Whole-Genome Duplication and Purifying Selection Contributes to the Functional Redundancy of Auxin Response Factor (ARF) Genes in Foxtail Millet (Setaria italica L.) by You Chen, Bin Liu, Yujun Zhao, Wenzhe Yu, Weina Si

“…Auxin response factors (ARFs) play crucial roles in auxin-mediated response, whereas molecular genetics of ARF genes was seldom investigated in Setaria italica, an important crop and C4 model plant. …”
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Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET by Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner

“…Optimal combinations of paratopes assembled into a biparatopic antibody have the capacity to mediate high-grade target cross-linking on cell membranes, leading to degradation of the target, as well as antibody and payload delivery in the case of an antibody-drug conjugate (ADC). …”
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Effects of environmental bisphenol S exposure on male rat reproductive health and gut-blood-testicular axis integrity by Biran Zhu, Zequan Zhang, Ying Xie, Min Huang, Yu Chen, Yong Yang, Xiongjie Shi, Jian Han, Lihua Yang, Min Zhao

“…Additionally, BPS altered serum metabolites, including phosphatidic acid and diacylglycerol, which are involved in Fc gamma R-mediated phagocytosis and linked to inflammation. Furthermore, histopathological analysis, western blot (WB), enzyme-linked immunosorbent assay (ELISA), and immunofluorescence results showed that exposure to BPS led to testicular damage, inflammation, activation of the p38 and ERK MAPK pathways, and disruption of the blood-testis barrier (BTB). …”
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Novel carbon dots with dual Modulatory effects on the bone marrow and spleen as a potential therapeutic candidate for treating spinal cord injury by Junjin Li, Hongda Wang, Yuanquan Li, Chunzhen Wang, Haiwen Feng, Yilin Pang, Jie Ren, Chuanhao Li, Erke Gao, Dejing Zhang, Dunxu Hu, Pengtian Zhao, Han Ding, Baoyou Fan, Tao Zhang, Xiaomeng Song, Zhijian Wei, Guangzhi Ning, Yong-Qiang Li, Shiqing Feng

“…Additionally, EJCDs attenuate the immune response in the spleen, leukocytes’ reservoir, following spinal cord injury by diminishing the local infiltration of monocytes and macrophages while promoting motor function recovery. These effects are mediated through the downregulation of CCAAT enhancer binding protein-β expression in the spleen and the upregulation of FZD4 protein expression in Lin− Sca-1+ c-kit+ cells (LSKs) within the bone marrow. …”
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Immunoinformatics Approach for Epitope-Based Peptide Vaccine Design and Active Site Prediction against Polyprotein of Emerging Oropouche Virus by Utpal Kumar Adhikari, Mourad Tayebi, M. Mizanur Rahman

“…In this report, we identified both T-cell and B-cell epitopes of the most antigenic OROV polyprotein with the potential to induce both humoral and cell-mediated immunity. Eighteen highly antigenic and immunogenic CD8+ T-cell epitopes were identified, including three 100% conserved epitopes (TSSWGCEEY, CSMCGLIHY, and LAIDTGCLY) as the potential vaccine candidates. …”
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Three-dimensional mapping of the altermagnetic spin splitting in CrSb by Guowei Yang, Zhanghuan Li, Sai Yang, Jiyuan Li, Hao Zheng, Weifan Zhu, Ze Pan, Yifu Xu, Saizheng Cao, Wenxuan Zhao, Anupam Jana, Jiawen Zhang, Mao Ye, Yu Song, Lun-Hui Hu, Lexian Yang, Jun Fujii, Ivana Vobornik, Ming Shi, Huiqiu Yuan, Yongjun Zhang, Yuanfeng Xu, Yang Liu

“…Tight-binding model analysis indicates that the large altermagnetic splitting arises from strong third-nearest-neighbor hopping mediated by Sb ions. The large band/spin splitting near Fermi level in metallic CrSb, together with its high T N (up to 705 K) and simple spin configuration, paves the way for exploring emergent phenomena and spintronic applications based on altermagnets.…”
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Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment by Yi Ouyang, Yan Chen, Ting Xu, Yihao Sun, Sheng Zhao, Chunmei Chen, Yixin Tan, Liang He, Hui Liu

“…Abundant reactive oxygen species (ROS) are generated in 4T1 tumor cells through an Mn2+-mediated Fenton-like reaction. After that, the generated Mn4+ can react with glutathione (GSH) through redox reaction to produce Mn2+ and deplete GSH, disrupting the reducing capacity and benefiting the production of ROS in tumor cells. …”
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Corticosterone rapidly modulates dorsomedial hypothalamus serotonin and behavior in an estrogen- and progesterone-dependent manner in adult female rats: potential role of organic c... by Jamie L. Scholl, Joshua T. Rogers, Na Feng, Gina L. Forster, Michael J. Watt, Jazmine D. W. Yaeger, Michael W. Buchanan, Christopher A. Lowry, Kenneth J. Renner

“…These results suggest that ovarian hormones in combination with corticosterone modulate OCT3-mediated 5-HT clearance in the DMH, potentially representing an adaptive mechanism that allows sexually receptive females to respond rapidly to acute stressors.…”
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Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway by Laura La Paglia, Angela Listì, Stefano Caruso, Valeria Amodeo, Francesco Passiglia, Viviana Bazan, Daniele Fanale

“…Here, we have discussed the potential role of ANGPTL4 in mediating the cross talk between metabolic syndromes, such as diabetes and obesity, and cancer through regulation of its expression by PPARs.…”
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Lifestyle and Dietary Factors Associated with the Evolution of Cardiometabolic Risk over Four Years in West-African Adults: The Benin Study by Charles Sossa, Hélène Delisle, Victoire Agueh, Roger Sodjinou, Gervais Ntandou, Michel Makoutodé

“…CMR deteriorated in 21% of subjects. Diet and lifestyle mediated location and income effects on CMR evolution. …”
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Nitrogen enrichment and vascular plant richness loss reduce bryophyte richness by Maeve Lin, Ariel Bergamini, Noémie A. Pichon, Eric Allan, Steffen Boch

“…However, it is unclear whether land-use effects are direct or mediated by changes in vascular plants. Increases in vascular plant cover are likely to decrease bryophyte abundance through light competition. …”
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Classification of Resting-State Status Based on Sample Entropy and Power Spectrum of Electroencephalography (EEG) by Ahmed M. A. Mohamed, Osman N. Uçan, Oğuz Bayat, Adil Deniz Duru

“…An electroencephalogram (EEG) is a significant source of diagnosing brain issues. It is also a mediator between the external world and the brain, especially in the case of any mental illness; however, it has been widely used to monitor the dynamics of the brain in healthy subjects. …”
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Heart Rate Monitoring During Behavioral Stress Tests in Bold and Shy Rainbow Trout (<i>Oncorhynchus mykiss</i>) by Eleftherios Kasiouras, Gautier Riberolles, Albin Gräns, Andreas Ekström, Johan Höjesjö, Jonathan A. C. Roques, Erik Sandblom, Lynne U. Sneddon

“…Rainbow trout (<i>Oncorhynchus mykiss</i>) exhibit divergent personalities, ranging from bold to shy, which correlate with cortisol-mediated stress responses. To determine whether personality affects the sympathetic nervous system, heart rate was measured during three potentially stressful events as a proxy for sympathetic nervous system responses. …”
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Conductive Composite Biosensor System for Electrochemical Indinavir Drug Detection by Natasha Ross, Nicolette Hendricks-Leukes, Rachel Fanelwa Ajayi, Priscilla Baker, Emmanuel I. Iwuoha

“…In this study, a biosensor with cobalt(III) sepulchrate trichloride {CoSep3+} as diffusional mediator was constructed. The biosensor platform consisted of CYP3A4 immobilized onto a gold nanoparticle (GNP) overoxidized polypyrrole (OvOxPpy) carrier matrix. …”
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Health Keeping in the Views of Students: Features and Formation Factors by A. V. Liadova

“…The theoretical and methodological background includes theories of social constructivism, digitalization of health and mediatization. The empirical data consist of data from the author’s research (methods – survey (online questionnaire)) and those presented in relevant publications. …”
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Normal tissue radioprotection by amifostine via Warburg-type effects by Michael I. Koukourakis, Alexandra Giatromanolaki, Christos E. Zois, Dimitra Kalamida, Stamatia Pouliliou, Ilias V. Karagounis, Tzu-Lan Yeh, Martine I. Abboud, Timothy D. W. Claridge, Christopher J. Schofield, Efthimios Sivridis, Costantinos Simopoulos, Savvas P. Tokmakidis, Adrian L. Harris

“…Abstract The mechanism of Amifostine (WR-2721) mediated radioprotection is poorly understood. The effects of amifostine on human basal metabolism, mouse liver metabolism and on normal and tumor hepatic cells were studied. …”
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ABA-induced active stomatal closure in bulb scales of Lanzhou lily by Lei Gong, Hai-Qing Liu, Ye Hua, Ya-Yun Zhang, Md. Mahadi Hasan

“…Abscisic acid (ABA) mediated stomatal closure is a highly effective mode of active stomatal regulation under drought stress. …”
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Study of the Mastery of Digital Self-Efficacy through the Learning Process among Students of Universities in the Livestock Sector by Ayu Intan Sari, Ida Nugroho Saputro, Sutrisno Hadi Purnomo, Endang Tri Rahayu, Shanti Emawati

“…Another finding, digital literacy mediates the influence of institutional support, instructor influence, and peer influence on student digital self-efficacy. …”
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Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development by Han Koo, Kyung Chan Park, Hyun Ahm Sohn, Minho Kang, Dong Joon Kim, Zee-Yong Park, Sehoon Park, Sang Hyun Min, Seong-Hwan Park, Yeon-Mi You, Yohan Han, Bo-Kyung Kim, Chul-Ho Lee, Yeon-Soo Kim, Sang J. Chung, Young Il Yeom, Dong Chul Lee

“…In summary, KRAS-driven cancer development critically depends on the deubiquitination of KRAS protein mediated by USP9X/NDRG3, and KRAS-addicted cancers could be effectively targeted by inhibiting the KRAS-NDRG3 interaction.…”
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Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in β-Cells through the Activation of GPR40-PLC-IP3 Pathway by Ximei Shen, Beibei Fan, Xin Hu, Liufen Luo, Yuanli Yan, Liyong Yang

“…GPR40 was involved in metformin reversing metabolic inflammation key marker TLR4 activation-mediated β-cell injury. Furthermore, downstream signaling protein PLC-IP3 of GPR40 was involved in the protective effect of metformin on meta-inflammation, and the above process of metformin was partially regulated by AMPK activity. …”
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