Risk perception of COVID-19, depressive symptoms and Internet addiction among undergraduates: a longitudinal study by Hongpo Zhang, Hongpo Zhang, Dandan Zhang, Wanghua Ji, Shun Peng

“…Subsequently, 1,008 of the T1 participants (87.42%) completed the depressive symptoms scale and Internet addiction scale 6 months later, in June 2023 (T2).Results(1) Risk perception of COVID-19 was significantly and positively predicted depressive symptoms and Internet addiction 6 months later; (2) Depressive symptoms played a mediating role between risk perceptions and Internet addiction; (3) PTG moderated the first-stage link between risk perception and Internet addiction, and this relationship was more robust for low PTG than for high PTG.ConclusionThese findings advance our understanding of the relationship and mechanisms between risk perception of COVID-19 and Internet addiction, and further support developing interventions to strengthen PTG for mitigating negative outcomes during major crises.…”
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Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction by Shuang Wang, Chao Xu, Yuanman Yu, Jie Li, Tianwu Chen, Jing Wang, Changsheng Liu

“…PET's inert surface, lower bioactivity, and mechanical abrasion trigger an M1 macrophage-mediated inflammatory response, leading to excessive, disorganized scar tissue. …”
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The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis by Kun Meng, Yuying Li, Xiaoyi Yuan, Hui-Min Shen, Li-Ling Hu, Danya Liu, Fujin Shi, Dandan Zheng, Xinyu Shi, Nengqiao Wen, Yun Cao, Yun-Long Pan, Qing-Yu He, Chris Zhiyi Zhang

“…Mechanistically, TPM3P9 binds to the RRM1 domain of the splicing factor RBM4 to inhibit RBM4-mediated exon skipping in the transcription factor TCF7L2. …”
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Herpes Simplex Virus-2 Glycoprotein Interaction with HVEM Influences Virus-Specific Recall Cellular Responses at the Mucosa by Sarah J. Kopp, Christopher S. Storti, William J. Muller

“…Infection of susceptible cells by herpes simplex virus (HSV) requires the interaction of the HSV gD glycoprotein with one of two principal entry receptors, herpes virus entry mediator (HVEM) or nectins. HVEM naturally functions in immune signaling, and the gD-HVEM interaction alters innate signaling early after mucosal infection. …”
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Face-work in North American Presidential Debates: A Corpus-based Multi-theoretical Approach by Rosa María Martínez Abellán

“…Since the first televised debates in 1960, presidential campaigns have become increasingly mediatized and the need to defend against face-damage has increased, for there is still a need to uphold a favorable presidential image despite the prominence of impoliteness in these events. …”
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Influence of <i>Apis mellifera syriaca</i> Bee Venom on Nociception and Inflammatory Cytokine Profiles in Experimental Hyperalgesia by Mohamad Ayoub, Salma Fayjaloun, Rabih Roufayel, Dany El Obeid, Ziad Fajloun, Mohamad Rima, Marc Karam

“…Hyperalgesia is a condition marked by an abnormal increase in pain sensitivity, often occurring in response to tissue injury, inflammation, or prolonged exposure to certain medications. Inflammatory mediators, such as cytokines IL-1β, IL-6, and TNF-α, play a central role in this process, amplifying pain perception. …”
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Epithelial-to-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma and Pancreatic Tumor Cell Lines: The Role of Neutrophils and Neutrophil-Derived Elastase by Thomas Große-Steffen, Thomas Giese, Nathalia Giese, Thomas Longerich, Peter Schirmacher, G. Maria Hänsch, Matthias M. Gaida

“…Rapid dyshesion of the tumor cells was seen, most likely due to an elastase-mediated degradation of E-cadherin. In parallel, the transcription factor TWIST was upregulated, β-catenin translocated into the nucleus, ZEB1 appeared in the nucleus, and keratins were downregulated. …”
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Impact of Real-Time Continuous Glucose Monitoring Use on Glucose Variability and Endothelial Function in Adolescents with Type 1 Diabetes: New Technology—New Possibility to Decreas... by Milena Jamiołkowska, Izabela Jamiołkowska, Włodzimierz Łuczyński, Joanna Tołwińska, Artur Bossowski, Barbara Głowińska Olszewska

“…Parameters of glycaemic variability were analyzed during first and last sensor use, together with brachial artery flow-mediated dilatation (FMD) to assess endothelial function. …”
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Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration by Preeti Singh, Peter S. Hanson, Christopher M. Morris

“…SIRT2 protection was mediated, in part, through elevated SOD2 expression. …”
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Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention by Rodrigo Fonseca, Yuan Xiao Zhu, Laura A. Bruins, Joseph Ahmann, Cecilia de Bonolo Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Seth Welsh, Erin Meermeier, Kiran K. Mangalaparthi, Richard K. Kandasamy, Greg Ahmann, J. Erin Wiedmeier-Nutor, Akhilesh Pandey, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

“…Simultaneous inhibition of MCL-1, BCL-XL, and upstream PI3K, RTK (FGF, EGF, and IGF1) mediated signaling enhanced VTX sensitivity. Post-translational modifications of MCL-1, particularly its stabilization via acetylation and phosphorylation, were investigated, although their inhibition only marginally increased VTX sensitivity. …”
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Betaine enhances SCAPs chondrogenic differentiation and promotes cartilage repair in TMJOA through WDR81 by Meiyue Wang, Zejie Wu, Xiaoyu Zheng, Yishu Huang, Yizhou Jin, Jiaxin Song, Wanzhen Lei, Hua Liu, Riyue Yu, Haoqing Yang, Runtao Gao

“…Abstract Background The cartilage tissue regeneration mediated with mesenchymal stem cells (MSCs) is considered as a viable strategy for temporomandibular joint osteoarthritis (TMJOA). …”
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Targeting Transcriptional Regulators Affecting Acarbose Biosynthesis in <i>Actinoplanes</i> sp. SE50/110 Using CRISPRi Silencing by Saskia Dymek, Lucas Jacob, Alfred Pühler, Jörn Kalinowski

“…Eleven genes affecting the yield of acarbose were identified. The CRISPRi-mediated knockdown of seven of these genes significantly reduced acarbose biosynthesis, whereas the knockdown of four genes enhanced acarbose production.…”
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Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis by Gamal Shiha, Ahmed Nabil, Ahmed Lotfy, Reham Soliman, Ayman A. Hassan, Islam S. Ali, Doaa F. Gad, Faten Zahran

“…Stem cells secrete cytokines and growth factors that showed paracrine-mediated antifibrotic and anti-inflammatory effects in vivo and in vitro. …”
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Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice by Nitin Puri, Yevgeniy Arefiev, Robert Chao, David Sacerdoti, Hibba Chaudry, Alexandra Nichols, Krithika Srikanthan, Athar Nawab, Dana Sharma, Vishal Hari Lakhani, Rebecca Klug, Komal Sodhi, Stephen J. Peterson

“…Our results highlight a modulatory effect of HO on iron homeostasis mediated through the suppression of hepatic hepcidin.…”
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The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages by Mariana Oliveira Arruda, Saulo José Figueiredo Mendes, Simone Aparecida Teixeira, Ludmilla Santos Silva de Mesquita, Maria Nilce de Sousa Ribeiro, Stanley de Sousa Lima Galvão, Marcelo Nicolás Muscará, Elizabeth Soares Fernandes, Valério Monteiro-Neto

“…Overall, the LHAE obtained from peppermint modulates macrophage-mediated inflammatory responses, by stimulating the antioxidant pathway in these cells. …”
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Evaluation of Proteins Released to Medium in Yeast-Bacteria Co-culture System by Çağatay Tarhan, Ayşegül Yanık

“…With traditional pure culture-oriented cultuvation techniques, interactions mediated by small molecules are not taken into account, resulting in the precise nature of the interactions being largely unknown. …”
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β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway by Yu Cai, Hua Yang, Hui Xu, Shanglai Li, Bingru Zhao, Zhibo Wang, Xiaolei Yao, Feng Wang, Yanli Zhang

“…Mechanistically, the protective effects of NMN against GCs function were mediated via the AMPK/mTOR pathway. Collectively, our findings elucidate the metabolic characteristics associated with sheep prolificacy and demonstrate that NMN effectively protects GCs from LPS-induced dysfunction and enhances ovarian responsiveness via the AMPK/mTOR pathway. …”
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A minimal gene set characterizes TIL specific for diverse tumor antigens across different cancer types by Zhen Zeng, Tianbei Zhang, Jiajia Zhang, Shuai Li, Sydney Connor, Boyang Zhang, Yimin Zhao, Jordan Wilson, Dipika Singh, Rima Kulikauskas, Candice D. Church, Thomas H. Pulliam, Saumya Jani, Paul Nghiem, Suzanne L. Topalian, Patrick M. Forde, Drew M. Pardoll, Hongkai Ji, Kellie N. Smith

“…Abstract Identifying tumor-specific T cell clones that mediate immunotherapy responses remains challenging. …”
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Structural Modifications Reveal Dual Functions of the C-4 Carbonyl Group in the Fatty Acid Chain of Ipomoeassin F by Arman Khosravi, Precious Nnamdi, Alexa May, Kelsey Slattery, Robert E. Sammelson, Wei Q. Shi

“…Ipomoeassin F (Ipom-F) is a plant-derived macrocyclic resin glycoside that potently inhibits cancer cell growth through blockage of Sec61-mediated protein translocation at the endoplasmic reticulum. …”
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MAC30 Knockdown Inhibits Proliferation and Enhance Apoptosis of Gastric Cancer by Suppressing Wnt/β-Cateninsignaling Pathway by Xiaohong Wu, Yong Zhang, Junping Guo, Xun Yan, Li Shen, Jianping Zhou, Jun Zhao, Min Zhuang, Zhihong Cao

“…However, the promotion of apoptosis by mitochondrial pathway was mediated by Bax/Bcl-2 upregulation. Present work showed the effect of downregulated MAC30 expression on proliferation and apoptosis of gastric cancer cell through Wnt/β-catenin signaling pathway. …”
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