Phospholipid Adsorption Polymeric Materials for Detection of Xylazine and Metabolite in Blood and Urine by Xue Gao, Hao Guo, Chaokang Gu

“…However, the content of xylazine is difficult to detect precisely due to matrix effect in testing practices. In this paper, a method application for phospholipid adsorption polymeric materials to determine xylazine in blood and urine samples was proposed, developed, and validated. …”
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Fast and Sensitive Method for Determination of Domoic Acid in Mussel Tissue by Elena Barbaro, Roberta Zangrando, Carlo Barbante, Andrea Gambaro

“…The sample preparation was also evaluated through qualitative and quantitative evaluations of the matrix effect. These evaluations were conducted both on the DA-free matrix spiked with known DA concentration and on the reference certified material (RCM). …”
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Selective and Accurate Determination Method of Propofol in Human Plasma by Mixed-Mode Cation Exchange Cartridge and GC-MS by Jae Sung Pyo

“…The other validation parameters, recovery and matrix effect, ranged from 96.6% to 99.4% and 95.3% to 101.4%, respectively. …”
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Development of the High Sensitivity and Selectivity Method for the Determination of Histamine in Fish and Fish Sauce from Vietnam by UPLC-MS/MS by Quang Hieu Tran, Thanh Tan Nguyen, Kim Phuong Pham

“…The influence of the matrix effect on the accuracy, repeatability, and recovery of the method was negligible. …”
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Determination and Pharmacokinetics of Okanin in Rat Plasma by UltraHigh Performance Liquid Chromatography Coupled with Triple-Quadrupole Tandem Mass Spectrometry by Yurui Shi, Rongda Chen, Jing Xie, Li Li, Guiming Liu, Meizhu Zheng, Ning Zhang

“…By gradient elution, IS and analyte were separated on a C18 column for 7 min at a flow rate of 0.25 mL/min with acetonitrile-0.1% acetic acid mobile phase. The stability, matrix effect, extraction recovery, accuracy, precision, linearity, and selectivity of the method were firstly demonstrated. …”
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Quantification of Rhodojaponin II and Rhodojaponin III in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry by Cheng Sun, Wanhang Wang, Xi Bao, Dizhong Chen, Shenshen Mei, Jianshe Ma, Xiajuan Jiang

“…Moreover, both intraday and interday precision were below 15%, while accuracy ranged from 88% to 115%. Additionally, matrix effect fell within the range of 90%–110%, and recoveries ranged from 78% to 87%. …”
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Disperse Solid-Phase Extraction Cleanup for the Determination of 1-Deoxynojirimycin in Mulberry Leaves with Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry by Lei Zhang, Yiran Zhou, Jing Meng, Jia Li

“…Additionally, the matrix effect was assessed as negligible. Compared with methods by gas chromatography (GC) and liquid chromatography (LC) via real sample detection, the proposed method acquired better stability and detection efficiency. …”
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Establishment of a UPLC-MS/MS Method for Studying the Effect of Salt-Processing on Tissue Distribution of Twelve Major Bioactive Components of Qing’e Pills in Rats by Jingxia Hou, Shangyang Lin, Jinlan Lu, Yu Wu, Li Wu, Zhipeng Chen, Weidong Li

“…The method was fully validated for its selectivity, accuracy, precision, stability, matrix effect, and extraction recovery. Then, the validated method was successfully applied for simultaneous determination of the 12 chemical components in Qing’e pills in tissues for the first time. …”
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Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC-MS/MS by Tulsidas Mishra, Pranav S. Shrivastav

“…Accuracy, precision, matrix effect, recovery, and stability of the analytes were evaluated as per US FDA guidelines. …”
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Determination of remifentanil in neonatal dried blood spots by liquid chromatography-tandem mass spectrometry by Trontelj Jurij, Rozman Aleš, Mrhar Aleš

“…The method was validated in terms of accuracy, precision, recovery, matrix effect, and stability, and was successfully applied to a small pilot study. …”
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Simultaneous Quantification of γ-Hydroxybutyrate, γ-Butyrolactone, and 1,4-Butanediol in Four Kinds of Beverages by Shaoming Jin, Xiao Ning, Jin Cao, Yaonan Wang

“…The recoveries of the three compounds at three spiked levels (2.5, 5.0, and 10.0 μg/mL) in the four kinds of beverages studied were between 90 and 110%, while the relative standard deviations (RSDs) were all <10%. The matrix effect was negligible using this simple and appropriate preprocessed procedure. …”
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Simultaneous Determination of Lamotrigine, Oxcarbazepine, Lacosamide, and Topiramate in Rat Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry by Erjie Qiu, Lu Yu, Qishun Liang, Congcong Wen

“…The relative standard deviations (RSD) of intraday and interday were less than 15%. The matrix effect was within 91%–105%, and the recovery was better than 88%. …”
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Simultaneous determination of 74 pesticide residues in Panax notoginseng by QuEChERS coupled with gas chromatography tandem mass spectrometry by Huijun Li, Jieshan Wu, Chao Chen, Wenfeng Xin, Wensheng Zhang

“…Matrix-matched calibration was recommended to combat the matrix effect. A good linearity was observed in the range of 10 − 500 ng/mL with correlation coefficients ≥ 0.9950. …”
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Multianalytical Method Validation for Qualitative and Quantitative Analysis of Solvents of Abuse in Oral Fluid by HS-GC/MS by Bruna Claudia Coppe, Bruna Tassi Borille, Taís Regina Fiorentin, Ana Laura Bemvenuti Jacques, Ana Claudia Fagundes, Stela Maris de Jezus Castro, Lysa Silveira Remy, Flavio Pechansky, Renata Pereira Limberger

“…Accuracy, precision, matrix effect, and residual effect presented satisfactory results, meeting the criteria accepted for the validation of bioanalytical methods. …”
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Simultaneous Determination of Five Chromones of Radix Saposhnikoviae Extract in Rat Plasma by UPLC-MS/MS: Application to a Comparative Pharmacokinetic Study in Normal and Febrile R... by Li Meng, Hui Gao, Bin Chen, Peng-peng Liu, Guo-shun Shan, Fan Zhang, Tian-zhu Jia

“…The results showed that all analytes had good linearity (r>0.9902), between-day and within-day precisions less than 15%, accuracy between −5.50% and 5.53%, and extraction recovery between 88.26% and 97.65%. Both the matrix effect and stability met the requirements. This method was successfully applied for the comparative pharmacokinetics of five active components of RS in normal and febrile rats. …”
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Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics by Xiuwei Shen, Xiangyi Dai, Yifan He, Congcong Wen, Qingwei Zhang

“…The recovery was >88%, and the matrix effect was 87–94%. The oral bioavailability of senegenin and tenuifolin in mice was 8.7% and 4.0%, respectively. …”
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Fast and Simple LC-MS/MS Method for Rifampicin Quantification in Human Plasma by Žane Temova Rakuša, Robert Roškar, Anita Klančar Andrejc, Tina Trdan Lušin, Nataša Faganeli, Iztok Grabnar, Aleš Mrhar, Albin Kristl, Jurij Trontelj

“…The method showed almost complete recovery (92%) and absence of any significant matrix effect as demonstrated by uniform responses from QC samples prepared in blood plasma from 6 volunteers (RSD <5%). …”
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Determination of Tenacissoside G, Tenacissoside H, and Tenacissoside I in Rat Plasma by UPLC-MS/MS and Their Pharmacokinetics by Fan Chen, Yizhe Ma, Ying Cui, Wanhang Wang, Chenchen Mei, Jingjing Nie, Congcong Wen, Xiuwei Shen, Xuzhao Zhou

“…The results of precision, accuracy, recovery, matrix effect, and stability met the requirements of biological sample detection methods. …”
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Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application by Shuang-long Li, Yong-liang Zhu, Yi Zhang, Shu-han Liu, Xiang-die Wang, Xiang-jun Qiu

“…Besides, the values of intraday and interday precision were 2.25–8.40% and 3.94–5.46%, respectively, and the range of the accuracy values varied from −1.44 to 2.34%. Matrix effect, extraction recovery, and stability were compliant with FDA approval guidelines in terms of bioanalytical method validation. …”
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Electrochemical Degradation of Reactive Yellow 160 Dye in Real Wastewater Using C/PbO2-, Pb + Sn/PbO2 + SnO2-, and Pb/PbO2 Modified Electrodes by Mohamed Gaber, Nasser Abu Ghalwa, Abdalla M. Khedr, Munther F. Salem

“…The prepared C/PbO2, Pb+Sn/PbO2+SnO2 and Pb/PbO2 electrodes were found to be highly efficient in the treatment of effluents obtained from dyeing factory which contain RY160 dye with very slight matrix effect.…”
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