Strengthening research preparedness for crises: lessons from Norwegian government agencies in using randomized trials and quasi-experimental methods to evaluate public policy inter... by Unni Gopinathan, Ingeborg Elgersma, Therese Dalsbø, Mona Bjørbæk, Atle Fretheim

“…The surveyed agencies stressed the importance of legislation providing clear guidelines on when differential treatment can be justified and when informed consent requirements can be waived, as well as faster and clearer processes for managing privacy concerns related to data access. Crucially, greater political acceptance for systematically and gradually implementing reforms, including using randomization, could strengthen evidence-informed public policy, enhancing the scaling-up of effective interventions and deprioritizing ineffective ones.…”
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Dexmedetomidine versus Dexamethasone as Perineural Adjuvants in Supraclavicular Brachial Plexus Block: An Interventional Study by Charmi Hitenbhai Shah, Jinesh Pareshbhai Kothari, Nilesh Vrajmohan Shah, Rajsi Rajan Shah, Sara Mary Thomas

“…However, the incidence of hypotension and bradycardia was higher with dexmedetomidine, which could be managed with routine clinical measures.…”
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Comparisons of open surgical repair, thoracic endovascular aortic repair, and optimal medical therapy for acute and subacute type B aortic dissection: a systematic review and meta-... by Jianping Liu, Xiaohong Chen, Juan Xia, Long Tang, Yongheng Zhang, Lin Cao, Yong Zheng

“…Abstract Background Various treatments have been employed in managing type B aortic dissection (TBAD), encompassing open surgical repair (OSR), thoracic endovascular aortic repair (TEVAR), and optimal medical therapy (OMT). …”
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Enhanced antitumor activity of combined hepatic arterial infusion chemotherapy with Lenvatinib and PD-1 inhibitors in unresectable hepatocellular carcinoma: a meta-analysis by Lingling Zhao, Cheng Xu, Jiewen Deng, Yang Ni

“…No life-threatening AEs were reported.ConclusionThe HAIC-L-P regimen correlated with enhanced tumor responses and prolonged survival, alongside manageable adverse effects, indicating its potential as a viable therapeutic strategy for individuals afflicted with uHCC.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024594109.…”
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Acceptability and Implementation Challenges of Benzathine Penicillin G Secondary Prophylaxis for Rheumatic Heart Disease in Ethiopia: A Qualitative Study by Eshetie Melese Birru, Kevin T. Batty, Laurens Manning, Stephanie L. Enkel, Brioni R. Moore

“…Highlights: • Key barriers included (a) resistance from healthcare providers to administer benzathine penicillin G (BPG) due to their concerns about injection-related severe adverse events, and potential repercussions should an event occur, (b) poor community and healthcare provider awareness of the disease and its treatment, (c) lack of resources to manage adverse events, and (d) injection pain. • Key enablers included (a) perceived superior treatment benefits of BPG and (b) co-administration of lidocaine/analgesics to reduce injection pain. • Recommendations to address identified challenges include (a) improved training/education on RHD diagnosis, disease progression, and treatment, (b) improved access to supportive resources, (c) active adverse reaction monitoring and reporting, and (d) encouraging the provision/access of globally subsidized BPG suspension formulations in pre-filled syringes.…”
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Peer-assisted telemedicine hepatitis-C treatment for people who use drugs in rural communities: a mixed methods study by Kim Hoffman, Gillian Leichtling, Sarah Shin, Andrew Seaman, Tonhi Gailey, Hunter C. Spencer, P. Todd Korthuis

“…., housing vouchers) (2) Key clinician-level factors such as capacity for unscheduled peer-facilitated appointments, having dedicated time for case consults with peers, and clinicians trained in working with PWUD and skilled in identifying related clinical concerns (3) Key systems-level elements such as standing lab orders, challenges related to specialty pharmacies and Medicaid managed care organizations, and streamlined communication strategies between peers and clinicians. …”
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Efficacy and safety of various drug combinations in treating plaque Psoriasis: A meta-analysis [version 2; peer review: 2 approved] by Nayak Snehasis, Karshe Haji Ali, Pendyala Siri, Ngabo Herve, Sayed Zafar

“…Topical corticosteroids, calcineurin inhibitors, and oral corticosteroids help to manage plaque psoriasis symptoms, but combination therapies might offer greater effectiveness and improved safety profiles. …”
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Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction by Xiaoying Ma, Zhen Li, Lu Zhang, Hui Qian, Qinkai Chen, Ye Tao, Yunfan Li, Dandan Wang, Zhizhen Hu, Weili Luo, Ping Li, Hai Yu, Changlin Mei, Xueqing Yu, Yuanfeng Zhou

“…Adverse events were mild and manageable, with no reports of severe anaphylaxis. Discussion Preclinical and clinical evidence signifies that Pegmolesatide is a unique, potent PEGylated EPO-memetic peptide (EMP) with a prolonged PD efficacy and PK half-life and a good safety-tolerability profile. …”
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Unified Mobile App for Streamlining Verbal Autopsy and Cause of Death Assignment in India: Design and Development Study by Harleen Kaur, Stuti Tripathi, Manjeet Singh Chalga, Sudhir K Benara, Amit Dhiman, Shefali Gupta, Saritha Nair, Geetha Menon, B K Gulati, Sandeep Sharma, Saurabh Sharma

“…Based on annual caseload projections, the smallest administrative public health unit, health and wellness centers, is anticipated to handle 35‐40 VA cases annually, while medical officers at primary health centers are projected to manage 150‐200 physician-certified VAs each year. …”
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Testing the Feasibility, Acceptability, and Potential Efficacy of an Innovative Digital Mental Health Care Delivery Model Designed to Increase Access to Care: Open Trial of the Dig... by Natalia Macrynikola, Kelly Chen, Erlend Lane, Nic Nguyen, Jennifer Pinto, Shirley Yen, John Torous

“…Secondary outcomes included change in functional impairment, self-efficacy in managing emotions, and flourishing. ResultsOf the 258 enrolled participants, 215 (83.3%) completed the 8-week program. …”
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Comprehensive health assessment of retired martial arts athletes: bone density, dietary intake, physical activity, and wellbeing by Tasneem Alshaer, Nihad Battikhi, Adam Tawfiq Amawi, Khalid Trabelsi, Khalid Trabelsi, Haitham Jahrami, Haitham Jahrami, Philippe Bouedo, Hadeel Ali Ghazzawi

“…These findings underscore the importance of continued physical activity for health and suggest that both retired athletes and non-athletes should adopt a balanced lifestyle to manage weight and stress effectively.…”
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Efficacy and Safety Outcomes of Intravitreal Dexamethasone Implant Therapy for the Treatment of Adult Coats’ Disease by Qingshan Chen, Saying Liang, Xizhen Wang, Chenli Hu, Jieting She, Zi Li

“…A consecutive case series of adult Coats’ disease managed with or without intravitreal dexamethasone implant (Ozurdex®, Allergan Inc., Irvine, California, USA) injection was retrospectively evaluated. …”
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Jovens e os Stories do Instagram: estudo netnográfico durante a pandemia da Covid-19 by Alan César Belo Angeluci, Brasilina Passarelli, Carolina Gois Falandes, Milena Possar Garcia

“…In Dix, everyday posts, humour, and sensitive topics prevailed, with less image editing, anticipating the photo dump phenomenon. Conclusion. By managing these spaces, young people can assume different identities, with media and information literacies being important resources for their online practices and expression of feelings.…”
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Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial by Diana Ovejero, Anna Ribes, Judit Villar-García, Marta Trenchs-Rodriguez, Daniel Lopez, Xavier Nogués, Robert Güerri-Fernandez, Natalia Garcia-Giralt

“…Abstract Background Post-Acute COVID Syndrome (PACS) is a complex disorder that currently lacks effective evidenced-based therapies to manage it. This randomized controlled trial aims to evaluate the effects of balneotherapy (BT) on PACS symptomatology. …”
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Enzymatic Activity and Horizontal Gene Transfer of Heavy Metals and Antibiotic Resistant Proteus vulgaris from Hospital Wastewater: An Insight by Manzar Alam, Nilofer Bano, Tarun Kumar Upadhyay, Reem Binsuwaidan, Nawaf Alshammari, Amit Baran Sharangi, Radhey Shyam Kaushal, Mohd Saeed

“…It could provide cutting-edge methods for treating infectious diseases, which are essential for managing and assessing the risks associated with hospital wastewater, especially in the case of P. vulgaris.…”
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Comparative the efficacy and safety of Gosuranemab, Semorinemab, Tilavonemab, and Zagotenemab in patients with Alzheimer’s disease: a systematic review and network meta-analysis of... by Wenting Cai, Wenting Cai, Hui Zhang, Hui Zhang, Yan Wu, Yan Wu, Yao Yao, Jinping Zhang

“…Most safety analysis results showed no statistical difference.ConclusionThe results indicated that anti-tau protein monoclonal antibodies, such as Semorinemab and Tilavonemab, showed promise in terms of efficacy and safety for managing AD. Further studies are needed to confirm these findings, assess long-term effects, and refine treatment protocols.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/#myprospero, CRD42024583388.…”
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Interplay between BMI, neutrophil, triglyceride and uric acid: a case-control study and bidirectional multivariate mendelian randomization analysis by Haoyuan Lyu, Na Fan, Hao Wen, Xin Zhang, Herong Mao, Qinglai Bian, Jiaxu Chen

“…Understanding the causal correlation between UA and health indicators, specifically its association with the body’s inflammatory conditions, is crucial for preventing and managing various diseases. Methods A retrospective analysis was conducted on 4,286 cases utilizing the Spearman correlation method. …”
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Incidence and predictors of adverse birth outcomes among women who gave birth at Assosa general hospital, Northwest Ethiopia: a retrospective cohort study by Habtamu Tadesse Gudeta, Shalama Lekasa Nagari, Dessalegn Emana Jabana, Mustefa Aflegn Legese, Demekisa wondimu Biyena, Fantahun Cheklie Kassie

“…Improving maternal health services, nutrition education, early diagnosis, and treatment can help to manage most of these predictors.…”
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Rapid weight loss and combat athletes: a study on psychological resilience and mechanical hyperalgesia by Esin Çağla Çağlar, Levent Ceylan, Sermin Ağralı Ermiş, Furkan Çamiçi, Murat Eliöz, Recep Nur Uzun, Güner Çiçek, Muhammet Kusan, Mustafa Tolga Bayraktar, Fatma Neşe Şahin, Hamza Küçük

“…Future research should explore interventions to optimize resilience and manage pain during RWL periods, focusing on individualized support strategies for athletes. …”
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Evaluation of Performance Metrics Required in Proper Selection of SDN Controller for Integrated Satellite-Terrestrial Networks by Oluwatobi A. Ayofe, Mu'azu J. Musa, Zanna M. Abdullahir, Abdoulie M.S. Tekanyi, Aliyu D. Usman, Ezekiel E. Agbon, Emmanuel A. Otsapa, Agburu O. Adikpe, Matthew Iyobhebhe, Paul Thomas Muge

“… SDN controllers are increasingly becoming an integral part of modern communication networks due to their ability to centrally control and manage networks from a global point of view. One of the application areas in which the SDN paradigm is gaining traction is the Integration of Satellite and Terrestrial Networks (ISTN). …”
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