Impact of elexacaftor-tezacaftor-ivacaftor in lung transplantation for cystic fibrosis in the United States by Tahuanty A. Pena, MD, MS, Brittany Wright, PharmD, Kalpaj R. Parekh, MBBS, Julia Kleney-Tait, MD, PhD

“…Conclusions: The introduction of ETI has dramatically reduced the need for lung transplants among pwCF, reflecting significant improvements in lung function and disease management. These findings underscore the transformative impact of CFTR modulators like ETI on the natural history of CF, highlighting the importance of continued advancements in precision medicine for genetic disorders. …”
Get full text

SARS-CoV-2 excretion and genetic evolution in nasopharyngeal and stool samples from primary immunodeficiency and immunocompetent pediatric patients by Haifa Khemiri, Ilhem Ben Fraj, Alessio Lorusso, Najla Mekki, Iolanda Mangone, Mariem Gdoura, Adriano Di Pasqual, Cesare Cammà, Valeria Di Lollo, Asma Cherni, Henda Touzi, Amel Sadraoui, Zina Meddeb, Nahed Hogga, Imen Ben Mustapha, Mohamed-Ridha Barbouche, Monia Ouederni, Henda Triki, Sondes Haddad-Boubaker

“…Thus, specialized care is essential for effectively managing PID patients.…”
Get full text

The intestinal microbial community and function of Riptortus pedestris at different developmental stages and its effects on development by Yanbin Wang, Rong Li, Chunjing Wang, Ting Sun, Hongjuan Zhang, Fang Zhao, Jiehui Liu, Yuqiong Hao, Xiansheng Xie

“…This study provides the basis for stinkbug management strategies that focus on the pivotal gut microbiota.…”
Get full text

Phenotypic and WGS-derived antibiotic resistance patterns of Salmonella Enteritidis isolates from retail meat and environment during 2014 to 2019 in China by Liya Zheng, Qiannan Di, Xuebin Xu, Liyuan Liu, Chunbo Qu, Phil Bremer, Phil Bremer, Xiujuan Zhou

“…Most MDR strains (81.43%) had NAL-AMP-FIS-STR ± TET profiles, showing a fluctuating trend from 2015 to 2019, likely influenced by tetracycline withdrawal management. WGS identified four types of mutations in the gyrA gene were associated with nalidixic acid resistance. …”
Get full text

Effects of internet-based cognitive behavioral therapy on anxiety and depressive symptoms among patients with cardiovascular and cerebrovascular diseases: a systematic review and m... by Shuangyu Wang, Lishuo Gao, Congyu Wang, Jinbing Bai, Mengshuang Shen, Xuejie Zhao, Mei Lin

“…Shorter programs (< 9 weeks) were better for anxiety, whereas longer programs (≥ 9 weeks) were more effective for depression.ConclusionsICBT is an effective intervention for managing anxiety and depression in CVD patients. Tailoring ICBT interventions based on symptom type, module number, and program duration can optimize outcomes. …”
Get full text

Concentrations, Deposition, and Effects of Nitrogenous Pollutants in Selected California Ecosystems by Andrzej Bytnerowicz, Pamela E. Padgett, Sally D. Parry, Mark E. Fenn, Michael J. Arbaugh

“…Long-term, complex interactions between N deposition and other environmental stresses such as elevated ozone (O3), drought, insect infestations, fire suppression, or intensive land management practices may affect water quality and sustainability of California forests and other ecosystems.…”
Get full text

A vacuum lyophilization and bacterial tablet-based method for culture medium evaluation and potential use in probiotic products by Wen Cui, Liang Zhao, Yuwen Shi, Wei Feng, Xiao Chen, Hui Liu

“…However, this method requires highly complicated biosafety management, detailed standard strains record-keeping and substantial working time.Methods and resultsBacterial tablet is considered to be a novel strategy for bacteria culture medium evaluation. …”
Get full text

Co-location of seaweed farming with offshore wind energy: a quick scoping review by Brianna Coffey, Cortni Borgerson, Pankaj Lal, Colette J. Feehan

“…Seaweed farming is increasingly recognized as a sustainable marine resource management opportunity, but it also poses socioeconomic and environmental risks that require careful evaluation. …”
Get full text

Automatic detection, identification and counting of deep-water snappers on underwater baited video using deep learning by Florian Baletaud, Florian Baletaud, Florian Baletaud, Sébastien Villon, Antoine Gilbert, Jean-Marie Côme, Sylvie Fiat, Corina Iovan, Laurent Vigliola

“…Deep-sea demersal fisheries in the Pacific have strong commercial, cultural, and recreational value, especially snappers (Lutjanidae) which make the bulk of catches. Yet, managing these fisheries is challenging due to the scarcity of data. …”
Get full text

Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging by Oliver Lester Saldanha, Jiefu Zhu, Gustav Müller-Franzes, Zunamys I. Carrero, Nicholas R. Payne, Lorena Escudero Sánchez, Paul Christophe Varoutas, Sreenath Kyathanahally, Narmin Ghaffari Laleh, Kevin Pfeiffer, Marta Ligero, Jakob Behner, Kamarul A. Abdullah, Georgios Apostolakos, Chrysafoula Kolofousi, Antri Kleanthous, Michail Kalogeropoulos, Cristina Rossi, Sylwia Nowakowska, Alexandra Athanasiou, Raquel Perez-Lopez, Ritse Mann, Wouter Veldhuis, Julia Camps, Volkmar Schulz, Markus Wenzel, Sergey Morozov, Alexander Ciritsis, Christiane Kuhl, Fiona J. Gilbert, Daniel Truhn, Jakob Nikolas Kather

“…While this increase poses challenges for radiologists, artificial intelligence (AI) offers potential solutions to manage this workload. However, the development of AI models is often hindered by manual annotation requirements and strict data-sharing regulations between institutions. …”
Get full text

Prevalence of specific learning disability in children and its association with somatic symptom disorder – data from a tertiary care centre of South India by Nishanth Rajan, Priya Jose, Peter Prasanth Kumar Kommu, Shanthi Kannan

“…The medical records of all patients who were evaluated by a child psychologist were audited through hospital information management software-specific learning disabilities were assessed using the NIMHANS Learning Disability score. …”
Get full text

SC-ResNeXt: A Regression Prediction Model for Nitrogen Content in Sugarcane Leaves by Zihao Lu, Cuimin Sun, Junyang Dou, Biao He, Muchen Zhou, Hui You

“…This approach offers an affordable technical solution for small farmers to optimize nitrogen management for sugarcane plants, potentially leading to yield improvements. …”
Get full text

Partial versus complete prostatectomy specimen sampling: prospective non-inferiority study for pT3a tumours and surgical margin involvement by Mike Kliffen, Eelco R P Collette, Michael A den Bakker, Sjoerd O Klaver, André N Vis

“…Furthermore, partial sampling compared with complete sampling does not change postoperative clinical management.…”
Get full text

Unraveling the relationship between obstructive sleep apnea and osteoarthritis: A multivariate mendelian randomization highlighting the role of BMI as a confounding factor by Xin Xu, Hui Yu, Mingyi Yang, Jiale Xie, Ke Xu, Erliang Li, Xianjie Wan, Jiachen Wang, Guoqiang Wang, Ying Pan, Peng Xu, Junfei Guo

“…These findings underscore obesity as the primary shared risk factor, highlighting the importance of weight management as a key strategy for mitigating the risks of both conditions. …”
Get full text

Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment by Congcong Fang, Longqin Lv, Shanping Mao, Huimin Dong, Baohui Liu

“…Simultaneously, early screening and canonical management of PD with cognitive deficits are very imperative to postpone the disease progression and improve the prognosis of patients. …”
Get full text

Performance Evaluation of Mutual Funds Using the Value-Based DEA Method by Khadijeh Ghaziyani, Seyede Fatemeh Bagheri, Babak Ejlali

“…Originality/Value: The issue is related to the events that have taken place in the country, which are strongly affected by the economic recession and the banking system, which mainly include sanctions and the global financial crisis and liquidity fluctuations and exchange rate fluctuations; therefore, the conclusions in this study will be potentially valuable for fund managers and investors.…”
Get full text

Improved Clinical Outcomes with Appropriate Meropenem De-escalation in Patients with Febrile Neutropenia by Tyler Luu, Austin Fan, Reid Shaw, Hina Dalal, Jenna Adams, Maressa Santarossa, Gail Reid, Stephanie Tsai, Nina M. Clark, Fritzie S. Albarillo

“…Introduction: Antibiotic stewardship is a critical aspect of managing cancer patients with febrile neutropenia (FN) to limit the development of drug-resistant organisms and minimize adverse drug effects. …”
Get full text

Somatic symptoms in schizophrenia: Association with socio-demographic and clinical characteristics, disability and quality of life by Mamta Sood, Ragul Ganesh, Ananya Mahapatra, Rohit Verma, Rakesh K. Chadda

“…Thus during routine clinical practice, somatic symptoms should be assessed and managed in these patients.…”
Get full text

Influence of environmental factors on the growth and reproduction of Pistia stratiotes L. by Mohamed Sbaghi, Mohamed El Aalaoui

“…Understanding these environmental influences is crucial for effective cultivation and management of this species in diverse ecological settings.…”
Get full text

Pre-Season Precipitation and Temperature Have a Larger Influence on Vegetation Productivity than That of the Growing Season in the Agro-Pastoral Ecotone in Northern China by Yuanyuan Zhang, Qingtao Wang, Xueyuan Zhang, Zecheng Guo, Xiaonan Guo, Changhui Ma, Baocheng Wei, Lei He

“…These findings not only emphasize the critical role of both historical and contemporary climate conditions in shaping vegetation growth but also provide valuable insights into how to adjust agricultural and animal husbandry management strategies to improve regional climate adaptation based on climate information from previous seasons in fragile regions.…”
Get full text