Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds by Shannen Lau, Bim Graham, Ben J. Boyd, Colin W. Pouton, Paul J. White

“…Conjugation of siRNA to macromolecules such as serum albumin has multiple potential benefits, including enhanced extravasation via albumin-mediated transcytosis across endothelial cells and reduced renal clearance. …”
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An Empirical Study on the Behavioral Intention of College Students’ Online Ideological and Political Learning by Miaomiao Ren, Yan Ma, Wenxiang Fan, Mingyong Li, Yuming Feng

“…The results show that there are group differences in system perception, technology acceptance perception, and behavioral intention among college students with different genders and grades; different dimensions of information system quality have different effects on behavioral intention; perceived ease of use is an important mediating variable, which has a direct positive impact on the use attitude; perceived usefulness and use attitude have positive direct effects on behavioral intention; and perceived usefulness has a higher predictive effect on behavioral intention. …”
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Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization by Danyue Li, Weilv Xu, Suhui He, Xinyue Li, Yumeng Wang, Qian Lv, Nan Chen, Lu Dong, Feng Guo, Fushan Shi

“…In this study, SCU demonstrated efficacy in hindering pyroptosis mediated by the NOD-like receptor protein 3 (NLRP3) inflammasome, absent in melanoma 2 (AIM2) inflammasome, NLR-family CARD-containing protein 4 (NLRC4) inflammasome, and that activated through the non-canonical pathway. …”
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Environmental high temperature (heat stroke) causes articular cartilage damage in vivo and in vitro by Sun yingfei, Yang feng, Ma haoning

“…The results showed that HS activated ZBP-1-mediated PAN-apoptosis. In vivo, our group further evaluated the impact of HS on articular cartilage. …”
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The Role of Immersive Experience in Anxiety Reduction: Evidence from Virtual Reality Sessions by Dominika Wilczyńska, Tamara Walczak-Kozłowska, David Alarcón, María José Arenilla, Jose Carlos Jaenes, Marcelina Hejła, Mariusz Lipowski, Joanna Nestorowicz, Henryk Olszewski

“…Therefore, this study investigates the potential of a newly designed VR experience to alleviate anxiety by focusing on the mediating role of VR-induced immersion. Methods: The study included 419 individuals aged 10 to 80 years, with 29 aged 10–15 years and 390 above 15 years, who were randomly assigned to experimental and control groups on the basis of project-defined criteria, including a random allocation to the wheelchair-using group. …”
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SDZ MRL 953, A Novel Synthetic Lipid a Analogue, Induces Tolerance to the Lethal Effects of Endotoxin and Enhances Nonspecific Immunity by Charles Lam, Eberhard Schütze, Emmanuel Quakyi, Ekke Liehl, Peter Stütz

“…Current strategies for treating septic shock by removal of endotoxin (lipopolysaccharides [LPS]) or putative mediators have only been partially effective. An attractive alternative appears to be the induction of hyporesponsiveness to LPS by synthetic lipid A analogues. …”
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Is Thymoglobulin or Rituximab the Cause of This Serum Sickness? A Case Report of Serum Sickness Dilemma and Literature Review by Amarpreet Sandhu, Antonia Harford, Pooja Singh, Eduardo Alas

“…Serum sickness is an immune-complex-mediated systemic illness that can occur after treatment with monoclonal or polyclonal antibodies such as Rituxan (Rituximab) or antithymocyte globulin (Thymoglobulin), respectively. …”
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Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury? by Hadis Sabour, Abbas Norouzi Javidan, Sahar Latifi, Mohammad Reza Hadian, Seyed-Hassan Emami Razavi, Farzad Shidfar, Mohammad Reza Vafa, Hamidreza Aghaei Meybodi

“…Moreover it seems that positive association between HDL and BMD is not mediated through increased bone formation.…”
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Role of p16INK4A in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells by Razmik Mirzayans, Bonnie Andrais, Gavin Hansen, David Murray

“…These observations are made with cells that express wild-type p53, a key mediator of the DNA damage response. In this paper, we examine the growing evidence suggesting a negative regulatory relationship between p16 and p53 and discuss recent reports that implicate a role for p16 in replicative senescence and ionizing radiation-induced premature senescence in human cells that lack wild-type p53 function.…”
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Clinical Feature of Intrahepatic B-Lymphocytes in Chronic Hepatitis B by Ashraf Mohamadkhani, Elnaz Naderi, Masoud Sotoudeh, Aezam Katoonizadeh, Ghodratollah Montazeri, Hossein Poustchi

“…The susceptible B lymphocytes to hepatitis B virus might be implicated in the development of immune mediated inflammation of HBV-induced hepatic injury. …”
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Positive Association of Metabolic Syndrome with a Single Nucleotide Polymorphism of Syndecan-3 (rs2282440) in the Taiwanese Population by Betty Chia-Chen Chang, Lee-Ching Hwang, Wei-Hsin Huang

“…Further investigation is needed to see if this association is mediated by mere adiposity or SDC3 polymorphism is also linked with other components of MetS such as lipid metabolism.…”
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L’Arbre des rues de Mexico : une ressource au-delà de son exploitabilité by Nora Itri

“…In this context, the tree acquires the status of "mediator", between a deeply artificialized environment created by humankind and the underlying biological territory that makes up the Mexico City Valley. …”
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Functional and Practical Insights Into the Genetic Basis of Takayasu Arteritis by Desiré Casares‐Marfil, Amr H. Sawalha

“…Large‐scale genetic studies have significantly contributed to the identification of genetic variation associated with immune‐mediated diseases. To date, five genome‐wide association studies (GWAS) have been performed in TAK, identifying multiple genetic susceptibility loci across the genome. …”
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Exosomal MicroRNAs Derived from Human Amniotic Epithelial Cells Accelerate Wound Healing by Promoting the Proliferation and Migration of Fibroblasts by Bin Zhao, Xiaodong Li, Xiaomin Shi, Xueqin Shi, Wei Zhang, Gaofeng Wu, Xujie Wang, Linlin Su, Dahai Hu

“…However, it is still unclear precisely which molecule or which group of molecules carried within hAEC-derived exosomes (hAEC-Exos) mediated wound healing. Here, we explored purified hAEC-Exos together with either proteinase K (PROse) or RNase A on the effect of fibroblasts and cutaneous wound healing. …”
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Immune Dysfunction in Tourette Syndrome by Ishraga Elamin, Mark J. Edwards, Davide Martino

“…Genes related to both cell- and antibody-mediated immune responses may be over-expressed at specific ages in youngsters with TS. …”
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Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease by Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Ilza Pajeva, Ivanka Tsakovska

“…A detailed analysis was performed regarding proteins which PPARγ-mediated expression changes had been confirmed to be prosteatotic by most experimental evidence. …”
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Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy by Yu-Gui Zhang, Jiang-Tao Niu, Hong-Wei Wu, Xin-Lei Si, Shu-Juan Zhang, Dong-Hui Li, Tian-Tian Bian, Yue-Feng Li, Xing-Ke Yan

“…Actin-binding proteins (ABPs), by interacting with actin, regulate the polymerization, depolymerization, bundling, and cross-linking of actin filaments, directly or indirectly, thereby mediating the maintenance of cell morphology, cell movement, and many other biological functions. …”
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Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function by Luis Miguel Román-Pintos, Geannyne Villegas-Rivera, Adolfo Daniel Rodríguez-Carrizalez, Alejandra Guillermina Miranda-Díaz, Ernesto Germán Cardona-Muñoz

“…Oxidative stress induced by hyperglycemia is mediated by several identified pathways: polyol, hexosamine, protein kinase C, advanced glycosylation end-products, and glycolysis. …”
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Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1 by Pauline Malinge, Xavier Chauchet, Jérémie Bourguignon, Nicolas Bosson, Sébastien Calloud, Tereza Bautzova, Marie Borlet, Mette Laursen, Vinardas Kelpsas, Nadia Rose, Franck Gueneau, Ulla Ravn, Giovanni Magistrelli, Nicolas Fischer

“…Our results demonstrate that, despite a less prominent role in natural antibodies, the LC can mediate high affinity binding to different antigens and neutralize their biological function. …”
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Exploration of the mechanism of fermented turmeric preventing glucolipid metabolic disorder: Insights into signaling of microbiota-SCFAs-brown adipose tissue axis in mice by Xingliang Xiang, Yukun Liu, Zhaoxiang Zeng, Xueyan Zhao, Qingxin Shi, Xing Huang, Haijun Yang, Chengwu Song, Shunqing Xu, Shuna Jin

“…Consequently, the SCFAs mediating crosstalk between microbiota and BAT could contribute to anti-GMD activity. …”
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