IL-10 Induction from Implants Delivering Pancreatic Islets and Hyaluronan by Paul L. Bollyky, Robert B. Vernon, Ben A. Falk, Anton Preisinger, Michel D. Gooden, Gerald T. Nepom, John A. Gebe

“…The second device is a bioengineered implant consisting of a polyvinyl alcohol sponge scaffold, supportive collagen hydrogel, and alginate spheres mediating sustained release of HA in fluid form. Pancreatic islets that expressed ovalbumin (OVA) antigen were implanted within this device for 14 days into immunodeficient mice that received OVA-specific DO.11.10 T cells and a subsequent immunization with OVA peptide. …”
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DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel‐Induced Pain and Anxiety in Male Mice by Lixia Tian, Xu‐Hui Li, Yu‐Long Zhao, Hui‐Yuan Yi, Xue‐Ru Liu, Rongrong Yao, Xue‐Mei Hou, Xuan Zhu, Fu‐Quan Huo, Tao Chen, Lingli Liang

“…These findings suggest that the DNMT3a‐mediated upregulation of GABAARβ1 in the mPFC contributes to PTX‐induced neuropathic pain and anxiety, highlighting DNA methylation‐dependent epigenetic regulation as a potential therapeutic target for addressing chemotherapy‐induced cortical dysfunction.…”
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Drug allergy by Samira Jeimy, Tiffany Wong, Moshe Ben-Shoshan, Ana Maria Copaescu, Ghislaine A. C. Isabwe, Anne K. Ellis

“…Abstract Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity reactions (HSRs) with varying mechanisms and clinical presentations. …”
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Hyperuricemia-induced complications: dysfunctional macrophages serve as a potential bridge by Wenyi Gu, Wenyi Gu, Jiajing Zhao, Yu Xu, Yu Xu, Yu Xu

“…The third mechanism pertains to the effects on oxidative stress mediators. In this review, we summarize the underlying mechanisms of hyperuricemia, focusing on the effects of macrophages, therapeutic approaches, and clinical trials addressing hyperuricemia-caused dysfunction. …”
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Mast Cell Activation Syndrome in COVID-19 and Female Reproductive Function: Theoretical Background vs. Accumulating Clinical Evidence by Dariusz Szukiewicz, Piotr Wojdasiewicz, Mateusz Watroba, Grzegorz Szewczyk

“…This review presents the importance of MCs and the mediators from their granules in the female reproductive system, including pregnancy, and discusses the mechanism of potential disorders related to MCAS. …”
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Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes by Murali Ganesan, Anup S. Pathania, Grace Bybee, Kusum K. Kharbanda, Larisa Y. Poluektova, Natalia A. Osna

“…We conclude that exosome-mediated crosstalk between IFN-activated macrophages and HBV-replicating hepatocytes plays a protective role via the up-regulation of ISGs and suppression of HBV replication. …”
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Establishing a CRISPR/Cas9 genome editing framework in pigeonpea (Cajanus cajan L.) by targeting phytoene desaturase (PDS) gene disruption by Kameshwaran Senthil, Maniraj Rathinam, Manisha Parashar, Narasimham Dokka, Shaily Tyagi, Vandana Mathur, Sandhya Sharma, Kishor Gaikwad, Ramcharan Bhattacharya, Rohini Sreevathsa

“…The system was validated by Agrobacterium tumefaciens-mediated apical meristem-targeted in planta and in vitro embryonic axis explant transformations, with gene knockout confirmed by albino/bleached phenotypes. …”
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Selenium improves the flavor-promoting substances of summer tea (Camellia sinensis) by altering the expression of flavonoid and amino acids metabolic genes by Ruiming Zhang, Huishan Tang, Xinlong Hu, Yuqiong Chen, Dejiang Ni, Mingle Wang

“…However, the specific mechanisms underlying the Se-mediated improvement of summer tea quality remain unclear. …”
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Stevenleaf from Gynostemma Pentaphyllum inhibits human hepatoma cell (HepG2) through cell cycle arrest and apoptotic induction by Sayed Sajid Hussain, Fan Zhang, Yuanyuan Zhang, Kiran Thakur, Mahrukh Naudhani, Carlos L. Cespedes-Acuña, Zhaojun Wei

“…SV induced the mTOR-mediated cell apoptosis in HepG2 cells via activation of Akt and AMPK. …”
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The Renin-Angiotensin-Aldosterone System in Vascular Inflammation and Remodeling by Maricica Pacurari, Ramzi Kafoury, Paul B. Tchounwou, Kenneth Ndebele

“…Inflammatory factors such as ICAM-1, VCAM-1, TNFα, IL-6, and CRP have key roles in mediating vascular inflammation and blocking RAAS negatively modulates the levels of these inflammatory molecules. …”
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Lack of Noradrenergic Modulation of Indirect Semantic Priming by Jacquelyne S. Cios, Regan F. Miller, Ashleigh Hillier, Madalina E. Tivarus, David Q. Beversdorf

“…In the context of this previous work, this suggests that more automatic processes such as priming and more controlled searches of the lexical and semantic networks such as problem solving may be mediated, at least in part, by distinct mechanisms with differing effects of pharmacological modulation.…”
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Self-Assembling Multifunctional Peptide Dimers for Gene Delivery Systems by Kitae Ryu, Gyeong Jin Lee, Ji-yeong Choi, Taewan Kim, Tae-il Kim

“…Bafilomycin A1-treated transfection results suggest that the transfection of MPD is mediated via endosomal escape by endosome buffering ability. …”
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The discovery of high endothelial venules. A historical note by Domenico Ribatti

“…HEVs are specialized blood vessels mediating lymphocyte trafficking to lymph nodes and other secondary lymphoid organs. …”
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Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b by Shuang Liang, Yu-Shuang Sun, Lu Li, Yao Long, Meng Wang, Hou-Zhi Yang, Chun-Di Li, Yan Wang, Shan-Shan Li, Xu Chen, Xin Jin

“…In this study, we investigated the cardiac repolarization and ion channel expression in pregnant subjects and mice models and studied the effects of P4 administrations on these pregnancy-mediated adaptations. P4 administrations shortened the prolongation of QTC intervals and action potential duration (APD) that occurred during pregnancy, which was mainly attributable to the reduction in the voltage-gated potassium (Kv) current under basal conditions. …”
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Monomorphic Ventricular Tachycardia as a Presentation of Giant Cell Myocarditis by Michael H. Chiu, Cvetan Trpkov, Saman Rezazedeh, Derek S. Chew

“…It is a rare disorder which involves T lymphocyte-mediated myocardial inflammation. Diagnosis is challenging and requires a high index of suspicion since therapy may improve an otherwise uniformly fatal prognosis. …”
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Industrial Structure, R&D Staff, and Green Total Factor Productivity of China: Evidence from the Low-Carbon Pilot Cities by Shengqian Guo, Xue Tang, Ting Meng, Jincan Chu, Han Tang

“…This paper investigates the relation between low-carbon pilot policy (LCC) and green total factor productivity and discusses the mediating effect of industrial structure and the number of R&D staff (RDS). …”
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CRISPR-Cas9 in basic and translational aspects of cancer therapy by Maryam Samareh Salavatipour, Zahra Poursalehi, Negin Hosseini Rouzbahani, Sohaib Mohammadyar, Mohammad Vasei

“…Finally, we described the progress made by this technology in boosting immune-mediated cell therapy in oncology, such as CAR-T cells, CAR-NK cells, and CAR-M cells. …”
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Complexity and Controversies over the Cytokine Profiles of T Helper Cell Subpopulations in Tuberculosis by Marcos Vinicius da Silva, Monique Gomes Salles Tiburcio, Juliana Reis Machado, Djalma Alexandre Alves Silva, Denise Bertulucci Rocha Rodrigues, Virmondes Rodrigues, Carlo Jose Freire Oliveira

“…Additionally, many new roles and cellular sources have been described for IL-10, demonstrating a critical role for this cytokine as regulatory, rather than merely pathogenic cytokine, involved in the establishment of chronic latent infection, in the clinical cure after treatment and in keeping antibacillary effector mechanisms active to prevent immune-mediated damage.…”
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Identification of hub genes and pathogenesis in Kawasaki disease based on bioinformatics analysis by Min Cao, Zhenhu Zhang, Qian Liu, Yuda Zhang

“…Conclusions: These 13 key genes may mediate the occurrence and development of KD through various processes such as immune regulation, inflammatory response, glucose metabolism, autophagy, and apoptosis, which provide valuable references for the diagnosis and treatment of KD.…”
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QSAR modeling of benzoquinone derivatives as 5-lipoxygenase inhibitors by T.K. Shameera Ahamed, Vijisha K. Rajan, K. Muraleedharan

“…The inhibitors of 5-LOX control the overproduction of pro-inflammatory mediators known as leukotrienes (LTs) and thus have therapeutic relevance in the treatment of various diseases like asthma, rheumatoid arthritis, inflammatory bowel disease and certain types of cancers. …”
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