, both equally sensitive to ER, to identify metabolic biomarkers of ferroptosis.ResultsOur studies showed that ER treatment rapidly depleted cellular glutathione and cysteine and enhanced formation of ophthalamate (OPH) in both cells. …”
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Features of model coronaviruses distribution in feline organs and tissues in the context of COVID-19 pathogenesis study by V. N. Afonyushkin, O. E. Sysoeva, O. S. Kozlova, D. V. Shamovskaya

“…Firstly, the pathological process esare likely to be immune-mediated and the immun esystem quites lowly ensurest heelimination of the virus from the organism. …”
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RNA N4‐acetylcytidine modification and its role in health and diseases by Qiang Wang, Yixiao Yuan, Qiang Zhou, YingDong Jia, Jing Liu, GuangJun Xiao, Chunhong Li, Xiulin Jiang

“…This review first outlines the key regulatory enzyme mediating ac4C modification, N‐acetyltransferase 10 (NAT10), including its critical roles in regulating RNA stability, transcriptional efficiency, and translational fidelity. …”
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Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism by Lu Wang, Lu Wang, Menghan Xi, Menghan Xi, Wei Cao, Haiyan Qin, Di Qin, Shuai Chen, Siyuan Zhou, Yujun Hou, Ying Chen, Xianjun Xiao, Qianhua Zheng, Dehua Li, Ying Li

“…MicroRNAs (miRNAs) serve as key regulatory molecules mediating host-microbiota interactions. However, the specific fecal miRNAs regulating microbiota composition and metabolism in EA-treated constipated mice, along with their key targets, remain unidentified. …”
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Low-Dose Oxygen Enhances Macrophage-Derived Bacterial Clearance following Cigarette Smoke Exposure by William G. Bain, Ashutosh Tripathi, Pooja Mandke, Jonathan H. Gans, Franco R. D’Alessio, Venkataramana K. Sidhaye, Neil R. Aggarwal

“…Our findings demonstrate a novel, protective role for low-dose oxygen following cigarette smoke and bacteria exposure that may be mediated by enhanced macrophage phagocytosis.…”
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Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review by Wesam Ahmed Nasif, Abeer Shaker El-Moursy Ali, Mohammed Hasan Mukhtar, Aali Marzouq H. Alhuzali, Yahya Ahmed Yahya Alnashri, Ziyad Ishaq Ahmed Gadah, Eyyad Adeeb A. Edrees, Hussam Abdulaziz Mabruk Albarakati, Hussam Saud Muhji Aloufi

“…A D-dimer is a complex protein molecule that is formed during plasmin-mediated degradation of the fibrin network. Thus, it serves as a marker of thrombotic activity. …”
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Digital Flow: Insights from English Teacher Educators by Mojtaba Maghsoudi, Ali Mansouri Nejad

“…Quantitative data analysis including correlation, One-way ANOVA, Independent-samples t-test, complemented by face-to-face interviews, uncovered noteworthy insights: Firstly, moderate to low correlations were found between the three stages of flow experienced by teacher educators in the computer-mediated environment. Secondly, male teacher educators displayed a moderately higher level of flow antecedents and flow experience compared to their female counterparts within the virtual setting. …”
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AGS3-based optogenetic GDI induces GPCR-independent Gβγ signalling and macrophage migration by Waruna Thotamune, Sithurandi Ubeysinghe, Chathuri Rajarathna, Dinesh Kankanamge, Koshala Olupothage, Aditya Chandu, Bryan A. Copits, Ajith Karunarathne

“…Therefore, we propose OptoGDI as a powerful tool for optically dissecting GDI-mediated signalling pathways and triggering GPCR-independent Gβγ signalling in cells and in vivo.…”
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CHIP away at the marrow-clot connection: inflammation, clonal hematopoiesis, and thromboembolic disease by Angela Todorovski, Tzu-Fei Wang, Marc Carrier, Yan Xu

“…In this review, we provide an overview of CHIP as a mediator of thromboembolic diseases and discuss emerging therapeutics aimed at intervening on this thrombo-inflammatory nexus.…”
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Differentially Expressed microRNAs in Peritoneal Dialysis Effluent-Derived Exosomes from the Patients with Ultrafiltration Failure by Weifei Wu, Xu Wu, Zhiqun Cheng, Zhenzhen Yang, Minhui Lu, Jing Cheng

“…Functional analyses revealed that these DE-miRNAs were significantly enriched in pathways of cancer, ubiquitin-mediated proteolysis, axon orientation, and the Rap1 and Ras signaling pathways. …”
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The Impact of Cognitive Anxiety and the Rating of Pain on Care Processes in a Vigilance Task: The Important Part Played by Age by Luis Pinel, Miguel A. Perez-Nieto, Marta Redondo, Luis Rodríguez-Rodríguez, Leticia L. Mateos

“…Most of the studies in the field of chronic pain have focused on care as a mediating variable on the perception of painful stimuli and emotions. …”
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Microscopic Mechanism of the Interaction in the Adsorption of Caramel Pigments onto Rosin-Based Decolorizing Resin for Sugar by WEI Yanhong, WANG Jiaxin, JIAO Li, LIAO Chunyu, LEI Fuhou, LI Wen

“…The interaction mechanism was primarily mediated by the electrophilic reaction between carboxylate and protonated tertiary amine groups, followed by weak hydrogen bonding, with the resin acting as a hydrogen bond donor. …”
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Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation by Nagarajan Selvamurugan, Zhiming He, Daniel Rifkin, Branka Dabovic, Nicola C. Partridge

“…Expression of Runx2 was increased by PEMF treatment and the miR21-5p inhibitor prevented the PEMF stimulation of Runx2 expression in differentiating cells. Thus, PEMF could mediate its effects on bone metabolism by activation of the TGF-β signaling pathway and stimulation of expression of miR21-5p in hBMSCs.…”
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Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy by Kaichiro Sawada, Masao Toyoda, Noriko Kaneyama, Sawako Shiraiwa, Hitomi Moriya, Han Miyatake, Eitaro Tanaka, Naoyuki Yamamoto, Masaaki Miyauchi, Moritsugu Kimura, Takehiko Wada, Masafumi Fukagawa

“…The results suggested that podocyte detachment during early stage of DN is mediated through upregulation of α3β1-integrin.…”
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PRDM16 Enhances Osteoblastogenic RUNX2 via Canonical WNT10b/β-CATENIN Pathway in Testosterone-Treated Hypogonadal Men by Siresha Bathina, Mia Prado, Virginia Fuenmayor Lopez, Georgia Colleluori, Lina Aguirre, Rui Chen, Dennis T. Villareal, Reina Armamento-Villareal

“…We previously reported that <i>PRDM16</i> mediated the improvement in body composition in testosterone (T)-treated hypogonadal men by shifting adipogenesis to myogenesis. …”
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Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone? by Lara Russo, Serena Babboni, Maria Grazia Andreassi, Jalil Daher, Paola Canale, Serena Del Turco, Giuseppina Basta

“…Numerous factors, including extracellular vesicles, mediate pathological communication between the vascular system and adipose tissue, amplifying metabolic imbalances. …”
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