KDM6A facilitates Xist upregulation at the onset of X inactivation by Josephine Lin, Jinli Zhang, Li Ma, He Fang, Rui Ma, Camille Groneck, Galina N. Filippova, Xinxian Deng, Chizuru Kinoshita, Jessica E. Young, Wenxiu Ma, Christine M. Disteche, Joel B. Berletch

“…The effects of both homozygous and heterozygous Kdm6a KO on Xist expression during the onset of XCI were measured by RT-PCR and RNA-FISH. Changes in gene expression and in H3K27me3 enrichment were investigated using allele-specific RNA-seq and Cut&Run, respectively. …”
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Evaluation of Ecological Resilience of Agricultural Ecosystems in Razavi Khorasan Province: Comparison of Integrated and Non-Integrated Ecosystems by Pegah Naghipour, Alireza Koocheki, Mahdi Nasiri mahalati, Soroor Khorramdel

“…The resilience of households in each group was evaluated based on 5 components (asset, adaptive capacity, biodiversity, intensification, and use of ecosystem services), each measured by a number of indicators. The scores of 5 components were aggregated after weighting, by using factor analysis, and normalization to develop a composite resilience index in 1-5 scale.Results and DiscussionThe results showed a significant relationship between the resilience of rural households and the 5 mentioned components where intensification had negative correlation with resilience while the impact of assets, adaptation capacity, biodiversity and use of ecosystem services on household resilience was positive with the highest correlation for biodiversity. …”
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Social Progress and Economic Growth based on Simultaneous Equations of Panel Data by Seyed Ehsan Hosseinidoust, Akbar Khodabakhshi, Saeedeh Ahmadi

“…The Social Development Index is a scale for measuring social well-being, which is a completely new way of looking at well-being among countries in the world without referring to GDP. …”
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Des vestiges d’un possible aqueduc à Lyon, à l’angle des rues Appian et des Fossés-de-Trion by Tony Silvino

“…The preserved entity measures about 0.50 m. The second structure is located 2.20 m to the west of the first. …”
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[Translated article] Preoperative instillation of epinephrine and lidocaine can reduce surgical time in the endoscopic treatment of GTPS by R. Seijas Vazquez, F. Montaña I Pararols, A. Ferré-Aniorte, P. Laiz Boada, M. Vázquez Gómez, R. Cugat

“…Materials and methods: A prospective cohort was retrospectively divided based on the use or absence of a preoperative instillation of physiological saline solution with epinephrine and lidocaine. Surgical time was measured in each procedure and compared between the two groups. …”
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Design and validation of a questionnaire on habits, health and exercise in the use of baby carriers by Yaiza Taboada-Iglesias, María del Carmen Iglesias-Pérez, Águeda Gutiérrez-Sánchez

“…Results: The factor analysis showed that the questionnaire is appropriate for measuring the dimensions or carriage factors established a priori. …”
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La instilación preoperatoria de epinefrina y lidocaína puede reducir el tiempo quirúrgico del tratamiento endoscópico del SDTM by R. Seijas Vazquez, F. Montaña I Pararols, A. Ferré-Aniorte, P. Laiz Boada, M. Vázquez Gómez, R. Cugat

“…Materials and methods: A prospective cohort was retrospectively divided based on the use or absence of a preoperative instillation of physiological saline solution with epinephrine and lidocaine. Surgical time was measured in each procedure and compared between the two groups. …”
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Decreased vitamin D increase the risk for subclinical hypothyroidism in individuals with T2DM: a cross-sectional study by Yaling Fang, Yaling Fang, Xin Wen, Hui You, Yueye Huang, Shen Qu, Xingchun Wang, Le Bu

“…Thyroid and 25 hydroxyvitamin D(25(OH)D) levels were measured. Patients were categorized into lower and higher VD groups based on the median. …”
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Carriage of Extended-Spectrum-β-Lactamase- and AmpC-β-Lactamase-Producing Enterobacteriaceae (ESBL-PE) in Healthy Community and Outpatient Department (OPD) Patients in Nepal by Dipendra Kumar Mandal, Shiv Kumar Sah, Shyam Kumar Mishra, Sangita Sharma, Hari Prasad Kattel, Sanjeet Pandit, Pranav Kumar Yadav, Ujjwal Laghu, Rajani Lama, Niranjan Prasad Sah, Jeevan Bahadur Sherchand, Keshav Parajuli, Anup Bastola, Sher Bahadur Pun, Basista Prasad Rijal, Bharat Mani Pokharel

“…The significant increase of these isolates and increased rate of drug resistance indicates a serious threat that stress the need to implement the surveillance system and a proper control measure so as to limit the spread of ESBL-producing Enterobacteriaceae (ESBL-PE) in both OPD as well as in community. …”
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Genetic and Molecular Characterization of Avian Influenza A(H9N2) Viruses from Live Bird Markets (LBM) in Senegal by Mamadou Malado Jallow, Moussa Moise Diagne, Marie Henriette Dior Ndione, Mamadou Aliou Barry, Ndiendé Koba Ndiaye, Davy Evrard Kiori, Marie Pedapa Mendy, Déborah Goudiaby, Gamou Fall, Malick Fall, Ndongo Dia

“…Despite extensive experience with influenza surveillance in humans in Senegal, there is limited knowledge about the actual situation and genetic diversity of avian influenza viruses (AIVs) circulating in the country, hindering control measures and pandemic risk assessment. Therefore, as part of the “One Health” approach to influenza surveillance, we conducted active AIV surveillance in two live bird markets (LBMs) in Dakar to better understand the dynamics and diversity of influenza viruses in Senegal, obtain genetic profiles of circulating AIVs, and assess the risk of emergence of novel strains and their transmission to humans. …”
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Application of five-tone music therapy combined Wu Qin Xi exercise in nursing of patients with cervical spondylosis (五音疗法联合五禽戏锻炼在颈椎病护理中的应用)... by WANG Jitao (王稷陶), SUN Yanrong (孙艳荣), WANG Jiating (王佳婷), LIU Ying (刘营), ZHENG Mengqi (郑梦绮)

“…The intervention effect, score of Evaluation Scale for Cervical Vertigo (ESCV) and patient satisfaction with nursing service were measured and compared between two groups. Results The total effective rate of intervention was 95. 12%(39/41)in the observation group, which was higher than 80. 05%(33/41)in the control group(P＜0. 05). …”
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New design paradigm for federated edge learning towards 6G:task-oriented resource management strategies by Zhiqin WANG, Jiamo JIANG, Peixi LIU, Xiaowen CAO, Yang LI, Kaifeng HAN, Ying DU, Guangxu ZHU

“…For the user scheduling problem, the proposed user scheduling (TLM) scheme is compared with three other common scheduling schemes in the simulation, and the average precision is shown when the communication time is 6 000 s and 14 000 s, where the average Accuracy is obtained by measuring the IoU, the intersection of union, of the predicted value and the true value. …”
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Trends in Mental Health Outcomes of College Students Amid the Pandemic (Roadmap mHealth App): Longitudinal Observational Study by Gautham Jayaraj, Xiao Cao, Adam Horwitz, Michelle Rozwadowski, Skyla Shea, Shira N Hanauer, David A Hanauer, Muneesh Tewari, Kerby Shedden, Sung Won Choi

“…Participants completed various self-reported measures, including the Patient Health Questionnaire-9 for depression, Generalized Anxiety Disorder-7 for anxiety, and additional metrics for coping, flourishing, and loneliness. …”
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Short- and long-term effects of transcutaneous spinal cord stimulation on autonomic cardiovascular control and arm-crank exercise capacity in individuals with a spinal cord injury... by Samuel J E Lucas, Tom E Nightingale, Jet J C S Veldhuijzen van Zanten, Shin-Yi Chiou, Alex J Wadley, Rebekah A I Lucas, Daniel D Hodgkiss, Shane J T Balthazaar, Joseph F Welch, Phoebe A Cox

“…Secondary outcomes for AIM 2 include cardiometabolic health biomarkers, cardiac function, arterial stiffness, 24-hour blood pressure lability, energy expenditure, respiratory function, neural drive to respiratory muscles, seated balance and HRQoL (eg, bowel, bladder and sexual function). Outcome measures will be assessed at baseline, pre-intervention, post-intervention and after a 6-week follow-up period (HRQoL questionnaires only).Ethics and dissemination Ethical approval has been obtained from the Wales Research Ethics Committee 7 (23/WA/0284; 03/11/2024). …”
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The Comparison of Cost-Effectiveness Between Magnetic Resonance Spectroscopy and Provocative Discography in the Identification of Chronic Low Back Pain Surgery Candidates by Wilson L, Beall DP, Eastlack RK, Berven S, Lotz JC

“…A non-invasive alternative using Magnetic Resonance Spectroscopy (MRS) offers a potential solution.Context/Purpose: We assess cost-effectiveness of MRS with NOCISCAN diagnostic algorithm compared to PD for identifying lumbar discs requiring surgical intervention.Study Design/Setting: We conducted cost-effectiveness analysis using modelling.Patient Sample: We used data from a clinical study of 139 CLBP patients who met criteria for and received PD of lumbar spine and presented with an ODI score ≥ 40; comparing PD and MRS-based diagnostics.Outcome Measures: We considered diagnostic costs, adverse events, surgical costs and outcomes based on a 15-point improvement on the Oswestry Disability Index.Methods: Incremental cost-effectiveness ratios (ICERS) and probabilistic sensitivity analyses were determined. …”
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Effect of laser lithotripsy of giant bile duct stones under endoscopic retrograde cholangiopancreatography and nursing management (内镜逆行胰胆管造影术下胆总管巨大结石激光碎石效果观察及护理)... by WANG Shuang (王爽), ZHENG Hongmei (郑红梅), GAO Donghua (高冬华), XU Bing (许冰), PENG Dan (彭丹)

“…Objective To compare the efficacy of dual-frequency dual-pulse laser lithotripsy under endoscopic retrograde cholangiopancreatography (ERCP) and traditional endoscopic mechanical lithotripsy in the treatment of patients with common bile duct stones, and summarize perioperative nursing measures. Methods From May 2018 to May 2022, the clinical data of 200 patients with common bile duct stones who underwent ERCP treatment and lithotripsy were retrospectively analyzed, of which 69 patients were treated with dual-frequency dual-pulse laser lithotripsy (Laser group) and 131 patients were treated with mechanical lithotripsy (Mechanical group), and the success rate of stone extraction, operation time, postoperative hospital stay time and complications of two groups of patients were compared. …”
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Effectiveness of acupuncture on glycolipid metabolism in patients with coronary heart disease: A systematic review and meta-analysis by Yuxin Sun, Yu Liu, Jian Xiong, Xiao Li, Ying Wei, Qianhua Zheng, Xiang Li, Wenchuan Qi, Fanrong Liang

“…For secondary outcome measures, combination therapy improved TC (SMD = −0.97; 95 % CI, −1.44 to −0.51; P < 0.0001), TG (MD = −0.39; 95 % CI, −0.58 to −0.20; P < 0.0001), hs-CRP (MD = −0.98; 95 % CI, −1.43 to −0.52; P <0.0001), 2hPG (MD = −1.45; 95 % CI, −1.74 to −1.16; P < 0.00001), and ORR (RR, 1.27; 95 % CI, 1.19–1.36; P < 0.00001) levels more than standard therapy alone.However, the combination therapy did not prevail in lowering HDL-C (MD = 0.11; 95 % CI, 0.07–0.14; P < 0.00001) compared with standard therapy alone. …”
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Prevalence, Risk Factors, and Coinfection of Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis among Primary School Children in Biase, Southern Nigeria by Kenneth Nnamdi Opara, Eteye Udobong Wilson, Clement Ameh Yaro, Luay Alkazmi, Nsima Ibanga Udoidung, Friday Maduka Chikezie, Bassey Eyibio Bassey, Gaber El-Saber Batiha

“…Although the degree of infection is quite low or moderate, there is a need to intensify and sustain control measures such as provision of sustainable clean water supply, health education intervention, and chemotherapy.…”
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Identification of positive selection signatures associated with milk and composition traits in Murciano-Granadina and Barki by Hossein Mohammadi, amir hossien khaltabadi farahani, Mohammad Hossein Moradi

“…This study aimed to identify effective genes and genomic regions on positive signature of selection in Murciano-Granadina and Barki goats using selection signature method.Material and Methods: In this study, data from 923 Murciano-Granadina and 68 Barki goats genotyped using Caprine 50 K Bead Chip were used to identify genomic regions under selection associated with important traits. Quality control measures were performed in Plink by setting an animal call rate of 0.90, SNP call rate of 0.95, and SNPs with minor allele frequencies (MAF) lower than 0.05 or that do not conform to the Hardy–Weinberg expectation (P value ≤ 0.000001) and unknown position. …”
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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study by Liye Lai, Dave Laurence Juntilla, Monica Del, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

“…Results A total of 3,501 observations from 2,556 participants, with methylation measured at least once across two visits, were included in the analyses. …”
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