Mechanism and Therapeutic Prospect of miRNAs in Neurodegenerative Diseases by Ya-Min Ma, Lan Zhao

“…It is a powerful negative regulator of gene expression. It mediates the information exchange between different cellular pathways in cellular homeostasis and stress response and regulates the differentiation, plasticity, and neurotransmission of neurons. …”
Get full text

Peripheral Mechanisms of Symptom Generation in Irritable Bowel Syndrome by Stephen M Collins

“…This and other inflammatory stimuli may induce a hyperalgesic state and alter motor function in patients with IBS. Substances that mediate these changes are not fully understood, but there is growing recognition of the role of serotonin as a sensitizing agent.…”
Get full text

Finding the Correct Partner: The Meiotic Courtship by Tomás Naranjo

“…In the worm Caenorhabditis elegans, each chromosome carries a pairing center consisting of a chromosome-specific DNA-protein complex, and in the fission yeast Schizosaccharomyces pombe, the sme2 locus encodes a meiosis-specific non-coding RNA that mediates on homologous recognition. In addition, mismatch correction plays a relevant role, especially in polyploids, which evolved genetic systems that suppress pairing between non-homologous related (homoeologus) chromosomes.…”
Get full text

Neutrophil Leukocyte: Combustive Microbicidal Action and Chemiluminescence by Robert C. Allen

“…In burning, the spin barrier is overcome when energy causes homolytic bond cleavage producing radicals capable of reacting with diradical O2 to yield oxygenated radical products that further participate in reactive propagation. Neutrophil mediated combustion is by a different pathway. Changing the spin quantum state of O2 removes the symmetry restriction to reaction. …”
Get full text

Cytokines and Myelination in the Central Nervous System by Thomas Schmitz, Li-Jin Chew

“…The intracellular signaling pathways of selected cytokines have also been highlighted to illustrate current knowledge of receptor-mediated events. By learning to interpret the actions of cytokines and by improving methods to target appropriate predictors of disease risk selectively, a more comprehensive understanding of altered immunoregulation will aid in the development of advanced treatment options for patients with inflammatory white matter disorders.…”
Get full text

"[T]hings among the ruins" : les choses contre le roc dans The Song of the Lark et The Professor’s House de Willa Cather by Céline Manresa

“…In order to face the alienating immensity of the landscape, Cather draws on the mediating power of material things and objects harboured in the cliff-dwellings. …”
Get full text

L’accommodation dans le débat politique britannique Question Time. Quelle modélisation pour quelles stratégies ? by Laurent Rouveyrol

“…Dwelling on the concept of “positioning processes” (rapports de places) this framework enables us to encompass a wide range of discursive and linguistic phenomena observable in mediatized interaction, ranging from macro to micro orders, such as the “enunciative staging processes”, by which speakers achieve different degrees of involvement in their speech. …”
Get full text

Ion Channel Activities in Neural Stem Cells of the Neuroepithelium by Masayuki Yamashita

“…This synchronization is mediated by voltage fluctuations in the membrane potential of the nuclear envelope due to Ca2+ release and the counter movement of K+ ions; the voltage fluctuation induces alternating current (AC), which is transmitted via capacitative electrical coupling to the neighboring cells. …”
Get full text

Activation of Brain Attention Systems in Individuals with Symptoms of ADHD by P. Dennis Rodriguez, Gordon C. Baylis

“…The main difference occurred at the frontal site, indicating that individuals with ADHD symptoms have deficits in the anterior attentional system, which mediates signal detection. Behavioral measures of signal sensitivity revealed that the ADHD-Inattentive and the ADHD-Hyperactive/Impulsive groups had more difficulty with the attention-demanding Go/NoGo respond-to-target task, while behavioral measures of response bias indicated that the ADHD-Hyperactive/Impulsive and the ADHD-Combined groups responded more liberally in the inhibition-demanding Go/NoGo suppress-to-target task.…”
Get full text

Participatory Budgeting and Financial Accountability in Kabale District Local Government by Perpetua, Arinaitwe

“…Conclusively, there is a strong positive relationship between participatory budgeting and financial accountability, mediated by monitoring and internal control mechanism. …”
Get full text

Biological embodiment of educational attainment and future risk of breast cancer: findings from a French prospective cohort by Cyrille Delpierre, Raphaële Castagné, Eloïse Berger, Gianluca Severi, Marie-Christine Boutron-Ruault, Laura Baglietto, Laure Dossus, Amandine Gelot, Richard Dudouet

“…Associations persisted after adjustment for cofounders and a large set of potential mediators for two of the investigated cardiovascular markers (OR DBP-high=0.75 (95% CI 0.57; 1.00), OR SBP-high=0.61 (95% CI 0.46; 0.81); model 2). …”
Get full text

Gambaran Hitung Jenis Leukosit pada Pasien Penyakit Paru Obstruktif Kronik yang Dirawat di RSUP Dr. M. Djamil Padang by Revi Sofiana Martantya, Ellyza Nasrul, Masrul Basyar

“…Asap rokok, polusi udara, dan infeksi berulang pada saluran napas akan mengaktivasi makrofag alveolus dan melepaskan mediator inflamasi yang merangsang progenitor granulositik dan monositik di sumsum tulang sehingga mempengaruhi hitung jenis leukosit pada darah tepi. …”
Get full text

Two Novel 30K Proteins Overexpressed in Baculovirus System and Their Antiapoptotic Effect in Insect and Mammalian Cells by Wei Yu, Qing Li, Yuhua Yao, Yanping Quan, Yaozhou Zhang

“…This study suggested that Slp and Lsp-t exhibit similar biological activities as their known 30K-protein counterparts and mediate an inhibitory effect against H2O2-induced apoptosis.…”
Get full text

The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review by Xia-qing Wang, Tahmineh Mokhtari, Yu-xuan Zeng, Lu-peng Yue, Li Hu

“…The findings can be categorized as follows: (1) D2-like receptors may exert a higher analgesic potency, but D1-like receptors act in different manners across several mechanisms in the mentioned regions; (2) in the spinal cord and striatum, antinociception of DA is mainly mediated by D2-like receptors, while in the NAc and PAG, both D1- and D2-like receptors are involved as analgesic targets; and (3) D2-like receptor agonists can act as adjuvants of μ-opioid receptor agonists to potentiate analgesic effects and provide a better approach to pain relief.…”
Get full text

Enigma of Retrotransposon Biology in Mammalian Early Embryos and Embryonic Stem Cells by Ying Yin, Liquan Zhou, Shuiqiao Yuan

“…In addition, retrotransposons may mediate epigenetic memory, regulate gene expression posttranscriptionally, defend virus infection, and so on. …”
Get full text

Prevalence and dynamics of antimicrobial resistance in pioneer and developing Arctic soils by Shamik Roy, Robin A. Dawson, James A. Bradley, Marcela Hernández

“…We also observed a strong negative relationship between soil age and ARG diversity mediated by soil organic matter – suggesting facilitation due to the alleviation of nutrient limitation. …”
Get full text

Overexpression of Bacterial mtlD Gene in Peanut Improves Drought Tolerance through Accumulation of Mannitol by Tengale Dipak Bhauso, Thankappan Radhakrishnan, Abhay Kumar, Gyan Prakash Mishra, Jentilal Ramjibhai Dobaria, Kirankumar Patel, Manchikatla Venkat Rajam

“…GG 20 using Agrobacterium tumefaciens-mediated transformation. A total of eight independent transgenic events were confirmed at molecular level by PCR, Southern blotting, and RT-PCR. …”
Get full text

Second-Hand Smoke Increases Bronchial Hyperreactivity and Eosinophilia in a Murine Model of Allergic Aspergillosis by Brian W. P. Seymour, Edward S. Schelegle, Kent E. Pinkerton, Kathleen E. Friebertshauser, Janice L. Peake, Viswanath P. Kurup, Robert L. Coffman, Laurel J. Gershwin

“…Immunological data that supports this exacerbation of airway hyperresponsiveness being mediated by an enhanced type 1 hypersensitivity response include: eosinophilia in peripheral blood and lung sections. …”
Get full text

Television in and After the Archive: Catalogues, Databases, Interfaces and Other Ways to Organize Audiovisual Records by Giulia Taurino, Georgia Aitaki

“…This editorial essay introduces the VIEW Journal of European Television History and Culture Special Issue on how algorithmic curation mediates archival practices and influences the management, preservation and accessibility of television content. …”
Get full text

Molecular dynamics simulations reveal key roles of the LIF receptor in the assembly of human LIF signaling complex by Bo Gao, Hanrui Liu, Mengkai Zhu, Shun Zhang, Meiniang Wang, Yijun Ruan, Yue Zheng

“…Key residues F178 and K181 in FXXK motif, along with K124 in LIF helix B, mediate hydrophobic interactions, hydrogen bonding and allosteric regulation, collectively stabilizing the LIF-LIFR interaction. …”
Get full text