Evaluation of Serum Vascular Adhesion Protein-1 as a Potential Biomarker in Thyroid Cancer by Zhigang Hu, Pengxin Zhao, Kaili Zhang, Leilei Zang, Haiying Liao, Weiyuan Ma

“…Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion. The prognostic value of VAP-1 has been determined in gastric cancer. …”
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Uric Acid-Induced Adipocyte Dysfunction Is Attenuated by HO-1 Upregulation: Potential Role of Antioxidant Therapy to Target Obesity by Komal Sodhi, Jordan Hilgefort, George Banks, Chelsea Gilliam, Sarah Stevens, Hayden A. Ansinelli, Morghan Getty, Nader G. Abraham, Joseph I. Shapiro, Zeid Khitan

“…These beneficial effects of CoPP were reversed by SnMP, supporting a role for HO activity in mediating these effects. These findings demonstrate that increased levels of HO-1 appear crucial in modulating the phenotype of adipocytes exposed to uric acid and in downregulating XO and NADPH oxidase levels.…”
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Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21 by Yang Jiang, Shuang Wei, Shiming Shen, Yuxiao Liu, Weitong Su, Dong Ding, Zengpeng Zheng, Haokai Yu, Tingting Zhang, Qiuli Yang, Jiuxiang Zhao, Yi Shen, Xia Fang, Liangcai Lin, Dongguang Xiao, Aoyuan Cui, Qin Wan, Yadong Zhang, Yu Li, Cuiying Zhang

“…These ethyl lactate‐mediated beneficial effects are abolished by inhibition of SIRT1 through injection of EX527. …”
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Monoclonal anti-CD38 therapy in human myeloma: retrospects and prospects by Alberto L. Horenstein, Angelo C. Faini, Angelo C. Faini, Fabio Morandi, Erika Ortolan, Paola Storti, Nicola Giuliani, Nicola Giuliani, Paul G. Richardson, Fabio Malavasi, Fabio Malavasi

“…CD38 was selected early on as a target for mAb-mediated therapy for MM, driven by findings from an early Cluster of Differentiation (CD) Workshop. …”
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Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells by Hidehito Saito, Keisuke Okita, Noemi Fusaki, Michael S. Sabel, Alfred E. Chang, Fumito Ito

“…Here, we describe the derivation of human iPSCs from melanoma TILs expressing high level of PD-1 by Sendai virus-mediated transduction of the four transcription factors, OCT3/4, SOX2, KLF4, and c-MYC. …”
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Paroxysmal sympathetic hyperactivity and refractory hypotension in Guillain-Barré syndrome with autoimmune encephalitis: a case report and literature review by Jun-Ping Wang, Yan-Bo He

“…Guillain-Barré syndrome (GBS) is an acute inflammatory peripheral nerve disorder mediated by autoimmune mechanisms. However, its co-occurrence with autoimmune encephalitis (AE) is rare. …”
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The impact of reward systems for lecturers, communication culture, intrinsic motivation, and transformational leadership on institutional effectiveness in Islamic higher education by Handoko Handoko, Mesiono Mesiono, Rusydi Ananda

“…This study aims to analyze the influence of reward systems, communication culture, and intrinsic motivation on the institutional effectiveness of Islamic higher education institutions in Binjai City, emphasizing the mediating role of transformational leadership. The research is motivated by the importance of professional and high-quality educational management in addressing globalization challenges and meeting societal demands for higher education. …”
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Pre-therapeutic efficacy of the CDK inhibitor dinaciclib in medulloblastoma cells by Marta Buzzetti, Sonia Morlando, Dimitrios Solomos, Ammara Mehmood, Alexander W. I. Cox, Mattia Chiesa, Yuri D’Alessandra, Michela Garofalo, Caroline H. Topham, Gianpiero Di Leva

“…Specifically, we demonstrated that MCL-1 is a key apoptotic mediator for MB cells and co-treatment of dinaciclib with BH3 mimetics boosts the therapeutic efficacy of dinaciclib. …”
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Influence of Rectal Decompression on Abdominal Symptoms and Anorectal Physiology following Colonoscopy in Healthy Adults by Chih-Hsun Yi, Tso-Tsai Liu, Wei-Yi Lei, Jui-Sheng Hung, Chien-Lin Chen

“…Our study indicates that the mechanisms that improved abdominal symptoms by rectal decompression might be mediated by a central pathway instead of a peripheral mechanism.…”
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Cell-Type-Specific Differentiation and Molecular Profiles in Skin Transplantation: Implication of Medical Approach for Genetic Skin Diseases by Noritaka Oyama, Fumio Kaneko

“…Recent studies have emerged the importance of α-smooth muscle actin- (SMA-) positive myofibroblasts, via stage- and cell-specific contribution of TGFβ, PDGF, ET-1, CCN-2 signalling pathways, and mastocyte-derived mediators (e.g., histamine and tryptase), for the functional reorganisation of the grafted skin. …”
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Thiazolidinedione-Induced Fluid Retention: Recent Insights into the Molecular Mechanisms by Jerzy Bełtowski, Jolanta Rachańczyk, Mirosław Włodarczyk

“…In addition, thiazolidinediones may augment sodium reabsorption in the proximal tubule by stimulating the expression and activity of apical Na+/H+ exchanger-3 and basolateral Na+- cotransporter as well as of Na+,K+-ATPase. These effects are mediated by PPARγ-induced nongenomic transactivation of the epidermal growth factor receptor and downstream extracellular signal-regulated kinases (ERK).…”
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Cellular Anti-Inflammatory and Antioxidant Activities of Bamboo Sasa albomarginata Leaf Extract and Its Constituent Coumaric Acid Methyl Ester by Shiori Kojima, Masatoshi Hakamata, Toshimichi Asanuma, Rie Suzuki, Jun-ichi Tsuruda, Takeshi Nonoyama, Yinzhi Lin, Hitomi Fukatsu, Naoki Koide, Kazuo Umezawa

“…The Sasa albomarginata extract inhibited inflammatory mediators such as LPS-induced NO, IL-6, and ROS production in mouse monocyte leukemia RAW264.7 cells. …”
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Localization of Presynaptic Plasticity Mechanisms Enables Functional Independence of Synaptic and Ectopic Transmission in the Cerebellum by Katharine L. Dobson, Tomas C. Bellamy

“…In the cerebellar molecular layer parallel fibre terminals release glutamate from both the active zone and from extrasynaptic “ectopic” sites. Ectopic release mediates transmission to the Bergmann glia that ensheathe the synapse, activating Ca2+-permeable AMPA receptors and glutamate transporters. …”
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Exercise reduced the formation of new adipocytes in the adipose tissue of mice in vivo. by Timothy D Allerton, Jonathan J Savoie, Mark D Fitch, Marc K Hellerstein, Jacqueline M Stephens, Ursula White

“…Although the skeletal muscle has been a primary focus, exercise also mediates robust adaptations in white adipose tissue. …”
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The impact of perceived caregiver anxiety and stress during childhood on late-life depression: evidence from the China Health and Retirement Longitudinal Study by Liuyin Jin, Liuyin Jin, Dongdong Wang, Dengxian Yang, Qiong Jin, Mengye Cao, Yuanyuan Li, Jiajie Yang, Guoming Xie, Wenwu Zhang

“…After adjusting for covariates, the association for male caregivers weakened, highlighting the potential role of other mediators.DiscussionThe results highlight the critical importance of parental mental health, especially maternal anxiety, in mitigating intergenerational mental health risks. …”
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Autoantibodies Targeting AT1 Receptor from Patients with Acute Coronary Syndrome Upregulate Proinflammatory Cytokines Expression in Endothelial Cells Involving NF-κB Pathway by Weijuan Li, Zhi Li, Yaoqi Chen, Songhai Li, Yuanyuan Lv, Wenping Zhou, Mengyang Liao, Feng Zhu, Zihua Zhou, Xiang Cheng, Qiutang Zeng, Yuhua Liao, Yumiao Wei

“…AT1-AAs may play a great role in the pathogenesis of the acute coronary syndrome by mediating vascular inflammatory effects involved in the NF-κB pathway.…”
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Neurobiological Mechanisms Underlying Psychological Dysfunction After Brain Injuries by Prashin Unadkat, Tania Rebeiz, Erum Ajmal, Vincent De Souza, Angela Xia, Julia Jinu, Keren Powell, Chunyan Li

“…The review highlights promising therapeutic avenues for addressing injury-associated psychological dysfunction, emphasizing Nrf2, neuropeptides, and nonpharmacological therapies as multi-mechanistic interventions capable of modulating upstream mediators to address the complex interplay of factors underlying psychological dysfunction in brain injury. …”
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Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1 by Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran

“…These inhibitory effects were mediated by reduction in viral RNA replication and viral E and NS1 protein expression, but not by interference with virus entry into cells or NS1 oligomerization. …”
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Gender Dynamics in Online Religious Leadership in Nigeria: Investigating How Digital Platforms Shape Communication, Authority, and Influence by Bukola L. Oloba, Anne M. Blankenship

“…The advent of digital platforms has introduced a new paradigm, offering both male and female leaders with avenues to expand their communication, authority, and influence. Utilizing mediatization theory, this research investigated how online spaces allow women to bypass traditional patriarchal structures, engage broader audiences, and influence religious narratives. …”
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Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis by Kaiyi Zhu, Jia Guo, Xiaoxue Yu, Que Wang, Chao Yan, Quan Qiu, Weiqing Tang, Xiuqing Huang, Hongna Mu, Lin Dou, Yunfei Bian, Qinghua Han, Tao Shen, Jian Li, Chuanshi Xiao

“…Using a neonatal rat ventricular myocyte hypoxia/reoxygenation model, we investigated the role of its potential mechanisms of necroptosis in globular adiponectin-mediated protection in hypoxia/reoxygenation-induced cardiomyocyte injury as compared to apoptosis. …”
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