Allocentric and egocentric spatial representations coexist in rodent medial entorhinal cortex by Xiaoyang Long, Daniel Bush, Bin Deng, Neil Burgess, Sheng-Jia Zhang

“…These results demonstrate a unity of spatial coding that can guide efficient navigation and suggest that MEC may be one locus of interactions between egocentric and allocentric spatial representations in the mammalian brain.…”
Get full text

Everolimus for Compassionate Use in Multiple Basal Cell Carcinomas by Laura Eibenschutz, Delia Colombo, Caterina Catricalà

“…Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) and has been shown to have antineoplastic activity in addition to its use as an immunosuppressive agent for the prevention of organ transplant rejection. …”
Get full text

Suspension of Mitotic Activity in Dentate Gyrus of the Hibernating Ground Squirrel by Victor I. Popov, Igor V. Kraev, Dmitri A. Ignat'ev, Michael G. Stewart

“…Neurogenesis occurs in the adult mammalian hippocampus, a region of the brain important for learning and memory. …”
Get full text

Regulation and Function of the Peg3 Imprinted Domain by Hongzhi He, Joomyeong Kim

“…A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb genomic interval of the human and mouse genomes, constituting the Peg3 imprinted domain. …”
Get full text

A Toxicological Evaluation of a Standardized Hydrogenated Extract of Curcumin (CuroWhite™) by Alastimmanahalli Narasimhiah Ravikumar, Joby Jacob, Sreeraj Gopi, Tumkur Subbarao Jagannath

“…The test item was not mutagenic in the bacterial reverse mutation test or in vitro mammalian chromosomal aberration test, and no in vivo genotoxic activity was observed in rat bone marrow in the micronucleus test. …”
Get full text

Immunometabolism of Tregs: mechanisms, adaptability, and therapeutic implications in diseases by Yuming Lu, Yifan Wang, Tiantian Ruan, Yihan Wang, Linling Ju, Mengya Zhou, Luyin Liu, Dengfu Yao, Min Yao

“…The activation, differentiation, and function of Tregs are influenced by various metabolic pathways, such as the Mammalian targets of rapamycin (mTOR) pathway and glycolysis. …”
Get full text

The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas by Elias A. El Habr, Christos Adamopoulos, Georgia Levidou, Aggeliki A. Saetta, Penelope Korkolopoulou, Christina Piperi

“…Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. …”
Get full text

Beneficial Effects of Resveratrol-Mediated Inhibition of the mTOR Pathway in Spinal Cord Injury by Jingying Zhou, Xue Huo, Benson O. A. Botchway, Luyao Xu, Xiaofang Meng, Songou Zhang, Xuehong Liu

“…The clinical features of SCI are divided into acute, subacute, and chronic phases according to its pathophysiological events. The mammalian target of rapamycin (mTOR) signaling pathway plays an important role in cell death and inflammation in the acute phase and neuroregeneration in the subacute/chronic phases at different times. …”
Get full text

Research Progress in Lactoferrin’s Role in Alleviating Intestinal Barrier Dysfunction by LI Yi, REN Xinxin, WANG Qin, HE Xiaoyun

“…Lactoferrin, a glycoprotein abundant in mammalian milk, exhibits a range of biological functions such as antioxidant, anti-inflammatory and antibacterial functions. …”
Get full text

CAMSAP2 is required for bridging fiber assembly to ensure mitotic spindle assembly and chromosome segregation in human epithelial Caco-2 cells. by Naoko Nishizawa, Riku Arai, Koki Hiranuma, Mika Toya, Masamitsu Sato

“…In mammalian epithelial cells, cytoplasmic microtubules are mainly non-centrosomal, through the functions of the minus-end binding proteins CAMSAP2 and CAMSAP3. …”
Get full text

Evaluation of the genome in bird breeding by A. F. Yakovlev, N. V. Dement’eva

“…Genomic breeding in the poultry industry has a number of differences from similar technology used in agricultural mammalian species. The existence of two categories of chromosomes (macro- and microchromosomes) with different rates of recombination, the preferred genomic females evaluation, rapid change of generations make their own features. …”
Get full text

Characterization of Chitosan Films for Tissue Engineering Applications by A. Ghanem, M. Katalinich

“…These properties indicate that chitosan may be suitable as a surface for mammalian cell growth and tissue engineering. The attachment and growth of NIH-3T3 fibroblasts on chitosan films and controls was measured. …”
Get full text

Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic β-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1 by Satoshi Okano

“…This review, based mainly on the author’s investigation of the unique features of Tg mice, presents reported results and recent findings related to molecular processes associated with mammalian cryptochromes, especially their involvement in the regulation of metabolism. …”
Get full text

iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System by Andrés Javier Orqueda, Carla Alejandra Giménez, Federico Pereyra-Bonnet

“…When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. …”
Get full text

Kank Is an EB1 interacting protein that localises to muscle-tendon attachment sites in Drosophila. by Sara M R Clohisey, Nikola S Dzhindzhev, Hiroyuki Ohkura

“…Human Kank1 was identified as a tumour suppressor and has documented roles in actin regulation and cell polarity in cultured mammalian cells. We found that Drosophila Kank binds EB1 directly and this interaction is essential for Kank localisation to microtubule plus ends in cultured cells. …”
Get full text

Revisiting two hypotheses on the “domestication syndrome” in light of genomic data by A. S. Wilkins

“…The tasks that lie ahead to fully ascertain the genetic bases of the “domestication syndrome” and the behaviors that characterize mammalian domestication are discussed briefly.…”
Get full text

Bacteriophages: Uncharacterized and Dynamic Regulators of the Immune System by Anshul Sinha, Corinne F. Maurice

“…Despite tremendous advances in our comprehension of how the gut microbiota is involved in human health and interacts with the mammalian immune system, most studies are incomplete as they typically do not consider bacteriophages. …”
Get full text

LncRNAs: New Players in Apoptosis Control by Marianna Nicoletta Rossi, Fabrizio Antonangeli

“…The discovery that the mammalian genome is largely transcribed and that almost half of the polyadenylated RNAs is composed of noncoding RNAs has attracted the attention of the scientific community. …”
Get full text

AhR governs lipid metabolism: the role of gut microbiota by Wanru Zheng, Mengkuan Liu, Xinyu Lv, Cuimei He, Jie Yin, Jie Ma

“…The Aryl Hydrocarbon Receptor (AhR) is widely present in mammalian bodies, showing high affinity for various exogenous substances such as polycyclic aromatic hydrocarbons (PAHs) and coumarin. …”
Get full text

From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases by Isabelle Acquatella-Tran Van Ba, Thibaut Imberdis, Véronique Perrier

“…We will then describe the recent reports on mammalian synthetic prions and recombinant prions that strongly support the protein-only hypothesis. …”
Get full text