Personalized screening strategies for TP53 R337H carriers: a retrospective cohort study of tumor spectrum in Li-Fraumeni syndrome adult carriersResearch in context by Pedro A.F. Galante, Gabriela D.A. Guardia, Janina Pisani, Renata L. Sandoval, Mateus C. Barros-Filho, Ana Carolina Leite Vieira Costa Gifoni, Diogo F.C. Patrão, Patricia Ashton-Prolla, Vitor Fiorin de Vasconcellos, Claire Freycon, Arnold Levine, Pierre Hainaut, Maria Isabel Achatz

“…Summary: Background: Li-Fraumeni Syndrome (LFS) is a predisposition associated with early onset malignant tumors caused by germline pathogenic variants in the TP53 gene. …”
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Immune cells in thyroid adenoma and carcinoma: uncovering a hidden value of assessing tumor-host interplay and its potential application in thyroid cytopathology by Iryna Omelianenko, Iryna Omelianenko, Nazarii Kobyliak, Nazarii Kobyliak, Tetyana Falalyeyeva, Tetyana Falalyeyeva, Oleksii Seleznov, Pavlina Botsun, Lyudmila Ostapchenko, Oleksandr Korotkyi, Liudmyla Domylivska, Olena Tsyryuk, Galyna Mykhalchyshyn, Tetiana Shapochka, Oksana Sulaieva, Oksana Sulaieva

“…The number of immune cells in cytological specimens correlated with CD8+ (r = 0.693; p < 0.001) and CD163+ cells (r = 0.559; p < 0.001) in histological samples, reflecting the differences in the tumor immune microenvironment between benign and malignant thyroid neoplasms.ConclusionTC demonstrated high immunogenicity compared to TA, which correlated to the number of immune cells in cytological specimens. …”
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Targeting KRAS G12C and G12S mutations in lung cancer: In silico drug repurposing and antiproliferative assessment on A549 cells by Mansour S. Alturki, Nada Tawfeeq, Amal Alissa, Zahra Ahbail, Mohamed S. Gomaa, Abdulaziz H. Al Khzem, Thankhoe A. Rants'o, Mohammad J. Akbar, Waleed S. Alharbi, Bayan Y. Alshehri, Amjad N. Alotaibi, Fahad A. Almughem, Abdullah A. Alshehri

“…The RAS protein is a notable target in cancer research, being the most often mutated oncogene in human malignancies. The RAS G12X mutation is predominantly found in non-small cell lung cancer, including G12C and G12S variants, which are associated with a poor prognosis. …”
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T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications by Claudio Fozza, Maurizio Longinotti

“…In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features. …”
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A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature by Abdullateef Abdulkareem, Ryan S. D’Souza, Oluwaseun Shogbesan, Anthony Donato

“…Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. …”
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A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature by Scott Schoninger, Yamen Homsi, Alexandra Kreps, Natasa Milojkvovic

“…Multiple myeloma (MM) is a malignant plasma cell proliferation producing large numbers of monoclonal immunoglobulins. …”
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DIABETES INSIPIDUS: LITTLE-KNOWN FACTS by L. Yu. Morgunov

“…The most common causes of diabetes insipidus are neurosurgical operations on the pituitary gland due to its defeat by benign and malignant tumors, the neoplasms themselves, lymphocytic hypophysitis. …”
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Tracing the Spectrum of Inborn Errors of Immunity from Past to Present by Safa Barış, Talal A. Chatila

“…Human inborn errors of immunity (IEI) constitute a constellation of genetic disorders with profound implications for immune system function, leading to recurrent infections, immune dysregulations, and malignancies. The field of IEI has undergone a tremendous evolution over the course of seventy years, with substantial strides in comprehending the clinical and immunological aspects of monogenic disorders. …”
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Coexistence of Primary GEJ Adenocarcinoma and Pedunculated Gastric Gastrointestinal Stromal Tumor by Aroub Alkaaki, Basma Abdulhadi, Murad Aljiffry, Mohammed Nassif, Haneen Al-Maghrabi, Ashraf A. Maghrabi

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive system, although they account for only 0.1–3% of all gastrointestinal (GI) malignancies. They can arise anywhere along the GI tract with gastric predominance. …”
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Double M-plasty in Patients with Basosquamous Carcinoma. A Case Report by Carlos Manuel Collado Hernández, Francisco Matos Figueredo, Vivian Pérez Núñez

“…Skin cancer is the most common malignant tumor in humans and its presence has increased in recent years. …”
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Futuristic Developments and Applications in Endoluminal Stenting by Joel Ferreira-Silva, Renato Medas, Mohit Girotra, Monique Barakat, James H. Tabibian, Eduardo Rodrigues-Pinto

“…Endoscopic stenting is a well-established option for the treatment of malignant obstruction, temporary management of benign strictures, and sealing transmural defects, as well as drainage of pancreatic fluid collections and biliary obstruction. …”
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Clinical significance of exosomal noncoding RNAs in hepatocellular carcinoma: a narrative review by Jae Sung Yoo, Min Kyu Kang

“…Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide, with poor prognosis owing to its high frequency of recurrence and metastasis. …”
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New Immunotherapeutic Approaches for Glioblastoma by Gustavo Ignacio Vázquez Cervantes, Dinora F. González Esquivel, Saúl Gómez-Manzo, Benjamín Pineda, Verónica Pérez de la Cruz

“…Glioblastoma (GBM) is the most common primary malignant brain tumor with a high mortality rate. The current treatment consists of surgical resection, radiation, and chemotherapy; however, the median survival rate is only 12–18 months despite these alternatives, highlighting the urgent need to find new strategies. …”
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Recent Advances in Thoracic X-Ray Computed Tomography for Pulmonary Imaging by Bruce J Precious, Rekha Raju, Jonathon Leipsic

“…Dual-energy CT has proven to be useful in the characterization of pulmonary blood pool in the setting of pulmonary embolism, characterization of diffuse lung parenchymal diseases, evaluation of thoracic malignancies and in imaging of lung ventilation using inhaled xenon. …”
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Myxoid Chondrosarcoma of Maxilla in a Pediatric Patient: A Rare Case Report by Pranali Nimonkar, Nitin Bhola, Anendd Jadhav, Anuj Jain, Rajiv Borle, Rajul Ranka, Minal Chaudhary

“…Myxoid variant of chondrosarcoma is an uncommon potentially lethal malignant tumor which is even rare in pediatric age group. …”
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Radiographically Occult Carcinomatous Spread of Breast Cancer to the Liver: A Challenging Case by Trish Millard, Akriti Gupta, Christiana Brenin, Paul Marshall, Patrick Dillon

“…Metastatic carcinomatosis to the liver is a pattern of malignant infiltration that tends to provoke hepatic fibrosis. …”
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Combined Therapy for Distant Metastasis of Sacral Chordoma by Birol Özkal, Can Yaldız, Peyker Temiz, Cüneyt Temiz

“…Chordomas are known as rare primary malign tumours that have formed from primitive notochord remains. …”
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Two Case Presentations Infected by Trichosporon asahii and Treated with Voriconazole Successfully by Hikmet Gulsah Tanyildiz, Sule Yesil, Sule Toprak, Mehmet Onur Candir, Gurses Sahin

“…Neutropenia developing due to malignancies is an important risk factor for fungal infection. …”
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Anaesthetic management of a child with Wolf–Hirschhorn syndrome by Priyanka Das, Shalini Subramanian

“…Further, presence of various anomalies, concurrent seizures, predisposition to cardiac failure and post-operative occurrence of malignant hyperthermia pose anaesthetic challenges in patients with WHS. …”
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Duodenal Pyloric Gland Adenoma in a 59-Year-Old Asian Male by Mia Manabat, Matthew Jackson, Kha Ngo, Laurence Stawick

“…It is important that gastroenterologists are aware of these lesions and their risk of malignant transformation. More studies are needed to describe the long-term behavior of pyloric gland adenomas and to recommend appropriate endoscopic surveillance of these lesions.…”
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