Synthesis, Cytotoxicity, and Antileishmanial Activity of N,N'-Disubstituted Ethylenediamine and Imidazolidine Derivatives by Gustavo S. G. de Carvalho, Patrícia A. Machado, Daniela T. S. de Paula, Elaine S. Coimbra, Adilson D. da Silva

“…In addition, none of compounds were cytotoxic against mammalian cells. The leishmanicidal activity can be related with inhibition of polyamine synthesis and cellular penetration within biological membranes.…”
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Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation. by Michael O Isei, Meredith Crockett, Emily Chen, Joel Rodwell-Bullock, Trae Carroll, Peter A Girardi, Keith Nehrke, Gail V W Johnson

“…Here, we use immortalized mouse hippocampal neuronal cell lines to extend that result into mammalian cells. Specifically, we show that phosphomimetic tau at Ser-396/404 (EC) or Thr-231/Ser-235 (EM) partly inhibits mitophagy induction by paraquat, a potent inducer of mitochondrial oxidative stress. …”
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Whole organism and tissue-specific analysis of pexophagy in Drosophila by Francesco G. Barone, Marco Marcello, Sylvie Urbé, Natalia Sanchez-Soriano, Michael J. Clague

“…Enhancement of pexophagy was achieved by feeding flies with the iron chelator deferiprone, in line with past results using mammalian cells. Specific drivers were used to visualize pexophagy in neurons, and to demonstrate that specific depletion in the larval central nervous system of Hsc70-5, the Drosophila homologue of the chaperone HSPA9/mortalin, led to a substantial elevation in pexophagy.…”
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Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues by Jeremy C. Tran, Christopher J. Kuffner, Alexander M. Marzilli, Ryan Emily Miller, Zachary E. Silfen, Jeffrey B. McMahan, D. Christopher Sloas, Christopher S. Chen, John T. Ngo

“…Abstract Synthetic Notch (SynNotch) receptors function like natural Notch proteins and can be used to install customized sense-and-respond capabilities into mammalian cells. Here, we introduce an adaptor-based strategy for regulating SynNotch activity via fluorescein isomers and analogs. …”
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Transcytosis of T4 Bacteriophage Through Intestinal Cells Enhances Its Immune Activation by Amanda Carroll-Portillo, October Barnes, Cristina N. Coffman, Cody A. Braun, Sudha B. Singh, Henry C. Lin

“…Interactions between bacteriophages with mammalian immune cells are of great interest and most phages possess at least one molecular pattern (nucleic acid, sugar residue, or protein structure) that is recognizable to the immune system through pathogen associated molecular pattern (PAMP) receptors (i.e., TLRs). …”
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Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining by Cynthia L. Hendrickson, Shubhadeep Purkayastha, Elzbieta Pastwa, Ronald D. Neumann, Thomas A. Winters

“…In mammalian cells, DNA double-strand breaks (DSBs) are primarily repaired by nonhomologous end joining (NHEJ). …”
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Helminth Parasites and the Modulation of Joint Inflammation by Chelsea E. Matisz, Jason J. McDougall, Keith A. Sharkey, Derek M. McKay

“…Helminth parasites are accomplished masters at modifying their hosts' immune activity, and so attention has focused on rodent-helminth model systems to uncover the workings of the mammalian immune response to metazoan parasites, with the hope of revealing molecules and/or mechanisms that can be translated into better treatments for human autoimmune and idiopathic disorders. …”
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Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes by Baobing Zhao, Hui Liu, Yang Mei, Yijie Liu, Xu Han, Jing Yang, Amittha Wickrema, Peng Ji

“…Abstract Mammalian terminal erythropoiesis involves several characteristic phenomena including chromatin condensation and enucleation. …”
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Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene by Mst. Hasina Akter, Md. Abdur Razzaque, Liu Yang, Toshio Fumoto, Kiyoto Motojima, Tomohiro Yamaguchi, Fumiko Hirose, Takashi Osumi

“…Many mammalian genes are clustered on the genomes, and hence the genes in the same cluster can be regulated through a common regulatory element. …”
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Purification of Anti-Mycobacterium tuberculosis MPT64 Immunoglobulin-Y from Egg-Yolk Supernatant Using Thiophilic Adsorption Chromatography by Sri Agung Fitri Kusuma, Muhammad Fadhlillah, Intan Timur Maisyarah, Shintani Ayunda Khairunnisa, Muhammad Yusuf, Yaya Rukayadi, Toto Subroto

“… The significance of immunoglobulin Y (IgY) as a particular antibody equal to mammalian IgG is well understood. However, due to a lack of reliable purification procedures, producing highly pure IgY remains problematic. …”
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Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells by Sebastian Pieperhoff, Mareike Barth, Steffen Rickelt, Werner W. Franke

“…Of these special cell-cell junctions containing desmosomal glycoproteins or proteins we review the composite junctions (areae compositae) connecting the cardiomyocytes of mature mammalian hearts and their importance in relation to human arrhythmogenic cardiomyopathies. …”
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Cilia-Inspired Bionic Tactile E-Skin: Structure, Fabrication and Applications by Jiahe Yu, Muxi Ai, Cairong Liu, Hengchang Bi, Xing Wu, Wu Bin Ying, Zhe Yu

“…Among these, cilia-like microstructures with high aspect ratios, whose inspiration is mammalian hair and the lateral line system of fish, have attracted significant attention for their unique ability to enable E-skin to detect weak signals, even in extreme conditions. …”
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Plant thionins: structure, biological functions and potential use in biotechnology by T. I. Odintsova, M. P. Slezina, E. A. Istomina

“…Thionins are toxic to different types of cells including mammalian cancer cell lines. Transgenic plants expressing thionin genes display enhanced resistance to pathogens. …”
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Silvicultural Attempts to Induce Browse Resistance in Conifer Seedlings by Bruce A. Kimball, Fred Pfund, Mark Gourley, Doreen L. Griffin, John H. Russell

“…It appears that silvicultural manipulation via sulfur application and/or soil amendment cannot accelerate or alter the ontogenetical changes that may naturally defend seedlings against mammalian herbivores. In a brief trial with captive deer, redcedar browse resistance was influenced by seedling maturation, but not monoterpene content. …”
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Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration by Preeti Singh, Peter S. Hanson, Christopher M. Morris

“…Sirtuins are highly conserved lysine deacetylases involved in ageing, energy production, and lifespan extension. The mammalian SIRT2 has been implicated in Parkinson’s disease (PD) where studies suggest SIRT2 promotes neurodegeneration. …”
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Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase by Liset Westera, Alisha M. Jennings, Jad Maamary, Martin Schwemmle, Adolfo García-Sastre, Eric Bortz

“…Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans. …”
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<i>Trypanosoma cruzi</i>: Genomic Diversity and Structure by Alfonso Herreros-Cabello, Francisco Callejas-Hernández, Núria Gironès, Manuel Fresno

“…Trans-sialidases are the most prevalent genes in the genome with a key role in the infection process, while mucins and MASPs are also significant glycosylated proteins expressed on the parasite surface, essential for its biological functions, as host–parasite interaction, host cell invasion or protection against the host immune system, in both insect and mammalian stages. Collectively, in this review, some of the most recent advances in the structure and composition of the <i>T. cruzi</i> genome are reviewed.…”
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Genome editing using CRISPR/ Cas9 system: a practical guide by A. G. Menzorov, V. A. Lukyanchikova, A. N. Korablev, I. A. Serova, V. S. Fishman

“…Nowadays, CRISPR/Cas systems can be used not only to modify genomes, but also to control expression levels of defined genes, visualize loci of interest in the space of living cell nuclei, change methylation status of mammalian CpG sites, and to serve many other purposes. …”
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Hyaluronan Synthesis, Catabolism, and Signaling in Neurodegenerative Diseases by Larry S. Sherman, Steven Matsumoto, Weiping Su, Taasin Srivastava, Stephen A. Back

“…The glycosaminoglycan hyaluronan (HA), a component of the extracellular matrix, has been implicated in regulating neural differentiation, survival, proliferation, migration, and cell signaling in the mammalian central nervous system (CNS). HA is found throughout the CNS as a constituent of proteoglycans, especially within perineuronal nets that have been implicated in regulating neuronal activity. …”
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Clinicopathological features of two ultra-rare cases of malignant perivascular epithelioid cell tumors (PEComas) involving the uterus with recent updates by Bharat Rekhi, Santosh Menon

“…In view of multiple tumor deposits, the second patient was induced with a mammalian target of rapamycin (m-TOR) inhibitor (everolimus) but unfortunately died of the disease. …”
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