Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update by Arif Malik, Misbah Sultana, Aamer Qazi, Mahmood Husain Qazi, Gulshan Parveen, Sulayman Waquar, Abdul Basit Ashraf, Mahmood Rasool

“…Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. …”
Get full text

The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis by Javier Conde, Isabel Fernández‐Pisonero, L. Francisco Lorenzo‐Martín, Rocío García‐Gómez, Berta Casar, Piero Crespo, Xosé R. Bustelo

“…They also identify specific mevalonate‐pathway‐dependent processes that contribute to the malignant features of breast cancer cells.…”
Get full text

OFFICIAL MEDICATIONS FOR ANTI-TUMOR GENE THERAPY by E. R. Nemtsova, O. A. Bezborodova, R. I. Yakubovskaya, A. D. Kaprin

“…Gendicine™ and Oncorine™ are based on the wild type p53 gene and are designed for treatment of patients with head and neck malignancies. Replicating adenovirus is the delivery system in Gendicine™, whereas oncolytic adenovirus is the vector for gene material in Oncorine™. …”
Get full text

Radiofrequency Ablation Compared to Surgery for the Treatment of Benign Thyroid Nodules by Stella Bernardi, Chiara Dobrinja, Bruno Fabris, Gabriele Bazzocchi, Nicoletta Sabato, Veronica Ulcigrai, Massimo Giacca, Enrica Barro, Nicolò De Manzini, Fulvio Stacul

“…RFA, however, did not allow for any pathologic analysis of the nodules, which, in 6 patients who had undergone surgery (8%), revealed that the nodules harboured malignant cells. Conclusions. RFA might transform our approach to benign thyroid nodules.…”
Get full text

Association between HIV status and Positive Prostate Biopsy in a Study of U.S. Veterans by Wayland Hsiao, Katrina Anastasia, John Hall, Michael Goodman, David Rimland, Chad W. M. Ritenour, Muta M. Issa

“…HIV infection is associated with increased incidence of malignancies, such as lymphomas and testicular cancers. …”
Get full text

Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt/β-catenin signaling pathway by Jiawei He, Anhui Yang, Xuyu Zhao, Yang Liu, Shuyan Liu, Di Wang

“…The incidence rate of colon cancer ranks the third among malignant tumors worldwide. Gloeostereum incarnatum (GI), a fungus with homology of medicine and food, has multiple pharmacological activities. …”
Get full text

CD4+CD25highCD127low/-FoxP3+ Regulatory T-Cell Population in Acute Leukemias: A Review of the Literature by M. Niedźwiecki, O. Budziło, E. Adamkiewicz-Drożyńska, D. Pawlik-Gwozdecka, M. Zieliński, L. Maciejka-Kembłowska, T. Szczepański, P. Trzonkowski

“…However, observations confirming these facts are scarce; thus, extrapolating them to the population of children with hematological malignancies needs to be verified in additional studies.…”
Get full text

IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…Thus, IGF-1R may be a potential therapeutic target for patients with different malignancies. However, its mechanism in NPC is not fully investigated. …”
Get full text

Understanding the role of nerves in head and neck cancers - a review by Krzysztof Rutkowski, Michał Gola, Michał Gola, Janusz Godlewski, Janusz Godlewski, Anna Starzyńska, Anna Starzyńska, Giulia Marvaso, Giulia Marvaso, Federico Mastroleo, Federico Mastroleo, Maria Giulia Vincini, Maria Giulia Vincini, Alice Porazzi, Mattia Zaffaroni, Barbara Alicja Jereczek-Fossa, Barbara Alicja Jereczek-Fossa

“…Carcinogenesis is a complex, multidimensional molecular process leading to cancer development, and in recent years, the role of nerves in the pathogenesis of various malignancies has been increasingly recognized. Thanks to the abundant innervation of the head and neck region, peripheral nervous system has gained considerable interest for its possible role in the development and progression of HNCs. …”
Get full text

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells. by Karsten Jürchott, Ralf-Jürgen Kuban, Till Krech, Nils Blüthgen, Ulrike Stein, Wolfgang Walther, Christian Friese, Szymon M Kiełbasa, Ute Ungethüm, Per Lund, Thomas Knösel, Wolfgang Kemmner, Markus Morkel, Johannes Fritzmann, Peter M Schlag, Walter Birchmeier, Tammo Krueger, Silke Sperling, Christine Sers, Hans-Dieter Royer, Hanspeter Herzel, Reinhold Schäfer

“…This suggests that MEK/ERK-dependent, YBX1-regulated target genes are involved in executing malignant properties.…”
Get full text

Mucin-Poor Mucinous Tubular and Spindle Cell Carcinoma of the Kidney Presented with Multiple Metastases Two Years after Nephrectomy: An Atypical Behaviour of a Rare, Indolent Tumou... by I. Sokolakis, C. Kalogirou, L. Frey, M. Oelschläger, M. Krebs, H. Riedmiller, H. Kübler, D. Vergho

“…Although it is considered as a relatively indolent malign entity, it can metastasise even years after successful primary surgical treatment. …”
Get full text

Tumor Reduction with Pazopanib in a Patient with Recurrent Lumbar Chordoma by Maurício Fernando Silva Almeida Ribeiro, Micelange Carvalho de Sousa, Samir Abdallah Hanna, Marcos Vinicius Calfat Maldaun, Ceci Obara Kurimori, Luiz Guilherme Cernaglia Aureliano de Lima, Romulo Loss Mattedi, Rodrigo Ramella Munhoz

“…Chordomas are rare malignancies of bone origin that occur in the axial skeleton, typically the skull base and lumbar/sacral regions. …”
Get full text

Extracellular Vesicles and Tunnelling Nanotubes as Mediators of Prostate Cancer Intercellular Communication by Jessica K. Heatlie, Joanna Lazniewska, Courtney R. Moore, Ian R. D. Johnson, Bukuru D. Nturubika, Ruth Williams, Mark P. Ward, John J. O’Leary, Lisa M. Butler, Doug A. Brooks

“…Using live cell imaging microscopy, we observed extensive formation of TNTs and EVs operating between PCa, non-malignant, and immune cells. PCa cells were capable of transferring lysosomes, mitochondria, lipids, and endoplasmic reticulum, as well as syndecan-1, sortilin, Glut1, and Glut4. …”
Get full text

Research progress and application status of organoid in breast cancer subtypes by Qiuxia Zhang, Min Wang, Li You, Chen Chen, Jia Feng, Miao Song, Kui Yang, Xuexue Liu, Guangrong Li, Jinbo Liu

“…Breast cancer (BC) is a prevalent malignant tumor that poses a significant health risk to women. …”
Get full text

Phosphorylation of p53 Serine 15 Is a Predictor of Survival for Patients with Hepatocellular Carcinoma by Taewoo Yang, Yegyun Choi, Jae Won Joh, Steve K. Cho, Dae-Shick Kim, Sung-Gyoo Park

“…Hepatocellular carcinoma (HCC) is one of the most common malignant cancers with a poor prognosis. Several commonly investigated immunohistochemical markers in resected HCC have potential prognostic value, but the prognostic utility of p53 expression in HCC has remained elusive. …”
Get full text

A novel prognostic score of recurrence for endometrial cancer patients with staging surgery by Tomoka Maehana, Naoki Kawahara, Junya Kamibayashi, Motoki Matsuoka, Keita Waki, Ryuji Kawaguchi, Fuminori Kimura

“…Abstract Background Recently, there have been an increasing number of reports on the association between inflammatory markers and the prognosis of malignant tumors. However, the current inflammatory indicators have limited accuracy. …”
Get full text

Molecular Mechanism of Local Drug Delivery with Paclitaxel-Eluting Membranes in Biliary and Pancreatic Cancer: New Application for an Old Drug by Sookhee Bang, Sung Ill Jang, Su Yeon Lee, Yi-Yong Baek, Jieun Yun, Soo Jin Oh, Chang Woo Lee, Eun Ae Jo, Kun Na, Sugeun Yang, Don Haeng Lee, Dong Ki Lee

“…Implantation of self-expanding metal stents (SEMS) is palliation for patients suffering from inoperable malignant obstructions associated with biliary and pancreatic cancers. …”
Get full text

Rectal cancer with severe distal spreading by A. A. Nevolskikh, T. P. Berezovskaya, N. A. Gorban, L. M. Kondrashova, L. N. Titova

“…At a choice of operation risk of residual malignant process in visually unchanged tissues distally from tumor should be taken in account.…”
Get full text

NLRP12/C1qA positive feedback in tumor-associated macrophages regulates immunosuppression through LILRB4/NF-κB pathway in lung adenocarcinoma by Jiaxin Yin, Yuxiao Song, Yang Fu, Jun Wang, Zhimin Zhang, Shasha Ruan, Gaoli Liu, Bicheng Zhang

“…NLRP12-overexpressing TAMs promoted tumor cells’ malignant progression and inhibited T cells’ proliferation and cytotoxic function. …”
Get full text

Pancreatic Inflammatory Pseudotumor-Like Follicular Dendritic Cell Tumor by Madison Mograbi, Michael S. Stump, David T. Luyimbazi, Mohammad H. Shakhatreh, Douglas J. Grider

“…Follicular dendritic cell sarcoma (FDCS) is a rare and underdiagnosed malignant neoplasm which characteristically presents as a solitary, slow-growing mass with no discrete symptoms. …”
Get full text