Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution by Xiaohui Tong, Nianjun Yu, Rongchun Han, Tongsheng Wang

“…Moreover, by influencing canonical energy sensors like adenosine monophosphate-activated protein kinase (AMPK) or mammalian target of rapamycin (mTOR), Dicer favors catabolism in the periphery. …”
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Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells by Fu-qing Zhong, Yang Li, Xian-qiang Mi

“…Plasmids encoding Kir6.2 was constructed and heterologously expressed in cultured mammalian HEK-293 cells. The patch-clamp and data acquisition systems were used to record KATP channel current before and after irradiation. …”
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Chloroquine Inhibits Dengue Virus Type 2 Replication in Vero Cells but Not in C6/36 Cells by Kleber Juvenal Silva Farias, Paula Renata Lima Machado, Benedito Antônio Lopes da Fonseca

“…These data suggest that the inhibition of virus infection induced by chloroquine is due to interference with acidic vesicles in mammalian cells.…”
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PAI-1 Expression Is Required for HDACi-Induced Proliferative Arrest in ras-Transformed Renal Epithelial Cells by Stephen P. Higgins, Craig E. Higgins, Paul J. Higgins

“…Malignant transformation of mammalian cells with ras family oncogenes results in dramatic changes in cellular architecture and growth traits. …”
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Impacts of host phylogeny, diet, and geography on the gut microbiome of rodents. by Sufia Akter Neha, John D Hanson, Jeremy E Wilkinson, Robert D Bradley, Caleb D Phillips

“…Mammalian gut microbial communities are thought to play a variety of important roles in health and fitness, including digestion, metabolism, nutrition, immune response, behavior, and pathogen protection. …”
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Triphenylmethane derivatives have high in vitro and in vivo activity against the main causative agents of cutaneous leishmaniasis. by Renata Celi Carvalho de Souza Pietra, Lucas Fonseca Rodrigues, Eliane Teixeira, Levi Fried, Benjamin Lefkove, Ana Rabello, Jack Arbiser, Lucas Antônio Miranda Ferreira, Ana Paula Fernandes

“…A high degree of selectivity of antiparasitic activity over toxicity to mammalian cells was observed. Afterwards, GV and TPM 6 were tested in a topical formulation in mice infected with L. …”
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DDX1 is required for non-spliceosomal splicing of tRNAs but not of XBP1 mRNA by Teruhiko Suzuki, Satoko Takagi, Junta Funada, Yuka Egawa, Mana Yamakawa, Takahiko Hara

“…To analyze the functions of DDX1 in mammalian cells, we generated DDX1 cKO cells from the polyploid human U2OS cell line and found that splicing of intron-containing tRNAs was significantly disturbed in DDX1-deficient cells, whereas endoplasmic reticulum (ER) stress-induced splicing of XBP1 mRNA was unaffected. …”
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Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of <i>Candida albicans</i> Biofilms by Muhammad Aamir Hassan, Sadaf Noor, Jungmi Park, Ahmed Nabawy, Maitri Dedhiya, Robin Patel, Vincent M. Rotello

“…Eugenol and methyl eugenol/terbinafine T-GNEs had an additive efficacy, while carvacrol (CT-GNE) worked synergistically with terbinafine, providing effective antifungal treatment with minimal mammalian cell toxicity. Confocal microscopy demonstrated that CT-GNE penetrated the dense <i>C. albicans</i> biofilm and disrupted the fungal cell membrane. …”
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GPX modulation promotes regenerative axonal fusion and functional recovery after injury through PSR-1 condensation by Su-Hyuk Ko, Kyung-Ah Cho, Xin Li, Qitao Ran, Zhijie Liu, Lizhen Chen

“…Extending these findings to mammalian nerve repair, we show that loss of Glutathione peroxidase 4 (GPX4), a crucial suppressor of ferroptosis, promotes functional recovery after sciatic nerve injury. …”
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Transcriptome Analysis of Bovine Ovarian Follicles at Predeviation and Onset of Deviation Stages of a Follicular Wave by Pengfei Li, Jinzhu Meng, Wenzhong Liu, George W. Smith, Jianbo Yao, Lihua Lyu

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Small-Molecule Hormones: Molecular Mechanisms of Action by Monika Puzianowska-Kuznicka, Eliza Pawlik-Pachucka, Magdalena Owczarz, Monika Budzińska, Jacek Polosak

“…Small-molecule hormones play crucial roles in the development and in the maintenance of an adult mammalian organism. On the molecular level, they regulate a plethora of biological pathways. …”
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Determination of mutagenicity of chemical compounds, physical factors and environmental pollutants by the Drosophila melanogaster wing somatic mutation and recombination test by L. P. Zakharenko, I. K. Zakharov

“…Recombination or mutational events in the cell leads to the formation of mutant spots/clones visible by microscopic analysis of the wing surface. The Drosophila and mammalian detoxication system is arranged on similar principles, which are based on the action of cytochrome P450. …”
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Identification of Stem Leydig Cells Derived from Pig Testicular Interstitium by Shuai Yu, Pengfei Zhang, Wuzi Dong, Wenxian Zeng, Chuanying Pan

“…Stem Leydig cells (SLCs), located in the testicular interstitial compartment in the mammalian testes, are capable of differentiating to testosterone-synthesizing Leydig cells (LCs), thus providing a new strategy for treating testosterone deficiency. …”
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Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders by Heechul Jun, Syed Mohammed Qasim Hussaini, Michael J. Rigby, Mi-Hyeon Jang

“…Adult neurogenesis, the process of generating new neurons from neural stem cells, plays significant roles in synaptic plasticity, memory, and mood regulation. In the mammalian brain, it continues to occur well into adulthood in discrete regions, namely, the hippocampus and olfactory bulb. …”
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Does fast running limit numerical variability of the vertebral column in rabbits and hares (Leporidae: Lagomorpha)? by Megu Gunji, Nuttakorn Taewcharoen, Fumio Yamada, Emma Sherratt

“…In mammalian vertebral columns, locomotive ability is expected to be an evolutionary driver of variation in the number of vertebrae; in species evolved to run fast or have a flexible vertebral column, they generally have limited numerical variation and low occurrence of malformed vertebrae to maintain their running performance. …”
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Synthesis, Cytotoxicity, and Antileishmanial Activity of N,N'-Disubstituted Ethylenediamine and Imidazolidine Derivatives by Gustavo S. G. de Carvalho, Patrícia A. Machado, Daniela T. S. de Paula, Elaine S. Coimbra, Adilson D. da Silva

“…In addition, none of compounds were cytotoxic against mammalian cells. The leishmanicidal activity can be related with inhibition of polyamine synthesis and cellular penetration within biological membranes.…”
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Whole organism and tissue-specific analysis of pexophagy in Drosophila by Francesco G. Barone, Marco Marcello, Sylvie Urbé, Natalia Sanchez-Soriano, Michael J. Clague

“…Enhancement of pexophagy was achieved by feeding flies with the iron chelator deferiprone, in line with past results using mammalian cells. Specific drivers were used to visualize pexophagy in neurons, and to demonstrate that specific depletion in the larval central nervous system of Hsc70-5, the Drosophila homologue of the chaperone HSPA9/mortalin, led to a substantial elevation in pexophagy.…”
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Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues by Jeremy C. Tran, Christopher J. Kuffner, Alexander M. Marzilli, Ryan Emily Miller, Zachary E. Silfen, Jeffrey B. McMahan, D. Christopher Sloas, Christopher S. Chen, John T. Ngo

“…Abstract Synthetic Notch (SynNotch) receptors function like natural Notch proteins and can be used to install customized sense-and-respond capabilities into mammalian cells. Here, we introduce an adaptor-based strategy for regulating SynNotch activity via fluorescein isomers and analogs. …”
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Transcytosis of T4 Bacteriophage Through Intestinal Cells Enhances Its Immune Activation by Amanda Carroll-Portillo, October Barnes, Cristina N. Coffman, Cody A. Braun, Sudha B. Singh, Henry C. Lin

“…Interactions between bacteriophages with mammalian immune cells are of great interest and most phages possess at least one molecular pattern (nucleic acid, sugar residue, or protein structure) that is recognizable to the immune system through pathogen associated molecular pattern (PAMP) receptors (i.e., TLRs). …”
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Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining by Cynthia L. Hendrickson, Shubhadeep Purkayastha, Elzbieta Pastwa, Ronald D. Neumann, Thomas A. Winters

“…In mammalian cells, DNA double-strand breaks (DSBs) are primarily repaired by nonhomologous end joining (NHEJ). …”
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