Microsatellite loci variability in apple cultivars developed at VIR by A. V. Shlyavas, A. A. Trifonova, I. S. Chepinoga, A. S. Sidnin, K. V. Boris

“…The obtained data on the allelic composition of the studied cultivars can be used for their identification and contribute to more efficient collection  management. Further studying and SSR genotyping of VIR’s apple collection and comparison with the data obtained in the presented work can help to identify the origin of cultivars with unknown pedigrees.…”
Get full text

Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT by Mateusz Koziński, Doruk Oner, Jakub Gwizdała, Catherine Beigelman-Aubry, Pascal Fua, Angela Koutsokera, Alessio Casutt, Argyro Vraka, Michele De Palma, John-David Aubert, Horst Bischof, Christophe von Garnier, Sahand Jamal Rahi, Martin Urschler, Nahal Mansouri

“…Conclusions Our approach shows potential for improving BOS diagnosis by enabling early detection and management. The ability to detect BOS from standard-resolution scans at any stage of respiration makes this method more accessible than previous approaches. …”
Get full text

Early results of primary total hip arthroplasty performed in young adults at a regional Saudi-Arabian orthopedics center: a prospective observational study by Walid M. Al-Shaer, Ali H. Al-Yami, Mokhtar Ahmed Al-Sayed, Ali Mohammed Al-Zaidan, Emad Ruddah Al-Sufyani, Ahmed A. Khalifa, Raad M. M. Al-Thaqafi, Abdulmohsen H. Al-Hamyani, Mohammed M. Al-Subaie

“…Primary total hip arthroplasty is the option for managing end-stage hip disease, even in younger patients when hip preservation surgeries are invalid. …”
Get full text

Ductal Carcinoma In Situ (DCIS) Diagnosed by MRI-Guided Biopsy among BRCA1/BRCA2 Mutation Carriers by Renata Faermann, Eitan Friedman, Orit Kaidar-Person, Jonathan Weidenfeld, Malka Brodsky, Anat Shalmon, Osnat Halshtok Neiman, Michael Gotlieb, Yael Yagil, David Samoocha, Dana Madorsky Feldman, Miri Sklair-Levy

“…Future prospective studies should validate these results and assess the actual impact they might have on clinical management of BRCA PSV carriers.…”
Get full text

Closed-loop systems for plants expressing animal proteins: a modernized framework to safeguard the future of agricultural innovation by Kristin A. Bresnahan, Justin M. Ferber, J. Thomas Carrato, Thomas J. Stoddard, Patrick V. Palad, Magi Richani

“…Implementing a fit-for-purpose closed-loop system (CLS) is crucial for effectively identifying, managing, and mitigating the potential risks and liabilities associated with PMF product development, production, and processing. …”
Get full text

Hantavirus antibody seroprevalence and risk factors among adults in West Kazakhstan, 2023 by Ulyana Gubareva, Ulyana Gubareva, Ulyana Gubareva, Roberta Horth, Roberta Horth, Dilyara Nabirova, Dilyara Nabirova, Nur Tukhanova, Nur Tukhanova, Elmira Utegenova, Elmira Utegenova, Zhanna Shapiyeva, Zangar Turliyev, Nazym Tleumbetova, Nurbek Maykanov, Manar Smagul, Alan L. Landay, Gavin Cloherty, Gavin Cloherty, Francisco Averhoff, Francisco Averhoff, Edmond F. Maes

“…Relevant public health interventions should include educating the population about promoting preventive practices, workplace hygiene, rodent control measures, and enhanced case diagnosis and management.…”
Get full text

Emerging trends in the construction market under increasing sanctions pressure by N. Yu. Yaskova, L. I. Zaitseva

“…Meanwhile, the observed time compression of the emergence of new growing external challenges, which revealed and made it possible to identify latent processes slowing down the modernization of the construction industry, prompted the authors to change the generally accepted perspective of studying the construction market from the use of the method of decomposition of its segments to the implementation of the methodological approach of “time management in restructured space” in order to complement the megapolis concept of settlement with the strategy of accelerated development of territories in the points and corridors of economic.Results. …”
Get full text

Composition and the predicted functions of fungal communities and the key drivers in acidic soils of Jiaodong Peninsula, China by Jing Liu, Zafran Gul Wazir, Guoqin Hou, Guizhen Wang, Fangxu Rong, Yuzhi Xu, Kai Liu, Mingyue Li, Aiju Liu, Hongliang Liu, Hongwen Sun

“…As being more tolerant than bacteria to soil acidification, so it would be more meaningful for agricultural management and crop yield to characterize fungal community in acidic soils and manifest its key drivers.MethodThis study investigated the composition and diversity of fungal communities and its key driving factors by collecting 90 soil samples from the acidic region of Jiaodong Peninsula China, spanning 3 × 104 km2.ResultsThe results indicated that most soil pH values ranged from 5.01 to 6.42, and the exchangeable acidity (EA) content raised significantly (p < 0.01) along with soil acidic degree increasing. …”
Get full text

Exploring the synergistic effect of rose distillation waste and biostimulant beside other organic amendments onRosa damascena seedlings’ growth by Soumia El Malahi, Lahcen Irahoui, Wafaa Mokhtari, Mounia Ennami, Houda Taimourya, Jamaa Zim, Abdallah Zayani, Bahija Zakeri, Khalid Dhassi, Mimoun Mokhtari, Lalla Mina Idrissi Hassani

“…Conclusion: The findings of the study offer valuable insights into the sustainable management of rose production. The use of rose distillation waste as an organic amendment not only enhances plant growth but also positively impacts nutrient content in leaves. …”
Get full text

Evaluation of Inflammatory Markers and Clinical Outcomes in COVID-19 Patients with Concurrent <i>Clostridioides difficile</i> Infection: A Comparative Cohort Analysis by Flavia Ignuta, Adrian Vlad, Teodor Cerbulescu, Stana Loredana, Felix Bratosin, Ovidiu Rosca, Lavinia Stelea, Daciana Nistor

“…Timely recognition of <i>C. difficile</i> co-infection and use of targeted anti-inflammatory and supportive therapies may improve patient management. Future studies should expand on these findings to optimize care and guide therapeutic strategies.…”
Get full text

Efficacy of medical thoracoscopy combined with fibrinolytic therapy in the treatment of complicated parapneumonic effusions and empyema by Feng-Fu Zhan, Mao-Hong Huang, Yan-Ping Du, Yan Chen, Han-Han Chen, Yi-Li Lin, Yi-Yuan Chen, Ling Cai, Xiao-Bin Zhang

“…Conclusions Medical thoracoscopy combined with fibrinolytic therapy offers significant advantages in the management of complicated parapneumonic effusions and empyema. …”
Get full text

Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

“…These phytocompounds demonstrate potential for better management of AD in the future.…”
Get full text

Functional near-infrared spectroscopy for the assessment and treatment of patients with disorders of consciousness by Nan Wang, Nan Wang, Nan Wang, Yifang He, Sipeng Zhu, Dongsheng Liu, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Jianghong He, Jingqi Li, Juanning Si, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

“…BackgroundAdvances in neuroimaging have significantly enhanced our understanding of brain function, providing critical insights into the diagnosis and management of disorders of consciousness (DoC). Functional near-infrared spectroscopy (fNIRS), with its real-time, portable, and noninvasive imaging capabilities, has emerged as a promising tool for evaluating functional brain activity and nonrecovery potential in DoC patients. …”
Get full text

How to protect the proximal bronchial tree during stereotactic radiotherapy of ultracentral lung tumors: Lessons from MR-guided treatment by Sebastian Regnery, Efthimios Katsigiannopulos, Hin Lau, Philipp Hoegen-Saßmannshausen, Fabian Weykamp, Claudia Katharina Renkamp, Carolin Rippke, Fabian Schlüter, Sophia Albert, Jan Meis, Marietta Kirchner, Alexandra Balzer, Nicolaus Andratschke, Matthias Guckenberger, Jürgen Debus, Sebastian Klüter, Juliane Hörner-Rieber

“…Non-adaptive SBRT appears safe with advanced breathing motion management and PRV, but yields inferior PTV coverage.…”
Get full text

Using positive deviance to enhance HIV care retention in South Africa: development of a compassion-focused program to improve the staff and patient experience by Allison J. Ober, Donald H. Skinner, Laura M. Bogart, Leletu Busakwe, Wadene Davids, Hassan Mahomed, Debbie Ling, Virginia Zweigenthal

“…Nevertheless, some facilities manage to consistently retain PWH in care. We used a participatory positive deviance (PD) approach to discover characteristics of primary care facilities with above-average 12-month retention rates to develop an intervention. …”
Get full text

Performance of seawater-derived Mg(OH)2 as a sustainable coating solution for hydrogen sulfide-induced corrosion mitigation in concrete pipes by Janelle Patricia S. Moa, Bea Angela C. Gaw, John Louis O. Co, Kyle Anderson C. Coo, Kenneth Jae T. Elevado, Cheryl Lyne C. Roxas

“…In the Philippines, concrete pipe systems are critical for wastewater management, flood control, and irrigation, accounting for approximately 70% of all installations. …”
Get full text

Helping people with psychosis with a low-cost intervention DIALOG+: protocol for the economic evaluation in a randomised control trial in India and Pakistan by Victoria Jane Bird, Sara Evans-Lacko, Lakshmi Venkatraman, Padmavati Ramachandran, Ashar Muhammad Malik, Renata Peppl, Sana Zehra Zehra Sajun, Onaiza Qureshi, Krishna Priya, Hufsa Sarwar

“…The economic evaluation will support efforts to scale up low-cost healthcare interventions such as DIALOG+ to rural and unserved areas, which is otherwise challenging in the resource-constrained health systems in many LMICs.Conclusion The evidence on the cost-effectiveness of DIALOG+ will contribute to efforts to improve community-based care and the quality of life for millions of people suffering from mental health problems in India and Pakistan who experience psychosis.Ethics and dissemination This study is approved by the Queen Mary Ethics of Research Committee (UK), Institutional Ethics Committee of SCARF (India), IRD’s Independent Institutional Review Board (IRD_IRB_2021_01_005) (Pakistan), Karawan-e-Hayat Management Committee (Institutional Approval) (Pakistan), Jinnah Postgraduate Medical Centre Research Committee (NO.F.2-81/2021-GENL/60224/JPMC) (Pakistan), Aga Khan’s Ethics Research Committee (2021-5933-17533) (Pakistan) and National Bio-Ethics Committee, Pakistan (Ref: No.4–87/NBC-774/22/2037 Date: 17 May 2022).The findings of this research will be widely disseminated through research publications and engagement with the communities and the healthcare providers in the public and not-for-profit sectors.Trial registration number ISRCTN13022816.…”
Get full text

Clinical performance of two commercially available rapid antigen tests for influenza, RSV, and SARS-CoV-2 diagnostics by Laura E. Savolainen, Joanna Peltola, Risto Hilla, Tapio Åman, Markku Broas, Ilkka S. Junttila

“…However, an option to confirm negative RAT by NAAT should be available.IMPORTANCERapid diagnostics of respiratory viruses is essential for clinical management, infection control, and epidemiological surveillance. …”
Get full text

Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction by Julian Cheong Kiat Tay, Shaw Yang Chia, Siew Hui Michelle Koh, David Kheng Leng Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Shao Guang Lee, Patrick Zhan Yun Lim, Jonathan Yap

“…Further therapeutic studies to guide management of this challenging group of patients are warranted.…”
Get full text

Under-nutrition and its associated factors among adult second-line antiretroviral treatment users in Northern Ethiopia by Seteamlak Adane Masresha, Atitegeb Abera Kidie, Getahun Fentaw Mulaw, Fentaw Wassie Feleke, Mesfin Wudu Kassaw, Tadesse Mamo Dejene, Aychew Kassie Gidafie, Fassikaw Kebede Bizuneh

“…Multiple imputation method was applied to manage variables having up to 25% missing values by using R-Version 3.6.2 software. …”
Get full text