Metabolomics identifies plasma biomarkers of localized radiation injury by Lucie Ancel, Stéphane Grison, Olivier Gabillot, Jules Gueguen, Ljubica Svilar, Bernard Le Guen, Gaëtan Gruel, Marc Benderitter, Jean-Charles Martin, Maâmar Souidi, Radia Tamarat, Stéphane Flamant, Mohamed Amine Benadjaoud

“…More precisely, two independent mice cohorts were used to conduct a broad-spectrum profiling study followed by a suspect screening analysis performed on plasma metabolites by mass spectrometry. An integrative analysis was conducted through a multi-block sparse partial least square discriminant analysis (sPLS-DA) to establish multi-scale correlations between specific metabolites levels and biological, physiological (injury severity), and functional parameters (skin perfusion). …”
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Volatile organic compounds of hoary stock are responsible for suppressing downy mildew of grape in an intercropping system by Weiping Deng, Fei Du, Rongliang Yang, Hanyang Yao, Min Yang, Xinyue Mei, Chen Ye, Su Li, Yixiang Liu, Huichuan Huang, Shusheng Zhu

“…The collected VOCs were subjected to gas chromatography-mass spectrometry (GC–MS) analysis and in vitro bioassays. …”
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Simultaneous Quantification of 25-Hydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 in Rats Shows Strong Correlations between Serum and Brain Tissue Levels by Ying Xue, Xin He, Huan-De Li, Yang Deng, Miao Yan, Hua-Lin Cai, Mi-Mi Tang, Rui-Li Dang, Pei Jiang

“…Therefore, we developed a novel analysis method by using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to simultaneously quantify the concentrations of 25-hydroxyvitamin D3 (25(OH)D3) and 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) in the serum and brain of rats fed with different dose of vitamin D3. …”
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Cerebellar lipid dysregulation in SCA3: A comparative study in patients and mice by Alexandra F. Putka, Varshasnata Mohanty, Stephanie M. Cologna, Hayley S. McLoughlin

“…Liquid chromatography-mass spectrometry uncovered widespread lipid reductions in patients with SCA3. …”
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Pharmacokinetics of Transdermal Flunixin Meglumine Following a Single Dose in Marine Toads (Rhinella marina) by Gregory Scott, Meghan M. Louis, Julie A. Balko, Claire M. Bublitz, Brigid V. Troan, Ronald E. Baynes, Dustin Smith, Larry J. Minter

“…Plasma was analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. Samples were analyzed individually and reported as a mean of the samples at each timepoint. …”
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Fat Body Metabolome Revealed Glutamine Metabolism Pathway Involved in Prepupal <i>Apis mellifera</i> Responding to Cold Stress by Xinjian Xu, Mingjie Cao, Chenyu Zhu, Lingqing Mo, Huajiao Huang, Jiaying Xie, Bingfeng Zhou, Shujing Zhou, Xiangjie Zhu

“…In this study, the ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS)-based non-target metabolome was analyzed between the cold-treated (CT, 20 °C, 36 h) and control (CK, 35 °C) fat body in prepupal honeybees. …”
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Synthesis and antitumor activity of some novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives by Albratty Mohammed, El-Sharkawy Karam Ahmed, Alam Shamsher

“…Structures of the newly synthesized compounds were established using IR, 1H NMR, 13C NMR and mass spectrometry and their antitumor activity was investigated. …”
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Material and Technique Analysis of Qing Dynasty Official Style Architectural Polychrome Paintings in Hangzhou, Zhejiang, China by Ling Shen, Dan Hua, Baisu Nan, Yao Yao, Hong Duan, Jiakun Wang

“…Through multi-techniques such as optical microscopy (OM), scanning electron microprobe with energy dispersive X-ray spectroscopy analysis (SEM-EDX), micro-Raman spectroscopy, micro-Fourier Transform Infrared spectroscopy (μ-FTIR), and pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS), it was found that there is a significant difference from the reported common non-ground architectural paintings in the south, typically having four-layer structures with a white base and ground plaster layer in preparation for painting. …”
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Chemical Composition and Antimicrobial Activity of Essential Oil of <i>Camphora glanduliferum</i> ‘Honganzhang’ by Yang Yang, Qiuting Xiang, Yinan Yang, Donglv Shu, Jiawen Yan, Lijun Huang, Xiumei Yang, Jing Peng, Xingliang Chen, Guoqun Yang

“…After extracting <i>C. glanduliferum</i> ’Honganzhang’ essential oils (CGHEO) by steam distillation, gas chromatography-mass spectrometry (GC-MS) was used to analyze its chemical components. …”
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Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…Methods: We generated a mouse model of SCM induced by lipopolysaccharide (LPS) and then obtained comprehensive metabolic and genetic data from SCM mouse hearts using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) and RNA sequencing (RNA-seq). …”
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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches by Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse, Hai-Young Kim

“…We used a forced degradation method involving concentration-dependent oxidation by peracetic acid, in which Met oxidation is site-specifically quantified by liquid chromatography-mass spectrometry. Conventional biophysical techniques report nuanced results, in which CD detects no change to the secondary structure and little change in the tertiary structure. …”
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Elevated fasting serum xylitol levels are associated with a lower risk of incident type 2 diabetes among individuals with prediabetes in the Chinese population by Yicheng Qi, Xiaoyong Li, Yu Liu, Meng Wang, Yiming Wu, Qing Su, Li Qin, Jing Ma

“…The baseline levels of serum polyols in the fasting state were quantified using time-of-flight mass spectrometry. Multivariate conditional logistic regression was performed to assess the effects of the differential polyol levels on the risk of incident diabetes from prediabetes. …”
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Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity by Jaeseong Oh, Sojeong Yi, Namyi Gu, Dongseong Shin, Kyung-Sang Yu, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang

“…Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. …”
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Model Analytical Development for Physical, Chemical, and Biological Characterization of Momordica charantia Vegetable Drug by Deysiane Oliveira Brandão, Geovani Pereira Guimarães, Ravely Lucena Santos, Fernando José de Lima Ramos Júnior, Karla Monik Alves da Silva, Fabio Santos de Souza, Rui Oliveira Macêdo

“…The herbal medicine raw material derived from the leaves and fruits in different particle sizes was analyzed using thermoanalytical techniques as thermogravimetry (TG) and differential thermal analysis (DTA), pyrolysis coupled to gas chromatography/mass spectrometry (PYR-GC/MS), and nuclear magnetic resonance (1H NMR), in addition to the determination of antimicrobial activity. …”
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Aroma profiling of long shelf-life yoghurt from milk with varying acidity: Insights from sensory evaluation and instrumental analysis by Jia Wang, Dongjie Zhang, Jie Li, Tingting Zou, Rong Wen, Yaqiong Hou, Huanlu Song, Hongliang Li, Hairan Ma, Jiao Shi

“…In this study, the aroma components of long shelf-life yoghurt produced from milk with varying acidity levels were identified using the Stir Bar Sorptive Extraction (SBSE) coupled with comprehensive two-dimensional gas chromatography−olfactometry−mass spectrometry technology (GC × GC-O-MS) for the first time. …”
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Simultaneous determination of nirmatrelvir, ritonavir, and beta-D-N4-hydroxycytidine in human plasma and epithelial lining fluid using LC-MS/MS and its clinical application to comp... by Wenjing Zhang, Lin Xia, Zhilong Yuan, Mengdan Liu, Yang Jiao, Zhuo Wang

“…The analysis method was developed and validated to simultaneously quantify nirmatrelvir, ritonavir, and beta-D-N4-hydroxycytidine (NHC) in human plasma and bronchoalveolar lavage fluid (BALF) by electrospray ionization mass spectrometry.Our method was validated over a linear range of 30–10000 ng/mL for both matrices, with precision and accuracy within 15 % across four concentrations. …”
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Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation by Rasangi Tennakoon, Teija M.I. Bily, Farah Hasan, Sunidhi Syal, Aaron Voigt, Tugce B. Balci, Kyle S. Hoffman, Patrick O’Donoghue

“…In contrast, cells expressing tRNAAlaCUG selectively decreased insoluble polyQ aggregate formation by 2-fold. Mass spectrometry confirmed Ala mis-incorporation at an average level of ∼20% per Gln codon. …”
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Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440 by Jakob Grether, Holger Dittmann, Leon Willems, Tabea Schmiegelt, Elvio Henrique Benatto Perino, Philipp Hubel, Lars Lilge, Rudolf Hausmann

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Data on compositional diversity of textural varieties of lake superior-type Banded Iron Formation (BIF) of the Njweng prospect, Mbalam iron ore district, southern CameroonMendeley... by Dieudonne Charles Isidore Ilouga, Cheo Emmanuel Suh, Akumbom Vishiti, Elisha Muntum Shemang

“…Chemical analysis was accomplished using a combination of the Inductively Coupled Plasma Emission Spectrometry (ICP-ES) and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) on the major and trace elements respectively. …”
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Monitoring of the Gasoline Oxygenate MTBE and BTEX Compounds in Groundwater in Catalonia (Northeast Spain) by J. Fraile, J.M. Niaerola, L. Olivella, M. Figueras, A. Ginebreda, M. Vilanova, D. Barcela

“…Headspace (HS) gas chromatography with flame ionisation detection (HS-GC-FID) and purge and trap (P) gas chromatography-mass spectrometry (P) were used for the determination of methyl-tert-butyl ether (MTBE) and benzene, toluene, and xylenes (BTEX) in groundwater. …”
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