Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation by Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

“…The 3D OSCC model provides powerful preclinical tools for drug screening and mechanistic studies of this devastating malignancy. In this review, we discuss the role of the tumor-immune microenvironment (TIME) in tumorigenesis and the 3D in vitro cultures in recreating the tumor microenvironment paving the way for the development of personalized medicine in OSCC.…”
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Juvenile Polyposis Syndrome in a Young Girl from Northern Tanzania by Jay Lodhia, David Msuya, Abdallah Msemo, Huda Akrabi, Patrick Amsi, Deborah Mchaile, Kondo Chilonga

“…Juvenile polyposis syndrome is an inherited condition with significant morbidity and a high risk of colon malignancy. It is important for early screening and diagnosis and hence management in its early stages as there are no specific standard guidelines for children.…”
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Endoscopic Detection of Gastric Metastases in Skin Melanoma by M. Yu. Kabanov, K. V. Sementsov, D. B. Degterev, M. Ya. Belikova, D. K. Savchenkov, T. E. Koshelev, A. K. Stechishina

“…The patient had a complex examination, including computed tomography, which revealed a presumed malignancy of the right lung with secondary changes in the chest and abdominal organs. …”
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SMARCA4-Deficient Carcinoma of Unknown Primary Presenting with Fatal Paraneoplastic Hypercalcemia in a Heart Transplant Recipient: First Report in a Male Patient by Abbas Agaimy, Deike Strobel, Thomas Strecker

“…Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a rare SMARCA4-driven aggressive malignancy of young age characteristically associated with paraneoplastic hypercalcemia. …”
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The Role of the TGF-β Coreceptor Endoglin in Cancer by Eduardo Pérez-Gómez, Gaelle del Castillo, Juan Francisco Santibáñez, Jose Miguel Lêpez-Novoa, Carmelo Bernabéu, Miguel Quintanilla

“…These studies suggest that endoglin behaves as a suppressor of malignancy in experimental and human epithelial carcinogenesis, although it can also promote metastasis in other types of cancer. …”
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tRNA-derived small RNAs: their role in the mechanisms, biomarkers, and therapeutic strategies of colorectal cancer by Bo Zhang, Yanru Pan, Zhe Li, Kefeng Hu

“…Abstract Colorectal cancer (CRC) is the third most prevalent malignancy and the second leading cause of cancer-related mortality worldwide, with an increasing shift towards younger age of onset. …”
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Cerebral Venous Thrombosis Mimicking a Discrete Brain Mass: A Case Report and Literature Review by Dana DiRenzo, Zsuzsanna H. McMahan, Naman S. Desai, Rebecca Manno, Michelle Petri

“…The differential diagnosis for a focal brain lesion in a patient with systemic lupus erythematosus (SLE) is broad and includes infection, malignancy, and vascular and inflammatory etiologies. …”
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A cross-sectional study to evaluate ocular manifestations in end-stage renal disease patients attending tertiary care center by D. S. Kaushik, K. V. Ashwini, Srivatsa Angraje

“…The study excluded patients with corneal dystrophy, renal transplant history, ocular trauma, or malignancy. Data on dialysis duration, frequency, and ESRD etiology were collected. …”
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Compliance of thyroid nodules through ultrasound-guided trucut/core needle biopsy with Thyroid imaging, reporting, and data system score and surgical pathology by Ahmed M. Hassan, Ahmed Abd Elrady Ahmed, Radwa Nabawy Abd Allah Abd El Wahab, Noha M. Nagla

“…The most prevalent diagnosis in the normocalcemic group (39.63%) was simple goiter, while in the hypocalcemic group was malignancy (44.44%). In terms of preoperative diagnosis, there was a substantial diversity among the 2 groups. …”
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Unusual Presentation of a Colonic Sarcoidosis by Sami Daldoul, Wissem Triki, Kaouther El Jeri, Abdeljelil Zaouche

“…Endoscopic and radiologic descriptions are highly suggestive of a malignancy. The patient underwent a laparotomy, and a right hemicolectomy was performed. …”
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Oral plasmablastic lymphoma: at the origin of the discovery of an HIV infection by Rahman Nurhayu Ab, Hussain Faezatul Arbaeyah, Eng Kam Chuan

“…Introduction: Plasmablastic lymphoma is a rare and aggressive malignancy derived from a B cell lineage. It has a predilection for extranodal sites, particularly arises de novo in the oral cavity. …”
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Primary Bronchopulmonary Actinomycosis Masquerading as Lung Cancer: Apropos of Two Cases and Literature Review by Stamatis Katsenos, Iosif Galinos, Panagiota Styliara, Nikoletta Galanopoulou, Konstantinos Psathakis

“…The disease can mimic lung malignancy given its nonspecific clinical and radiological presentation, thus posing a diagnostic dilemma to the attending physician. …”
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Quality of life in gynecological cancer patients: focusing in religious aspects by Wastu Adi Mulyono, Wahyu Ekowati, Fera Agusti Ningrum, Salma Nurhikmah, Nadia Bella Maharani

“…Background: Gynecological cancer is a malignancy that attacks the reproductive organs, affecting not only physical health but also psychological and emotional well-being, often causing depression and anxiety. …”
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ALK-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation by Uroosa Ibrahim, Amina Saqib, Maryam Rehan, Jean Paul Atallah

“…Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder that can be familial in etiology or a result of infections, malignancy, and autoimmune or inflammatory disorders. …”
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Submandibular Lateral Ectopic Thyroid Tissue: Ultrasonography, Computed Tomography, and Scintigraphic Findings by Metin Çeliker, Fatma Beyazal Çeliker, Arzu Turan, Mehmet Beyazal, Hatice Beyazal Polat

“…Pathological examination of the specimen showed normal thyroid follicle cells with no signs of malignancy. The submandibular mass is a rarely encountered lateral ectopic thyroid tissue. …”
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A Tragical Paediatric Case History of Intraorbital and Intracranial Epithelioid Hemangioendothelioma by K. Aniba, M. Laghmari, M. Lmejjati, H. Ghannane, S. Ait Benali

“…Epithelioid hemangioendothelioma (EHE) is a rare tumor of intermediate malignancy. We report a case of intracranial and intraorbitar EHE. …”
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Extramedullary Hematopoiesis in a Sentinel Lymph Node as an Early Sign of Chronic Myelomonocytic Leukemia by Joslin M. Bowen, Anamarija M. Perry, Erin Quist, Mojtaba Akhtari

“…Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy with features of both a myeloproliferative neoplasm and a myelodysplastic syndrome. …”
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Typical Facial Lesions: A Window of Suspicion for Progressive Disseminated Histoplasmosis—A Case of Asian Prototype by Prasan K. Panda, Siddharth Jain, Rita Sood, Rajni Yadav, Naval K. Vikram

“…The differential diagnosis of leishmaniasis, tuberculosis, leprosy, fungal infection, lymphoproliferative malignancy, and other granulomatous disorders was considered, but he succumbed to his illness. …”
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Vitamin C-Induced Oxalate Nephropathy by Jorge Lamarche, Reji Nair, Alfredo Peguero, Craig Courville

“…Oral or parenteral administration of this vitamin has been used in multiple settings such as an alternative treatment of malignancy or as an immune booster. This article presents a clinical case in which ingestion of high amounts of vitamin C lead to oxalate nephropathy. …”
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A Rare Case of Multiorgan Calciphylaxis in a Patient with Stage 5 Chronic Kidney Disease by Abdulrahman Ahmad, Ali Albaghli, Adel Michael, Khaled Refaat, Mohammad Omar, Ahmad Ibrahim, Bahaa Elmenshawy, Ashraf Maher, Rasha Alramah, Sami Mikhail, Mustafa Almahmid, Husain Alenezi, Yahya Elshebiney

“…Histopathological analysis confirms the diagnosis of calcific uremic arteriolopathy and rules out the presence of malignancy. CUA is a systematic disease that involves multiple organs, and to the best of our knowledge this is the first reported case involving the penis, bladder, and eyes.…”
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