Presentation and Surgical Management of Duodenal Duplication in Adults by Caroline C. Jadlowiec, Beata E. Lobel, Namita Akolkar, Michael D. Bourque, Thomas J. Devers, David W. McFadden

“…Clinical presentations include pancreatitis, biliary obstruction, gastrointestinal bleeding from ectopic gastric mucosa, and malignancy. A case of duodenal duplication in a 59-year-old female is presented, and her treatment course is reviewed with description of combined surgical and endoscopic approach to repair, along with a review of historic and current recommendations for management. …”
Get full text

Stably Integrated for Assessment of Invasion Kinetics by Kelly N. Flentie, Min Qi, Seth T. Gammon, Yasmin Razia, Felix Lui, Luciano Marpegan, Aashish Manglik, David Piwnica-Worms, Jeffrey S. McKinney

“…Bioluminescence reported Salmonella invasion of disparate eukaryotic cell lines, including neoplastic melanoma, colon adenocarcinoma, and glioma cell lines used in animal models of malignancy. In each case, Salmonella invasion of eukaryotic cells was invC dependent.…”
Get full text

Exploring novel immunotherapy biomarker candidates induced by cancer deformation. by Se Min Kim, Namu Park, Hye Bin Park, JuKyung Lee, Changho Chun, Kyung Hoon Kim, Jong Seob Choi, Hyung Jin Kim, Sekyu Choi, Jung Hyun Lee

“…To achieve this, the study places a strong emphasis on investigating Ig genes, a characteristic of immune checkpoint inhibitors, particularly genes expressing Ig-like domains with altered expression levels induced by "cancer deformation," a condition associated with cancer malignancy. Human cells can express approximately 800 Ig family genes, yet only a few Ig genes, including PD-1 and PD-L1, have been developed into immunotherapy drugs thus far. …”
Get full text

Breast Cancer Suspicion in a Transgender Male-to-Female Patient on Hormone Replacement Therapy Presenting with Right Breast Mass: Breast Cancer Risk Assessment and Presentation of... by Krystina Tongson, Victoria Konovalova, Naveen Dhawan, Steffi Sharma, Jaya Bahl, Mohammad Masri

“…This case describes a MtF transgender who presented with a breast lesion concerning for malignancy following hormonal replacement therapy. The patient additionally had a strong family history of breast cancer. …”
Get full text

Treatment of primary esophageal lymphomas: A review by Joe El Khoury, Remy Daou, Neal Kim, Josiane Bou Eid, Brandon Imber, Joachim Yahalom, Carla Hajj

“…Primary esophageal lymphoma is a rare malignancy that is difficult to diagnose and treat. …”
Get full text

Early Recurrence of Ovarian Cancer during Pregnancy after Primary Staging Surgery in the First Trimester by Munetoshi Akazawa, Kazunori Hashimoto

“…Even in the case of nonadvanced cancer, it has the potential to be an extremely aggressive malignancy under the irregular hormonal environment of pregnancy.…”
Get full text

MLLT11 siRNA Inhibits the Migration and Promotes the Apoptosis of MDA-MB-231 Breast Cancer Cells by Xiangrong Liu, Wenqi Bai, Jianrong Li, Jinfeng Ma, Yan Liu, Zhixiang Wang, Linjie Hu, Zheng Li, Dimitri Papukashvili, Nino Rcheulishvili, Fusheng Wang, Xiaoqing Lu

“…Breast cancer is considered the most prevalent malignancy due to its high incidence rate, recurrence, and metastasis in women that makes it one of the deadliest cancers. …”
Get full text

Imaging Findings of Ovarian Adenofibroma in Multiparous Woman by Sangavi Jeyaraj, Jaya Selin Praveena Joseph, Ashok Ranjan, Senthil Kumar Aiyappan

“…Apart from this, her past medical history was unremarkable, and there was no family history of malignancy. Her general condition was fair, and her vitals were normal, with a blood pressure of 110/70 mmHg and a pulse rate of 82 beats per minute.…”
Get full text

Prognostic Impact of DNA-Image-Cytometry in Neuroendocrine (Carcinoid) Tumours by H. Raatz, A. Böcking, S. Hauptmann

“…Establishing prognosis proves particularly difficult with neuroendocrine tumours (NETs) as a benign looking histology can be associated with a malignant behaviour. In order to identify prognostic factors we examined 44 gastrointestinal and pulmonary, paraffin‐embedded NETs histologically and immunohistochemically. …”
Get full text

Case Report: Gastric Carcinoma Diagnosed at the Second Trimester of Pregnancy by Tayfur Cift, Begüm Aydogan, Murat Akbaş, Burcu Aydın, Fuat Demirkiran, Dogu V. Bakkaloglu, Sennur Ilvan

“…All these factors may contribute to a very high mortality of this malignancy during pregnancy.…”
Get full text

Bile Duct Strictures Caused by Solid Masses: MR in Differential Diagnosis and as a Prognostic Tool to Plan the Endoscopic Treatment by Tomasz Gorycki, Michał Studniarek

“…Significantly higher SIR values were encountered in malignant lesions in T2W images () and STIR T2W images (). …”
Get full text

Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft tolerance by Ji Won Han, Su-Hyung Park

“…Prolonged immunosuppressive therapy in liver transplantation (LT) is associated with significant adverse effects, such as nephrotoxicity, metabolic complications, and heightened risk of infection or malignancy. Regulatory T cells (Tregs) represent a promising target for inducing immune tolerance in LT, with the potential to reduce or eliminate the need for life-long immunosuppression. …”
Get full text

Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient by Tiphaine Goletto, Flora Crockett, Selim Aractingi, Cecile Toper, Patricia Senet, Jacques Cadranel, Jean-Marc Naccache

“…The major causes of death are malignancy and myocardial infarction. Increased telomere attrition and decay are thought to play a causative role in the clinical and pathological manifestations of the disease. …”
Get full text

Cytokine Storm Syndrome Responsive to IL-1 Inhibition in Trisomy 21 by Aimee Magnarelli, Julia Shalen, Maria J. Gutierrez

“…They can lead to organ failure and are triggered by various factors, including infections, malignancy, inborn errors of immunity, and autoimmune conditions. …”
Get full text

A multiscale model of the bone marrow and hematopoiesis by Ariosto Silva, Alexander R. A. Anderson, Robert Gatenby

“…Our goal is the development of a spatially-explicit in silico model of the bone marrow to understand both its normal function and the evolutionary dynamics that govern the emergence of bone marrow malignancy.Here we introduce a multiscale computational model of the bone marrow that incorporates three distinct spatial scales, cell, hematopoietic subunit, whole marrow.Our results, using parameter estimates from literature, recapitulates normal bone marrow function and suggest an explanation for the fractal-like structure of trabeculae and sinuses in the marrow, which would be an optimization of the hematopoietic function in order to maximize the number of mature blood cells produced daily within the volumetric restrictions of the marrow.…”
Get full text

A Patient with Advanced Gastric Cancer Presenting with Extremely Large Uterine Fibroid Tumor by Kwang-Kuk Park, Song-I Yang

“…Simultaneous uterine fibroid tumor with other malignancies is generally observed without resection. …”
Get full text

“The Great Mimicker”: An Unusual Etiology of Cytopenia, Diffuse Lymphadenopathy, and Massive Splenomegaly by Mazen Zaarour, Chanudi Weerasinghe, Elias Moussaly, Shafinaz Hussein, Jean-Paul Atallah

“…Interestingly, lymph node biopsy showed noncaseating granulomas suggestive of sarcoidosis, without evidence of malignancy.…”
Get full text

Primary sclerosing cholangitis by Marina G Silveira, Keith D Lindor

“…The multiple complications of PSC include pruritus, fatigue, vitamin deficiencies, metabolic bone disease, peristomal varices, bacterial cholangitis, dominant biliary strictures, gallbladder stones and polyps, and malignancy, particularly cholangiocarcinoma, which is the most lethal complication of PSC.…”
Get full text

Bilateral Choroidal Metastasis from Non-Small Cell Lung Cancer by Tariq Namad, Jiang Wang, Annemarie Tilton, Nagla Abdel Karim

“…The choroidal metastases require a multidisciplinary care and should be among the differential patients with malignancy who present with ocular symptoms.…”
Get full text

A rare manifestation of adrenocortical carcinoma as a mimic of pheochromocytoma: a case report and literature review by Joanna Sobolewska, Wioleta Respondek, Przemyslaw Witek

“…The primary management in the care of patients with adrenal incidentalomas is to determine the oncologic risk, namely, the possibility of malignancy. The first place among adrenal incidentaloma lesions requiring diagnosis and treatment promptly is adrenocortical carcinoma (ACC). …”
Get full text