Efficacy and safety of pembrolizumab in patients with advanced endometrial cancer: a systematic review and meta-analysis by Biqiong Pan, Xiaojun Lai, Jiefang Lu, Xiaoyan Bao, Zengke Fan, Jie Sun

“…Two randomized controlled trials (RCTs) found that the pembrolizumab group had a higher incidence of grade 3 or 4 AEs compared to the control group (OR: 2.23; 95% CI: 1.23, 4.04; p = 0.008).ConclusionPembrolizumab monotherapy or combination significantly improves survival in recurrent or advanced EC and has manageable toxicity albeit with a relatively high incidence of treatment-related AEs.…”
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LEVERAGING AI TOOLS FOR ENHANCING PROJECT TEAM DYNAMICS: IMPACT ON SELF-EFFICACY AND STUDENT ENGAGEMENT by Olena Kuzminska, Denys Pohrebniak, Mariia Mazorchuk, Viacheslav Osadchyi

“…Based on the results of the free choice of project and team management tools, we categorised three groups among the 56 participants of the experiment according to the use or non-use of AI tools to enhance group dynamics, followed by self-assessment of the effectiveness of the selected tools in increasing their levels of self-efficacy and social engagement. …”
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Two-Dimensional Shear-Wave Elastography: Accuracy in Liver Fibrosis Staging Using Magnetic Resonance Elastography as the Reference Standard by Puwitch Charoenchue, Jiraporn Khorana, Taned Chitapanarux, Nakarin Inmutto, Wittanee Na Chiangmai, Amonlaya Amantakul, Suwalee Pojchamarnwiputh, Apichat Tantraworasin

“…<b>Background:</b> The accurate staging of liver fibrosis is crucial for managing chronic liver disease (CLD). Although magnetic resonance elastography (MRE) is the reference standard for noninvasive fibrosis assessment, its cost, specialized hardware, and operational demands restrict accessibility. …”
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Staphylococci and mammaliicocci: Which species are important for udder health on organic dairy farms? by C.E. Jeffrey, P.R.F. Adkins, S. Dufour, J.W. Barlow

“…ABSTRACT: Variation in species distribution and diversity of staphylococci and mammaliicocci (SaM) causing intramammary infections in dairy cattle is associated with different management practices. Disparate selective pressures on organic dairies could potentially result in population differences of these mastitis-causing bacteria. …”
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Can integrated care interventions strengthen primary care and improve outcomes for patients with chronic diseases? A systematic review and meta-analysis by Yuqi Zhang, Jonathan Stokes, Laura Anselmi, Peter Bower, Jin Xu

“…Although primary care has a central role in managing chronic disease, and integration may be important in strengthening this role, previous research has shown insufficient attention to the relationships between primary care and integration. …”
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Approaches to implementing and financing primary health care in Kenya: a case of seven counties by Janette Karimi, Salim Hussien, Elizabeth Wangia, Mercy-Irene Kimani, Mohamud Mohamed, Melissa Wanda, Rosemarie Muganda, Rachel Ndirangu, Daniel Mwai, Mercy Wanjala, Fadhila Richter

“…All participating counties adopted Sub-County Health Management Teams (SCHMTs) as the MDTs due to staffing limitations at primary care facilities consequently inhibiting the capacity for effective MDT engagement. …”
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Long-term effect of repeated application of pig slurry digestate on microbial communities in arable soils by Daniela Mora-Salguero, Lionel Ranjard, Thierry Morvan, Samuel Dequiedt, Vincent Jean-Baptiste, Sophie Sadet-Bourgeteau

“…Conducted from 2012 to 2022 at an experimental field site in France, the study involved plots with identical agricultural soil management practices, differing only in fertilization treatments: mineral fertilizer, three different OW (cattle manure, pig slurry, pig slurry digestate), and a control with no organic or mineral fertilizer input. …”
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Shattering the Amyloid Illusion: The Microbial Enigma of Alzheimer’s Disease Pathogenesis—From Gut Microbiota and Viruses to Brain Biofilms by Anna Onisiforou, Eleftheria G. Charalambous, Panos Zanos

“…We discuss potential microbiome-based therapies as promising strategies for managing and potentially preventing AD progression. …”
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Ethnic Architectural Heritage Identification Using Low-Altitude UAV Remote Sensing and Improved Deep Learning Algorithms by Ting Luo, Xiaoqiong Sun, Weiquan Zhao, Wei Li, Linjiang Yin, Dongdong Xie

“…Ethnic minority architecture is a vital carrier of the cultural heritage of ethnic minorities in China, and its quick and accurate extraction from remote sensing images is highly important for promoting the application of remote sensing information in urban management and architectural heritage protection. Taking Buyi architecture in China as an example, this paper proposes a minority architectural heritage identification method that combines low-altitude unmanned aerial vehicle (UAV) remote sensing technology and an improved deep learning algorithm. …”
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Mechanisms of N₂O Emission in Drip-Irrigated Saline Soils: Unraveling the Role of Soil Moisture Variation in Nitrification and Denitrification by Fang Zhang, Zhi Qu, Qian Zhao, Zixuan Xi, Zhen Liu

“…Our study elucidates the characteristics of nitrogen transformation and N₂O emissions across various soil moisture contents within the soil water structure under drip irrigation conditions, providing a scientific basis for the formulation of precise irrigation management practices and strategies for efficient soil nitrogen utilization.…”
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Comparative Evaluation of Functional Outcomes in High Condylar Fractures Treated with Closed Methods with and without Temporomandibular Joint Arthrocentesis: A Research Protocol fo... by Sachindra Dubey, Nitin Bhola, Anchal Agarwal

“…It has emerged as a valuable tool in the multidisciplinary approach to managing TMDs, offering patients a minimally invasive option to relieve their symptoms and restore jaw function. …”
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Mechanisms and regulatory pathways of recessive land use transition by TAN Lin, CHEN Lan

“…It is rooted in the intervention system composed of regional resource endowments, engineering and technological systems, policy and institutional environments, cultural value recognition, and socio-economic development, featuring inherent relevance and dynamic adjustability. (3) Based on the underlying logic of “comprehensive land benefits - dominant land functions - land development rights”, regulatory pathways with element-coordinated governance, classification-based management guidelines, and well-improved institutional structure are constructed, which facilitate recessive land use transition. …”
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Unpacking the benefits of black soldier fly frass fertilizer towards nematode suppression and potato production by Emmanuel O. Anedo, Emmanuel O. Anedo, Emmanuel O. Anedo, Dennis Beesigamukama, Benson Mochoge, Nicholas K. Korir, Solveig Haukeland, Solveig Haukeland, Xavier Cheseto, Moses Nyongesa, Patrick Pwaipwai, Sevgan Subramanian, Abdou Tenkouano, Betty Kibaara, Chrysantus M. Tanga

“…Mineral fertilizers and synthetic nematicides are costly and cause negative impacts on humans and the environment, while organic fertilizers are less effective for soil health and nematode management. This study demonstrates the contribution of black soldier fly frass fertilizer (BSFFF) in nematode suppression and potato productivity when compared to commercial mineral fertilizer, organic fertilizer (SAFI), and nematicide. …”
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Development and validation of soil test crop response model for beetroot (Beta vulgaris) grown in ultisols of India by Ramasamy Arulmani, Ramasamy Arulmani, Kuppayevalasu Malayappagounder Sellamuthu, Kuppayevalasu Malayappagounder Sellamuthu, Subramaniam Maragatham, Subramaniam Maragatham, Alargarsamy Senthil, Alargarsamy Senthil, Seenapuram Palaniswami Thamaraiselvi, Seenapuram Palaniswami Thamaraiselvi, Palaniappan Malathi, Palaniappan Malathi, Govindaraja Sridevi, Govindaraja Sridevi

“…Soil Test Crop Response (STCR), a combined plant nutrient management system that enables to develop fertilizer prescription equations for balanced crop nutrition, higher yield, profitability, and better nutrient efficiency. …”
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Inflammatory Choroidal Neovascular Membranes: Clinical Profile, Treatment Effectiveness, and Visual Prognosis by Gonçalo Carrola, Mário Lima-Fontes, Fernando Falcão-Reis, Luís Figueira, Ângela Carneiro

“…Intensive follow-up was fundamental in the management of both the primary inflammatory and secondary neovascular conditions.…”
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Delineating Structural Features Related to Hydrothermal Alterations for Possible Mineralization in Share Area, Kwara State Nigeria Using Aeromagnetic Data by Warith Adewale Adebisi, Ismail Oluwaseye Folorunso, Hussain Olanrewaju Abubakar, Saminu Olatunji, Michael Opeoluwa Olaojo

“…These offer insights into subsurface geology that can be broadly applied in geophysical exploration and mineral resource management. The results reveal structural trends predominantly in the NE–SW direction, with some NW–SE alignments, indicative of hydrothermal alterations linked to mineral deposits. …”
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Comparative efficacy of plant derived extracts with the insecticide mospilan on two whitefly species Bemisia tabaci biotype B and Trialeurodes ricini by Hanaa S. Hussein, Mamdouh H. Idriss, Farouk H. El-Gayar, Hebatullah Yehia Saad Mousa, Mohamed Z. M. Salem

“…The current research lays the groundwork for the integrated pest management (IPM) of B. tabaci biotype B and T. ricini by employing natural extracts and pesticides blends.…”
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Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collab... by Giulia Turri, MD, Luigi Martinelli, MD, Daniela Rega, MD, Nicolò Tamini, MD, Lucia Paiano, MD, Simona Deidda, MD, QuocRiccardo Bao, MD, Laura Lorenzon, MD, PhD, Raffaele De Luca, MD, Caterina Foppa, MD, PhD, Valentina Mari, MD, Giovanni Taffurelli, MD, Arcangelo Picciariello, MD, PhD, Patrizia Marsanic, MD, Leandro Siragusa, MD, Francesco Bagolini, MD, Riccardo Nascimbeni, MD, Gianluca Rizzo, MD, PhD, Sara Vertaldi, MD, Michele Zuolo, MD, Giorgio Bianchi, MD, Lisa Marie Rorato, MD, Rossella Reddavid, MD, PhD, Gaetano Gallo, MD, PhD, Lorenzo Crepaz, MD, Alberto Di Leo, MD, Mario Trompetto, MD, Enrico Potenza, MD, Mauro Santarelli, MD, Nicola de’Angelis, MD, PhD, Francesco Ciarleglio, MD, Marco Milone, MD, PhD, Claudio Coco, MD, Guido Alberto Tiberio, MD, Gabriele Anania, MD, Giuseppe S. Sica, MD, PhD, Andrea Muratore, MD, Donato Francesco Altomare, MD, Isacco Montroni, MD, PhD, Maurizio De Luca, MD, Antonino Spinelli, MD, PhD, Michele Simone, MD, Roberto Persiani, MD, Gaya Spolverato, MD, Angelo Restivo, MD, Nicolò de Manzini, MD, Marco Braga, MD, Paolo Delrio, MD, Giuseppe Verlato, MD, PhD, Corrado Pedrazzani, MD, Adriana Gioia, Cristina Vacca, Dario Parini, Giovanni Tomasicchio, Marcello Calabrò, Bruno Sensi, Filomena Misuriello, Carlo Alberto Schena, Silvia Picotto

“…The aim of this study is to provide solid evidence to update the management of stage I colon cancer (CC) after surgery. …”
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Genotype-phenotype correlations for 17 Chinese families with inherited retinal dystrophies due to homozygous variants by Xue Fan, Zhen Li, Lingzhi Sha, Xunlun Sheng, Weining Rong

“…We have identified couples at high risk of having affected offspring and individuals with moderate to severe IRDs, providing a basis for genetic counseling, reproductive decision-making, disease prevention, and management. Our findings highlight the association between homozygous variants and more severe clinical phenotypes within these families, thus laying the groundwork for future genetic screening and intervention strategies.…”
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The novel manualized RELIEVE-group treatment for burdened relatives of cancer patients: a feasibility study by Jessica Neumann, Jessica Neumann, Jil Beckord, Jil Beckord, Helen Samira Hesse, Helen Samira Hesse, Carl Martin, Carl Martin, Carlotta Mons, Carlotta Mons, Diana Chur, Diana Chur, Jörg Hense, Jörg Hense, Mitra Tewes, Martin Teufel, Martin Teufel, Eva-Maria Skoda, Eva-Maria Skoda

“…A total of 33 relatives of cancer patients were recruited from the West German Tumor Center and participated in the five modules of the RELIEVE treatment which included an introduction, communication skills, stress and anxiety management and self-care. The primary outcome was assessed using a range of measures, including anxiety (GAD-7), depression (PHQ-8), stress (PSQ), self-efficacy (SES), need for support (SCNSP&amp;C-G), and quality of life (WGOQOL-BREF) before and after the completion of the treatment programme. …”
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