Matched Unrelated Donor Hematopoietic Cell Transplantation: Increased Usage and Improvements in Clinical Outcomes in Canada by Matthew D. Seftel, Grace Musto, David Allan, Oliver Bucher, Kevin Hay, Ivan Pasic, Tony Truong, Kristjan Paulson

“…Comparing the two donor sources, the 5-year overall survival (OS) after MUD HCT for patients with malignant diseases was inferior to MRD HCT in the early era (<i>p</i> < 0.001). …”
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Salivary metabolomics in oral cancer: A systematic review by Rita Antonelli, Giacomo Setti, Nathaniel S. Treister, Thelma A. Pertinhez, Elena Ferrari, Mariana Gallo, Ronell Bologna-Molina, Paolo Vescovi, Marco Meleti

“…Diagnosis of oral squamous cell carcinoma (OSCC) is frequently delayed, with most tumors being detected in advanced stages.Saliva may represent the ideal fluid for early detection of dysplastic and malignant oral lesions. Among available salivary analytical approaches (e.g., genomic, transcriptomic, proteomic), metabolomics appears promising in identifying the presence of small, specific molecules directly released from malignant cells that could potentially serve as diagnostic biomarkers.This systematic review evaluates the scientific evidence that supports the role of salivary metabolites in the early diagnosis of OSCC.Medline, Scopus and Web of Science databases were searched until February 2024. …”
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Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report by Carolin Seeling, Sonja Dahlum, Ralf Marienfeld, Vera Jan, Brigitte Rack, Uwe Gerstenmaier, Ambros J. Beer, Regine Mayer-Steinacker, Wolfgang Thaiss, Thomas F. E. Barth, Thomas Seufferlein, Nadine T. Gaisa, Stephan Stilgenbauer, Wolfgang Janni, Reiner Siebert, Hartmut Döhner, Verena I. Gaidzik

“…Abstract Background Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome characterized by a high familial incidence of various malignancies. It results from pathogenic/likely pathogenic heterozygous constitutional variants of the TP53 gene. …”
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The Transcription Factor SOX18 Inhibitor Small Molecule 4 Is a Potential Treatment of Cancer‐Induced Lymphatic Metastasis and Lymphangiosarcoma by Katja K. Koll, Martin M. Zimmermann, Patrick A. Will, Ulrich Kneser, Christoph Hirche

“…ABSTRACT Background Malignant tumors release growth factors, promoting lymphangiogenesis in primary tumors and draining sentinel lymph nodes, ultimately facilitating lymph node metastasis. …”
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Bullatine A suppresses glioma cell growth by targeting SIRT6 by Zhi Wang, Yushuai Zhu, Can Luo, Fan Zhang, Jiannong Zhao, Chuanyi Fu

“…However, patient survival time is still short, and there is currently no successful treatment for highly malignant gliomas. Bullatine A (BLA) is a diterpenoid alkaloid of the genus Aconitum which antirheumatic and anti-inflammatory pharmacological properties. …”
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Expression of IGF-1R in oral submucous fibrosis and oral squamous cell carcinoma – An RT-PCR study by Vivek Nayyar, Vinay Hazarey, Sindhu M. Ganvir, Hemant J. Purohit, Reshma Talkal, Kiran Jot

“…Objectives: With the rising number of cases of oral submucous fibrosis (OSMF) undergoing malignant transformation into oral squamous cell carcinoma (OSCC), it is needed to detect the changes at the earliest. …”
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Syringomatous Tumour Presenting as Inversion of a Supernumerary Nipple by Louise Öwall, Henrik Mygind, Åsa Rosenborg, Anne-Vibeke Lænkholm

“…Because of the growth pattern, SyT can be mistaken for a malignant tumour, and it is therefore important to keep this diagnosis in mind. …”
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Meningothelial Meningioma Component in a Prepubertal Testicular Teratoma by Ruchi Sinha, Madhu Kumari, Ranwir Kumar Sinha, Bindey Kumar

“…Teratomas are nonseminomatous germ cell tumors composed of elements derived from more than one germinal layers (endoderm, mesoderm, and ectoderm). Malignant transformation of teratoma in the testis is well known; however, benign somatic neoplasm arising in a testicular teratoma is a rare occurrence. …”
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Epithelioid Myofibroblastoma in an Old-Male Breast: A Case Report with MRI Findings by Seyma Yildiz, Zuhal Gucin, Ezgi Basak Erdogan

“…MFB may be confused as malignant, clinically, morphologically, or by imaging. …”
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Primary splenic diffuse large B-cell lymphoma presenting with a gastrosplenic fistula: Case report by Hurerah Nawaz, Josh Greaser, Irfan Amir Kazi, Ayesha Nasrullah

“…Primary splenic diffuse large B-cell lymphoma (PS-DLBCL) is a rare manifestation of malignant lymphoma. Although DLBCL is the most common subtype of non-Hodgkin lymphoma, primary splenic involvement is uncommon. …”
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An unusual case of acute chest pain by Ananda Datta, Raghavendrun Sivasankar

“…Although fractures of the ribs usually occur due to trauma, non-traumatic fractures can be seen in the setting of vigorous as well as repetitive coughing. Usually, ribs with malignant or osteoporotic involvement are susceptible to breaking. …”
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Giant Ulcerative Dermatofibroma by Turgut Karlidag, Erol Keles, Israfil Orhan, Mehmet Erkan Kaplama, Bengu Cobanoglu

“…Dermatofibrosarcoma protuberans, which is clinically and histopathologically of malignant character, displays difficulties in the diagnosis since it has similarities with basal cell carcinoma, epidermoid carcinoma, and sarcomas. …”
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Preoperative Imaging Assessment and Staging of Perihilar Cholangiocarcinoma: Tips and Pitfalls by Yu Shan Stephanie Yong, Zhuyi Rebekah Lee, Yock Teck Nicholas Soh, Su Chong Albert Low

“…The correlation between radiological, surgical, and pathological findings is illustrated through a pictorial review of pathologically proven cases. Benign and malignant mimics of pCCA are included to provide a comprehensive overview.…”
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A Case of Pneumothorax after Treatment with Lenvatinib for Anaplastic Thyroid Cancer with Lung Metastasis by Haruhiko Yamazaki, Hiroyuki Iwasaki, Toshinari Yamashita, Tatsuya Yoshida, Nobuyasu Suganuma, Takashi Yamanaka, Katsuhiko Masudo, Hirotaka Nakayama, Kaori Kohagura, Yasushi Rino, Munetaka Masuda

“…Pneumothorax during chemotherapy for a malignant tumor is considered a relatively rare complication. …”
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Primary Paratesticular Leiomyosarcoma: A Case Report and Literature Review by Zeineb Naimi, Semia Zarraa, Salma Kammoun, Safia Yahyaoui, Maha Driss, Chiraz Nasr

“…Paratesticular soft tissue sarcomas are very rare malignant mesenchymal tumors. With only few cases reported in the literature, data regarding diagnostic and management of these tumors are limited. …”
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Arsenic Exposure and the Induction of Human Cancers by Victor D. Martinez, Emily A. Vucic, Daiana D. Becker-Santos, Lionel Gil, Wan L. Lam

“…Millions of individuals worldwide are chronically exposed through drinking water, with consequences ranging from acute toxicities to development of malignancies, such as skin and lung cancer. Despite well-known arsenic-related health effects, the molecular mechanisms involved are not fully understood; however, the arsenic biotransformation process, which includes methylation changes, is thought to play a key role. …”
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Metastatic Chordoma: A Diagnostic Challenge on Fine Needle Aspiration by Ghassan Tranesh, Aziza Nassar

“…Chordomas are primary low grade malignant tumors of bone that usually arise within both ends of axial skeleton. …”
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Uveal Melanoma and its Various Presentations – A Series of Case Reports by Sujit Das

“…Choroidal melanoma is the most common primary intra-ocular malignant tumour and the second most common metastatic site. …”
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Targeting Signaling Pathways in Cancer Stem Cells for Cancer Treatment by Jeffrey Koury, Li Zhong, Jijun Hao

“…However, dysfunctions of these pathways are evident in multiple tumor types and malignancies. Specifically, aberrant activation of these pathways is implicated in modulation of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. …”
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Whistle from Afar: A Case of Endotracheal Metastasis in Papillary Thyroid Cancer by Bitoti Chattopadhyay, Biswamit Bhattacharya, Atri Chatterjee, Pijush Kanti Biswas, Nirod Baran Debnath

“…Endotracheal metastasis is a rare situation, usually associated with malignancies of breast and gastrointestinal tract, specially colon. …”
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