Neurobiology of Major Depressive Disorder by Rosa Villanueva

“…We survey studies which relate abnormal neurogenesis to major depressive disorder. Clinically, descriptive gene and protein expression analysis and genetic and functional studies revised here show that individual alterations of a complex signaling network, which includes the hypothalamic-pituitary-adrenal axis; the production of neurotrophins and growth factors; the expression of miRNAs; the production of proinflammatory cytokines; and, even, the abnormal delivery of gastrointestinal signaling peptides, are able to induce major mood alterations. …”
Get full text

Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…Major depressive disorder (MDD) is a common mental disorder with chronic tendencies that seriously affect regular work, life, and study. …”
Get full text

Efficacy of Electroconvulsive Therapy for Neuropathic Pain Comorbid with Major Depression by Masashi Ueda, Yuki Konishi, Kohei Sakurai, Atsuko Ikenouchi, Reiji Yoshimura

“…We report a case of a 41-year-old male with postinjury neuropathic pain comorbid with major depression in which electroconvulsive therapy (ECT) was effective in relieving both neuropathic pain and major depression. …”
Get full text

Randomization and placebo effects in clinical trials of major depressive disorder by James A. Rogers, Stephen Senn

Get full text

Major Depressive Disorder and Sleep Disturbance in Patients with Chronic Pain by Patricia C Emery, Keith G Wilson, John Kowal

“…BACKGROUND: Disturbed sleep is a common problem in both chronic pain and major depressive disorder (MDD). Moreover, many patients with chronic pain are depressed.…”
Get full text

The Effects of Alexithymia on Self-Reflection and Insight in Major Depressive Disorder by Aysu Yakin Olgun, Meliha Zengin Eroglu

“…Methods: We accepted 80 patients diagnosed with major depression who were in outpatient care at our psychiatry clinic between September and December 2020, along with 80 healthy controls. …”
Get full text

Major Depressive Disorder and Measures of Cellular Aging: An Integrative Review by Patricia Anne Kinser, Debra E. Lyon

“…Major depressive disorder (MDD) affects millions of individuals and causes significant suffering worldwide. …”
Get full text

Recognition model for major depressive disorder in Arabic user-generated content by Esraa M. Rabie, Atef F. Hashem, Fahad Kamal Alsheref

Get full text

Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder by Jinkun Zeng, Qinghua Luo, Lian Du, Wei Liao, Yongmei Li, Haixia Liu, Dan Liu, Yixiao Fu, Haitang Qiu, Xirong Li, Tian Qiu, Huaqing Meng

“…We collected longitudinal diffusion tensor imaging in the first-episode, drug-naïve major depressive disorder (MDD) patients n=24 before and after a predefined time window ECT treatment. …”
Get full text

Study of Life Events and Quality of Life in Patients of Major Depressive Disorder by Alkesh Patil, Aparna Sengupta, Ashwini Mule, Sagar Karia

“…Objectives: The aim of this research was to study the relationship of major depressive disorder with quality of life and stressful life events in adults. …”
Get full text

Prediction of individual patient outcomes to psychotherapy vs medication for major depression by Devon LoParo, Boadie W. Dunlop, Charles B. Nemeroff, Helen S. Mayberg, W. Edward Craighead

“…Abstract Treatments for major depressive disorder (MDD) include antidepressant medications and evidence-based psychotherapies, which are approximately equally efficacious. …”
Get full text

Flavins and Flavoproteins in the Neuroimmune Landscape of Stress Sensitization and Major Depressive Disorder by Schrier MS, Smirnova MI, Nemeth DP, Deth RC, Quan N

“…Lauderdale, FL, USACorrespondence: Matt Scott Schrier, Florida Atlantic University, Building: MC-17, Room: 229E, 5353 Parkside Drive, Jupiter, FL, 33458, USA, Email mschrier@health.fau.eduAbstract: Major Depressive Disorder (MDD) is a common and severe neuropsychiatric condition resulting in irregular alterations in affect, mood, and cognition. …”
Get full text

PPARD May Play a Protective Role for Major Depressive Disorder by Tao Yang, Juhua Li, Liyuan Li, Xuehua Huang, Jiajun Xu, Xia Huang, Lijuan Huang, Kamil Can Kural

“…However, whether PPARD is involved in the pathological development of major depressive disorder (MDD) is largely unknown. To explore the potential connection between PPARD and MDD, we first conducted a literature-based data mining to construct a PPARD-driven MDD regulating network. …”
Get full text

Asymptomatic Deep Vein Thrombosis in a Patient with Major Depressive Disorder by Takuto Ishida, Takeshi Katagiri, Hiroyuki Uchida, Takefumi Suzuki, Koichiro Watanabe, Masaru Mimura

“…We report on an inpatient with major depressive disorder in a catatonic state in whom an asymptomatic proximal deep vein thrombosis of 11 × 70 mm was detected through routine screening, using doppler ultrasound scanning. …”
Get full text

Association of inflammation cytokines with cognitive function in first-episode major depressive disorder by Yan Qing Xi, Yan Qing Xi, Yan Qing Xi, Zong Qi Wang, Zong Qi Wang, Zong Qi Wang, Guo Juan Li, Guo Juan Li, Guo Juan Li, Zhuo Qun Hao, Zhuo Qun Hao, Zhuo Qun Hao, Jia Hui Nie, Jin Xiang Li, Yu Ting Tan, Xiao Dong Hu, Xiao Dong Hu, Gen Wei Wang, Sha Liu, Sha Liu, Yan Fang Wang, Yan Fang Wang, Yan Fang Wang

Subjects: Get full text

Neuromodulation of Attentional Control in Major Depression: A Pilot DeepTMS Study by Jodie Naim-Feil, John L. Bradshaw, Dianne M. Sheppard, Oded Rosenberg, Yechiel Levkovitz, Pinhas Dannon, Paul B. Fitzgerald, Moshe Isserles, Abraham Zangen

“…While Major Depressive Disorder (MDD) is primarily characterized by mood disturbances, impaired attentional control is increasingly identified as a critical feature of depression. …”
Get full text

Hybrid electroconvulsive therapy in an adolescent with major depressive disorder: a case report by Jing-ya Zhang, Jia Li, Nan Wang, Xin-hui Xie, Xin-hui Xie, Lun Zeng

“…Here, we report a case study of a 14-year-old male student with major depressive disorder (MDD) suffering from severe suicidality and significant impairment in social functioning who achieved effective antidepressant effects with HECT and improved cognitive function. …”
Get full text

Prevalence of major depression in elder people attending a national hospital in Lima by Magnolia Matutti Rosas, Orlando Tipismana Neyra

“…Objective: To describe, analyze prevalence and predictive risk factors associated with major depression, seniors attended outpatient psychiatric, and uninsured. …”
Get full text

Vegetable intake and major depressive disorder: insights and future directions for nutritional psychiatry by John Patrick C Toledo

Subjects: Get full text

On the Differential Diagnosis of Anxious from Nonanxious Major Depression by means of the Hamilton Scales by George Konstantakopoulos, Vasilios G. Masdrakis, Manolis Markianos, Panagiotis Oulis

“…Objective. Anxious major depressive disorder (A-MDD) is differentially diagnosed from nonanxious MDD (NA-MDD) as MDD with a cut-off score ≥7 on the HAM-D anxiety-somatization factor (ASF). …”
Get full text