ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway by Liang Jiang, Shuai Zhang, Ning An, Guoqing Chai, Changhong Ye

“…The effect of ASPM on cell proliferation, migration, invasion, and cell cycle was explored in ATC cell lines by in vitro inhibition of ASPM, while ASPM-mediated tumorigenicity was investigated in a xenograft tumor model. …”
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Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines by Mohammed S. Albadah, Hafedh Dekhil, Shaffi Ahamed Shaik, Mohammed A. Alsaif, Mustafa Shogair, Shahid Nawaz, Assim A. Alfadda

“…Whether this relation is mediated through an interaction with adipokines remains unclear. …”
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Bundle sheath cell-dependent chloroplast movement in mesophyll cells of C4 plants analyzed using live leaf-section imaging by Yuta Kato, Takao Oi, Yoshikatsu Sato, Mitsutaka Taniguchi

“…However, it remains unclear whether M chloroplast movement is an intercellular response mediated by BS cells. One major challenge to resolve this is the difficulty in observing chloroplast movement due to scattering and absorption of observation light in live-leaf tissues. …”
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Surface Treatment on Nickel Oxide to Enhance the Efficiency of Inverted Perovskite Solar Cells by Kaijie Wang, Ye Tian, Heng Jiang, Meng Chen, Shuangyan Xu

“…Low-temperature annealing (100°C) cannot convert the precursor materials to fully covered NiOx film, while the PSC based on mediate-temperature annealing (300°C) NiOx has larger resistance and thus lower efficiency. …”
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Removing limitations surrounding terpenoid biosynthesis by biotechnological techniques in Ferula sp.: A review by Zahra Aghaali, Jun-Li Yang, Mohammad Reza Naghavi, Meisam Zargar

“…This review examines the potential of hairy root culture, CRISPR/Cas-mediated genome editing, and metabolic engineering, including gene overexpression and enzyme engineering, for enhancing Ferula capacity tailored to industrial and medicinal needs. …”
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Educational insights into digital entrepreneurship: the influence of personality and innovation attitudes by João M. Lopes, Sofia Gomes, Elisabete Nogueira

“…However, this relationship becomes significant when the relationship between personality traits and digital entrepreneurial intention is mediated by an innovative digital attitude. Furthermore, the intensifying role of digital entrepreneurial education was demonstrated in converting students' innovative digital attitudes into their digital entrepreneurial intention. …”
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Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans by Erzsébet Orosz, Károly Antal, Zoltán Gazdag, Zsuzsa Szabó, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi, Tamás Emri

“…Many of them, including the downregulation of the mitotic cell cycle, as the MSB stress-specific upregulation of FeS cluster assembly and the MSB stress-specific downregulation of nitrate reduction, tricarboxylic acid cycle, and ER to Golgi vesicle-mediated transport, showed AtfA dependence. To elucidate the potential global regulatory role of AtfA governing expression of a high number of genes with very versatile biological functions, we devised a model based on the comprehensive transcriptomic data. …”
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The involvement of CgCaspase-3 in regulating the expressions of proinflammatory cytokines through NF-κB/Rel signaling pathway in oysters by Zihan Wang, Xiaopeng Li, Jiejie Sun, Shuyi Mu, Wei Wu, Renle Chang, Lingling Wang, Linsheng Song

“…Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a prominent mediator of apoptosis and participates in the cell death signaling cascade. …”
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Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease by Qingquan Chen, Shirong Huang, Yue Wu, Shuyu Zhang, Qicai Liu, Min Chen

“…Inflammatory bowel disease (IBD) is a group of immune-mediated conditions. Immune activity is varied by age and gender. …”
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Lung-homing nanoliposomes for early intervention in NETosis and inflammation during acute lung injury by Jungbum Kim, Donghyuk Seo, So-Yeol Yoo, Hye-Jin Lee, Jisun Kim, Ji Eun Yeom, Jae-Young Lee, Wooram Park, Kyung Soo Hong, Wonhwa Lee

“…Here we report a pulmonary targeting lung-homing nanoliposome (LHN) designed to attenuate excessive Neutrophil Extracellular Trap formation (NETosis) through sivelestat and DNase-1, coupled with an anti-inflammatory effect mediated by 25-hydroxycholesterol (25-HC), offering a promising intervention for the acute phase of ALI. …”
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Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors by Gabriela Placoná Diniz, Marcela Sorelli Carneiro-Ramos, Maria Luiza Morais Barreto-Chaves

“…TH-induced cardiac hypertrophy in vivo is accompanied by increased cardiac Transforming Growth Factor-β1 (TGF-β1) levels, which is mediated by Angiotensin II type 1 receptors (AT1R) and type 2 receptors (AT2R). …”
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Animating the critical zone: beavers as critical zone engineers by Clifford Adamchak, Clifford Adamchak, Katherine B. Lininger, Eve-Lyn S. Hinckley, Eve-Lyn S. Hinckley

“…In particular, they can effectively restore degraded riparian areas and improve water quality and quantity, causing implications for many important ecosystem services. Beaver-mediated river corridor processes in the context of a changing climate require investigation to determine how both river corridor function and critical zone processes will shift in the future. …”
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A CDFT-Based Computational Peptidology (CDFT-CP) Study of the Chemical Reactivity and Bioactivity of the Marine-Derived Alternaramide Cyclopentadepsipeptide by Norma Flores-Holguín, Juan Frau, Daniel Glossman-Mitnik

“…Alternaramide is a cyclic pentadepsipeptide isolated from marine sources that has been shown to present weak antibiotic activity against Bacillus subtilis and Staphylococcus aureus as well as inhibitory effects on inflammatory mediator expressions. Thus, this work reports the results of a computational study of the chemical reactivity and bioactivity properties of this cyclopentadepsipeptide considering a CDFT-based computational peptidology (CDFT-CP) methodology that results from the combination of the chemical reactivity descriptors that arise from conceptual density functional theory (CDFT) together with some cheminformatics tools that can be used to estimate the associated physicochemical parameters, to improve the process of virtual screening through a similarity search, and to identify the ability of the peptide to behave as a potential useful drug, complemented with an analysis of its bioactivity and pharmacokinetics indices related to the ADMET (absorption, distribution, metabolism, excretion, and toxicity) features. …”
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A double dissociation between semantic and spatial cognition in visual to default network pathways by Tirso RJ Gonzalez Alam, Katya Krieger-Redwood, Dominika Varga, Zhiyao Gao, Aidan J Horner, Tom Hartley, Michel Thiebaut de Schotten, Magdalena Sliwinska, David Pitcher, Daniel S Margulies, Jonathan Smallwood, Elizabeth Jefferies

“…We show that functional subdivisions of visual cortex and DMN sit at opposing ends of parallel streams of information processing that support visually mediated semantic and spatial cognition, providing convergent evidence from univariate and multivariate task responses, intrinsic functional and structural connectivity. …”
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Lung Matrix Metalloproteinase Activation following Partial Hepatic Ischemia/Reperfusion Injury in Rats by Giuseppina Palladini, Andrea Ferrigno, Vittoria Rizzo, Eleonora Tarantola, Vittorio Bertone, Isabel Freitas, Stefano Perlini, Plinio Richelmi, Mariapia Vairetti

“…Although the underlying mechanism needs further investigation, this is the first study in which the MMP activation in a distant organ is reported; this event is probably TNF-alpha-mediated and the lung appears as the first remote organ to be involved in hepatic I/R injury.…”
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Health Equity and Its Economic Determinants (HEED): protocol for a pan-European microsimulation model for health impacts of income and social security policies by Alastair H Leyland, Srinivasa Vittal Katikireddi, Anna Pearce, Mikael Rostila, Matteo Richiardi, Daniel Kopasker

“…The Health Equity and Its Economic Determinants project aims to assess the potential impacts of different taxation and social security policies across Europe on population health and health inequalities using a computer-based simulation that provides projections over multiple health domains.Methods and analysis In the first phase, key input parameters for the model will be estimated using estimation techniques that control for the effects of prior exposure on time-varying confounders and mediators (g-methods). The second phase will involve developing and validating the microsimulation model for the UK. …”
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Binding affinity screening of polyphenolic compounds in Stachys affinis extract (SAE) for their potential antioxidant and anti-inflammatory effects by Hun Hwan Kim, Se Hyo Jeong, Min Yeong Park, Pritam Bhangwan Bhosale, Abuyaseer Abusaliya, Sang Joon Lee, Jeong Doo Heo, Hyun Wook Kim, Je Kyung Seong, Dong Il Kim, Kwang Il Park, Gon Sup Kim

“…Inflammation protects the body from biological stimuli, and pro-inflammatory mediators are negatively affected in the immune system. …”
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Differentially expressed whey proteins of donkey and bovine colostrum revealed with a label-free proteomics approach by Mohan Li, Qilong Li, Haikun Yu, Xiumin Zhang, Dehao Li, Wanying Song, Yan Zheng, Xiqing Yue

“…Gene Ontology analysis revealed that these DEWPs were mainly related to cellular components, such as extracellular exosome, plasma membrane, and mitochondrion; biological processes, such as oxidation-reduction process, cell-cell adhesion, and small guanosine triphosphate (GTP) ase-mediated signal transduction; and molecular functions, such as GTP binding, GTPase activity, and soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor activity. …”
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Extrusion-Based Printing of Myoblast-Loaded Fibrin Microthreads to Induce Myogenesis by Hanson S. Lee, Bryanna L. Samolyk, George D. Pins

“…Various biofabrication strategies have been developed to create engineered skeletal muscle constructs that mimic native matrix and cellular microenvironments to enhance muscle regeneration; however, there remains a need to create scalable engineered tissues that provide mechanical stability as well as structural and spatiotemporal signaling cues to promote cell-mediated regeneration of contractile skeletal muscle. …”
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Didactics of African Languages and English for Specific Purposes: Integrated Approaches for Hybrid Learning by Ibrahima KARAMOKO & Nongoiala Sidiky SILUE

“…Furthermore, it is suggested that teachers play a crucial role as mediators, using technological tools to facilitate these linguistic and didactic exchanges. …”
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