Molecular Pathogenesis of MALT Lymphoma by Katharina Troppan, Kerstin Wenzl, Peter Neumeister, Alexander Deutsch

“…However, these genetic abnormalities alone are not sufficient for malignant transformation. There is now increasing evidence suggesting that the oncogenic product of translocation cooperates with immunological stimulation in oncogenesis, that is, the association with chronic bacterial infection or autoaggressive process. …”
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A simple model of carcinogenic mutations with time delay and diffusion by Monika Joanna Piotrowska, Urszula Foryś, Marek Bodnar, Jan Poleszczuk

“…In the paper we consider a system of delay differential equations (DDEs) of Lotka-Volterra type with diffusion reflecting mutations from normal to malignant cells. The model essentially follows the idea of Ahangar and Lin (2003) where mutations in three different environmental conditions, namely favorable, competitive and unfavorable, were considered. …”
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A select inhibitor of MORC2 encapsulated by chimeric membranecoated DNA nanocage target alleviation TNBC progression by Xiaohan Su, Yunbo Luo, Yali Wang, Peng Qu, Jun Liu, Shiqi Han, Cui Ma, Shishan Deng, Qi Liang, Xiaowei Qi, Panke Cheng, Lingmi Hou

“…Triple-negative breast cancer (TNBC) is the most malignant type of breast cancer and lacks effective targeted therapeutic drugs, resulting in a high recurrence rate and worse outcome. …”
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Adult Type Granulosa Cell Tumor: A Very Rare Case of Sex-Cord Tumor of the Testis with Review of the Literature by Dimosthenis Miliaras, Eleftherios Anagnostou, Ioannis Moysides

“…However, the adult type testicular GCTs may be potentially malignant as it also happens in female patients with such neoplasms. …”
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Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features by Karl Grenier, Gulbeyaz Altinel, Zari Dastani, Atilla Omeroglu

“…Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. …”
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Case report: Periorbital pilomatricoma: a rare benign skin tumor misdiagnosed as cellulitis by Rahul Kumar, Jane Z. Spadaro, Jane Z. Spadaro, Alon Kahana, Alon Kahana, Alon Kahana

“…Histopathology is required to rule out pilomatrix carcinoma, a malignant variant.…”
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A Pediatric Case of Cowden Syndrome with Graves’ Disease by Cláudia Patraquim, Vera Fernandes, Sofia Martins, Ana Antunes, Olinda Marques, José Luís Carvalho, Jorge Correia-Pinto, Carla Meireles, Ana Margarida Ferreira

“…Cowden syndrome (CS) is a rare dominantly inherited multisystem disorder, characterized by an extraordinary malignant potential. In 80% of cases, the human tumor suppressor gene phosphatase and tensin homolog (PTEN) is mutated. …”
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Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma by Siu Ying Angel Nip, Kam Lun Hon, Wing Kwan Alex Leung, Alexander K. C. Leung, Paul C. L. Choi

“…We report a rare case of a male infant with neonatal hemangiomatosis with diffuse peritoneal involvement, which mimicked a malignant-looking tumor on imaging, and discuss therapeutic options and efficacy. …”
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Primary Angiosarcoma of the Spleen: An Oncological Enigma by Myoteri Despoina, Dellaportas Dionysios, Ayiomamitis Georgios, Strigklis Konstantinos, Kouroumpas Efstratios, Zizi-Sermpetzoglou Adamantia

“…Surgical extirpation is the mainstay of treatment of this highly malignant disease. Case Presentation. An 82-year-old woman was admitted with left pleural effusion and a palpable left upper quadrant abdominal mass, secondary to splenomegaly by two large splenic tumors. …”
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Mitotically Active Plexiform Fibrohistiocytic Tumor by Ebru Zemheri, Şeyma Özkanlı, Serkan Şenol, Filiz Ozen, Cigdem Ulukaya Durakbaşa, İlkin Zindancı, Hamit Okur

“…Plexiform fibrohistiocytic tumor is an intermediate malignant tumor situated in superficial soft tissues. …”
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Müllerianosis of the urinary bladder in pre- and postmenopausal women: a literature review by Dimitrios Diamantidis, Georgios Tsakaldimis, Stavros Lailisidis, Evangelia Deligeorgiou, Nikolaos Panagiotopoulos, Nektraria Kritsotaki, Charalampos Kafalis, Chousein Chousein, Stilianos Giannakopoulos, Christos Kalaitzis

“…Despite its benign nature, due to its ability to mimic malignant conditions such as bladder carcinoma, diagnosis might be challenging. …”
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Chimeric Antigen Receptor-Modified T Cells for Solid Tumors: Challenges and Prospects by Yelei Guo, Yao Wang, Weidong Han

“…Recent studies have highlighted the successes of chimeric antigen receptor-modified T- (CART-) cell-based therapy for B-cell malignancies, and early phase clinical trials have been launched in recent years. …”
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Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands by Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan, Zhaohui Sunny Zhou

“…NKG2D, a homodimeric activating receptor expressed on NK cells, recognizes a diverse class of stress ligands expressed by cells experiencing infection, malignant transformation, chronic inflammation, and other cellular stresses. …”
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Fingolimod exerts in vitro anticancer activity against hepatocellular carcinoma cell lines via YAP/TAZ suppression by Du Jiamin, Qian Meijia, Yuan Tao, Zhang Bo, Chen Xueqin, An Ning, He Qiaojun, Yang Bo, Ye Song, Zhu Hong

“…The deregulation of the Hippo signalling pathway, especially the overexpression and activation of downstream effector Yes-associated protein (YAP), has been demonstrated to result in the rapid malignant evolution of HCC. In this context, multiple efforts have been dedicated to targeting YAP for HCC therapy, but effective YAP inhibitors are still lacking. …”
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Spinous Process Osteochondroma as a Rare Cause of Lumbar Pain by Bárbara Rosa, Pedro Campos, André Barros, Samir Karmali, Esperança Ussene, Carlos Durão, João Alves da Silva, Nuno Coutinho

“…The most concerning complication of osteochondromas is malignant transformation, a rare event.…”
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Bmi1 Severs as a Potential Tumor-Initiating Cell Marker and Therapeutic Target in Esophageal Squamous Cell Carcinoma by Xiaochen Wang, Kang Li, Maosheng Cheng, Ganping Wang, Hui Han, Fangfang Chen, Wenjing Liao, Zhi Chen, Jianwen Chen, Yong Bao, Liang Peng, Demeng Chen

“…Esophageal squamous cell carcinoma (ESCC) is a frequent malignant tumor with low 5-year overall survival. Targeting ESCC tumor-initiating cells (TICs) may provide a new research avenue to achieve better therapeutic effects of ESCC. …”
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Retinocytoma Undergoing Retinoblastoma Transformation in an Adult Patient by J. Navaratnam, R. Faber, N. Eide, M. Lund-Iversen, Ø. Garred, F. L. Munier

“…Initially, the tumor was diagnosed as a retinocytoma with clinical suspicion of malignant transformation into retinoblastoma and treated by four sessions of laser photocoagulation. …”
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Primary Sarcoma of the Specialised Prostatic Stroma: A Case Report and Review of the Literature by Rosanna Zamparese, Francesco Corini, Antonio Braccischi, Antonella D'Angelo, Lucilla Diamanti, Marina Del Vecchio, Willy Giannubilo, Vladimiro Mambelli

“…Primary sarcoma tumours of the prostate are rare and are classified, according to their histology, as stromal tumours of uncertain malignant potential (STUMP) and stromal prostatic sarcoma (PS; low and high grade). …”
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Primitive Neuroectodermal Tumor of the Liver: A Case Report by Eduardo Cambruzzi, Enilde Eloena Guerra, Hamilton Cardoso Hilgert, Herbert Jorge Schmitz, Vinícius Lopes Silva, Daniel Marini Milani, Ricardo Pedrini Cruz, Raul Pruinelli

“…Primitive neuroectodermal tumor (PNET) represents a high malignant neoplasia that usually affects the central nervous system and soft tissues. …”
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Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management by Laura M. S. Seeber, Ronald P. Zweemer, René H. M. Verheijen, Paul J. van Diest

“…In the Western world, endometrial cancer (EC) is the most common malignant tumor of the female genital tract. Solid tumors like EC outgrow their vasculature resulting in hypoxia. …”
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