Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai by Juan-José Escuder-Rodríguez, Andrea Rodríguez-Alonso, Lía Jove, Macarena Quiroga, Gloria Alfonsín, Angélica Figueroa

“…Moreover, Hakai potential as a cancer biomarker and its prognostic value in malignant disease also emphasize its untapped potential in precision medicine, which would also be discussed in detail in our review. …”
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Hepatitis C Virus Infection and Mixed Cryoglobulinemia by Gianfranco Lauletta, Sabino Russi, Vincenza Conteduca, Loredana Sansonno

“…B-cell clonal expansion starts as an antigen-driven event and expands towards indolent and malignant B-cell proliferation. Occurrence of intrahepatic B-cell clonalities correlates with extrahepatic clinical manifestations of HCV infection. …”
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Diagnosis of Fanconi Anemia: Mutation Analysis by Multiplex Ligation-Dependent Probe Amplification and PCR-Based Sanger Sequencing by Johan J. P. Gille, Karijn Floor, Lianne Kerkhoven, Najim Ameziane, Hans Joenje, Johan P. de Winter

“…Fanconi anemia (FA) is a rare inherited disease characterized by developmental defects, short stature, bone marrow failure, and a high risk of malignancies. FA is heterogeneous: 15 genetic subtypes have been distinguished so far. …”
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Self-Renewal Signalling in Presenescent Tetraploid IMR90 Cells by Anda Huna, Kristine Salmina, Elina Jascenko, Gunars Duburs, Inna Inashkina, Jekaterina Erenpreisa

“…Endopolyploidy and genomic instability are shared features of both stress-induced cellular senescence and malignant growth. Here, we examined these facets in the widely used normal human fibroblast model of senescence, IMR90. …”
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Mapping naturally presented T cell antigens in medulloblastoma based on integrative multi-omics by Julia Velz, Lena K. Freudenmann, Gioele Medici, Marissa Dubbelaar, Malte Mohme, David R. Ghasemi, Jonas Scheid, Daniel J. Kowalewski, Angelica B. Patterson, Anna M. Zeitlberger, Katrin Lamszus, Manfred Westphal, Matthias Eyrich, Martina Messing-Jünger, Andreas Röhrig, Harald Reinhard, Kévin Beccaria, Rogeiro B. Craveiro, Beat M. Frey, Martin Sill, Sven Nahnsen, Marie Gauder, Konstantina Kapolou, Manuela Silginer, Tobias Weiss, Hans-Georg Wirsching, Patrick Roth, Michael Grotzer, Niklaus Krayenbühl, Oliver Bozinov, Luca Regli, Hans-Georg Rammensee, Elisabeth J. Rushing, Felix Sahm, Juliane S. Walz, Michael Weller, Marian C. Neidert

“…Abstract Medulloblastoma is the most frequent malignant primary brain tumor in children. Despite recent advances in integrated genomics, the prognosis in children with high-risk medulloblastoma remains devastating, and new tumor-specific therapeutic approaches are needed. …”
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The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer by Austin R. Dosch, Mary P. Martos, Samara Singh, Karishma Kodia, Nipun B. Merchant, Nagaraj S. Nagathihalli

“…As the inception and outgrowth of liver metastases are primary drivers of prognosis in GI malignancies; further research into the complex mechanisms involved in this critical process is urgently needed.…”
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A shallow convolutional neural network for cerebral neoplasm detection from magnetic resonance imaging by Hossein Sadr, Zeinab Khodaverdian, Mojdeh Nazari, Mohammad Yamaghani

“…The result of this study not only enables healthcare professionals to quickly and accurately identify brain malignancies but also automates the diagnostic process and minimizes dependence on manual interpretation. …”
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Mullerian Adenosaroma of the Cervix with Sarcomatous Overgrowth and Heterologous Elements Presenting as a Recurrent Cervical Polyp by Slim Charfi, Rim Kallel, Hela Mnif, Sameh Ellouze, Mohamed Dhouib, Mohamed Guermazi, Abdelmajid Khabir, Tahya Sellami-Boudawara

“…Mullerian adenosarcoma of the cervix is a rare tumor composed of benign epithelial and malignant stromal components. Sarcomatous overgrowth and heterologous elements in cervical adenosarcoma are extremely infrequent. …”
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NonHodgkin's Lymphoma with Peritoneal Localization by E. Curakova, M. Genadieva-Dimitrova, J. Misevski, V. Caloska-Ivanova, V. Andreevski, B. Todorovska, U. Isahi, M. Trajkovska, P. Misevska, N. Joksimovic, S. Genadieva-Stavric, S. Antovic, N. Jankulovski

“…The cytology from the ascites and pleural effusion did not detect any malignant cells. Due to the rapid disease progression the patient died after twenty-two days of admission. …”
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Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma by Ana Almazán-Moga, Patricia Zarzosa, Isaac Vidal, Carla Molist, Irina Giralt, Natalia Navarro, Aroa Soriano, Miguel F. Segura, Arantza Alfranca, Javier Garcia-Castro, José Sánchez de Toledo, Josep Roma, Soledad Gallego

“…Although the existence of CSC has been reported for eRMS, their existence in aRMS, the most malignant subtype, has not been demonstrated to date. …”
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Proteomic Technology “Lens” for Epithelial-Mesenchymal Transition Process Identification in Oncology by Monica Neagu, Carolina Constantin, Marinela Bostan, Constantin Caruntu, Simona Rebeca Ignat, Sorina Dinescu, Marieta Costache

“…The epithelial-mesenchymal transition (EMT) is a complex transformation process that induces local and distant progression of many malignant tumours. Due to its complex array of proteins that are dynamically over-/underexpressed during this process, proteomic technologies gained their place in the EMT research in the last years. …”
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Lenalidomide-Associated Immune Thrombocytopenia: A Case Report and Review of the Literature by William Forehand III, Germame Ajebo, Michael Toscano, Anand Jillella, Paul Dainer

“…More recently, it has been introduced for use in treating other hematologic malignancies. Although the drug is known to cause myelosuppression, there have been rare reports of lenalidomide-associated immune thrombocytopenia (ITP). …”
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Langerhans Cell Histiocytosis of the Thyroid with Multiple Cervical Lymph Node Involvement Accompanying Metastatic Thyroid Papillary Carcinoma by A. Bahar Ceyran, Serkan Şenol, Barış Bayraktar, Şeyma Özkanlı, Z. Leyla Cinel, Abdullah Aydın

“…Papillary thyroid carcinoma is the most common malignant epithelial tumor of the thyroid gland. Langerhans cell histiocytosis presenting with papillary thyroid carcinoma is rare. …”
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Molecular and Phylogenetic Analysis of Bovine Papillomavirus Type 1: First Report in Iraqi Cattle by Mohammed A. Hamad, Ahmed M. Al-Shammari, Shoni M. Odisho, Nahi Y. Yaseen

“…BPV is a widely spread oncogenic virus in Iraqi cattle and is associated with the formation of both benign and malignant lesions, resulting in notable economic losses in dairy and beef cattle. …”
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A Nonpalpable Nodule in Ectopic Axillary Breast Tissue: Consider Phyllodes Tumor by Eva Ruvalcaba-Limón, Verónica Bautista-Piña, Julio Ramírez-Bollas, Ruby Espejo-Fonseca, Sergio Rodríguez-Cuevas

“…Benign and malignant pathology can develop in ectopic axillary breast tissue, such as fibroadenomas, phyllodes tumors, and breast cancer. …”
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Uterine Tumor Resembling Ovarian Sex-Cord Tumors Initially Diagnosed as a Prolapsed Fibroid by Fernando Augusto Rozário Garcia, Vanessa Pereira Gaigher, Rodrigo Neves Ferreira, Antônio Chambô Filho

“…UTROSCT are considered of uncertain malignant potential and no particular form of treatment is formally recommended, with hysterectomy currently being the treatment of choice. …”
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Delayed Cerebral Radiation Necrosis after Neutron Beam Radiation of a Parotid Adenocarcinoma: A Case Report and Review of the Literature by Christopher S. Hong, Hamza N. Gokozan, José J. Otero, Michael Guiou, J. Bradley Elder

“…Neutron beam radiation is a highly potent form of radiotherapy that may be used to treat malignant tumors of the salivary glands. This report describes a patient who underwent neutron beam radiation for a parotid adenocarcinoma and who developed biopsy-confirmed temporal lobe radiation necrosis thirty months later. …”
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Expression of interleukin-17 in oral tongue squamous cell carcinoma and its effect on biological behavior by Lina Jiang, Zhenghao Ma, Luwen Song, Chenchen Zhu, Jiancheng Li, Zhenxing Su, Hongsheng Liu

“…Abstract Tongue squamous cell carcinoma (TSCC) is a common malignant oral cancer characterized by substantial invasion, a high rate of lymph node and distant metastasis, and a high recurrence rate. …”
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Application of HPLC Combined with Laser Induced Fluorescence for Protein Profile Analysis of Tissue Homogenates in Cervical Cancer by Sujatha Bhat, Ajeetkumar Patil, Lavanya Rai, V. B. Kartha, Santhosh Chidangil

“…ROC and Youden's index curves for both normal and malignant standard sets show good diagnostic accuracy with high AUC values. …”
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Evaluation of Tumor Viability for Primary and Bone Metastases in Metastatic Castration-Resistant Prostate Cancer Using Whole-Body Magnetic Resonance Imaging by Hiromichi Iwamura, Yasuhiro Kaiho, Jun Ito, Go Anan, Nozomi Satani, Tomonori Matsuura, Ryo Tamura, Kazuhiro Murakami, Kaneki Koyama, Makoto Sato

“…In contrast, CT-guided needle biopsy from bone metastasis of the lumbar vertebra revealed no malignant cells. Based on these findings, we reasoned that viable tumor cells inducing disease progression may primarily exist in the primary lesions and not in the metastatic lesions, and combined prostate radiotherapy and systemic hormonal therapy resulted in successful clinical response and disease control. …”
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