Fragrant olive (Osmanthus fragrans Lour.) flower extract attenuates dexamethasone-induced muscle atrophy through stimulation of PI3K/Akt pathway in C2C12 myotubes and C57BL/6 mice by Taeuk Kim, Seungok Lee, Sein Lee, Hyejung Han, Chul-Hong Kim, Dong-Woo Lee, Jae-Kwan Hwang

“…In C2C12 myotubes, OFWE improved the protein synthesis by upregulating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin pathway and muscle differentiation by activating myogenesis-related genes. …”
Get full text

Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model by Ibrahim Maina Hassan, Wan Norhamidah Wan Ibrahim, Ferdaus Binti Mohamat Yusuf, Siti Aqlima Ahmad, Syahida Ahmad

“…Reactive oxygen species generation in mammalian cells profoundly affects several critical cellular functions, and the lack of efficient cellular detoxification mechanisms which remove these radicals may lead to several human diseases. …”
Get full text

Temporal Study of Environmental DNA and Acoustic Data Reveals Coexistence of Sympatric Bat Species in a North American Ecosystem by Vrinda M. Suresh, Trevor Hébert, Kirsten Isabel Verster, Elizabeth A. Hadly

“…ABSTRACT Bats are a species‐rich mammalian order that provide a host of ecosystem services, but presently face threats from habitat loss, disease, climate change, and insect declines. …”
Get full text

Functional analysis of a novel homozygous missense IVD gene variant: a case report with dual genetic diagnoses by Yuying Zhu, Ke Wu, Hanying Wen

“…Mutant IVD gene pcDNA3.1(+)-MUT-3xFlag and control pcDNA3.1(+)-WT-3xFlag mammalian expression vectors were constructed. Both vectors were transformed into HEK293T cells. …”
Get full text

Comparative and Developmental Anatomy of Cardiac Lymphatics by A. Ratajska, G. Gula, A. Flaht-Zabost, E. Czarnowska, B. Ciszek, E. Jankowska-Steifer, J. Niderla-Bielinska, D. Radomska-Lesniewska

“…The second collector assumes a different route in various species. In most mammalian species the collectors run along major branches of coronary arteries, have valves and a discontinuous layer of smooth muscle cells.…”
Get full text

Threats and the active protection of birds in a riverbed: postulates for the strategy of the preservation of the middle Vistula River avifauna by Dariusz Bukaciński, Monika Bukacińska, Arkadiusz Buczyński

“…In 2015-2018, apart from mammalian predation, key threats included the pressure of feral cats and dogs and the growing presence of people on the islands. …”
Get full text

Everolimus Implicated in Case of Severe Gastrointestinal Hemorrhage by Paul Gonzales, Seth Klusewitz, Johanna Marowske, John Gancayco, Michael B. Osswald, Robert Setlik

“…With treatment advancements, including targeted agents such as Everolimus, a mammalian target of rapamycin (mTOR) inhibitor, survivability and quality of life continue to improve. …”
Get full text

Proteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats by Qingqing Li, Fengrong Zhang, Xianyu Li, Qing Wang

“…Nervonic acid (NA), a vital long-chain monounsaturated fatty acid found in mammalian nervous tissue, shows promising therapeutic potential in neurological disorders. …”
Get full text

Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone? by Lara Russo, Serena Babboni, Maria Grazia Andreassi, Jalil Daher, Paola Canale, Serena Del Turco, Giuseppina Basta

“…Overnutrition disturbs key metabolic pathways, including insulin/insulin-like growth factor signaling (IIS), the mammalian target of rapamycin (mTOR), and AMP-activated protein kinase. …”
Get full text

Relationship between androgen receptor and androgen receptor-related protein expression in breast cancers focusing on morphologically identified carcinoma with apocrine differentia... by Haruto Nishida, Ami Kato, Ryo Kaimori, Kazuhiro Kawamura, Tsutomu Daa

“…Nuclear phosphorylated-mammalian target of rapamycin was highly expressed in CAD cases compared with that in other BC groups, with a 33.3% sensitivity and 97.7% specificity. …”
Get full text

Carrageenan-Induced Colonic Inflammation Is Reduced in Bcl10 Null Mice and Increased in IL-10-Deficient Mice by Sumit Bhattacharyya, Liquan Xue, Suzanne Devkota, Eugene Chang, Stephan Morris, Joanne K. Tobacman

“…The common food additive carrageenan is a known activator of inflammation in mammalian tissues and stimulates both the canonical and noncanonical pathways of NF-κB activation. …”
Get full text

An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp by Tennille K. Marx, Robin Reddeman, Amy E. Clewell, John R. Endres, Erzsébet Béres, Adél Vértesi, Róbert Glávits, Gábor Hirka, Ilona Pasics Szakonyiné

“…No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames), in an in vitro mammalian chromosomal aberration test, or in an in vivo mouse micronucleus study. …”
Get full text

Evidence for Bone Marrow Adult Stem Cell Plasticity: Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Trans... by Ivana Catacchio, Simona Berardi, Antonia Reale, Annunziata De Luisi, Vito Racanelli, Angelo Vacca, Roberto Ria

“…In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. …”
Get full text

Distinguishing classes of neuroactive drugs based on computational physicochemical properties and experimental phenotypic profiling in planarians. by Danielle Ireland, Christina Rabeler, Sagar Rao, Rudy J Richardson, Eva-Maria S Collins

“…Organismal behavioral testing is needed to fill the gap, but mammalian studies are too time-consuming and cost-prohibitive for the early stages of drug discovery. …”
Get full text

The use of the model organism Caenorhabditis elegans in the investigation of the adverse effects of electronic cigarettes by Kamila Melnikov, Alžbeta Kaiglová, Soňa Kucharíková

“…Preliminary observations made in C. elegans can provide insight into the consequences of exposure to fundamental cellular physiology, which can then be used for future research in humans and mammalian models.…”
Get full text

IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta. by Marjo K Hytönen, Julius Rönkkö, Sruthi Hundi, Tarja S Jokinen, Emilia Suonto, Eeva Teräväinen, Jonas Donner, Rita La Rovere, Geert Bultynck, Emil Ylikallio, Henna Tyynismaa, Hannes Lohi

“…These findings highlight the first spontaneous mammalian phenotype caused by a nonsense variant in ITPR3, leading to the loss of IP3R3. …”
Get full text

A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis by Elbio Leiguez, Karina Cristina Giannotti, Mariana do Nascimento Viana, Márcio Hideki Matsubara, Cristina Maria Fernandes, José Maria Gutiérrez, Bruno Lomonte, Catarina Teixeira

“…MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid metabolism and inflammatory processes. …”
Get full text

Severe immunodeficiency spectrum associated with NHEJ1 gene mutation: Cernunnos/XLF deficiency by Ana María Navarro, Gabriela Mantilla, Jorge Andrés Fernández, Mario Fernando Unigarro, Alfonso Suárez, María Claudia Ortega

“…This gene participates in the DNA non-homologous end-joining pathway, repairing double-strand breaks in the DNA of mammalian cells. The clinical features include growth retardation, microcephaly, triangle-shaped face, recurrent infections, fibroblast’s excessive sensitivity to gamma-ionizing radiation, and hypogammaglobulinemia; also, low counts of subpopulations of B and T lymphocytes, with normal values of natural-killer cells. …”
Get full text

Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging by Charini Maladeniya, Taniya Darshani, Sameera R. Samarakoon, Frank R. Fronczek, W. M. C. Sameera, Inoka C. Perera, Theshini Perera

“…L1 displays intense fluorescence from the 1LC excited state, while C1 gives phosphorescence from the 3LC state. Mammalian cell toxicity of ligands and complexes was assessed with NCI–H292 nonsmall-cell lung cancer cells. …”
Get full text

Inflammation and ER Stress Downregulate BDH2 Expression and Dysregulate Intracellular Iron in Macrophages by Susu M. Zughaier, Brandon B. Stauffer, Nael A. McCarty

“…Recently, a short chain butyrate dehydrogenase type 2 (BDH2) protein was reported to contain an iron responsive element and to mediate cellular iron trafficking by catalyzing the synthesis of the mammalian siderophore that binds labile iron; therefore, BDH2 plays a crucial role in intracellular iron homeostasis. …”
Get full text