Clinical integration of germline findings from a tumor testing precision medicine program by Maria Carolina Sanabria-Salas, Nina C. Anggala, Brittany Gillies, Kirsten M. Farncombe, Renee Hofstedter, Larissa Peck, Helia Purnaghshband, Laura Redondo, Emily Thain, Wei Xu, Peter Sabatini, Philippe L. Bedard, Raymond H. Kim

“…However, this progress remains inconsistent across institutions, largely owing to a lack of systematic approaches for managing these findings. This study outlines the development of a clinical pathway for identifying potential germline variants from an institutional tumor-sequencing research program at Princess Margaret Cancer Centre. …”
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Inter-individual Variability in Psychological Outcomes of Supervised Exercise in Adults with Type 2 Diabetes / Variabilidad interindividual en los efectos psicológicos del ejercici... by Marco Guicciardi, Romina Lecis, Davide Massidda, Lucina Corgiolu, Adelina Porru, Matteo Pusceddu, Francesca Spanu

“… Abstract: Exercise is a key component in the management of Type 2 Diabetes Mellitus (T2DM), however despite the strong evidence of its protective effects, a majority of the population with this diagnosis remains inactive and those who start an exercise program are not willing to train themselves over the long-term. …”
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Prevalence of asymptomatic Leishmania donovani infection and associated factors in Ethiopia: a systematic review and meta-analysis by Habtamu Belay, Adugna Abera, Esayas Aklilu, Tesfahun Bishaw, Ayinalem Alemu, Geremew Tasew, Berhanu Erko

“…This will minimize role of man as reservoir host of asymptomatic L. donovani infection VL and hence aid in disease control and management.…”
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Treatment options for Achilles tendinopathy: a scoping review of preclinical studies by Nathanael Opoku Agyeman-Prempeh, Huub Maas, George L. Burchell, Neal L. Millar, Maarten H. Moen, Theodoor Henri Smit

“…Background Achilles tendinopathy (AT) management can be difficult, given the paucity of effective treatment options and the degenerative nature of the condition. …”
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Comprehensive genomic surveillance reveals transmission profiles of extensively drug-resistant tuberculosis cases in Pará, Brazil by Davi Josué Marcon, Davi Josué Marcon, Abhinav Sharma, Alex Brito Souza, Alex Brito Souza, Rafaella Bonfim Barros, Valnete das Graças Dantas Andrade, Ricardo José de Paula Souza Guimarães, Luana Nepomuceno Gondim Lima, Luana Nepomuceno Gondim Lima, Lúcia Helena Martins Tavares Monteiro, Ana Judith Pires Garcia Quaresma, Ana Judith Pires Garcia Quaresma, Layana Rufino Ribeiro, Layana Rufino Ribeiro, Philip Noel Suffys, Robin Mark Warren, Carlos Augusto Abreu Alberio, Karla Valéria Batista Lima, Karla Valéria Batista Lima, Emilyn Costa Conceição

“…Clinical and bacteriological information was obtained from the National Laboratory Management Environment and the Special TB Treatment Information System. …”
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Nationwide cervical precancer screening in Ghana: concurrent HPV DNA testing and visual inspection under an expanded hub-and-spoke model by Kofi Effah, John Allotey, Ethel Tekpor, Comfort Mawusi Wormenor, Joseph Emmanuel Amuah, Ernest Antwi-Boasiako, Erasmus Nikoi Kotey, Seyram Kemawor, Isaac Gedzah, Helena Maame Ama Frempong, Stephen Danyo, Edna Sesenu, Bernard Hayford Atuguba, Nana Owusu Mensah Essel, Patrick Kafui Akakpo

“…This approach, combined with concurrent testing (hr-HPV DNA testing and visual inspection), holds promise for mitigating loss to follow-up among women requiring additional evaluation and lesion management.…”
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Influence of cervical muscle strength and pain severity on functional balance and limits of stability in elderly individuals with chronic nonspecific neck pain: a cross-sectional s... by Shaker Hassan S. Alshehri, Ravi Shankar Reddy, Mohammad A. ALMohiza, Mastour Saeed Alshahrani, Batool Abdulelah Alkhamis, Hani Hassan Alnakhli, Ghada Mohammed Koura, Ajay Prashad Gautam, Debjani Mukherjee, Raee S. Alqhtani, Saeed Y. Al Adal, Abdullah Mohammed Alyami, Faisal M. Alyazedi

“…Pain severity moderates the relationship between cervical muscle strength and balance outcomes, emphasizing the importance of integrating muscle strengthening and pain management in rehabilitation programs for elderly individuals with CNSNP to optimize postural control and minimize fall risk.…”
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Evaluation of a content-based image retrieval system for radiologists in high-resolution CT of interstitial lung diseases by Benjamin Böttcher, Marly van Assen, Roberto Fari, Philipp L. von Knebel Doeberitz, Eun Young Kim, Eugene A. Berkowitz, Felix G. Meinel, Carlo N. De Cecco

“…This can provide educational benefits and more time-efficient management of complex cases. Key Points A content-based image retrieval (CBIR) software improves diagnostic accuracy and confidence for in-training radiologists for interstitial lung disease (ILD) assessment on computed tomography (CT). …”
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Genetic diversity and antifungal susceptibilities of environmental Cryptococcus neoformans and Cryptococcus gattii species complexes by Mohamed Taha, Yasmine H. Tartor, Rana M Abd Elaziz, Ibrahim Elsohaby

“…Maintaining continued surveillance of the antifungal susceptibility of environmental C. neoformans and C. gattii isolates is desirable for better managing cryptococcosis by identifying resistant isolates and revealing the emergence of intrinsically resistant species. …”
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Evaluation of extracts from used Xpert MTB/RIF cartridges for detection of resistance to second-line anti-tuberculosis drugs in patients with multidrug-resistant tuberculosis in Et... by Tilahun Ketema, Mulualem Tadesse, Zegeye Bonsa, Getu Balay, Wakjira Kebede, Mekidim Mekonnen, Gemeda Abebe

“…Abstract Background Early and accurate diagnosis of drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB). …”
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Advancements in Hyaluronic Acid Effect in Alveolar Ridge Preservation: A Narrative Review by Paul Andrei Nistor, Andreea Cândea, Iulia Cristina Micu, Andrada Soancă, Carmen Silvia Caloian, Alina Bârdea, Alexandra Roman

“…With respect to clinical significance enhancing the understanding of ARP management strategies and their effects on post-extraction sockets empowers clinicians to make more informed decisions. …”
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Time to first antenatal care visit and its predictors among women in Kenya: Weibull gamma shared frailty model (based on the recent 2022 KDHS data) by Bizunesh Fantahun Kase, Beminate Lemma Seifu, Kusse Urmale Mare, Abdu Hailu Shibeshi, Hiwot Altaye Asebe, Kebede Gemeda, Zufan Alamrie Asmare, Yordanos Sisay Asgedom, Bezawit Melak Fente, Afework Alemu Lombebo, Tsion Mulat Tebeje

“…Abstract Background The first trimester of pregnancy is critical for fetal development, making early antenatal care visits essential for timely check-ups and managing potential complications. However, delayed antenatal care initiation remains a public health challenge in sub-Saharan Africa, including Kenya. …”
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Comparison of anterior versus posterior approach for the treatment of cervical compressive myelopathy due to ossification of the posterior longitudinal ligament by Amr A. A Gaber, Mohamad Alaa El-Din Habib, Mohamed AR AbdelFatah, Mostafa K. Ghobashy

“…Conclusion The findings of this MA indicate that anterior approach surgery is linked to superior postoperative neurological outcomes compared to the posterior method in managing cervical compressive myelopathy resulting from OPLL. …”
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Infectious keratitis following photorefractive keratectomy: a 13-year study at a tertiary center by Alireza Attar, Hossein Jamali, Julio Ortega-Usobiaga, Golnoush Mahmoudinezhad, Dagny Zhu, Mohammad Mohammadi

“…Conclusion This long-term study found a post-PRK keratitis rate of 0.018%, with gram-positive bacteria as the most common pathogens. Prompt management and regular follow-up assessments are essential for achieving satisfactory outcomes.…”
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In-Season Automated Mapping of Xinjiang Cotton Based on Cumulative Spectral and Phenological Characteristics by Yongsheng Huang, Yaozhong Pan, Yu Zhu, Xiufang Zhu, Xingsheng Xia, Qiong Chen, Jufang Hu, Hongyan Che, Xuechang Zheng, Lingang Wang

“…Obtaining timely, accurate, and automated data on the spatial distribution and planting area of cotton is crucial for production management and informed trade decision-making. In this regard, remote sensing technologies are important and effective means. …”
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High-performance CT features supporting accurate pre-operative tumor staging in colon cancer by Jianhua Yuan, Cangzheng Jin, Jianrong Si, Baobao Liu, Xiaohan Si, Jianzhi Chen

“…These high-performance markers will provide valuable insights to the clinicians in making appropriate decisions in the management of patients with colon cancer.…”
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Which PSMA PET/CT interpretation criteria most effectively diagnose prostate cancer? a retrospective cohort study by Le Ma, Yaxin Hao, Luoping Zhai, Wanchun Zhang, Xiaoming Cao, Kaiyuan Jia

“…This underscores the miPSMA score’s potential as a robust criterion for PCa and csPCa diagnosis, holding substantial promise for refining clinical decision-making and patient management strategies. Clinical trial number not applicable.…”
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Analysis of the accuracy of disease prediction in pediatric ward patients based on the modified early warning score for children: A randomized controlled trialWhat is already known... by Kang Lin, Xiaojun Weng, Bing Du, Ting Tian, Xiaoxiang Quan

“…The observation group received an intervention combining the PEWS with a graded nursing management model. The PEWS scores of the observation group were analyzed upon admission, and the value of PEWS in assessing the severity of illness was evaluated using a receiver operating characteristic (ROC) curve. …”
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Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…Further validation in clinical samples is required to establish its diagnostic and therapeutic potential, which could significantly improve the management of treatment-resistant prostate cancer. …”
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Clinical outcomes among HIV positive babies below 18 months of age, diagnosed under the Early Infant Diagnosis (EID) programme, India: a mixed-methods studyResearch in context by Suchit Kamble, Nilesh Gawde, Shilpa Bembalkar, Noopur Goel, Mohan Thorwat, Kalyani Nikhare, Sushmita Kamble, Radhika Brahme, Swapna Pawar, Harsh Kubavat, Bhawanisingh Kushwaha, Vinita Verma, Chinmoyee Das, Raman Gangakhedkar

“…A total of 67 In-depth interviews with healthcare providers and managers helped to understand the underlying causes. …”
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