EGFR Amplification and Glioblastoma Stem-Like Cells by Katrin Liffers, Katrin Lamszus, Alexander Schulte

“…Glioblastoma (GBM), the most common malignant brain tumor in adults, contains a subpopulation of cells with a stem-like phenotype (GS-cells). …”
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PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression by Marion Haas, Sabrina Cherfa, Léa Nguyen, Maxence Bourgoin, Gersende Caron, Elise Dessauge, Tony Marchand, Laurent Delpy, Patrick Auberger, Jérôme Moreaux, Arnaud Jacquel, Thierry Fest

“…Using a model of normal and malignant plasma cells, we show that inhibiting PIM2 kinase inhibits phosphorylated BAD production and activates ISR-mediated NOXA expression. …”
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Divergent Crosstalk Between Microglia and T Cells in Brain Cancers: Implications for Novel Therapeutic Strategies by Min-Hee Yi, Jinkyung Lee, Subin Moon, EunA So, Geonhyeok Bang, Kyung-Sub Moon, Kyung-Hwa Lee

“…<b>Methods</b>: This review comprehensively examines the complex cellular dialogue between microglia and T cells in two prominent brain malignancies: primary glioblastoma and secondary brain metastases. …”
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Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma by Nassir Mokarram, Ayden Case, Nadia N. Hossainy, Johnathan G. Lyon, Tobey J. MacDonald, Ravi Bellamkonda

“…Here, we review device-assisted drug delivery across the blood–brain barrier, emphasizing its application in glioblastoma, an aggressively malignant primary brain cancer in which the blood-brain barrier plays a central role. …”
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Comparative Study between Plastic and Metallic Stents for Biliary Decompression in Patients with Distal Biliary Obstruction by João Guilherme G. Cabral, Eloy Taglieri, Adriane Pelosof, Daniel Rosendo, José Celso Ardengh

“…This paper presents a retrospective comparison of plastic versus metallic stents in the drainage of malignant distal biliary obstructions. We compared single plastic stents (SPS), multiple plastic stents (MPS), and metallic stents (SEMS) regarding clinical decrease of TB < 2.0 mg/dL, long-term patency, and adverse event. 58 patients (38 women) with MDBO were included. …”
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Giant Congenital Melanocytic Nevi and Neurocutaneous Melanosis by Catarina Araújo, Cristina Resende, Francisco Pardal, Celeste Brito

“…This patient was diagnosed as having a neurocutaneous melanosis with malignant widespread leptomeningeal infiltration. Diffuse spinal involvement is unusual and is described in only another patient.…”
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Emerging advances in drug delivery systems (DDSs) for optimizing cancer complications by Kerui Li, Bei Guo, Junmou Gu, Na Ta, Jia Gu, Hao Yu, Mengchi Sun, Tao Han

“…This review focuses on common oncological complications, including cancer thrombosis, malignant serous effusion, tumor-associated infections, cancer pain, and treatment-related complications. …”
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Emerging technologies of single-cell multi-omics by Yi June Kim, Koichi Takahashi

“…These technologies have uncovered the intricate landscape of genetic clonality and transcriptional heterogeneity in both normal and malignant hematopoietic systems, highlighting their roles in differentiation, disease progression, and therapy resistance. …”
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Oral verrucous hyperplasia – A literature review by R. Santhosh Kumar, Divya Bose, Thayalan Dineshkumar, M. Harinisubasri, Rajkumar Krishnan, Rameshkumar Annasamy

“…Patients with OVH should be treated similar to oral verrucous carcinoma and should be continuously monitored for disease recurrence and malignant transformation.…”
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Implication of protein post translational modifications in gastric cancer by Houji Song, Mingze Zhang, Chengwang Guo, Xi Guo, Yuqi Ma, Yuntao Ma, Yuntao Ma

“…Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, and its occurrence and development are regulated by multiple molecular mechanisms. …”
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Melanophilin-induced primary cilia promote pancreatic cancer metastasis by Yu-Ying Chao, Ruei-Ci Lin, Ping-Jui Su, Chu-An Wang, Ting-Yuan Tu, Ya-Chin Hou, Yi-Tzui Tsai, I-Chen Peng, Shaw-Jenq Tsai, Yan-Shen Shan, Chia-Yih Wang

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors because of its high metastatic ability. …”
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Tumor-infiltrating lymphocytes mediate complete and durable remission in a patient with NY-ESO-1 expressing prostate cancer by Elke Jäger, Julia Karbach, Claudia Wahle, Dragan Kiselicki, Kathrin Brand, Evgueni Sinelnikov, Dirk Gustavus, Hans Hoffmeister, Hans-Bernd Prisack, Akin Atmaca

“…Adoptive transfer of autologous tumor-specific lymphocytes represents a viable treatment method for patients with advanced malignancies. Here, we report a patient’s case with metastatic hormone-refractory New York esophageal squamous cell carcinoma 1 (NY-ESO-1) expressing prostate cancer treated with in vitro expanded tumor-infiltrating lymphocytes (TILs) in conjunction with IL-2 and immune-checkpoint blockade. …”
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Inhibitory Effects of Far-Infrared Irradiation Generated by Ceramic Material on Murine Melanoma Cell Growth by Ting-Kai Leung, Chin-Feng Chan, Ping-Shan Lai, Chih-Hui Yang, Chia-Yen Hsu, Yung-Sheng Lin

“…Furthermore, cFIR treatment induced 6.4% and 12.3% increases in intracellular reactive oxygen species stained by 5-(and 6)-carboxyl-2′,7′-dichlorodihydrofluorescein diacetate and dihydrorhodamine 123, respectively. Since malignant melanomas are known to have high HSP70 expression and iNO activity, the suppressive effects of cFIR on HSP70 and NO may warrant future interest in antitumor applications.…”
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Kolorektal kansere sekonder gelişen kolokolik invajinasyon by Tevfik Küçükkartallar, Murat Çakır, Ahmet Tekin, Ebubekir Gündeş

“…Bu yazının amacı, invajinas- yonun yetişkinilerdeki insidansını bildirmek, değişken bulguları ve malign hastalıklarla yüksek birlikteliği hakkında bilgi vermek ve tedavi yöntemleri hakkında önerilerde bulunmaktır. …”
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Efficient Machine Learning and Deep Learning Techniques for Detection of Breast Cancer Tumor by Dlshad Abdalrahman Mahmood, Sadegh Abdullah Aminfar

“…Machine learning and deep learning, which effectively handle ambiguity in the identification of malignant tumors, provide an alternative method for dealing with the complexity of brain tissue. …”
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FTNet-HiLa: An adaptive multimodal histopathological image categorization network by Shuo Yin, Dong Zhang, YongKang Zhang, Xing Zhao, XuYing Zhao

“…Combined with FTNet-HiLa, it sets a new benchmark in benign-malignant classification. These findings highlight the improved performance of ViT models with HiLa and its scalability to multimodal applications.…”
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Case report: A case report and literature review on the efficacy of high-dose aumolertinib combined intrathecal pemetrexed by Ommaya reservoir for EGFR-mutated NSCLC with leptomeni... by Maoxi Zhong, Maoxi Zhong, Maoxi Zhong, Li Zhou, Li Zhou, Li Zhou, Jing Guo, Jing Guo, Jing Guo, Chuan Chen, Chuan Chen, Chuan Chen, Wei Wang, Wei Wang, Wei Wang, Xiaoping Huang, Xiaoping Huang, Xiaoping Huang, Yi Liu, Yi Liu, Yi Liu

“…This also indicates that the tumor is highly malignant and aggressive, which brings great challenges to treatment. …”
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A Rare Presentation of Checkpoint Inhibitor Induced Distal RTA by Andrew V. Doodnauth, Miriam M. Klar, Zohra R. Malik, Krunal H. Patel, Samy I. McFarlane

“…Immune checkpoint inhibitors have opened a new era in treating advanced malignancies, resulting in a rapid increase in utilization, given the remarkable clinical outcomes. …”
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Anesthesia Management in Scoliosis Surgery of Patients with Friedreich’s Ataxia: A Report of Four Cases by Muhammed Köse, Ercan Bal, Şemsi Mustafa Aksoy, Ayşe Lafçı

“…Patients were monitored with central venous pressure (CVP), bispectral index (BIS),invasive blood pressure and near infrared spectroscopy (NIRS). The risk of malignant hyperthermia and difficult airway are increased in patients with Friedreich's ataxia. …”
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Ameloblastic Carcinoma in a 2-Year-Old Child: A Case Report and Review of the Literature by Ngoc Bao Vu, Ngoc Tuyen Le, Risa Chaisuparat, Pasutha Thunyakitpisal, Ngoc Minh Tran

“…Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor in pediatric patients, only 22 cases have been reported in literature since 1932. …”
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