A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines by Linghong Huang, Xinyuan Sun, Qinhua Zuo, Ting Song, Ning Liu, Zonghua Liu, Wei Xue

“…The selected PROTAC drug (ARV-825) can specifically degrade BRD4 without harming immune cells. Specifically, magnetic nanoclusters (MNC) coated with calcium-doped manganese carbonate (Ca/MnCO3), were used to load PROTAC drug (ARV-825) and anti-PD1, forming the MNC@Ca/MnCO3/ARV/anti-PD1 system. …”
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Effects of Simultaneously Performed Dual-Task Training with Aerobic Exercise and Working Memory Training on Cognitive Functions and Neural Systems in the Elderly by Hikaru Takeuchi, Daniele Magistro, Yuka Kotozaki, Kosuke Motoki, Keyvan Kashkouli Nejad, Rui Nouchi, Hyeonjeong Jeong, Chiho Sato, Salvatore Sessa, Ryoichi Nagatomi, Massimiliano Zecca, Atsuo Takanishi, Ryuta Kawashima

“…Prior to and after training, all the subjects underwent cognitive testing, magnetic resonance imaging (MRI) involving diffusion tensor imaging (DTI), and functional MRI during performance of an N-back WM task. …”
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Varicella Zoster Virus-induced Acute Retinal Necrosis Following Acute Meningoencephalitis in a Patient with Presumed COVID-19 by Kiana Hassanpour, Faezeh Khorasanizadeh, Mahmood Nabavi, Narsis Daftarian, Alireza Ramezani

“…Case Report: A 58-year-old female presented to our emergency department with sudden unilateral visual loss following a recent hospitalization for viral meningoencephalitis. Magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis, polymerase chain reaction (PCR) of the aqueous humor, reverse transcription polymerase chain reaction (RTPCR) of the nasopharyngeal swab specimen, chest computed tomography (CT), and fundus photography were performed for the patient. …”
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Research on F10.7 Index Prediction Based on Factor Decomposition and Feature Enhancement by Shuainan Yan, Yanmei Cui, Bingxian Luo, Liqin Shi, Yanxia Cai

“…We incorporate additional features such as the soft X-ray flare index (FI _SXR ), magnetic type of the active region (new_Mag), and X-ray background flux (XBF) to enhance the understanding of the underlying physical processes of solar activity. …”
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Pulse-profile Modeling and Spin–Orbit Alignment in a Suzaku Sample of Accreting X-Ray Binary Pulsars by Silas G. T. Laycock, Rigel C. Cappallo, Pragati Pradhan, Dimitris M. Christodoulou, Biswajit Paul

“…The implications of our study are as follows: (a) apparently, accretion torques have had time to erase spin–orbit misalignment caused by supernova kicks in two-thirds of the systems; (b) many X-ray binary pulsars have dominant dipolar surface magnetic fields, in contrast to the recently reported exotic configurations in millisecond pulsars; and (c) if the binary inclinations can be determined by pulse-profile modeling, even for a subset of the ∼200 known X-ray binary pulsars, most of which orbital inclinations are as yet poorly constrained, it raises the prospect of tightening dramatically ongoing neutron-star mass determinations. …”
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Influences of Solar Wind Parameters on Energetic Electron Fluxes at Geosynchronous Orbit Revealed by the Deep SHAP Method by Jianhang Wang, Zheng Xiang, Binbin Ni, Deyu Guo, Yangxizi Liu, Junhu Dong, Jingle Hu, Haozhi Guo

“…Backpropagating the prediction results of this ANN model from 2011 to 2020, SHAP values for four solar wind parameters (interplanetary magnetic field (IMF) BZ, solar wind speed, solar wind dynamic pressure, and proton density) are calculated and comprehensively analyzed. …”
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Hypoxylon luteogranulatum (Hypoxylaceae, Xylariales), a novel species from Thailand with distinct chemical and ecological traits by Sarunyou Wongkanoun, Esteban Charria-Girón, Marjorie Cedeño-Sanchez, Boonchuai Chainuwong, Sayanh Somrithipol, Eric Kuhnert, Prasert Srikitikulchai, Natapol Pornputtapong, Frank Surup, Jennifer Luangsa-ard, Marc Stadler

“…Its identity was confirmed after purification by preparative high-performance liquid chromatography with nuclear magnetic resonance (NMR) data, and genome analysis of H. lechatii revealed the presence of different hybrid polyketide synthases-non-ribosomal peptide synthetases (PKS-NRPS) hybrid clusters. …”
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Combining interictal intracranial EEG and fMRI to compute a dynamic resting-state index for surgical outcome validation by Varina L. Boerwinkle, Kristin M. Gunnarsdottir, Bethany L. Sussman, Sarah N. Wyckoff, Emilio G. Cediel, Belfin Robinson, William R. Reuther, Aryan Kodali, Sridevi V. Sarma

“…We developed a novel seizure onset network characterization tool that combines dynamic biomarkers of resting-state intracranial stereoelectroencephalography (rs-iEEG) and resting-state functional magnetic resonance imaging (rs-fMRI), vetted against surgical outcomes. …”
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Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls by Niraj S. Patel, Michael R. Peterson, Grace Y. Lin, Ariel Feldstein, Bernd Schnabl, Ricki Bettencourt, Ekihiro Seki, Claude B. Sirlin, Rohit Loomba

“…Ectopic fat deposition in the pancreas and its relationship with hepatic steatosis and insulin resistance have not been compared between patients with nonalcoholic fatty liver disease (NAFLD) and healthy controls. Aim. Using a novel magnetic resonance imaging (MRI) based biomarker, the proton-density-fat-fraction (MRI-PDFF), we compared pancreatic fat content in patients with biopsy-proven NAFLD to healthy controls and determined whether it is associated with insulin resistance and liver fat content. …”
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Susceptibility map-weighted MRI can distinguish tremor-dominant Parkinson’s disease from essential tremor by Sungyang Jo, Chong Hyun Suh, Sangjin Lee, Jihyun Lee, MyungKi Yoon, Hwon Heo, Woo Hyun Shim, Sang Joon Kim, Eung Yeop Kim, Sun Ju Chung

“…Patients with PD exhibit loss of the dorsal nigral hyperintensity on brain magnetic resonance imaging (MRI). Novel MRI-based approaches, including susceptibility map-weighted imaging (SMwI), allow visualization of the dorsal nigral hyperintensity at an increased resolution. …”
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Case report: Prolonged and severe hungry bone syndrome after parathyroidectomy in X-linked hypophosphatemia by Giulia Puliani, Valeria Hasenmajer, Matteo Spaziani, Matteo Spaziani, Federico Frusone, Chiara Tarantino, Francesco Angelini, Ludovica Vincenzi, Riccardo Lubrano, Alessia Marcellino, Marco Biffoni, Andrea M. Isidori, Andrea M. Isidori

“…Neck ultrasonography, neck magnetic resonance imaging, and 99Tc-sestamibi parathyroid scintigraphy revealed two hyperplastic parathyroid glands. …”
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Post-traumatic pituitary stalk transection syndrome (PSTS) expeditiously manifested after a fall from a height combined with acute traumatic spinal cord injury: a rare case report... by Yohei Ishiki, Atsuko Tamaki, Ken-ichiro Honma, Ken Yonaha, Takamitsu Yabiku, Taiki Teruya, Moriyuki Uehara, Yoshiro Nakayama, Rei Chinen, Tsugumi Uema, Sawako Nakachi, Shiki Okamoto, Hiroaki Masuzaki

“…Importantly, these conditions are often confused due to their similar names and resembling findings on magnetic resonance imaging (MRI). PSIS has been thought to be a prenatal developmental event resulting from a couple of genetic aberrations. …”
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Extreme Heating of Minor Ions in Imbalanced Solar-wind Turbulence by Michael F. Zhang, Matthew W. Kunz, Jonathan Squire, Kristopher G. Klein

“…Additional features include a steep transition-range electromagnetic spectrum, proton-cyclotron waves propagating in the direction of the imbalance, significantly enhanced proton-to-electron heating ratios, ion temperatures that are considerably more perpendicular with respect to magnetic field, and extreme heating of heavier species in a manner consistent with mass scalings inferred from spacecraft measurements. …”
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Pediatric Intracochlear Schwannoma: Case Series and Review of the Literature by Enrico Liaci, Maurizio Negri, Francesco Maccarrone, Silvia Piccinini, Enrico Pasanisi, Andrea Bacciu, Filippo Di Lella

“…Putative diagnosis is made on the basis of magnetic resonance findings with signal characteristics that should remain the same at follow-up imaging. …”
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Intravoxel incoherent motion (IVIM) MRI-derived masseter muscle characteristics: a new diagnostic marker in head and neck cancer? by Kai-Lun Cheng, Hsueh-Ju Lu, Chao-Yu Shen, Chia-Wei Lin, Hui-Yu Wang, Ying-Hsiang Chou, Yeu-Sheng Tyan, Ping-Huei Tsai

“…Abstract Background To use intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) to evaluate the masseter muscle and tumors in patients with head and neck cancer (HNC) and to compare them with those of normal controls. …”
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A data driven approach for soft tissue biomarker identification linked to Chiari-like malformation and syringomyelia by Jake Cumber, Jake Cumber, Emma Scales-Theobald, Emma Scales-Theobald, Clare Rusbridge, Clare Rusbridge, Clare Rusbridge, Kevin Wells, Kevin Wells

“…CM is characterized by overcrowding of the brain and cervical spinal cord and is predisposed by skull-base shortening and miniaturization with brachycephalic toy dogs overwhelmingly represented. Magnetic resonance imaging (MRI) is conventionally used for diagnosis; however, CM is complex and ubiquitous in some dog breeds so that diagnosis of CM-P relies on a combination of clinical signs, MRI, and elimination of other causes of pain. …”
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NARX Neural Network Derivations of the Outer Boundary Radiation Belt Electron Flux by D. A. Landis, A. A. Saikin, I. Zhelavskaya, A. Y. Drozdov, N. Aseev, Y. Y. Shprits, M. F. Pfitzer, A. G. Smirnov

“…., 5 min time steps) with the most efficient number of hidden layers set to 10. Magnetic local time, Dst, Kp, solar wind dynamic pressure, AE, and solar wind velocity were found to perform as predicative indicators of GOES‐15 flux and therefore were used as the exogenous inputs. …”
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Multimodal fusion model for diagnosing mild cognitive impairment in unilateral middle cerebral artery steno-occlusive disease by Ziyi Yuan, Zhaodi Huang, Chaojun Li, Shengrong Li, Qingguo Ren, Xiaona Xia, Qingjun Jiang, Daoqiang Zhang, Qi Zhu, Xiangshui Meng, Xiangshui Meng

“…ObjectivesTo propose a multimodal functional brain network (FBN) and structural brain network (SBN) topological feature fusion technique based on resting-state functional magnetic resonance imaging (rs-fMRI), diffusion tensor imaging (DTI), 3D-T1-weighted imaging (3D-T1WI), and demographic characteristics to diagnose mild cognitive impairment (MCI) in patients with unilateral middle cerebral artery (MCA) steno-occlusive disease.MethodsThe performances of different algorithms on the MCI dataset were evaluated using 5-fold cross-validation. …”
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Association of altered cortical gyrification and working memory in male early abstinent alcohol-dependent individuals by Hai-ling Cao, Wei Wei, Ya-jing Meng, Yu-jie Tao, Xia Yang, Tao Li, Wan-jun Guo

“…This study aimed to explore cortical gyrification using the local gyrification index (LGI) between alcohol-dependent patients and controls. Methods: Magnetic resonance images were collected from 60 early abstinent patients with AD (5–12 days after stopping alcohol consumption) and 59 controls and preprocessed using FreeSurfer, followed by surface-based morphometry (SBM) analysis to compare the LGI between the two groups. …”
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MR Angiography of Peripheral Arterial Stents: In Vitro Evaluation of 22 Different Stent Types by Matthias C. Burg, Alexander C. Bunck, Harald Seifarth, Boris Buerke, Harald Kugel, Volker Hesselmann, Michael Köhler, Walter Heindel, David Maintz

“…To evaluate stent lumen visibility of a large sample of different peripheral arterial (iliac, renal, carotid) stents using magnetic resonance angiography in vitro. Materials and Methods. 21 different stents and one stentgraft (10 nitinol, 7 316L, 2 tantalum, 1 cobalt superalloy, 1 PET + cobalt superalloy, and 1 platinum alloy) were examined in a vessel phantom (vessel diameters ranging from 5 to 13 mm) filled with a solution of Gd-DTPA. …”
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