Conversion therapy for unresectable intrahepatic cholangiocarcinoma using gemcitabine plus S-1 combined with PD-1 inhibitors: a case report by Shuangying Zhao, Xiaodong Zhang, Jialiang Luo, Huanjun Yan, Jianlei Zhang, Rongfeng Lin, Kelei Zhu

“…Intrahepatic cholangiocarcinoma (iCCA) is a highly malignant tumor of the liver and gallbladder, which is usually diagnosed at an advanced stage and the opportunity for surgery is lost. …”
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Diving into Diagnostic Complexity: A Case Study of Spontaneous Hemothorax by Maryam Sarkhosh, Atiyeh Sadat Sajadi, Omid Moradi Moghaddam, Parisa Moradi Majd

“…Despite inconclusive rheumatologic tests, evaluations excluded malignancies and thromboembolic events, enabling transfusions and supportive care. …”
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Lymph Node Abscessation Secondary to Neoplasia in Two Dogs by Erin Close, Sarah Lumbrezer-Johnson, Eric Hostnik, Rhonda Burge, Ryan Jennings, Laura Selmic

“…A 5-year-old male neutered mixed breed dog and an 8-year-old female spayed golden retriever presented for cervical swelling which was later diagnosed as abscessation of the retropharyngeal lymph node with a malignant round cell tumor and carcinoma with multifocal squamous differentiation, respectively. …”
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Acute Interstitial Nephritis in a Patient with Non-Small Cell Lung Cancer under Immunotherapy with Nivolumab by Panagiotis I. Georgianos, Vasilios Vaios, Eleni Leontaridou, Georgia Karayannopoulou, Triantafyllia Koletsa, Athanasios Sioulis, Elias V. Balaskas, Pantelis E. Zebekakis

“…Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several “immune-mediated” adverse effects, but the reported renal toxicity of ICPIs is less well defined. …”
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Saving a Child’s Elbow Joint: A Novel Reconstruction for a Tumour of the Distal Humerus by Calogero Graci, Czar Louie Gaston, Robert Grimer, Lee Jeys, Korhan Ozkan

“…Reconstruction after wide resection of a malignant bone tumor can be obtained using several techniques such as the use of prostheses, allograft, autograft, or combined procedure. …”
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Lymph Node Metastasis after a Soft Tissue Sarcoma of the Leg: A Case Report and a Review of the Literature by S. D. Nelen, F. J. Vogelaar, F. Gilissen, J. C. Van der Linden, K. Bosscha

“…Soft tissue sarcomas (STSs) represent 1 percent of all adult malignancies and sarcomas only rarely spread to the regional lymph nodes. …”
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DiGeorge Syndrome Presenting as Hypocalcaemia-Induced Seizures in Adulthood by Adrian Zammit, Deborah Grech Marguerat, Josephine Psaila, Alexander Attard

“…Presentation in adulthood is rare but must be borne in mind when dealing with cases of hypocalcaemia even in the absence of florid phenotypic features. A link with malignant disease has also been reported and should lead to prompt investigation of concerning masses.…”
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From PD-1/PD-L1 to tertiary lymphoid structures: Paving the way for precision immunotherapy in cholangiocarcinoma treatment by Fang-Ju Huang, Ye-Ying Fang, Jia-Ying Wen, Jian-Jun Li, Qian Lin, Qin-Yan Su, Yi-Yang Chen, Lei Wang, Jian-Jia Zeng, Bang-Teng Chi, Rong-Quan He, Di-Yuan Qin, Li-Hua Yang, Gang Chen

“…Cholangiocarcinoma (CCA) is a highly malignant hepatobiliary tumor characterized by limited treatment options and poor prognosis. …”
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Xeroderma Pigmentosum: Man Deprived of His Right to Light by Subhash Mareddy, Jithendra Reddy, Subhas Babu, Preethi Balan

“…Xeroderma pigmentosum (XP) is a hereditary autosomal recessive disorder characterized by photo hypersensitivity of sun exposed tissues and subsequent several-fold increased risk for malignant changes resulting from impaired ability to repair UV-induced DNA damage. …”
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Iatrogenic Sinistral Hypertension Complicating Screening Colonoscopy by Oliver J. Ziff, A. M. James Shapiro

“…Colonoscopy is widely accepted as the gold-standard screening technique for detecting malignancies in the distal gastrointestinal tract in patients with symptoms suggestive of colon cancer. …”
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Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis by ZHANG Zongwen, FENG Li, FAN Zhisong

“…This article reviews the role and research progress of hnRNPH1 in the initiation and progression of malignant tumors.…”
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A pivotal decade for bispecific antibodies? by Marlena Surowka, Christian Klein

“…In the 2020s, the approval of additional bsAbs can be expected in hematological malignancies, solid tumors and non-oncology indications, establishing bsAbs as essential part of the therapeutic armamentarium.…”
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INI-1-Deficient Sinonasal Carcinoma: Case Report with Emphasis on Differential Diagnosis by Anwaar M. Alsayed, Eman A. Aljufairi, Amjad O. Alshammari, Khalid A. Alsindi, Omar A. Sabra

“…The morphologic appearance, specific immunophenotypic markers, and unique molecular make-up distinguish this entity from other various malignant neoplasms. We present a case of a 55-year-old male that presented with a large progressing palatine mass. …”
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Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer by Hany E. Marei, Khaled Bedair, Anwarul Hasan, Layla Al-Mansoori, Sara Caratelli, Giuseppe Sconocchia, Alice Gaiba, Carlo Cenciarelli

“…The T cell-based immunotherapy known as chimeric antigen receptor (CAR) T cell treatment, which uses the patient’s immune cells to fight cancer, has demonstrated remarkable efficacy in treating hematologic malignancies; nevertheless, the treatment effects in solid tumors, like breast cancer, have not lived up to expectations. …”
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Frequency of the Causes of Postmenopausal Bleeding, Results of a Tertiary Referral Center in Turkey by Umit Yasemin Sert, Ismail Guler, Tuncay Nas

“…We found that premalignant and malignant lesions were related to the patients’ BMI (body mass index), duration of postmenopause, the presence of diabetes, determination of thick endometrium by ultrasonography. …”
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Metastatic Breast Carcinoma to the Prostate Gland by Meghan E. Kapp, Giovanna A. Giannico, Mohamed Mokhtar Desouki

“…This case demonstrates the importance of considering a broad differential diagnosis and comparing histology and IHC to prior known malignancies in the setting of atypical presentation or rare tumors.…”
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A Novel Type of Non-coding RNA, nc886, Implicated in Tumor Sensing and Suppression by Yong Sun Lee

“…Thus, the significance of the nc886:PKR pathway in cancer is to sense and eliminate pre-malignant cells, which is analogous to PKR's role in cellular innate immunity. …”
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An Interesting Case of Intramuscular Myxoma with Scapular Bone Lysis by Jérôme Tirefort, Frank C. Kolo, Alexandre Lädermann

“…In the presence of an intramuscular growing mass with associated bone lysis, intramuscular myxoma as well as malignant tumor should be evoked. MRI has to be part of the initial radiologic appraisal but biopsy is essential to confirm the diagnosis. …”
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In Vivo Pharmacodynamic Imaging of Proteasome Inhibition by Erin A. Kimbrel, Tina N. Davis, James E. Bradner, Andrew L. Kung

“…Inhibiting the proteolytic activity of the 26S proteasome has been shown to have selective apoptotic effects on cancer cells and to be clinically efficacious in certain malignancies. There is an unmet medical need for additional proteasome inhibitors, and their development will be facilitated by surrogate markers of proteasome function. …”
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Orbital Cellulitis: A Rare Presentation of Metastatic Bronchial Carcinoma by Rohit Kumar, Wolfgang Issing

“…Orbital cellulitis and sinonasal malignancies have a similar pattern of clinical presentation, posing a potential diagnostic pitfall. …”
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