Primary Clear Cell Adenocarcinoma of the Cervix: A Clinical Analysis of 18 Cases without Exposure to Diethylstilbestrol by Dongying Wang, Chunhua Zhao, Li Fu, Yang Liu, Weiyang Zhang, Tianmin Xu

“…Cervical clear cell adenocarcinoma (CCAC) is a rare malignant tumor with independent biological behavior in the female reproductive system. …”
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Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

“…In addition, melanoma mouse tumor immunotherapy models were performed to explore the synergistical efficacy of antitumor immunity via prevention of tumor-specific T cell senescence combined with anti-programmed death-ligand 1 (anti-PD-L1) checkpoint blockade therapy.Results We report that both mouse malignant tumor cells and Treg cells can induce responder T cell senescence, similar as shown in human Treg and tumor cells. …”
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Elevated miR-221-3p inhibits epithelial–mesenchymal transition and biochemical recurrence of prostate cancer via targeting KPNA2: an evidence-based and knowledge-guided strategy by Dingchao Li, Jingang Jian, Manhong Shi, Zihao Chen, Anguo Zhao, Xuedong Wei, Yuhua Huang, Yalan Chen, Jianquan Hou, Yuxin Lin

“…Conclusions miR-221-3p down-regulation was a risk factor for PCa BRFS, and its over-expression could inhibit the malignant phenotype and EMT of PCa cells by directly targeting KPNA2. …”
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RNA m6A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells by Nan Zhang, Jie Yang, Yuan Zhao, Wenhong Li, Bo Zhao, Rongxian Li, Zuoshun He, Shiyan Gu

“…In present study, our data demonstrated that prolonged treatment of 1 μmol/L CdSO4 for 40 passages in bronchial epithelial cells (Beas-2B cells) resulted in the development of a malignant phenotype, which manifested as boosted proliferation, migration and invasion capacity as well as apoptosis reduction. …”
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Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…MACE IRs were similar in North America and Poland, and numerically higher versus Other countries. IRs for malignancies (excluding NMSC) were numerically higher in North America versus Poland/Other countries with tofacitinib. …”
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Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases by Xian Zhang, Jun Yang, Hong Hu, Yong Wang, Zhenfeng Zhang, Jinhao lv, Junping Li

“…Abstract Brain metastases (BM) are the most prevalent intracranial malignancies. Approximately 30–40% of cancer patients develop BM at some stage of their illness, presenting with a high incidence and poor prognosis. …”
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Rare and syndromic tumours in South African children: A novel report from Sub-Saharan Africa by Alessia Pisapia, Guy Shemesh, Derek Harrison

“…The 10 most common variants included: malignant peripheral nerve sheath tumours (N = 15, 8 %, OS=47 %), nasopharyngeal carcinoma (N = 14, 8 %, OS=64 %), malignant melanoma (N = 14, 8 %, OS=43 %), Ewings sarcoma (N = 13, 7 %, OS=54 %), clear cell sarcoma of the kidney (N = 9, 5 %, OS=67 %), hepatocellular carcinoma (N = 9, 5 %, OS=22 %), desmoplastic small round cell tumour (N = 7, 4 %, OS=57 %), synovial sarcoma (N = 7, 4 %, OS=71 %), undifferentiated sarcoma (N = 6, 3 %, OS=66 %), infantile fibrosarcoma (N = 6, 3 %, OS=66 %). …”
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NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity by Rui Ma, Zhenlong Li, Hejun Tang, Xiaojin Wu, Lei Tian, Zahir Shah, Ningyuan Liu, Tasha Barr, Jianying Zhang, Sean Wang, Srividya Swaminathan, Guido Marcucci, Yong Peng, Michael A. Caligiuri, Jianhua Yu

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Multinational cohort study of intracranial hemorrhage in patients with brain metastases receiving anticoagulation by Eva N. Hamulyák, Tzu-Fei Wang, Lisa Baumann Kreuziger, Varun Iyengar, Brian J. Carney, Ann Hoeben, Berna C. Özdemir, Rosana D. Cordova Serrano, Kristen M. Sanfilippo, Shira Rozenblatt, Ludo F.M. Beenen, Shlomit Yust-Katz, Erez Halperin, Ariela Arad, Aharon Lubetsky, Marc Carrier, Benjamin Massat, Harry R. Büller, Galia Spectre, Jeffrey I. Zwicker, Avi Leader, ABC Study Group

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Controlled Resistant Hypertension Following A Successful Renal Artery Stenting: A Rare Case Report in A Developing Country by Fatihatul Firdaus Munita, Badai Bhatara Tiksnadi, Januar Wibawa Martha, Margareta Ginanti Ratna

“…We report a case of a patient with uncontrollable hypertension with frequent episodes of malignant hypertension, treated with renal artery stenting. …”
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Siltuximab for chimeric antigen receptor T-cell therapy–related CRS and ICANS: a multicenter retrospective analysis by Amneet Bajwa, Qiuhong Zhao, Marcus Geer, Chenyu Lin, James Westholder, Joseph Maakaron, Monalisa Ghosh, David Frame, Ahmed Galal, Justin Tossey, Nausheen Ahmed, Evandro Bezerra, Nathan Denlinger, Marcos de Lima, Narendranath Epperla, Paolo Caimi, Timothy Voorhees

“…Abstract: Chimeric antigen receptor T-cell (CAR-T) therapies are effective in many hematologic malignancies; however, adverse events including cytokine release syndrome (CRS) and immune effector cell–associated neurotoxicity syndrome (ICANS) can affect a significant number of patients. …”
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The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas by Pinelopi Argyriou, Panagiota Economopoulou, Sotirios Papageorgiou

“…These agents have shown promising results in the treatment of lymphoid malignancies. On the other hand, new ATP-competitive mTOR inhibitors that provoke a broader inhibition of mTOR activity are in early stages of clinical development. …”
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Epidural Brain Metastases in a Patient with Early Onset Pancreatic Cancer: A Case Report and Literature Review by Aibek E. Mirrakhimov, Farah N. Khan

“…A 46-year-old Caucasian non-Jewish nonobese male with a history of PC diagnosed 3 months ago with metastases to the liver, omentum, malignant ascites, and a history of a pulmonary embolism was admitted to the hospital because of a new onset headache, nausea, and vomiting which started 2 days prior to the encounter. …”
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A Study On The Histopathological Analysis Of Nasal Masses Among Patients Attending The Ent Department Of Pakistan Institute Of Medical Sciences, Islamabad by Malik Jawad Faisal, Muhammad Arshad, Moniba Zafar, Ahmed Hasan Ashfaq, Syed Fahd Shah

“…Results: The most numerous groups of changes were non-cancerous nasal growth; 55 cases (68.25%), then 25 cases (32.25%) of nasal tumours, 16 benign, and 9 malignant cases in cancerous tumours. Conclusion: Nasal obstruction and rhinorrhea are the most commonly encountered symptoms in our community, with simple inflammatory nasal polyps being the predominant histological pattern. …”
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Case Report: Metastatic squamous cell carcinoma in the left atrium by Shuai Luo, Xiaoxue Tian, Ting Xu, Jinjing Wang

“…BackgroundMetastatic tumours are the most common malignant tumours affecting the heart. Cardiac metastatic tumour progression is rapid, with no specific treatments available, and the prognosis is typically poor. …”
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Cord Blood-Derived Hematopoietic Stem/Progenitor Cells: Current Challenges in Engraftment, Infection, and Ex Vivo Expansion by Katsuhiro Kita, Jong O. Lee, Celeste C. Finnerty, David N. Herndon

“…However, morbidity and mortality rates associated with hematopoietic malignancies still remain relatively high, even after cord blood transplantation. …”
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Post Varicella Necrotising Fasciitis Afflicting Upper Limb in Young Child: A Rare Case Report by Swarup Prabhu, Ayjaz Hussain, Tarun Gupta

“…Risk factors include immunosuppression, type 2 diabetes mellitus, chronic diseases like cirrhosis of liver and chronic kidney disease, malignancies, intravenous drug use, obesity, and age more than 60 years. …”
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CD19-directed chimeric antigen receptor T-cell therapy: what can we learn from the haematologist? by Marie José Kersten, Maria Theresa Kuipers

“…CD19-directed chimeric antigen receptor (CAR) T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for patients with autoimmune diseases. …”
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Clinical forms of 5 cases of circumcised penile cancer in immunocompetent subjects in Abidjan (Ivory Coast) by Evrard Kouame Yao, Abraham Hognou Yao, Donafologo Daouda Yeo, Tawakaltu Adebayo, Michel Tuo, Freddy Junior Zouan, Noel Coulibaly

“…Abstract Context Malignant tumours of the penis are rare. Their incidence varies around the world and increases with age. …”
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Iron Deficiency Anaemia Caused by Nonspecific (Idiopathic) Small Bowel Ulceration: An Uncommon Presentation of an Uncommon Disease by Gabriele Capurso, Edith Lahner, Nadia Pallotta, Francesco Panzuto, Gianfranco Delle Fave, Bruno Annibale

“…Ulcers of the small bowel are rare, and in most cases are due to infections, inflammatory bowel diseases, malignancies or drugs. When none of these causes is recognized, they are classified as ‘nonspecific’ or idiopathic. …”
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