Causal Association Between Skin Microbiota and Malignant Melanoma: Genetic Insights From Mendelian Randomization by Li X, Wu S, Pan Y, Wu Z, Du Z, Xie W, Zhou Q

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Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy by Yu Chen, Xuan Wang, Jie Dai, Li Zhou, Xuefeng Xia, Jun Guo, Xue Bai, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xuan Gao, Lirui Tang, Linzi Sun, Zhonghui Qi, Zelong Xu

“…Background Accumulating data suggest that mucosal melanoma, well known for its poor response to immune checkpoint blockade (ICB) and abysmal prognosis, is a heterogeneous subtype of melanoma with distinct genomic and clinical characteristics between different anatomic locations of the primary lesions. Primary malignant melanoma of the esophagus (PMME) is a rare, highly aggressive disease with a poorer prognosis compared with that of non-esophageal mucosal melanoma (NEMM). …”
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Multiple Endocrine Neoplasia Type 1 with Concomitant Existence of Malignant Insulinoma: A Rare Finding by Randhir Sagar Yadav, Ashik Pokharel, Deepshikha Gaire, Shumneva Shrestha, Ashbita Pokharel, Sumita Pradhan, Prasan Bir Singh Kansakar

“…Insulinoma which has an incidence of 0.4% is a rare pancreatic neuroendocrine tumor. Malignant insulinoma is extremely rare, while primary hyperparathyroidism is a common occurrence in MEN1. …”
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Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion by Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue

“…Background Although tumor necrosis factor receptor 2 (TNFR2) has been recognized as an attractive next-generation candidate target for cancer immunotherapy, the factors that regulate the gene expression and their mechanistic effects on tumor-infiltrating regulatory T cells (Treg cells) remain poorly understood.Methods Single-cell RNA sequencing analysis was employed to analyze the phenotypic and functional differences between TNFR2+ Treg cells and TNFR2− Treg cells. Malignant pleural effusion (MPE) from humans and mouse was used to investigate the potential mechanisms by which lactate regulates TNFR2 expression.Results Treg cells with high TNFR2 expression exhibited elevated levels of immune checkpoint molecules. …”
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Could Serum TSH Levels Predict Malignancy in Euthyroid Patients Affected by Thyroid Nodules with Indeterminate Cytology? by Carlo Cappelli, Ilenia Pirola, Elena Gandossi, Mario Rotondi, Davide Lombardi, Claudio Casella, Fiorella Marini, Maura Saullo, Barbara Agosti, Elena Di Lodovico, Luca Chiovato, Alberto Ferlin, Maurizio Castellano

“…Serum TSH levels in the upper-normal range were reported to be associated with increased risk of thyroid malignancy. However, measurement of TSH levels is currently not recommended for assessing the risk of malignancy in patients with newly diagnosed thyroid nodules. …”
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Necrosis in Preoperative Cross-Sectional Imaging and Postoperative Histology Is a Diagnostic Marker for Malignancy of Adrenocortical Tumors by Agata Dukaczewska, Stephan R. Marticorena Garcia, Simon Ponsel, Alexandra Webster, Frederike Butz, Eva M. Dobrindt, Johann Pratschke, David Horst, Martina T. Mogl, Catarina A. Kunze

“…Signs of possible necrosis in radiologic imaging and tumor necrosis in histology proved to be very good predictive markers for the diagnosis of malignant adrenocortical tumors.…”
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Suspected Intramural Spread of Dye during Transaortic Celiac Plexus Rhizolysis in Patient of Intra-abdominal Malignancy by Anurag Agarwal, Shivani Rastogi, Brihaspati Tiwari, Aayushi Bagga

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FBXO31-mediated ubiquitination of OGT maintains O-GlcNAcylation homeostasis to restrain endometrial malignancy by Na Zhang, Yang Meng, Song Mao, Huiling Ni, Canhua Huang, Licong Shen, Kun Fu, Lu Lv, Chunhong Yu, Piyanat Meekrathok, Chunmei Kuang, Fang Chen, Yu Zhang, Kai Yuan

“…Aberrant O-GlcNAcylation has been observed in many cancers including endometrial cancer (EC), a common malignancy in women. However, clinical characterization of dysregulated O-GlcNAcylation homeostasis in EC and interrogating its molecular mechanism remain incomplete. …”
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Primary Pulmonary Anaplastic Large Cell Lymphoma: A Rare Malignancy and Rare Cause of the Luftsichel Sign by Elizabeth Von Ende, Travis Kauffman, Philip A. Munoz, Santiago Martinez-Jiménez

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Hopf Bifurcation on a Cancer Therapy Model by Oncolytic Virus Involving the Malignancy Effect and Therapeutic Efficacy by F. Adi-Kusumo, L. Aryati, S. Risdayati, S. Norhidayah

“…We introduce a mathematical model that shows the interaction dynamics between the uninfected and the infected cancer cell populations with oncolytic viruses for the benign and the malignant cancer cases. There are two important parameters in our model that represent the malignancy level of the cancer cells and the efficacy of the therapy. …”
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Low-Rank Adaptation of Pre-Trained Large Vision Models for Improved Lung Nodule Malignancy Classification by Benjamin P. Veasey, Amir A. Amini

“…<italic>Conclusions:</italic> Integrating LoRA with out-of-domain pretrained LVMs offers a promising avenue for enhancing performance of lung nodule malignancy classification. The annotations for the NLSTx dataset are also released with this paper on GitHub at <uri>https://github.com/benVZ/NLSTx</uri>.…”
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A Rare Presentation of Autonomously Functioning Papillary Thyroid Cancer: Malignancy in Marine-Lenhart Syndrome Nodule by Mehmet Uludag, Nurcihan Aygun, Alper Ozel, Feyza Yener Ozturk, Rabia Karasu, Banu Yilmaz Ozguven, Bulent Citgez, Mehmet Mihmanli, Adnan Isgor

“…It is not possible to exclude malignancy due to the clinical and imaging findings. …”
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Diabetic Ketoacidosis in Klinefelter Syndrome Sans Malignancy with Unusually Elevated Levels of CEA: A Case Report by Wo X, Yu X, Miao L, Mao Y, Tang K

“…A series of exams were performed to exclude the possibility of malignant tumors, and the patient’s glucose and CEA levels were closely monitored.Results: After excluding the possibility of malignant tumors, the patient’s CEA level gradually decreased to normal after good glycemic control.Conclusion: This is the first report describing significant increases in CEA levels in KS patients with diabetes, which is of great clinical significance for the treatment of diabetes patients.Keywords: diabetic ketoacidosis, hyperglycemia, Klinefelter’s syndrome, carcinoembryonic antigen…”
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Integrated intraoperative predictive model for malignancy risk assessment of thyroid nodules with atypia of undetermined significance cytology by Cheng Li, Yong Luo, Yan Jiang, Qi Li

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A Patient with Fibroepithelial Polyp of the Ureter—A Rare Condition Mimicking Malignancy: A Case Report by Wolfgang Brummeisl, Hans-Martin Fritsche, Elisabeth Huber, Wolf F. Wieland, Roman Ganzer

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Cancer in a polyp of the large intestine – an interdisciplinary decision problem by Przemysław Stefaniak, Hanna Majewska, Dariusz Zadrożny, Janusz Godlewski

Subjects: “…malignant colorectal polyp…”
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The Safety and Efficacy of Chemical Pleurodesis Agents in Patients with Malignant Pleural Effusion Admitted in Tertiary Care Hospital by Venkateshwaran Kathamuthu, Rajeshkumar Balakrishnan, Saravanavasan Rajendran, Prabhakaran Rathinam

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Influences of age and sex on the diagnostic accuracy of human epididymis secretory protein 4 for malignant pleural effusion by Qian Yang, Yan Niu, Qianghua Zhou, Dan-Ni Yang, Hong-Zhe Zhu, Cheng Yan, Su-Na Cha, Ting-Wang Jiang, Li Yan, Wen-Qi Zheng, Jian-Xun Wen, Zhi-De Hu

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Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets? by Athina Kladi-Skandali, Kleita Michaelidou, Andreas Scorilas, Konstantinos Mavridis

“…Regarding digestive system malignancies, the oncogenic HOTAIR is one of the most widely studied lncRNAs in the preclinical level and has already been identified as a potent prognostic marker for major malignancies of the gastrointestinal tract. …”
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Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies by Yan-Ruide Li, Ying Fang, Siyue Niu, Yichen Zhu, Yuning Chen, Zibai Lyu, Enbo Zhu, Yanxin Tian, Jie Huang, Valerie Rezek, Scott Kitchen, Tzung Hsiai, Jin J. Zhou, Pin Wang, Wanxing Chai-Ho, Sunmin Park, Christopher S. Seet, Caspian Oliai, Lili Yang

“…Abstract Chimeric antigen receptor (CAR)-engineered T cell therapy holds promise for treating myeloid malignancies, but challenges remain in bone marrow (BM) infiltration and targeting BM-resident malignant cells. …”
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