Upregulation of FOXO3 in New-Onset Type 1 Diabetes Mellitus by Magdalena Zurawek, Marta Fichna, Piotr Fichna, Maria Czainska, Natalia Rozwadowska

“…Since the lack of Treg-mediated control has fundamental impact on type 1 diabetes mellitus (T1DM) development, we investigated FOXO3 expression in patients with T1DM. …”
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Sarcopenia and Age-Related Endocrine Function by Kunihiro Sakuma, Akihiko Yamaguchi

“…Since sarcopenia is largely attributed to various molecular mediators affecting fiber size, mitochondrial homeostasis, and apoptosis, numerous targets exist for drug discovery. …”
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Cancer Stem Cell Marker Endoglin (CD105) Induces Epithelial Mesenchymal Transition (EMT) but Not Metastasis in Clear Cell Renal Cell Carcinoma by Junhui Hu, Wei Guan, Libin Yan, Zhangqun Ye, Lily Wu, Hua Xu

“…Findings from this study support that CD105 plays a functional role in maintaining cancer stem cell and EMT phenotype, with MYC as a common mediator for both of these traits. Our work suggests that the ability to metastasize does not coincide with the cancer stem cell or EMT function of CD105.…”
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Bladder Cancer and Cancer Stem Cells: Basic Science and Implications for Therapy by Richard T. Bryan

“…The recently identified bladder cancer stem cells are considered to be mediators of resistance to current therapies and therefore represent strong candidate biological targets. …”
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Lipoprotein Biology During Induced Oogenesis in the Shortfinned Eel, <i>Anguilla australis</i>—Vascular Transport by Erin L. Damsteegt, Benedetta Mercuriali, Georgia Thomson-Laing, Joanna M. Ward, P. Mark Lokman

“…The ongoing presence of 11-ketotestosterone in the circulation and the increase in 17β-estradiol levels reinforced the importance of steroids in mediating the gonadotropic signal associated with hypophysation. …”
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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes by Elisa Molina Molina, Joan Josep Bech-Serra, Eloi Franco-Trepat, Ignasi Jarne, Daniel Perez-Zsolt, Roger Badia, Eva Riveira-Muñoz, Edurne Garcia-Vidal, Lluís Revilla, Sandra Franco, Ferran Tarrés-Freixas, Núria Roca, Gerardo Ceada, Karl Kochanowski, Dàlia Raïch-Regué, Itziar Erkizia, Rytis Boreika, Antoni E. Bordoy, Laia Soler, Sonia Guil, Jorge Carrillo, Julià Blanco, Miguel Ángel Martínez, Roger Paredes, Alejandro Losada, Pablo Aviles, Carmen Cuevas, Júlia Vergara-Alert, Joaquim Segalés, Bonaventura Clotet, Ester Ballana, Carolina de la Torre, Nuria Izquierdo-Useros

“…While plitidepsin inhibits cap- or internal ribosome entry sites (IRES)-mediated translation, its impact on N6-methyladenosine (m6A) translation is limited. …”
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Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133? by Jana Karbanová, Kristina Thamm, Christine A. Fargeas, Ilker A. Deniz, Aurelio Lorico, Denis Corbeil

“…Prominin-1+ EVs also mediate intercellular communication during embryonic development and adult homeostasis in healthy individuals, while disseminating biological information during diseases. …”
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Exploring behavioral determinants of residents’ ecological conservation in rural tourism development by Xizhou Tian, Yiling Jiang

“…The relationship between subjective norm and behavior is mediated by intention, while ecological environmental risk perception positively moderates the subjective norm-behavior relationship. …”
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Adaptive evolution of SARS-CoV-2 during a persistent infection for 521 days in an immunocompromised patient by Hanno Schmidt, Lea Schick, Jürgen Podlech, Angélique Renzaho, Bettina Lieb, Stefan Diederich, Thomas Hankeln, Bodo Plachter, Oliver Kriege

“…Amongst them were the substitutions S:K417T, S:N440S, S:K444R, S:V445A, S:G446N, S:L452Q, S:N460K, and S:E484V at positions that are notorious for their resistance-mediating effects. The substitution patterns found indicate ongoing adaptive evolution.…”
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Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2 by Yuchen Li, Jiayi Zhou, Tianxin Zhang, Xiaocong Li, Cheng Wu, Ziyi Zhao, Jianyuan Tang, Xiaoyu Tan, Qiongying Hu, Wenhao Liao

“…Further experiments showed that AS-IV suppresses heavy metal Cd-induced mitochondria-mediated apoptosis by regulating the Nrf2/HO-1 pathway. …”
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Immunological Regulation of Fibrosis During Heart Failure: It Takes Two to Tango by Vinay Kumar, Shyam S. Bansal

“…Immuno-fibrotic networks and their protein mediators, such as cytokines and chemokines, have increasingly been appreciated for their critical role in cardiac healing and fibrosis during cardiomyopathy. …”
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Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report by Evangelos Koumasopoulos, Evangelia-Anna Spiteri, Aigli G Vakrakou, Panagiotis Toulas, Georgios Velonakis, George Stranjalis, Leonidas Stefanis, Maria-Eleptheria Evangelopoulos, Maria Anagnostouli

“…In our opinion, the presented case supports the putative neoplastic nature of the disease, at least in the long term, and/or along with Epstein–Barr virus involvement, which is known that have been related to other immune-mediated diseases such as multiple sclerosis and malignancies, especially with specific human leukocyte antigen haplotypes. …”
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Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis by Bonnie Hei Man Liu, Yuezhen Lin, Xi Long, Sze Wan Hung, Anna Gaponova, Feng Ren, Alex Zhavoronkov, Frank W. Pun, Chi Chiu Wang

“…GBP2, HCK, and ITGB2 are upregulated in human endometriotic specimens. siRNA‐mediated knockdown of GBP2 and HCK significantly reduced cell viability and proliferation while stimulating apoptosis in endometrial stromal cells. …”
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Determining application rates of FYM and pressmud to improve soil health properties in salt degraded soils. by M L Dotaniya, M D Meena, R L Choudhary, M K Meena, V D Meena, H V Singh, R S Jat, R K Doutaniya, Kuldeep Kumar, Harpreet Singh, P K Rai

“…However, the key challenge is excessive concentration of salts. It adversely mediates the soil fertility parameters, physical properties and soil enzymatic activities. …”
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Bifunctional Tailoring of Platinum Surfaces with Earth Abundant Iron Oxide Nanowires for Boosted Formic Acid Electro-Oxidation by Bilquis Ali Al-Qodami, Heba H. Farrag, Sayed Youssef Sayed, Nageh K. Allam, Bahgat E. El-Anadouli, Ahmad M. Mohammad

“…The electrochemical impedance spectra could correlate the charge transfer resistances for FAO over the inspected set of catalysts to explore the role of FeOx in mediating the reaction mechanism.…”
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Workplace envy through the lens of leader–member exchange: evidence from higher educational institutions by Sunali Bindra, Bhumika Achhnani, Netra Neelam

“…The partial least squares (PLS) method was utilized, and the SMART-PLS 3.0 software tool was used to investigate the potential causal connections between the constructs. The mediating role of workplace envy and the role of perceived organizational support as a moderator of job satisfaction and intention to quit induced by Leader-member exchange (LMX) is analyzed. …”
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Engagement of the Mannose Receptor by Tumoral Mucins Activates an Immune Suppressive Phenotype in Human Tumor-Associated Macrophages by P. Allavena, M. Chieppa, G. Bianchi, G. Solinas, M. Fabbri, G. Laskarin, A. Mantovani

“…This study highlights that tumoral mucin-mediated ligation of the MR on infiltrating TAM may contribute to their immune suppressive phenotype.…”
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Effects of Pioglitazone on Asymmetric Dimethylarginine and Components of the Metabolic Syndrome in Nondiabetic Patients (EPICAMP Study): A Double-Blind, Randomized Clinical Trial by Pedram Shokouh, Adel Joharimoghadam, Hamidreza Roohafza, Masoumeh Sadeghi, Allahyar Golabchi, Maryam Boshtam, Nizal Sarrafzadegan

“…However, its previously demonstrated endothelial function-improving properties do not seem to be mediated by ADMA.…”
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Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis by Yewei Jia, Rui Li, Yixuan Li, Katerina Kachler, Xianyi Meng, Andreas Gießl, Yi Qin, Fulin Zhang, Ning Liu, Darja Andreev, Georg Schett, Aline Bozec

“…We uncover a non-canonical pathway that involves excessive autophagy-mediated ferritin degradation, highlighting the complex relationship between autophagy and ferroptosis in melanoma-induced osteocyte death. …”
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TLR10 overexpression modulates immune response in A549 lung epithelial cells challenged with SARS-CoV-2 S and N proteins by Špela Knez, Mojca Narat, Jernej Ogorevc

“…Our results suggest that TLR10 could mediate the extent of SARS-CoV-2 infection by downregulating the release of inflammatory cytokines and chemokines such as CXCL10, IL6, IL8, and IFNβ. …”
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