Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells by Raffaele Nuzzi, Monica Gunetti, Deborah Rustichelli, Barbara Roagna, Francesca Fronticelli Bardelli, Franca Fagioli, Ivana Ferrero

“…Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. …”
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Comparison of different decellularization methods for human anterior lens capsules by Jianfeng Yu, Pengfei Li, Kai Fan, Jiawei Luo, Huaijin Guan

“…Abstract Background Human anterior lens capsules (ALCs) have great potential in the treatment of multiple eye diseases, including corneal ulcers, glaucoma, age-related macular degeneration and macular holes. ALCs are also regarded as promising scaffolds for various ocular cells. …”
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Alzheimer’s Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model by Mariana Antonia Aguiar-Furucho, Francisco Javier Ropero Peláez

“…Several research studies point to the fact that sensory and cognitive reductions like cataracts, deafness, macular degeneration, or even lack of activity after job retirement, precede the onset of Alzheimer’s disease. …”
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The endocannabinoid system and ophthalmic pathologies: a review of molecular mechanisms and its implications for clinical practice by Tomasz Charytoniuk, Stanisław Półjanowski, Mateusz Michalak, Karolina Kaźmierczak, Bartłomiej Kałużny

“…Furthermore, various research indicated the involvement of ECS in the molecular basis of various pathologies, mostly glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD). Therefore, the researchers believe that this biological system, its receptors, pathways, and ligands might be considered as an auxiliary compound to reduce the number of patients suffering from ophthalmic diseases. …”
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Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians by Pearse A. Keane, Srinivas R. Sadda

“…Around this time, it also became clear that increased intraocular VEGF production was not limited to ischemic retinal diseases but was also a feature of choroidal vascular diseases such as neovascular age-related macular degeneration (AMD). Thus, a new therapeutic era emerged, utilizing VEGF blockade for the management of chorioretinal diseases characterized by vascular hyperpermeability and/or neovascularization. …”
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"Energetics of the outer retina II: Calculation of a spatio-temporal energy budget in retinal pigment epithelium and photoreceptor cells based on quantification of cellular process... by Christina Kiel, Stella Prins, Alexander J E Foss, Philip J Luthert

“…Impaired energy metabolism combined with high demands are expected to cause energy insufficiencies that make the OR susceptible to complex blinding diseases such as age-related macular degeneration (AMD). Here, anatomical, physiological and quantitative molecular data were used to calculate the ATP expenditure of the main energy-consuming processes in three cell types of the OR for the night and two different periods during the day. …”
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Posterior Chamber Hemorrhage during Fluorescein Angiography by Manuel A. P. Vilela

“…A 76-year-old male was referred for angiographic control of age-related macular degeneration. He was pseudophakic OU, BCVA 20/40 OU. …”
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Anti-Vascular Endothelial Growth Factors as a Potential Risk for Implant Failure: A Clinical Report by Elham Emami, Pierre de Grandmont, Mélanie Menassa, Nicholas Audy, Robert Durand

“…This clinical report presents a rare case of implant failure in a patient who received intravitreal injections of a vascular endothelial growth factor (VEGF) inhibitor for the treatment of age-related macular degeneration. Following CARE guidelines, the report presents a case rehabilitated with a mandibular 2-implant overdenture using the immediate-loading protocol and standard procedures. …”
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Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. by Nehal Nailesh Mehta, Ines D Nagel, Akshay Agnihotri, Anna Heinke, Lingyun Cheng, Dirk-Uwe Bartsch, William R Freeman, Maria-Laura Gomez

“…<h4>Purpose</h4>To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.…”
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Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases by Maria H. Madeira, Raquel Boia, Paulo F. Santos, António F. Ambrósio, Ana R. Santiago

“…This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.…”
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The Association of Retinal Disease with Vision Impairment and Functional Status in Medicare Patients by Vincent Garmo, Xiaohui Zhao, Carmen D. Ng, Aimee Near, Tania Banerji, Keiko Wada, Gary Oderda, Diana Brixner, Joseph Biskupiak, Ferhina S. Ali, Archad M. Khanani, Alicia Menezes, Ibrahim M. Abbass

“…**Background:** The association of neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO) with functional status in the general Medicare population are not well established. …”
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Multi-omic spatial effects on high-resolution AI-derived retinal thickness by V. E. Jackson, Y. Wu, R. Bonelli, J. P. Owen, L. W. Scott, S. Farashi, Y. Kihara, M. L. Gantner, C. Egan, K. M. Williams, B. R. E. Ansell, A. Tufail, A. Y. Lee, M. Bahlo

“…The macula is disproportionately affected by high disease burden retinal disorders such as age-related macular degeneration and diabetic retinopathy, which both involve metabolic dysregulation. …”
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Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

“…Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through anti-inflammatory activity in RPE cells. …”
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Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies? by Chunyan Xue, Richard Rosen, Adrienne Jordan, Dan-Ning Hu

“…The effects of lutein and zeaxanthin on the prevention and treatment of various eye diseases, including age-related macular degeneration, diabetic retinopathy and cataract, ischemic/hypoxia induced retinopathy, light damage of the retina, retinitis pigmentosa, retinal detachment, and uveitis, have been studied in different experimental animal models. …”
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Predictive Factors in OCT Analysis for Visual Outcome in Exudative AMD by Maria-Andreea Gamulescu, Georgios Panagakis, Carmen Theek, Horst Helbig

“…This is a retrospective analysis of 87 patients with exudative age-related macular degeneration who received three monthly intravitreal ranibizumab injections. …”
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Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications by Claudio Campa, Ciro Costagliola, Carlo Incorvaia, Carl Sheridan, Francesco Semeraro, Katia De Nadai, Adolfo Sebastiani, Francesco Parmeggiani

“…Choroidal neovascularization (CNV) is a common and severe complication in heterogeneous diseases affecting the posterior segment of the eye, the most frequent being represented by age-related macular degeneration. Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. …”
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Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease by Ishaq A. Viringipurampeer, Abu E. Bashar, Cheryl Y. Gregory-Evans, Orson L. Moritz, Kevin Gregory-Evans

“…Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. …”
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The Efficacy of Conbercept in Polypoidal Choroidal Vasculopathy: A Systematic Review by Yimin Wang, Mengxi Shen, Jinwei Cheng, Xiaodong Sun, Peter K. Kaiser

“…The use of antivascular endothelial growth factor (VEGF) therapy in polypoidal choroidal vasculopathy (PCV), a subtype of neovascular age-related macular degeneration (nAMD), has been well established in randomized clinical trials. …”
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RatDNA: DATABASE ON MICROARRAY STUDIES OF RATS BEARING GENES ASSOCIATED WITH AGE-RELATED DISEASES by O. S. Kozhevnikova, M. K. Martyschenko, M. A. Genaev, E. E. Korbolina, N. A. Muraleva, N. G. Kolosova, Y. L. Orlov

“…People do not die of «healthy» aging: at any age conditions whose probability increases with age become the cause of their death. Age-related macular degeneration (AMD) becomes the main cause of vision problems and sight loss in people aged above 50. …”
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Visual, Musculoskeletal, and Balance Complaints in AMD: A Follow-Up Study by Christina Zetterlund, Hans Olof Richter, Lars-Olov Lundqvist

“…To investigate whether patients with age-related macular degeneration (AMD) run a potentially higher risk of developing visual, musculoskeletal, and balance complaints than age-matched controls with normal vision. …”
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