Case report: Relapse of intrathyroidal parathyroid carcinoma in a patient with novel variants in MET and CDKN1C genes by Ekaterina Kim, Anastasiia Lavreniuk, Olga Spasskaya, Anna Eremkina, Rustam Salimkhanov, Liliya Urusova, Natalia Tarbaeva, Sergey Popov, Victoria Zakharova, Natalia Mokrysheva

“…Parathyroid carcinoma (PC) is one of the rarest malignant neoplasms of the human endocrine system, with a prevalence of approximately 0.005% of all oncological diseases. …”
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Potential inhibition of CXCL12/SDF-1 by small molecule Hesperetin in management of tobacco associated oral cancer by G. Radha, Ramya Ramadoss, Pradeep Kumar Yadalam, Rajeshkumar Shanmugam

“…Also topical drug delivery systems with Hesperetin can be planned in oral potentially malignant disorders.…”
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Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials by Tao Zeng, Lei Li, Yan Zhou, Liang Gao

“…With the advent of high-throughput technologies, numerous long noncoding RNAs (lncRNAs) aberrantly expressed in GBMs were discovered recently, some of them probably involved in GBM initiation, malignant progression, relapse and resistant to therapy, or showing diagnostic and prognostic value. …”
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CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies by Fang Wang, Ruiqi Zhang, Zhaokai Zhou, Run Shi, Fu Peng, Yudi Xu, Shuai Yang, Zhan Wang, Pengpeng Zhang, Rui Tu, Chun Zhang, Xingchen Liu, Jun Cai

“…Endocrine malignancies constitute a heterogeneous tumour group with diverse biological characteristics. …”
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An Unusual Presentation of a Posterior Mediastinal Schwannoma Associated with Traumatic Hemothorax by Ruchi Amin, Brett H. Waibel

“…Specific serological markers do not exist for this tumor, and radiographic findings can be variable, so tissue diagnosis is of importance in differentiating benign from malignant schwannomas, as well as other posterior mediastinal tumors. …”
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Metastatic Insulinoma in a Patient with Type 2 Diabetes Mellitus: Case Report and Review of the Literature by Noormuhammad Oosman Abbasakoor, Marie Louise Healy, Donal O'Shea, Donal Maguire, Cian Muldoon, Kieran Sheahan, Dermot O'Toole

“…Pancreatic neuroendocrine tumors (NETs) are extremely rare, and although insulinomas are the commonest, less than 10% of insulinomas are malignant. Most patients with insulinomas present with neuroglycopenic symptoms and weight gain attributable to insulin excess. …”
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Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases by Yuehong Chen, Jianhong Sun, Huan Liu, Geng Yin, Qibing Xie

“…Chimeric antigen receptor T (CAR-T) cells are T cells engineered to express specific synthetic antigen receptors that can recognize antigens expressed by tumor cells, which after the binding of these antigens to the receptors are eliminated, and have been adopted to treat several kinds of malignancies. Autoimmune diseases (AIDs), a class of chronic disease conditions, can be broadly separated into autoantibody-mediated and T cell-mediated diseases. …”
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Ovarian Fetiform Teratoma in 38 Years Nulliparous Woman: A Case Report by Desalew Gedamu, Mekitie Wondafrash, Meron Berhanu

“…It is important to distinguish this highly differentiated benign neoplasm with potential somatic malignant transformation from Fetus in fetu and ectopic pregnancy. …”
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Lipoma of the Ischiorectal Fossa: A Rare Case Report by Djavan Khubanov, Kamala Gasimova

“…Clinical evaluation included imaging with contrast-enhanced magnetic resonance imaging (MRI), which confirmed the presence of a 147x67 mm transverse lipomatous mass extending into the right gluteal fold without malignant features. Surgical resection was performed using the posterior midline approach, which allowed complete tumor removal with optimal cosmetic outcomes. …”
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Primary Breast Angiosarcoma: Avoiding a Common Trap by Christine Desbiens, Jean-Charles Hogue, Yves Lévesque

“…A highly vascular breast mass should always be considered malignant until proven otherwise. Surgical treatment seems to be the best course of action. …”
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Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia by Olga Zając-Spychała, Bogna Ukielska, Katarzyna Jończyk-Potoczna, Benigna Konatkowska, Jacek Wachowiak

“…The diagnosis of IRIS is even more difficult in patients with hematological malignancies complicated by “probable” invasive fungal infection, when fungal pathogen is still uncertain. …”
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Small cell lymphocytic lymphoma of eye annexes. Case presentation by Icilany Villares Álvarez, Julio Dámaso Fernández Águila, María de los A. García Dueñas, Alejandro Pérez Capote

“…Lymphomas are malignant diseases that originate in the immune system cells and are predominantly manifested by lymphadenopathy; sometimes the presentation is in extranodal places. …”
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Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features by John M. Petock, Ivan Y. Torshin, Yuan-Fang Wang, Garrett C. Du Bois, Carlo M. Croce, Robert W. Harrison, Irene T. Weber

“…The sequences and crystal structures of three Tcl1 proteins were analyzed in order to understand their interactions with Akt/PKB and the implications for lymphocyte malignancies. Tcl1 proteins are ~15 kD and share 25—80% amino acid sequence identity. …”
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Experience of treatment of presacral tumors by A. M. Kuzminov, S. A. Frolov, A. S. Borodkin, Yu. Yu. Chubarov, V. Yu. Korolik, Yu. F. Borisov

“…The highest relapse rate was observed at malignant tumors; such patients require the combined treatment at specialized oncologic clinic. …”
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Epstein-Barr Virus Infection in an Elderly Nonimmunocompromised Adult Successfully Treated with Rituximab by Jacob P. Smeltzer, Matthew T. Howard, Wilson I. Gonsalves, Thomas E. Witzig

“…In addition to causing a viral illness, it is also associated with various malignancies in particular B cell lymphomas and lymphoproliferative disorders. …”
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Gain in 1q is a Common Abnormality in Phyllodes Tumours of the Breast by Kowan J. Jee, Gyungyub Gong, Sei Hyun Ahn, Jeong Mi Park, Sakari Knuutila

“…The gain was observed both in benign and malignant tumours. Our study did not reveal any DNA copy number changes or allelic loss on 3p. …”
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The impact of innate immune response on the efficacy of oncolytic viruses by Kirill N. Trachuk, Nikolai B. Pestov, Yulia K. Biryukova, Nadezhda M. Kolyasnikova

“…Oncolytic viruses represent a promising class of immunotherapeutic agents for the treatment of malignant tumors. The proposed mechanism of action of various oncolytic viruses has initially been explained by the ability of such viruses to selectively lyse tumor cells without damaging healthy ones. …”
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Ewing Sarcoma of the External Ear Canal by Adem Binnetoglu, Tekin Baglam, Gulnur Tokuc, Kiymet Kecelioglu Binnetoglu, Fatma Gerin, Murat Sari

“…Ewing sarcoma (ES) is a high-grade malignant tumor that has skeletal and extraskeletal forms and consists of small round cells. …”
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Massive Fetomaternal Hemorrhage Caused by an Intraplacental Choriocarcinoma: A Case Report by Anna-Karina Aaris Henningsen, Lisa Leth Maroun, Hanne Havsteen, Jens Svare

“…Intraplacental choriocarcinoma is a rare but highly malignant trophoblastic neoplasm. When found near term the risk of maternal metastasis is high because of the late diagnosis. …”
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FIRST RUSSIAN EXPERIENCE OF USING THE INTEGRATED SYSTEM OF LASER THERMOABLATION THERAPY IN THE TREATMENT OF METASTATIC LIVER CANCER by D. V. Sidorov, S. O. Stepanov, M. V. Lozhkin, L. O. Petrov, O. V. Gutz, A. A. Kostin, A. G. Isaeva

“…The presented experience testifies to the justification of using laser destruction of metastatic malignant liver tumors and demonstrates the possibilities of laser thermoablation therapy in patients who can not perform radical surgical treatment.…”
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