Applying an Ecology Metaphor in a Mixed Methods Analysis of High School Science Program Infrastructure by Niyazi Erdogan, Carol L. Stuessy

“…We include a discussion of the implications for including SPI as an important mediating layer within the ecology of high schools. …”
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Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer by Yingxiang Yang, Chengyue Jin, Anthony Yeo, Bo Jin

“…An intracellular adaptor, myeloid differentiation factor 88 (MyD88) probably mediates this process. MyD88 is intimately involved with all TLRs except TLR3. …”
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Overview of 5-ASA in Therapy of Inflammatory Bowel Disease by CN Williams

“…The second drug delivery system depends on an enteric coating for delayed pH-dependent release or for a timed-released mechanism. 5-ASA inhibits 5-lipoxygenase, modulates leukocyte function and inhibits soluble mediator release, and is an effective scavenger action of free oxygen radicals, the relative importance of which is unknown. …”
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Ezetimibe: An Unusual Suspect in Angioedema by Tiffany Lu, Tarundeep Grewal

“…The mechanism, however, is unknown since it is not related to bradykinin or mast cell-mediated activation. Clinicians should advise patients taking Ezetimibe to report any swelling of the lips, face, and tongue and to immediately discontinue its use if these signs are present.…”
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Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism by Sander Kersten

“…An important group of transcription factors that mediates the effect of dietary fatty acids and certain drugs on plasma lipoproteins are the peroxisome proliferator activated receptors (PPARs). …”
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Update of Immunomodulatory Therapy for Inflammatory Bowel Disease by Charles N Bernstein

“…Furthermore, more specific mediators of the abnormal immune response have been identified, so that therapy can be more targeted. …”
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Aquaporin-2 in the early stages of the adenine-induced chronic kidney disease model. by Lucas H Oronel, Maria Ortiz, Carolina Yarza, Sofía Gayone, Carlos Davio, Mónica Majowicz, Maria Florencia Albertoni Borghese

“…Vasopressin (VP) was postulated as a mediator of CKD, mainly acting through its V2 receptors. …”
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Unlocking engagement: exploring the drivers of elderly participation in digital backfeeding through community education by Sijie Sun

“…Furthermore, social influence and facilitating conditions were found to positively affect willingness and behavior, mediated by perceived usefulness, ease of use, and technology anxiety. …”
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Strategies to innovate emergency care of status epilepticus by Jaideep Kapur

“…Generalized Convulsive status epilepticus (SE) is a neurological emergency because prolonged convulsions can cause respiratory compromise and neuronal injury. Compromised GABA-mediated inhibition is a defining feature of SE, and many current therapies are benzodiazepines, which are allosteric modulators of GABA-A receptors. …”
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Prognostic significance of ımmunhistochemical axl expression in pancreas ductal adenocarcinomas by Ozden Oz, Asuman Argon, Tulu Ayata Kebat, Ozlem Ozdemir, Savas Yakan

“…Conclusion: It was found that increased expression of Axl, which is known to increase EMT-mediated metastasis in carcinogenesis, may be an indicator of local spread and poor prognosis in PDAC patients. …”
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SLC1A4 Promotes Malignant Transformation of Hepatocellular Carcinoma by Activating the AKT Signaling by Jiaoyun Zheng, Jian Gong

“…In conclusion, SLC1A4 promotes the malignant transformation of HCC through activating signal transduction mediated by AKT. The findings in this study suggested that SLC1A4 may be a diagnostic indicator for the early HCC and a therapeutic target for the advanced HCC.…”
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Gene Therapy Approaches by Ahmed Jumaa Ahmed, Hogir Saadi

“…The addition of viral functions such as receptor-mediated uptake and nuclear translocation of DNA may eventually lead to the development of an artificial virus in order to improve the role of non-viral vectors. …”
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Mortality Clustering in the Family. Fast Life History Trajectories and the Intergenerational Transfer of Infant Death in Late 19th- and Early 20th-Century Antwerp, Belgium by Robyn Donrovich, Paul Puschmann, Koen Matthijs

“…These results remained robust after controlling for potential mediating and moderating factors. The results on the age of the mother at birth, her marital status, as well as the living environment suggest that at least part of the intergenerational transfer in infant mortality can be explained on the basis of life history theory: women who grew up in a high-risk family tended to reproduce earlier and faster, and often raised their children without a partner. …”
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Mortality Clustering in the Family. Fast Life History Trajectories and the Intergenerational Transfer of Infant Death in Late 19th- and Early 20th-Century Antwerp, Belgium by Robyn Donrovich, Paul Puschmann, Koen Matthijs

“…These results remained robust after controlling for potential mediating and moderating factors. The results on the age of the mother at birth, her marital status, as well as the living environment suggest that at least part of the intergenerational transfer in infant mortality can be explained on the basis of life history theory: women who grew up in a high-risk family tended to reproduce earlier and faster, and often raised their children without a partner. …”
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Cognitive Distortions in Depressed Women: Trait, or State Dependent? by Sedat BATMAZ, Sibel KOCBIYIK

“…Objective: According to the cognitive theory developed by Beck, cognitive distortions are important mediators for the onset and maintenance of depressive disorders. …”
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Chemical Profiles of Herbal Compress and Their Persistence Affected by Steaming and Storage Time by Elizabeth J. Panakkal, Prapakorn Tantayotai, Adeolu Adesoji Adediran, Theerawut Phusantisampan, Malinee Sriariyanun

“…The herbs were extracted with solid-liquid and Soxhlet-mediated extraction using 95% ethanol, hexane, and water as solvents. …”
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Evidence that flocking behavior is rewarded by singing, flock mates, and mu opioid receptors in the nucleus accumbens. by Alyse N Maksimoski, Taviah A Levenson, Changjiu Zhao, Lauren V Riters

“…This form of analgesia has been shown to be an indirect measure of opioid release, suggesting that the presence of flock mates may induce opioid-mediated reward. Consistent with this possibility, the numbers of mu opioid receptor immunolabeled cells in the nucleus accumbens correlated positively with measurements of gregarious song and other social behaviors. …”
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Human cytomegalovirus RNA2.7 inhibits ferroptosis by upregulating ferritin and GSH via promoting ZNF395 degradation. by Mingyi Xu, Shan Ruan, Jingxuan Sun, Jianming Li, Dan Chen, Yanping Ma, Ying Qi, Zhongyang Liu, Qiang Ruan, Yujing Huang

“…HCMV RNA2.7 promoted proteasome-mediated degradation of ZNF395 that resulted in upregulation of FTH1 and SLC7A11 to inhibit ferroptosis, therefore maintain survival in host cells and complete replication of virus.…”
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Anticholinesterase Toxicity and Oxidative Stress by Dejan Milatovic, Ramesh C. Gupta, Michael Aschner

“…However, the mechanism(s) involved in brain/muscle damage appear to be linked with alteration in antioxidant and the scavenging system leading to free radical-mediated injury. OPs and CMs cause excessive formation of F2-isoprostanes and F4-neuroprostanes, in vivo biomarkers of lipid peroxidation and generation of reactive oxygen species (ROS), and of citrulline, a marker of NO/NOS and reactive nitrogen species (RNS) generation. …”
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Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment by Tian Z, Wang X, Chen S, Guo Z, Di J, Xiang C

“…This review highlights the critical role of mitochondrial function in macrophage polarization and discusses therapeutic strategies mediated by biomaterials, including mitochondria-targeted biomaterials. …”
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