Metformin: A Potential Drug for COVID-19 by Anjali Devi Bettadapura Shankara Rao, Sujatha Puttalingaiah, Ananth B Koushik, Jadeppa Gowda

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Human neural stem cell–derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway by Jiayi Wang, Mengke Zhao, Dong Fu, Meina Wang, Chao Han, Zhongyue Lv, Liang Wang, Jing Liu

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De Novo Transcriptome Assembly and Differential Gene Expression Profiling of Three Capra hircus Skin Types during Anagen of the Hair Growth Cycle by Teng Xu, Xudong Guo, Hui Wang, Xiaoyuan Du, Xiaoyu Gao, Dongjun Liu

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MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi. by Sajith Raghunandanan, Kai Zhang, Yan Zhang, Raj Priya, Ching Wooen Sze, Yongliang Lou, Michael J Lynch, Brian R Crane, Mark H Kaplan, Chunhao Li, X Frank Yang

“…These findings reveal that MCP5, regulated by both the Rrp1 and Rrp2 pathways, is critical for establishing infection in mammalian hosts by evading NK cell-mediated host innate immunity and is important for the transmission of spirochetes from ticks to mammalian hosts. …”
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Colibactin-induced damage in bacteria is cell contact independent by Emily Lowry, Amir Mitchell

“…It has been widely studied in mammalian cells due to its potential role in tumorigenesis. …”
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Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude by Anne Neuss, Thomas Steimann, Jacinta Sofia Tomas Borges, Robert Dinger, Jørgen Barsett Magnus

“…Abstract Background For process development in mammalian cell cultivations, scale-up approaches are essential. …”
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Simple Meets Single: The Application of CRISPR/Cas9 in Haploid Embryonic Stem Cells by Zixi Yin, Lingyi Chen

“…However, the diploid status of most mammalian cells restricts the application of CRISPR/Cas9 in genetic screening. …”
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The Controversy, Challenges, and Potential Benefits of Putative Female Germline Stem Cells Research in Mammals by Zezheng Pan, Mengli Sun, Xia Liang, Jia Li, Fangyue Zhou, Zhisheng Zhong, Yuehui Zheng

“…However, in recent years, researchers have successfully isolated and cultured a type of germ cell from postnatal ovaries in a variety of mammalian species that have the abilities of self-proliferation and differentiation into oocytes, and this finding indicates that putative germline stem cells maybe exist in the postnatal mammalian ovaries. …”
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Myosin-based nucleation of actin filaments contributes to stereocilia development critical for hearing by Zane G. Moreland, Fangfang Jiang, Carlos Aguilar, Melanie Barzik, Rui Gong, Ghazaleh Behnammanesh, Jinho Park, Arik Shams, Christian Faaborg-Andersen, Jesse C. Werth, Randall Harley, Daniel C. Sutton, James B. Heidings, Stacey M. Cole, Andrew Parker, Susan Morse, Elizabeth Wilson, Yasuharu Takagi, James R. Sellers, Steve D. M. Brown, Thomas B. Friedman, Gregory M. Alushin, Michael R. Bowl, Jonathan E. Bird

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Generation of stably expressing IRF5 spliced isoform in Jurkat cells by Ashwinder Kaur, Chee-Mun Fang

“… Lentiviral transduction enables the generation of gain-of-function of a targeted gene in mammalian cells. Single-cell cloning through limiting dilution can establish a population of cells with homogenous transgene expression for exploring protein function. …”
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Abundance, Species Diversity, and Distribution of Diurnal Mammals in Humbo Community-Based Forest Area, Southern Ethiopia by Adanech Lemma, Wondimagegnehu Tekalign

“…The highest number of mammalian species were distributed in bushland habitat during both wet (n = 7) and dry (n = 7) seasons. …”
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Discovery of a parallel family of euglenatide analogs in Euglena gracilis by Ahmed H. Elbanna, Xinhui Kou, Dilip V. Prajapati, Surasree Rakshit, Rebecca A. Butcher

“…In comparison to the euglenatides, the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay, indicating that the triene is critical to the biological activity of the euglenatides. …”
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Role of the Endocannabinoid System in the Central Regulation of Nonmammalian Vertebrate Reproduction by Erika Cottone, Valentina Pomatto, Patrizia Bovolin

“…The endocannabinoid system (ECS) has a well-documented pivotal role in the control of mammalian reproductive functions, by acting at multiple levels, that is, central (CNS) and local (gonads) levels. …”
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Bioluminescence Imaging of Gene Expression in Utero by Meera T. Saxena, Sara J. Aton, Charles Hildebolt, Julie L. Prior, Ute Abraham, David Piwnica-Worms, Erik D. Herzog

“…These results demonstrate the feasibility of in utero imaging of mammalian gene expression, tracking of fetal gene expression from the same litter, and early detection of mammalian clock gene expression. …”
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<i>Galleria mellonella</i> (Greater Wax Moth) as a Reliable Animal Model to Study the Efficacy of Nanomaterials in Fighting Pathogens by Stefania Villani, Matteo Calcagnile, Christian Demitri, Pietro Alifano

“…In this context, <i>Galleria mellonella</i> could represent a valid alternative to traditional mammalian and non-mammalian animal models, due to its low cost, ease of handling, and valuable biological properties to investigate host–pathogen interactions. …”
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The Regulation and Functions of Endogenous Retrovirus in Embryo Development and Stem Cell Differentiation by Yangquan Xiang, Hongqing Liang

“…During the course of life, ERVs are associated with multiple aspects of chromatin and transcriptional regulation in development and pathological conditions. In mammalian embryos, ERVs are extensively activated in early embryo development, but with a highly restricted spatial-temporal pattern; and they are drastically silenced during differentiation with exceptions in extraembryonic tissue and germlines. …”
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Sirtuin activators as an anti-aging intervention for longevity by Puja Sah, Anita K. Rai, Donkupar Syiem

“…This review discusses mammalian sirtuins in aging, the small molecules that activate sirtuins, modulation of sirtuin activity, and its impact in alleviating the effects of aging.…”
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Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery by Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman, Philip A. Leighton

“…Domain antibodies have commonly been sourced from camelids with ex-vivo humanization or transgenic rodents expressing heavy chains without light chains, but these host species are all mammalian, limiting their capacity to elicit robust immune responses to conserved mammalian targets. …”
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Evolution and Development of Dual Ingestion Systems in Mammals: Notes on a New Thesis and Its Clinical Implications by Jeffrey R. Alberts, Rita H. Pickler

“…First, we apply an evolutionary perspective, recognizing that suckling-feeding is a universal, mammalian developmental sequence. We find that in mammalian evolution, feeding systems in offspring were established prior to the evolution of lactation, and therefore suckling is a separable feature that was added to feeding. …”
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Ensuring the Stability of the Genome: DNA Damage Checkpoints by Christine Latif, Susan H. Harvey, Susan J. O'Connell

“…This is reflected by the functional conservation of these pathways in all eukaryotes from yeast to mammalian cells. This review will examine the cellular response to DNA damage throughout the cell cycle. …”
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