Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy by Sandy El Bitar, Chanudi Weerasinghe, Elie El-Charabaty, Marcel Odaimi

“…Immune checkpoint blockade therapy is gaining popularity among oncologists for treatment of solid and hematologic malignancies. The widespread use of these agents resulted in increasing incidence of renal immune-related adverse events. …”
Get full text

Pediatric Granular Cell Tumor of the Breast: A Case Report and Review of the Literature by Nathan P. Heinzerling, Shannon M. Koehler, Sara Szabo, Amy J. Wagner

“…Although rare, these tumors do have malignant potential necessitating a correct and timely diagnosis.…”
Get full text

Unique Surgical Issues in the Management of a Giant Retroperitoneal Schwannoma and Brief Review of Literature by Santhosh Kuriakose, Syam Vikram, Surij Salih, Satheesan Balasubramanian, Nizamudeen Mangalasseri Pareekutty, Sangeetha Nayanar

“…CT scan reported a large heterogenous lesion in the abdominopelvic retroperitoneum (42 cm × 16 cm × 16 cm) as a malignant tumor. The unique problems we encountered were the enormous size, the location of major part of the tumor in the pelvis, the need for fertility preservation, the external iliac vessels stretching over the tumor making mobilization surgically demanding, and the prospects of neurological deficits. …”
Get full text

Long noncoding RNA DHRS4 antisense RNA 1 suppresses osteosarcoma cell proliferation and promotes apoptosis through a competitive endogenous RNA mechanism by Zhouzhou Tang, Zhihao Li, Guofeng Wu, Jianjun Li, Jianye Tan, Lixin Zhu

“…Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor. Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis. …”
Get full text

Mixed Gastric Carcinomas Show Similar Chromosomal Aberrations in Both their Diffuse and Glandular Components by Beatriz Carvalho, Tineke E. Buffart, Rui M. Reis, Thomas Mons, Cátia Moutinho, Paula Silva, Nicole C. T. van Grieken, Heike Grabsch, Cornelis J. H. van de Velde, Bauke Ylstra, Gerrit A. Meijer, Fátima Carneiro

“…Gastric cancer is one of the most frequent malignancies in the world. Nonetheless, the knowledge of the molecular events involved in the development of gastric carcinoma is far from complete. …”
Get full text

Primary tracheo‐bronchial adenoid cystic carcinoma: A surgical series with literature review by Kaouther Ben Amara, Imen Bouassida, Rahma Ayadi, Mariem Affes, Amina Abdelkbir, Mahdi Abdennadher, Salma Ben Othmen, Ayda Ayadi‐Kaddour, Hazem Zribi, Adel Marghli

“…TBACC is a rare and low‐to‐moderate grade malignant tumour. The choice of the surgical procedure and the appropriate approach is challenging to obtain a promising prognosis.…”
Get full text

Effects of Microtubule Stabilization by Epothilone B Depend on the Type and Age of Neurons by Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur

“…Paradoxically, administration of MSAs, which have been widely prescribed to treat malignancies, is well known to cause debilitating peripheral neuropathy and axon degeneration. …”
Get full text

False Positive 18F-FDG Uptake in Mediastinal Lymph Nodes Detected with Positron Emission Tomography in Breast Cancer: A Case Report by Gamze Uğurluer, Mustafa Kibar, Sinan Yavuz, Akin Kuzucu, Meltem Serin

“…Positron emission tomography with computed tomography detects malignancies using 2-[18F]-fluoro-2-deoxy-d-glucose (18F-FDG PET CT) with high accuracy and they contribute to decisions regarding diagnosis, staging, recurrence, and treatment response. …”
Get full text

P2X7 Receptor Function in Bone-Related Cancer by Elena Adinolfi, Francesca Amoroso, Anna Lisa Giuliani

“…Search of mRNA expression microchip databases and literature analysis demonstrate a high expression of P2X7 in primary bone tumors as well as in other malignancies such as multiple myeloma, neuroblastoma, breast, and prostate cancer. …”
Get full text

Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis by Sabina Boangher, Pascal Mespouille, Corina-Mihaela Filip, Sophie Goffette

“…Limbic encephalitis can be associated with malignant tumors such as lung carcinoma. Several cases reported in the literature have shown cognitive improvement after tumoral therapy. …”
Get full text

Orbital ameloblastoma: research and challenges of a rare benign tumor by Rui Zhang, Xiaoming Huang, Fengyuan Sun, Tong Wu

“…The mystery of it lies in that, although it is classified as a benign tumor, it exhibits high recurrence and malignant potential with high invasiveness, posing a serious threat to ocular health and the quality of life of patients. …”
Get full text

Isolated Sporothrix schenckii Monoarthritis by Aram Barbaryan, Wissam El Atrouni, Stefania Bailuc, Matthew W. Jones, Maharshi Bhakta, Khaldoun Haj Mahmoud, Aibek E. Mirrakhimov

“…In patients with underlying risk factors (HIV, alcoholism, diabetes mellitus, organ transplant patients, immunosuppressive medications, steroids, and malignancies), it can often have disseminated visceral, osteoarticular, meningeal, and pulmonary involvement. …”
Get full text

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia by Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Meng Shan, Fuqiang Wang, Yanglan Fang, Sining Liu, Lijun Wen, Suning Chen, Depei Wu, Yang Xu

“…Here, using the most prevalent RARG fusion, CPSF6-RARG (CR), as a representative, we reveal that the CR fusion, enhances the expansion of myeloid progenitors, impairs their maturation and synergizes with RAS mutations to drive more aggressive myeloid malignancies. Mechanistically, CR fusion interacts with histone deacetylase 3 (HDAC3) to suppress expression of genes associated with myeloid differentiation including the myeloid transcription factor PU.1. …”
Get full text

Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy by Fatemeh Dehghan, Yekta Metanat, Mandana Askarizadeh, Ehsan Ahmadi, Vahid Moradi

“…Currently, CAR-T cell therapy is known as an efficacious treatment for patients with relapsed/refractory hematologic malignancies. Nonetheless, this method faces several bottlenecks, including low efficacy for solid tumors, lethal adverse effects, high cost of autologous products, and the risk of GvHD in allogeneic settings. …”
Get full text

Basal Cell Carcinoma: 10 Years of Experience by Emanuele Cigna, Mauro Tarallo, Michele Maruccia, Valentina Sorvillo, Alessia Pollastrini, Nicolò Scuderi

“…Basal cell carcinoma (BCC) is a locally invasive malignant epidermal tumour. Incidence is increasing by 10% per year; incidence of metastases is minimal, but relapses are frequent (40%–50%). …”
Get full text

Interactions between key genes and pathways in prostate cancer progression and therapy resistance by Fan Wu, Hengsen Zhang, Miaomiao Hao

“…Prostate cancer is one of the most prevalent malignant tumors in men, particularly in regions with a high Human Development Index. …”
Get full text

The Diagnostic Challenge of an Infrequent Spectrum of Cryptococcus Infection by Francisco Barbosa De Araujo Neto, Camila Corona De Godoy Bueno, Liege Tambelini Gomes, Daniela Alejandra Ortiz Navas, Mark Wanderley, Stefanie Gallotti Borges Carneiro, Rita Karine Veras Gomes De Mello, Laura Mendes Coura, Larissa Sayuri Missumi, Henrique Durante, Ricardo Francisco Cintra Zagatti, Márcio Valente Yamada Sawamura

“…Although very infrequent, mediastinal cryptococcal infection (simulating masses) is a challenging but important differential diagnosis of benign and malignant lesions, since its treatment is usually clinical.…”
Get full text

Rat Sarcoma Virus Family Genes in Acute Myeloid Leukemia: Pathogenetic and Clinical Implications by Shaimaa Khattab, Adriatik Berisha, Natalia Baran, Pier Paolo Piccaluga

“…Acute myeloid leukemias (AMLs) comprise a group of genetically heterogeneous hematological malignancies that result in the abnormal growth of leukemic cells and halt the maturation process of normal hematopoietic stem cells. …”
Get full text

Primary large cell neuroendocrine carcinoma of the urethra: a case report by Jianbai Chen, Xiaorong Mou, Zhiming Zhang, Zhiyong Nie, Jianxin Qiu

“…BackgroundPrimary neuroendocrine carcinoma of the urethra is a very uncommon malignant tumor, and no reports have been made about large cell neuroendocrine carcinoma (LCNEC) in the past.Case descriptionA 43-year-old non-smoking female patient presented with symptoms of dysuria and urination-related pain at TangDu Hospital in April 2022. …”
Get full text

Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma by Sonja Kabatnik, Xiang Zheng, Georgios Pappas, Sophia Steigerwald, Matthew P. Padula, Matthias Mann

“…Abstract Signet Ring Cell Carcinoma (SRCC) is a rare and highly malignant form of adenocarcinoma with increasing incidence and poor prognosis due to late diagnosis and limited treatment options. …”
Get full text