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301
Propithecus verreauxi demography spanning 40 years at Bezà Mahafaly Special Reserve, southwest Madagascar
Published 2025-01-01“…Research on these species contributes to significant theoretical issues, including the evolution of mammalian life histories and social systems. Virtually all 107 extant lemur species are threatened with extinction or critically endangered, and a better understanding of demography and the drivers of demographic change is needed to inform management strategies for surviving wild populations. …”
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302
TCTEX1D2 is essential for sperm flagellum formation in mice
Published 2025-01-01“…Abstract Flagella and cilia are widely conserved motile structures, in mammalian, sperm possess flagella. Large protein complexes called dynein, including cytoplasmic dynein 2 and axonemal dynein, play a role in the formation of cilia and flagella. …”
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303
Neratinib as a Potential Therapeutic for Mutant RAS and Osimertinib-Resistant Tumours
Published 2022-09-01“…Neratinib catalytically inhibited the MAP4K mammalian STE20-like protein kinase 4 and also caused its degradation via macroautophagy. …”
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304
mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression
Published 2022-01-01“…When sepsis attacks the body, the excessive reactive oxygen species (ROS) production can result to endoplasmic reticulum stress (ERS) and eventually cause lymphocyte apoptosis. The mammalian target of rapamycin (mTOR) is essential for regulating lymphocyte apoptosis; we hypothesized that it mediates CD4+ T cell apoptosis during ROS-related ERS. …”
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305
Circadian Rhythms and Breast Cancer: The Role of Per2 in Doxorubicin-Induced Cell Death
Published 2015-01-01“…Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. …”
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306
Asymmetric distribution of G-quadruplex forming sequences in genomes of retroviruses
Published 2025-01-01“…We show that in most mammalian retroviruses, including human retroviruses, PQSs are significantly more prevalent on the negative (antisense) strand, with some notable exceptions such as HIV-1. …”
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307
D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology
Published 2012-01-01“…In mammalian systems, D-serine is perhaps the most biologically active D-amino acid described to date. …”
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308
Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines
Published 2017-01-01“…The secretion of extracellular membrane vesicles (EMVs) is a common phenomenon that occurs in archaea, bacteria, and mammalian cells. The EMVs of bacteria play important roles in their virulence, biogenesis mechanisms, and host cell interactions. …”
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309
Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology
Published 2009-01-01“…In particular, both the growth factor and cytokine erythropoietin (EPO), and members of the mammalian forkhead transcription factors of the O class (FoxOs), may offer the greatest promise for new treatment regimens, since these agents and the cellular pathways they oversee cover a range of critical functions that directly influence progenitor cell development, cell survival and degeneration, metabolism, immune function, and cancer cell invasion. …”
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310
Preparedness, prevention and control related to zoonotic avian influenza
Published 2025-01-01“…Abstract A risk assessment framework was developed to evaluate the zoonotic potential of avian influenza (AI), focusing on virus mutations linked to phenotypic traits related to mammalian adaptation identified in the literature. …”
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311
Bevacizumab Demonstrates Prolonged Disease Stabilization in Patients with Heavily Pretreated Metastatic Renal Cell Carcinoma: A Case Series and Review of the Literature
Published 2010-01-01“…These include the immunotherapeutics, alfa-interferon, and interleukin-2, and agents that target the vascular endothelial growth factor receptor (VEGFR) via its tyrosine kinase, such as sorafenib, sunitinib, and pazopanib, or the mammalian target of rapamycin (mTOR), such as temsirolimus and everolimus. …”
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312
Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells
Published 2018-01-01“…In this review, we discuss the function, structure, and transport aspects of two major mammalian zinc transporter types, importers and exporters. …”
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313
Capacitance Measurements of Exocytosis From AII Amacrine Cells in Retinal Slices
Published 2025-01-01“…The AII is an important inhibitory interneuron of the mammalian retina that plays an important role in integrating rod and cone pathway signals. …”
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314
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
Published 2024-12-01“…In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. …”
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315
Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes
Published 2025-01-01“…While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. …”
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316
Meta-analyses of Culex blood-meals indicates strong regional effect on feeding patterns.
Published 2025-01-01“…The percentage of blood-meals on amphibian, avian, human, non-human mammalian, and reptilian hosts was determined for each Culex species. …”
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317
The Canis tangle: a systematics overview and taxonomic recommendations
Published 2015-07-01“…Despite high research interest, the systematics and taxonomy of mammalian genus Canis are among the most convoluted and controversial: species boundaries are blurred and incongruent with any existing species concept, while genetic differences between species are low. …”
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318
ARM-Cortex M3-Based Two-Wheel Robot for Assessing Grid Cell Model of Medial Entorhinal Cortex: Progress towards Building Robots with Biologically Inspired Navigation-Cognitive Maps
Published 2017-01-01“…This article presents the implementation and use of a two-wheel autonomous robot and its effectiveness as a tool for studying the recently discovered use of grid cells as part of mammalian’s brains space-mapping circuitry (specifically the medial entorhinal cortex). …”
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319
Organophosphorus Nerve Agents: Types, Toxicity, and Treatments
Published 2020-01-01“…Organophosphorus compounds are reported to be the nonphysiological substrate for many mammalian organophosphate hydrolysing enzymes; therefore, the efficiency of these enzymes toward these compounds is inadequate. …”
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320
Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution
Published 2020-01-01“…Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery. …”
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