In Vitro Differentiation of First Trimester Human Umbilical Cord Perivascular Cells into Contracting Cardiomyocyte-Like Cells by Peter Szaraz, Matthew Librach, Leila Maghen, Farwah Iqbal, Tanya A. Barretto, Shlomit Kenigsberg, Andrée Gauthier-Fisher, Clifford L. Librach

“…Based on the expression of cardiomyocyte markers (cTnT, MYH6, SIRPA, and CX43) FTM and term HUCPVCs achieved significantly increased cardiomyogenic differentiation compared to bone marrow MSCs, while their immunogenicity remained significantly lower as indicated by HLA-A and HLA-G expression and susceptibility to T cell mediated cytotoxicity. When applying aggregate-based differentiation, FTM HUCPVCs showed increased aggregate formation potential and generated contracting cells within 1 week of coculture, making them the first MSC type with this ability. …”
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CircRNA TUBA1C promotes proliferation and glucose metabolism, and blocks apoptosis of osteosarcoma cells through sponging miR-143-3p by Yi-Bing Liu, Wen-Hao Dai, Jun-Jie Chang, Kang Wei

“…Finally, rescue experiments showed that inhibition of miR-143-3p in circTUBA1C-silenced OS cells significantly overrode the low-circTUBA1C-mediated miR-143-3p upregulation and OS cell progression in vitro and in vivo . …”
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Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota by Blanca S. Noriega, Marcos A. Sanchez-Gonzalez, Daria Salyakina, Jonathan Coffman

“…Fatty acids associated beneficial effects may be mediated, to an important extent, through changes in gut microbiota composition. …”
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Epigenetic Mechanisms in Type-2 Diabetes Mellitus: A Narrative Review by Deenadhayalan Ashok, Monisha Prasad, Mohammad Fareed, Anis Ahmad Chaudhary

“…The incidence of Type-2 Diabetes Mellitus (T2DM) has increased significantly in the last several decades, which is an important challenge for health professionals and researchers. The systems that mediate the interaction between environmental factors and the genes, such as epigenetics, may have a specific bearing on the aetiology of T2DM. …”
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T Cell Histiocyte Rich Large B Cell Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: An Uncommon Presentation of a Rare Disease by Uroosa Ibrahim, Gwenalyn Garcia, Amina Saqib, Shafinaz Hussein, Qun Dai

“…The pathophysiology is thought to involve cytokine-mediated evasion of T cell immune response by malignant B cells. …”
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Autoimmunity promotes chronic lymphocytic leukemia progression in an indolent disease model by Lisa Pfeuffer, Viola Siegert, Riccardo Trozzo, Katja Steiger, Roland Rad, Jürgen Ruland, Maike Buchner

“…This study investigates the connection between plasma cell-mediated autoimmunity and CLL progression using a mouse model that expresses an active Receptor Activator of NF-κB (RANK) in B cells (RK mice), where autoimmune manifestations coexist with CLL. …”
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SERS Detection of Hydrophobic Molecules: Thio-β-Cyclodextrin-Driven Rapid Self-Assembly of Uniform Silver Nanoparticle Monolayers and Analyte Trapping by Qi Yuan, Yunqing Wang

“…In this research, we present a simple self-assembly protocol for monolayer SERS mediated by 6-deoxy-6-thio-β-cyclodextrin (β-CD-SH). …”
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Impact of COVID-19 on Ocular Surface Health: Infection Mechanisms, Immune Modulation, and Inflammatory Responses by Duliurui Huang, Weixia Xuan, Zhijie Li

“…The review also examines the roles of cytokines and chemokines in mediating ocular surface inflammation and explores the impact of cytokine storms and chronic inflammation on ocular health. …”
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Bimolecular Complementation to Visualize Filovirus VP40-Host Complexes in Live Mammalian Cells: Toward the Identification of Budding Inhibitors by Yuliang Liu, Michael S. Lee, Mark A. Olson, Ronald N. Harty

“…In addition, we used the BiMC approach along with a VLP budding assay to test small molecule inhibitors identified by in silico screening for their ability to block eVP40 PTAP-mediated interactions with Tsg101 and subsequent budding of eVP40 VLPs. …”
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Social Reality in Discourse of «Objectification Turn» by I. V. Katerny

“…This results in the "postsocial relations", that is social enaction of various kinds of objects, which leads to the fact that non-human, non-living and even non-physical objects are increasingly replacing humans as partners to communicate with and deeply mediating social relations, making the latter dependent on them. …”
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Bone and Mineral Metabolism in Patients with Primary Aldosteronism by Luigi Petramala, Laura Zinnamosca, Amina Settevendemmie, Cristiano Marinelli, Matteo Nardi, Antonio Concistrè, Francesco Corpaci, Gianfranco Tonnarini, Giorgio De Toma, Claudio Letizia

“…This study supports the hypothesis that bone loss and fracture risk in PA patients are potentially the result of aldosterone mediated hypercalciuria and the consecutive secondary hyperparathyroidism.…”
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15-Deoxy-Δ12,14-prostaglandin J2 Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells by Carlos Antônio Trindade-da-Silva, Carolina Fernandes Reis, Lara Vecchi, Marcelo Henrique Napimoga, Marcelo Sperandio, Bruna França Matias Colombo, Patrícia Terra Alves, Laura Sterian Ward, Carlos Ueira-Vieira, Luiz Ricardo Goulart

“…The cyclopentenone prostaglandin 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is a natural ligand of peroxisome proliferator-activated receptor gamma (PPAR-γ) and a potential mediator of apoptosis in cancer cells. In the present study, we evaluated the effect of 15d-PGJ2 in human thyroid papillary carcinoma cells (TPC-1) using different doses of 15d-PGJ2 (0.6 to 20 μM) to determine IC50 (9.3 μM) via the MTT assay. …”
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Experiential quality and satisfaction in marine tourism: a gendered analysis of post-visit behavior and frequency of visits in Lampung, Indonesia by Mochammad Fahlevi

“…Experiential satisfaction also mediates the relationship between destination value and post-visit behavior, confirming its pivotal role in tourism research. …”
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The Effects of the COVID-19 Pandemic on Abnormal Uterine Bleeding According to the PALM-COEIN Classification by Onur Bektas, Kivilcim Bektas, Sirin Aydin, Gulsen Dogan Durdag, Husnu Celik

“…These include direct inflammation of the ovarian and endometrial tissues, potential defects in endometrial repair mechanisms secondary to inflammation, changes in the hypothalamic-pituitary-ovarian axis, immunological effects of vaccination, systemic inflammatory responses affecting the ovary and endometrium, changes in inflammatory and immune mediators, and immune cell activation. Additionally, increased production of vasodilatory substances such as prostaglandin E2 and prostacyclin, decreased production of local vasoconstrictors like prostaglandin F2α and endothelin-1, as well as increased plasminogen activator activity leading to enhanced thrombolysis and disruptions in endometrial hemostatic mechanisms. …”
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<i>Garcinia brasiliensis</i> Leaves Extracts Inhibit the Development of Ascitic and Solid Ehrlich Tumors by Lucas Sylvestre Silva, Eduardo Cavallini, Rafael André da Silva, Monielle Sant’Ana, Ariane Harumi Yoshikawa, Thiago Salomão, Bianca Huang, Paula Craice, Luiz Philipe de Souza Ferreira, Heitor Pedro Della Matta, Cristiane Damas Gil, Maria de Lourdes Gomes Pereira, Ana Paula Girol

“…In relation to tumor-induced animals, morphological changes, plasma enzymes, inflammatory mediators and the induction of apoptosis were analyzed, in addition to histopathological studies, to evaluate the inhibition of tumor growth. …”
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Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota by Huan Wang, Ye Li, Rui Wang, Huaifei Ji, Chenyang Lu, Xiurong Su

“…These positive effects are considered to be related with sciadonic acid (SCA) and are partially mediated by alterations in gut microbiota composition and functionality.…”
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Linking Sleep to Hypertension: Greater Risk for Blacks by A. Pandey, N. Williams, M. Donat, M. Ceide, P. Brimah, G. Ogedegbe, S. I. McFarlane, G. Jean-Louis

“…Results suggest that the race/ethnicity interaction is a significant mediator in the relationship between insufficient sleep and likelihood of having a diagnosis of hypertension.…”
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Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy? by Anna R. Carta, Augusta Pisanu, Ezio Carboni

“…Moreover, after the discovery of infiltrating activated Limphocytes in the substantia nigra (SN) of PD patients, most recent research supports a role of immune-mediated mechanisms in the pathological process leading to chronic neuroinflammation and dopaminergic degeneration. …”
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The added role of Doppler ultrasound evaluation of sickle cell disease vasculopathy as a state of arterial stiffness and decreased nitric oxide bioavailability by Marwa Mohammed Mohammed Onsy, Sonia Ali El-Saiedi, Douaa Mohammed Mohammed Elsheshtawy, Marwa Abd-Elhady Abd-Elsamad

“…Brachial artery parameters showed that baseline diameter was significantly higher (p < 0.001) and flow mediated dilatation (FMD) was significantly lower in patients than control (p < 0.001). …”
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Exosomal non-coding RNAs in the regulation of bone metabolism homeostasis: Molecular mechanism and therapeutic potential by Chengxiong Huang, Yu Xiao, Liming Qing, Juyu Tang, Panfeng Wu

“…In this review, we focus on the regulation mechanism and function of bone homeostasis mediated by exosomal ncRNAs (Exos-ncRNAs), including macrophage polarization, autophagy, angiogenesis, signal transduction and competing endogenous RNA (ceRNA). …”
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