AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis by Manikandan Palrasu, Khadija Kakar, Amarnath Marudamuthu, Hamida Hamida, Shruthi Thada, Yin Zhong, Shanieka Staley, Philip Brandon Busbee, Jie Li, Monica Garcia-Buitrago, Mitzi Nagarkatti, Prakash Nagarkatti

“…AhR directly targeted the dioxin response element 3 (DRE3) region on the α-defensin 1 promoter in IECs. AhR-mediated induction of α-defensin 1 in colitis mice reversed the gut microbial dysbiosis and alleviated colitis. …”
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Immunotherapeutic Potential of Lactobacillus Species as Immune Checkpoint Inhibitors in Cancer Immunotherapy by Renukadevi J, Sam Helinto J, Prena D

“…This review explores the immunotherapeutic potential of Lactobacillus species via adjuvant therapy with immune checkpoint inhibitors (ICIs), such as programmed cell death protein-1, programmed death ligand-1, and cytotoxic T-lymphocyte antigen-4 inhibitors, which have revolutionized cancer treatment by enhancing T-cell-mediated antitumor immunity. However, patient response remains questionable, prompting further study into the role of the gut microbiota in modulating these therapies. …”
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A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy by Youmei Xiao, Zhuoying He, Wanqiong Li, Danhong Chen, Xiaoshuang Niu, Xin Yang, Wenxuan Zeng, Mengfan Wang, Yuzhen Qian, Ye Su, Feiyu Luo, Guanyu Chen, Juan Liu, Xinghua Sui, Xiuman Zhou, Yanfeng Gao

“…The Pep-TACs platform facilitates the degradation of target proteins through the mechanism of recycling transferrin receptor (TFRC)-mediated lysosomal targeted endocytosis. Biological experiments demonstrate that covalent Pep-TACs can significantly degrade the expression of PD-L1 on tumor cells, dendritic cells and macrophages, especially under acidic conditions, and markedly enhance the function of T cells and tumor phagocytosis by macrophages. …”
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Musician’s dystonia: a perspective on the strongest evidence towards new prevention and mitigation treatments by Joy Grifoni, Joy Grifoni, Valeria Crispiatico, Anna Castagna, Rosa Maria Converti, Marina Ramella, Angelo Quartarone, Teresa L’Abbate, Teresa L’Abbate, Karolina Armonaite, Karolina Armonaite, Luca Paulon, Luca Paulon, Francescaroberta Panuccio, Franca Tecchio

“…This model integrates with established literature to form a comprehensive framework for understanding MD as an impaired FeeSyCy-mediated relationship between the individual and their environment, ultimately leading to trauma. …”
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Tetrodotoxin, fungal pathogen infection, and bacterial microbiome associations are variable in the skin microecosystems of two Taricha newt species by Talon Jost, Talon Jost, Alysha Henderson, Brandon LaBumbard, Krisztian Magori, Amber Stokes, Danica Bergin, Autumn Holley, Autumn Holley, Molly Bletz, Molly Bletz, Obed Hernández-Gómez, Gary Bucciarelli, Douglas C. Woodhams, Jonah Piovia-Scott, Jenifer B. Walke

“…A diverse metabolome exists on amphibian skin that mediates interactions between hosts and skin microbiomes. …”
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Development of a Novel Sensor System Based on Magnetic Microspheres to Detect Cardiac Troponin T by Junrong Zhang, Hongxiang Liu, Baofeng Xu, Sijun Huang, Rui Liu, Jinming Zhu, Yi Guo, Li Xu

“…Prognostic detection of biomarkers that specifically reflect myocardial damage in a patient’s blood has become an essential mediating measure to prevent the serious occurrence of AMI. …”
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Adipose-Derived Mesenchymal Stem Cells Enhance Ovarian Cancer Growth and Metastasis by Increasing Thymosin Beta 4X-Linked Expression by Yijing Chu, Min You, Jingjing Zhang, Guoqiang Gao, Rendong Han, Wenqiang Luo, Tingting Liu, Jianxin Zuo, Fuling Wang

“…Based on our findings, increased TMSB4X expression may play a role in accelerating the ADSC-mediated proliferation, invasion, and migration of ovarian cancers.…”
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Biological Effects of Culture Substrates on Human Pluripotent Stem Cells by Yohei Hayashi, Miho Kusuda Furue

“…We discuss the possible effect of integrin-mediated signaling pathways on maintaining hPSC self-renewal. …”
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Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model by Chih-Zen Chang, Chih-Lung Lin, Shu-Chuan Wu, Aij-Lie Kwan

“…High-mobility group box 1 (HMGB1) was shown to be an important extracellular mediator involved in vascular inflammation of animals following subarachnoid hemorrhage (SAH). …”
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Fabrication and Electrical Characterization of Low-Temperature Polysilicon Films for Sensor Applications by Filipa C. Mota, Inês S. Garcia, Aritz Retolaza, Dimitri E. Santos, Patrícia C. Sousa, Diogo E. Aguiam, Rosana A. Dias, Carlos Calaza, Alexandre F. Silva, Filipe S. Alves

“…This work demonstrates, for the first time, the fabrication of a 200 nm polycrystalline silicon thin film through a metal-induced crystallization process mediated by an AlSiCu alloy at temperatures as low as 450 °C on top of silicon and polyimide (PI) substrates. …”
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Effect of Mechanical Force Stress on the Inflammatory Response in Human Periodontal Ligament Cells by Thira Rojasawasthien, Supreda Suphanantachat Srithanyarat, Wajathip Bulanawichit, Thanaphum Osathanon

“…The review highlights the role of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α in mediating inflammatory responses, as well as the counteracting effects of anti-inflammatory cytokines like IL-4 and IL-10. …”
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Understanding the role of nerves in head and neck cancers - a review by Krzysztof Rutkowski, Michał Gola, Michał Gola, Janusz Godlewski, Janusz Godlewski, Anna Starzyńska, Anna Starzyńska, Giulia Marvaso, Giulia Marvaso, Federico Mastroleo, Federico Mastroleo, Maria Giulia Vincini, Maria Giulia Vincini, Alice Porazzi, Mattia Zaffaroni, Barbara Alicja Jereczek-Fossa, Barbara Alicja Jereczek-Fossa

“…This review explores nerve-cancer interactions, including perineural invasion (PNI), cancer-related axonogenesis, neurogenesis, and nerve reprogramming, with an emphasis on their molecular mechanisms, mediators and clinical implications. PNI, an adverse histopathologic feature, has been widely investigated in HNCs. …”
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Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins by A. Catania, G. Colombo, C. Rossi, A. Carlin, A. Sordi, C. Lonati, F. Turcatti, P. Leonardi, P. Grieco, S. Gatti

“…The candidacidal influences of α-MSH appeared to be mediated by increases in cell cyclic adenosine monophosphate (cAMP). …”
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The potential of self-access language centres in fostering lifelong global citizenship: towards a community of practice approach by Michael D. Smith, Ran Niboshi, Christopher Samuell, Simon F.N. Timms

“…Further, self-access provides a cost-effective, technology-mediated alternative to bilateral student mobility, whereby digital community-building occasions cross-cultural practice that may be extended throughout a learner’s life, irrespective of their financial status or place of study. …”
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Impact of Ramadan Intermittent Fasting on Oxidative Stress Measured by Urinary 15-F2t-Isoprostane by Mo'ez Al-Islam Ezzat Faris, Rand Nidal Hussein, Ref'at Ahmad Al-Kurd, Mohammed Ahmed Al-Fararjeh, Yasser Khalil Bustanji, Mohammad Khalil Mohammad

“…In conclusion, results suggest that increased body weight is associated with increased lipid peroxidation and oxidative stress, and the impact of RIF on oxidative stress is mediated by the changes in body weight at the end of the month.…”
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The Role of Pseudocereals in Celiac Disease: Reducing Nutritional Deficiencies to Improve Well-Being and Health by Carolina Caeiro, Caroline Pragosa, Marisa Carreira Cruz, Cidália Daniela Pereira, Sónia Gonçalves Pereira

“…Celiac disease or gluten-dependent enteropathy is a chronic autoimmune pathology triggered by dietary gluten in genetic predisposed individuals, mediated by transglutaminase 2 IgA autoantibodies and associated with a deteriorating immune and inflammatory response. …”
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Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation by Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang, Ping Zhao

“…In this study, the in vitro studies indicated that nuciferine-induced GLUT4 translocation was regulated by G protein-PLC-PKC and AMPK pathways and nuciferine-enhanced intracellular Ca2+ was mediated by G protein-PLC-IP3-IP3R pathway, the increase in intracellular Ca2+ caused by nuciferine was not directly related to GLUT4 translocation, but both promote glucose uptake. …”
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Multiomics identify the gene expression signature of the spinal cord during aging process by Lintao Xu, Jingyu Wang, Jinjie Zhong, Weiwei Lin, Gerong Shen, Ning He, Xingjia Mao, Chunyan Fu, Zhaobo Huang, Fengdong Zhao, Xin Ye, Yongjian Zhu, Mingzhi Zheng, Hui Li, Lin-lin Wang, Kai Zhong, Lijun Zhu, Ying-ying Chen

“…In summary, spatial and bulk transcriptomics elucidate the transcriptional characteristics of young versus senescent spinal cords, thus highlighting the role of Fth1 in mediating ferroptosis resistance in senescent mixed glial cells.…”
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Irisin: A Potential Link between Physical Exercise and Metabolism—An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People by Stefano Benedini, Elena Dozio, Pietro Luigi Invernizzi, Elena Vianello, Giuseppe Banfi, Ileana Terruzzi, Livio Luzi, Massimiliano Marco Corsi Romanelli

“…Irisin may be one potential mediator of the beneficial effects of exercise on metabolic profile.…”
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The Spread of Antibiotic Resistance Genes In Vivo Model by Shuan Tao, Huimin Chen, Na Li, Tong Wang, Wei Liang

“…Most drug resistance genes are located on plasmids, and the spread of drug resistance genes among microorganisms through plasmid-mediated conjugation transfer is the most common and effective way for the spread of multidrug resistance. …”
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