Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review by Michele Lanza, Giuditta Benincasa, Dario Costa, Claudio Napoli

“…Determining how, where, and when specific epigenetic changes trigger ocular diseases may provide useful clinical biomarkers for their prevention, diagnosis, and management, as well as innovative drug targets. PF-04523655, a 19-nucleotide methylated double-stranded siRNA targeting the RTP80 gene, showed a dose-related improvement in best-corrected visual acuity (BCVA) in patients affected by diabetic macular edema. …”
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Reproductive Diseases and Disorders of Female Camels: An Assessment and Pathological and Bacteriological Study in Eastern Ethiopia by Dinaol Belina, Amare Eshetu, Sisay Alemu, Bekyad Shasho, Tajudin Mohammed, Ahmedin Mohammed, Bahar Mummed, Dereje Regassa

“…On the other hand, a majority of camel herders had poor to no information and access to modern veterinary services; nevertheless, they had good indigenous knowledge on how to manage reproductive abnormalities. Considering the importance of camels in our study area, further research on camel reproductive diseases and abnormalities with wider sample and epidemiology need to be conducted using molecular and hormonal assay techniques.…”
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Risk Factors and Characteristics Associated with Visual Impairment and Eye Diseases in Moyamoya Disease: Insights from a National Database by Youyi Song, Xin Yang, Hongzhu Yang, Hongyun Mei, Xuedan Lu, Hao Xie, Qinfeng Yang, Wenbin Duan

“…Understanding these associations is crucial for improving patient management and outcomes. Methods This study utilized International Classification of Diseases (ICD) codes from both the 9th edition (ICD-9-CM) and 10th edition (ICD-10-CM) to define diagnoses, complications, and procedures within the National Inpatient Sample (NIS) Database. …”
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Describing quality of life trajectories in young Hispanic women with breast cancer: 5-year results from a large prospective cohort by Bryan F. Vaca-Cartagena, Ana S. Ferrigno Guajardo, Hatem A. Azim Jr, Federico Rotolo, Antonio Olivas-Martinez, Alejandra Platas, Alan Fonseca, Fernanda Mesa-Chavez, Marlid Cruz-Ramos, Ana Rodriguez, Alejandro Mohar, Cynthia Villarreal-Garza

“…Strategies to improve access to economic resources, manage treatment-related adverse effects, and support patients in discontinuing modifiable risk factors are needed.…”
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System Design and Optimisation Study on a Novel CCHP System Integrated with a Hybrid Energy Storage System and an ORC by Jie Ji, Zujun Ding, Xin Xia, Yeqin Wang, Hui Huang, Chu Zhang, Tian Peng, Xiaolu Wang, Muhammad Shahzad Nazir, Yue Zhang, Baolian Liu, Xiaoying Jia, Ruisheng Li, Yaodong Wang

“…Through the whole study, the main challenge lies within the design and the energy management of the integrated system.…”
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Phase Ib study of pembrolizumab in combination with trastuzumab emtansine for metastatic HER2-positive breast cancer by Sara M Tolaney, Tianyu Li, Edward T Richardson, Judith Agudo, Elizabeth A Mittendorf, Beth Overmoyer, Eric P Winer, Adrienne G Waks, Tanya E Keenan, Nabihah Tayob, Gerburg M Wulf, Victoria Attaya, Leilani Anderson, Ian E Krop, Eliezer M Van Allen

“…Ongoing trials will define if there is a role for checkpoint inhibition in the management of HER2-positive metastatic breast cancer.Trial registration number NCT03032107.…”
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Safety profile of EZH2 inhibitors for cancer: a systematic review and meta-analysis by Zhou Zhao, Xiufeng Chen, Huayang Pang, Yan Shi, Hao Sun

“…Conclusion EZH2 inhibitors demonstrate a manageable safety profile with a low incidence of severe TRAEs, emphasizing their potential as safe therapeutic options in cancer treatment. …”
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The relationship between dietary branched-chain and aromatic amino acids with the regulation of leptin and FTO genes in adipose tissue of patients undergoing abdominal surgery by Farshad Teymoori, Hossein Farhadnejad, Mostafa Norouzzadeh, Mitra Kazemi Jahromi, Niloufar Saber, Ebrahim Mokhtari, Golaleh Asghari, Emad Yuzbashian, Parvin Mirmiran, Alireza Khalaj, Maryam Zarkesh, Mehdi Hedayati, Mohammadreza Vafa

“…Further prospective studies are warranted to validate results and elucidate the potential for dietary interventions targeting amino acids intake in obesity management.…”
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Determination of Carbapenemase-Producing OXA- 48 and KPC Genes in Antibiotic-Resistant Gram-Negative Bacilli Isolated from Infectious Samples of Cardiovascular Patients Hospitalize... by Mina Owrang, Ebrahim Taheri Hossein Abad, Shakiba Shafaie

“…Conclusion: The present study demonstrates that the rate of drug resistance as well as the production of beta-lactamase enzymes, is significantly high in Gram-negative strains, including members of the Enterobacteriaceae family and Pseudomonas aeruginosa. As a result, the management and treatment of infections caused by these bacteria may pose substantial challenges.…”
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Factors associated with recognition at work among nurses and the impact of recognition at work on health-related quality of life, job satisfaction and psychological health: a singl... by Latifa Alahiane, Youssef Zaam, Redouane Abouqal, Jihane Belayachi

“…The trajectory analysis model found that supervisor recognition had the best impact on anxiety, job satisfaction and HRQOL.Conclusions Recognition from superiors is important in maintaining nurses’ psychological health, HRQOL and job satisfaction. Therefore, managers in hospitals should address the issue of recognition at work as a potential personal, professional and organisational lever.…”
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The role of C-reactive protein in predicting all-cause mortality among Chinese arthritis patients: implications for public health education and promotion by Shuchao Ye, Damei Ye, Changyi Lin, Dongming Lu, Xuelan You, Chaoyan Xu, Yongyang Wu

“…Efforts to control inflammation and promote health literacy regarding arthritis management may improve survival outcomes and reduce the public health burden associated with arthritis.…”
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Optimizing soil health through activated acacia biochar under varying irrigation regimes and cultivars for sustainable wheat cultivation by Lubaba Komal, Summera Jahan, Atif Kamran, Abeer Hashem, Graciela Dolores Avila-Quezada, Elsayed Fathi Abd_Allah

“…Wheat, a staple food crop globally, faces the challenges of limited water resources and sustainable soil management practices. The pivotal elements of the current study include the integration of activated acacia biochar (AAB) in wheat cultivation under varying irrigation regimes (IR). …”
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Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes by Laura J. Andreasen, Rikke K. Kirk, Christian Fledelius, Mark A. Yorek, Jens Lykkesfeldt, Thorbjorn Akerstrom

“…Current clinical guidelines for management of diabetic peripheral neuropathy (DPN) emphasize good glycemic control. …”
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Algorithm of Behaviour of Virtual Avatars During Public Speaking Training in a VR Environment by Karol Jędrasiak, Robert Robert Wolański, Damian Bereska

“…This algorithm integrates multiple aspects of human communication, including posture modelling, voice modulation, greet- ings mannerisms, eye contact management, gestural communication and interactive responsiveness. …”
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Investigation of Potential Profiles and Influencing Factors of Voice Behavior among Chinese Nurses by Shuangying Huang, Hanwen Chen, Liyan Zhang, Xianming Weng, Lingming Zhou, Xiaoqin Ma, Weiyi Wang

“…Heterogeneity was observed in the voice behavior of nurses, suggesting variations among individuals. The focus of nurse managers should be on nurses belonging to the C1 and C2 group, enabling them to implement early targeted prevention and care based on the distinctive characteristics and influencing factors associated with each latent profile.…”
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Application and comparison of five risk assessment methods in ferrous metal foundry enterprises with silica dust concentration exceeding the limit posts by Qimeng Li, Xiaoying Li, Ge Qin, Yuanmeng Qi, Jie Liu, Xiaocui Tang, Di Wu, Changfu Hao, Sihua Wang

“…In practical application, appropriate assessment methods should be selected according to specific situations and the results of multiple methods should be combined and analyzed comprehensively to ensure accurate identification and assessment of occupational hazards and provide a scientific basis for improving occupational safety and health management.…”
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Incorporating low haemoglobin into a risk prediction model for conversion in minimally invasive gynaecologic oncology surgeries by Kevin H. Nguyen, Hyundeok Joo, Solmaz Manuel, Lee-may Chen, Lee-lynn Chen

“…Background A well-known complication of laparoscopic management of gynaecologic masses and cancers is the need to perform an intraoperative conversion to laparotomy. …”
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DNA barcoding of terrestrial invasive plant species in Southwest Michigan by Sneha Nath, Joshua T. VanSlambrouck, Janelle W. Yao, Ashika Gullapalli, Fayyaz Razi, Yan Lu

“…To investigate whether DNA barcoding can aid in the detection and management of TIPS, we visited multiple nature areas in Southwest Michigan and collected a small piece of leaf tissue from 91 representative terrestrial plant species, most of which are invasive. …”
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Exploring the Prognostic Role of Trop-2, CD47, and CD163 Expression Levels on Survival Outcomes in Patients with Triple-Negative Breast Cancer by Ramazan Oguz Yüceer, Sedanur Aydın, Iclal Gelir, Tulay Koc, Ersin Tuncer, Mahmut Ucar

“…These findings offer promising prospects for future studies on combined antibody–drug conjugates (ADCs), as they may present opportunities to address multiple resistance mechanisms in the management of TNBC and enhance clinical outcomes.…”
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Protocol for the DisCoVeRy trial: multicentre, adaptive, randomised trial of the safety and efficacy of treatments for COVID-19 in hospitalised adults by Florence Ader, Jean-François Timsit, Yazdan Yazdanpanah, François-Xavier Lescure, Laetitia Moinot, Christelle Delmas, Hélène Espérou, Laurent Abel, Benjamin Leveau, Vinca Icard, Toni Alfaiate, Linda Wittkop, Charles Burdet, France Mentré, Marion Schneider, Nathan Peiffer-Smadja, Julien Poissy, Lila Bouadma, Bruno Lina, Florence Morfin-Sherpa, Maude Bouscambert, Alexandre Gaymard, Gilles Peytavin, Jeremie Guedj, Claire Andrejak, Cedric Laouenan, Drifa Belhadi, Axelle Dupont, Basma Basli, Anissa Chair, Samira Laribi, Julie Level, Marie-Capucine Tellier, Aline Dechanet, Dominique Costagliola, Sandrine Couffin-Cadiergues, Juliette Saillard, Claire Fougerou, Carole Cagnot, Soizic Le Mestre, Delphine Lebrasseur-Longuet, Ventzislava Petrov-Sanchez, Alpha Diallo, NoéMie Mercier, Sarah Tubiana, Benjamin Hamze, Ambre Gelley, Marion Noret, Eric D’Ortenzio, Oriane Puechal, Caroline Semaille

“…The objective of the trial is to evaluate the clinical efficacy and safety of different investigational re-purposed therapeutics relative to Standard of Care (SoC) in patients hospitalised with COVID-19.Methods and analysis DisCoVeRy is a phase III, open-label, adaptive, controlled, multicentre clinical trial in which hospitalised patients with COVID-19 in need of oxygen therapy are randomised between five arms: (1) a control group managed with SoC and four therapeutic arms with re-purposed antiviral agents: (2) remdesivir + SoC, (3) lopinavir/ritonavir + SoC, (4) lopinavir/ritonavir associated with interferon (IFN)-β−1a + SoC and (5) hydroxychloroquine + SoC. …”
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