Choosing preferable labels for the Japanese translation of the Human Phenotype Ontology by Kota Ninomiya, Terue Takatsuki, Tatsuya Kushida, Yasunori Yamamoto, Soichi Ogishima

“…The relationship between the HPO and Mammalian Phenotype translations was also investigated, with the eventual goal of harmonizing the two translations to facilitate phenotype-based comparisons of species in Japanese through cross-species phenotype matching. …”
Get full text

Structure simulation-based comparison of active site variations in fungal ornithine decarboxylases by Min Jeong Kim, Jeong Ho Chang

“…While the structures of mammalian and protozoan ODCs have been elucidated, fungal ODCs remain uncharacterized. …”
Get full text

Potential Application of Electrical Stimulation in Stem Cell-Based Treatment against Hearing Loss by Mingliang Tang, Xiaoqian Yan, Qilin Tang, Rongrong Guo, Peng Da, Dan Li

“…Deafness is a common human disease, which is mainly caused by irreversible damage to hair cells and spiral ganglion neurons (SGNs) in the mammalian cochlea. At present, replacement of damaged or missing hair cells and SGNs by stem cell transplantation therapy is an effective treatment. …”
Get full text

Propithecus verreauxi demography spanning 40 years at Bezà Mahafaly Special Reserve, southwest Madagascar by Joelisoa Ratsirarson, Jeannin Ranaivonasy, Richard Lawler, Isabella Fiorentino, Nelson Rios, Alison Richard

“…Research on these species contributes to significant theoretical issues, including the evolution of mammalian life histories and social systems. Virtually all 107 extant lemur species are threatened with extinction or critically endangered, and a better understanding of demography and the drivers of demographic change is needed to inform management strategies for surviving wild populations. …”
Get full text

TCTEX1D2 is essential for sperm flagellum formation in mice by Ryua Harima, Kenshiro Hara, Kentaro Tanemura

“…Abstract Flagella and cilia are widely conserved motile structures, in mammalian, sperm possess flagella. Large protein complexes called dynein, including cytoplasmic dynein 2 and axonemal dynein, play a role in the formation of cilia and flagella. …”
Get full text

Neratinib as a Potential Therapeutic for Mutant RAS and Osimertinib-Resistant Tumours by Paul Dent, Laurence Booth, Andrew Poklepovic, John F. Hancock

“…Neratinib catalytically inhibited the MAP4K mammalian STE20-like protein kinase 4 and also caused its degradation via macroautophagy. …”
Get full text

mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4+ T Cell Apoptosis Mediated by ROS in Septic Immunosuppression by Hao Wang, Jianwei Chen, Guangxu Bai, Wen Han, Ran Guo, Na Cui

“…When sepsis attacks the body, the excessive reactive oxygen species (ROS) production can result to endoplasmic reticulum stress (ERS) and eventually cause lymphocyte apoptosis. The mammalian target of rapamycin (mTOR) is essential for regulating lymphocyte apoptosis; we hypothesized that it mediates CD4+ T cell apoptosis during ROS-related ERS. …”
Get full text

Circadian Rhythms and Breast Cancer: The Role of Per2 in Doxorubicin-Induced Cell Death by Megan I. Mitchell, Anna-Mart Engelbrecht

“…Mammalian circadian rhythms form an integral physiological system allowing for the synchronisation of all metabolic processes to daily light/dark cycles, thereby optimising their efficacy. …”
Get full text

Potential Usefulness of Streptococcus pneumoniae Extracellular Membrane Vesicles as Antibacterial Vaccines by Chi-Won Choi, Edmond Changkyun Park, Sung Ho Yun, Sang-Yeop Lee, Seung Il Kim, Gun-Hwa Kim

“…The secretion of extracellular membrane vesicles (EMVs) is a common phenomenon that occurs in archaea, bacteria, and mammalian cells. The EMVs of bacteria play important roles in their virulence, biogenesis mechanisms, and host cell interactions. …”
Get full text

Erythropoietin, Forkhead Proteins, and Oxidative Injury: Biomarkers and Biology by Kenneth Maiese, Jinling Hou, Zhao Zhong Chong, Yan Chen Shang

“…In particular, both the growth factor and cytokine erythropoietin (EPO), and members of the mammalian forkhead transcription factors of the O class (FoxOs), may offer the greatest promise for new treatment regimens, since these agents and the cellular pathways they oversee cover a range of critical functions that directly influence progenitor cell development, cell survival and degeneration, metabolism, immune function, and cancer cell invasion. …”
Get full text

Preparedness, prevention and control related to zoonotic avian influenza by EFSA Panel on Animal Health and Animal Welfare (AHAW), ECDC, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dórea, Jordi Figuerola, Mette S. Herskin, Virginie Michel, Miguel Ángel Miranda Chueca, Eleonora Nannoni, Søren Saxmose Nielsen, Romolo Nonno, Anja B. Riber, Jan Arend Stegeman, Karl Ståhl, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Claire Brugerolles, Thorsten Wolff, Anna Parys, Erika Lindh, Neus Latorre‐Margalef, Marie‐Anne Rameix Welti, Ralf Dürrwald, Ramona Trebbien, Sylvie Van der Werf, Magnus Gisslén, Isabella Monne, Alice Fusaro, Claire Guinat, Alessio Bortolami, Leonidas Alexakis, Theresa Enkirch, Olov Svartstrom, Katriina Willgert, Francesca Baldinelli, Ludovica Preite, Malin Grant, Alessandro Broglia, Angeliki Melidou

“…Abstract A risk assessment framework was developed to evaluate the zoonotic potential of avian influenza (AI), focusing on virus mutations linked to phenotypic traits related to mammalian adaptation identified in the literature. …”
Get full text

Bevacizumab Demonstrates Prolonged Disease Stabilization in Patients with Heavily Pretreated Metastatic Renal Cell Carcinoma: A Case Series and Review of the Literature by Nicole M. Agostino, Rebecca Gingrich, Joseph J. Drabick

“…These include the immunotherapeutics, alfa-interferon, and interleukin-2, and agents that target the vascular endothelial growth factor receptor (VEGFR) via its tyrosine kinase, such as sorafenib, sunitinib, and pazopanib, or the mammalian target of rapamycin (mTOR), such as temsirolimus and everolimus. …”
Get full text

Function, Structure, and Transport Aspects of ZIP and ZnT Zinc Transporters in Immune Cells by Bum-Ho Bin, Juyeon Seo, Sung Tae Kim

“…In this review, we discuss the function, structure, and transport aspects of two major mammalian zinc transporter types, importers and exporters. …”
Get full text

Capacitance Measurements of Exocytosis From AII Amacrine Cells in Retinal Slices by Espen Hartveit, Margaret Veruki

“…The AII is an important inhibitory interneuron of the mammalian retina that plays an important role in integrating rod and cone pathway signals. …”
Get full text

TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease by Yunxia Du, Ming Wu, Shan Song, Yawei Bian, Yonghong Shi

“…In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. …”
Get full text

Lipid metabolism and microbial regulation analyses provide insights into the energy-saving strategies of hibernating snakes by Yuting Wei, Huirong Mao, Qiuhong Liu, Wenjie Fang, Tianxiang Zhang, Yongtao Xu, Weiwei Zhang, Biao Chen, Yunlin Zheng, Xiaolong Hu

“…While most studies have largely focused on mammalian hibernation, its reptilian equivalent has been less studied. …”
Get full text

Meta-analyses of Culex blood-meals indicates strong regional effect on feeding patterns. by Jet S Griep, Eve Grant, Jack Pilgrim, Olena Riabinina, Matthew Baylis, Maya Wardeh, Marcus S C Blagrove

“…The percentage of blood-meals on amphibian, avian, human, non-human mammalian, and reptilian hosts was determined for each Culex species. …”
Get full text

The Canis tangle: a systematics overview and taxonomic recommendations by V. Dinets

“…Despite high research interest, the systematics and taxonomy of mammalian genus Canis are among the most convoluted and controversial: species boundaries are blurred and incongruent with any existing species concept, while genetic differences between species are low. …”
Get full text

ARM-Cortex M3-Based Two-Wheel Robot for Assessing Grid Cell Model of Medial Entorhinal Cortex: Progress towards Building Robots with Biologically Inspired Navigation-Cognitive Maps by J. Cuneo, L. Barboni, N. Blanco, M. del Castillo, J. Quagliotti

“…This article presents the implementation and use of a two-wheel autonomous robot and its effectiveness as a tool for studying the recently discovered use of grid cells as part of mammalian’s brains space-mapping circuitry (specifically the medial entorhinal cortex). …”
Get full text

Organophosphorus Nerve Agents: Types, Toxicity, and Treatments by Sudisha Mukherjee, Rinkoo Devi Gupta

“…Organophosphorus compounds are reported to be the nonphysiological substrate for many mammalian organophosphate hydrolysing enzymes; therefore, the efficiency of these enzymes toward these compounds is inadequate. …”
Get full text